摘要
桥本氏甲状腺炎是一种自身免疫性疾病,临床检查以血清中TPOAb和TgAb的滴度显着增加为主,病理表现为淋巴细胞浸润、正常的甲状腺滤泡变小萎缩、间质纤维化。桥本氏甲状腺炎的实验模型构建是研究疾病的发病原因、病理机制和治疗方法的基础,本文主要从构建实验性桥本氏甲状腺炎的动物选择、动物模型构建方法、动物模型评价指标和细胞实验选择及相关机制验证方面进行综述,通过比较相关造模方式的优缺点,为相关工作者的基础研究提供参考和借鉴。
Hashimoto’s thyroiditis is an autoimmune disease.The clinical examination is mainly based on the significant increase of TPOAb and TgAb titers in the serum.The pathological manifestations are lymphocyte infiltration,normal thyroid follicles shrink and atrophy,interstitial fibrosis.The construction of the experimental model of Hashimoto’s thyroiditis is the basis for research the causes,pathological mechanisms and treatment methods.This article mainly focuses on the animal selection,animal model construction methods,animal model evaluation and cell experiments for selection and the verification of related mechanisms of Hashimoto’s thyroiditis.By comparing the advantages and disadvantages of related modeling methods,it can provide reference for the basic research of related workers.
作者
孙伯菊
吴丽丽
秦灵灵
张程斐
吴悠
秦帅
王明慧
刘铜华
Sun Boju;Wu Lili;Qin Lingling;Zhang Chengfei;Wu You;Qin Shuai;Wang Minghui;Liu Tonghua(Second Clinical Medical College,Beijing University of Traditional Chinese Medicine,Beijing 100028;Science and Technology Department,Beijing University of Traditional Chinese Medicine,Beijing 100028;Beijing University of Traditional Chinese Medicine,Beijing 102488;Key Laboratory of Traditional Chinese Medicine Health,Ministry of Education,Beijing University of Traditional Chinese Medicine,Beijing 100028;Chengdu University of Traditional Chinese Medicine Clinical Medical College,chengdu 611137;The First Clinical Medical College of Shaanxi University of Traditional Chinese Medicine,shanxi 712046)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2020年第7期2205-2210,共6页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家科学技术部国家国际科技合作专项项目(2015DFA30910):中药干预桥本氏甲状腺炎活性筛选技术与组方优化研究,负责人:刘铜华
