Welcome to the Special Issue highlighting the latest innovative research conducted by young scientists who have received the 2023 or the 2024 Innovative Young Scientist Awards.Established in 2023 by the University of ...Welcome to the Special Issue highlighting the latest innovative research conducted by young scientists who have received the 2023 or the 2024 Innovative Young Scientist Awards.Established in 2023 by the University of Science and Technology Beijing,the Innovative Young Scientist Award recognizes exceptional young scientists who have demonstrated sustained engagement in frontier research across mineral science,metallurgy,and materials science,with significant scientific contributions.Committed to fostering the next generation of scientific leaders,the award supports researchers aged under 45.Since its inception,the honor has been bestowed upon 20 recipients,with 10 outstanding researchers selected annually from a competitive pool of approximately 100 applicants.展开更多
The global issue of climate change presents young entrepreneurs with opportunities to explore new business models.FACED with the severe challenges presented by global climate change,pursuing a green lifestyle is a way...The global issue of climate change presents young entrepreneurs with opportunities to explore new business models.FACED with the severe challenges presented by global climate change,pursuing a green lifestyle is a way to achieve sustainable development.Many countries are exploring ways to reach a balance between economic development and environmental protection.展开更多
Introduction: Considering a disease of postmenopausal women, there is a noted trend of increasing breast cancer cases among premenopausal women. Our study aimed to determine the main risk factors for breast cancer in ...Introduction: Considering a disease of postmenopausal women, there is a noted trend of increasing breast cancer cases among premenopausal women. Our study aimed to determine the main risk factors for breast cancer in women aged 40 and under. Materials and Methods: This was a case-control study with exhaustive sampling of all respondents with histological proof over a 12-month period, matched by age. For all statistical tests, we used a significance threshold of 5%. Additionally provided are the ORs and their 95% confidence intervals, the mean, and standard deviation. Results: We collected 65 cases and 130 controls. The frequency of breast cancer in women aged 40 and under was 35.5%. The mean age was 35.6 ± 4.5 years among cases compared to 32.1 ± 7.9 years among controls. A significantly positive association was detected in both univariate and multivariate analysis between age and breast cancer [(OR) = 10.30;95% CI (1.99 - 53.23)] and [(OR) = 7.53;95% CI (1.82 - 31.23)];family history of breast cancer and breast cancer [(OR) = 9.99;95% CI (1.43 - 69.58)];smoking and breast cancer [OR = 13.11;95% CI (1.05 - 163.30)];sedentary lifestyle and breast cancer [OR = 3.36;95% CI (1.01 - 11.17)];and night work and breast cancer [(OR) = 72.05;95% CI (8.15 - 637.25)]. Conclusion: Earlier systematic screening and regular follow-up should be conducted in young women in our context.展开更多
Objectives:This study aimed to generate a theoretical framework based on empirical data to explain the behavioral patterns closely related to young and middle-aged patients with lymphoma throughout the disease.Methods...Objectives:This study aimed to generate a theoretical framework based on empirical data to explain the behavioral patterns closely related to young and middle-aged patients with lymphoma throughout the disease.Methods:This study followed the classic grounded theory methodology,involving procedures such as theoretical sampling,substantive coding,theoretical coding,constant comparison,and memo writing and sorting.Multiple data types were used based on the principle of“all is data,”including 34 participants providing interview data along with observation notes and 40 relevant secondary texts from the“Lymphoma House”network platform and the“Lymphoma House 086”public account.Two autobiographical books written by lymphoma patients were also selected as data resources.Data collection and analysis were conducted in an iterative process until theoretical saturation was reached.The COREQ checklist was followed to report this study.Results:The main concern of middle-aged and young patients with lymphoma was identifiedas restoring normality,while managing uncertainty was the main behavioral pattern for restoring normality.Uncertainty consists of two interrelated types:inherent uncertainty of illness and perceived uncertainty of patients.Four strategies are used to manage uncertainty:reconstructing certainty,adaptive coping,defensive buffering,and compensatory changing.Managing uncertainty is influenced by disease characteristics and perceptions,social resources,and cultural concepts.The consequence of managing uncertainty is reaching a new normality.Conclusions:Pervasive uncertainty significantly affects the daily lives of young and middle-aged patients with lymphoma.Consequently,strategies for managing disease-related uncertainty to sustain normality are commonly observed in this population.This theoretical framework for addressing uncertainty can serve as a foundation for understanding and developing tailored interventions to manage uncertainty.Future research should focus on managing uncertainty to help patients restore normality.展开更多
Objectives:This study aimed to classify young breast cancer patients into distinct ambivalence over emotional expression and to explore the factors influencingthe level of ambivalence over emotional expression.Methods...Objectives:This study aimed to classify young breast cancer patients into distinct ambivalence over emotional expression and to explore the factors influencingthe level of ambivalence over emotional expression.Methods:A total of 217 young breast cancer patients were enrolled from a tertiary Grade A oncology hospital in Tianjin,China,using the convenience sampling method.All participants completed the general questionnaire,Ambivalence over Emotion Expression Questionnaire(AEQ),and Family Adapt-Ability and Cohesion Evaluation Scales-Chinese Version(FACES-CV).We employed exploratory latent profileanalysis for ambivalence over emotional expression profilingand logistic regression analysis to identify the influentialfactors Results:The results of the latent profileanalysis supported the models of four latent profiles,which were definedas“low conflict-lowexpression reflection”(19.2%),“high conflict-high inhibition expression”(43.9%),“moderate conflict-highregret expression”(18.1%),and“moderate conflict-desire understand”(18.8%).Logistic regression revealed that family cohesion,marital status,residence,per capita monthly income,and cancer stage were the influencingfactors of ambivalence over emotional expression in young breast cancer patients(P<0.05)Conclusions:Levels of ambivalence over emotional expression ameast cancer patients with breast cancer were highly heterogeneous.Medical staff should provide psychological counseling and health education tailored to the unique characteristics of emotional expression ambivalence in different patient groups to promote healthy emotional expression among patients.展开更多
Objective:This randomized controlled trial aimed to assess the impact of a targeted educational intervention on the awareness and practice of genetic screening and counseling among young adults in Calabar Municipality...Objective:This randomized controlled trial aimed to assess the impact of a targeted educational intervention on the awareness and practice of genetic screening and counseling among young adults in Calabar Municipality,Cross River State.Materials and Methods:Participants(aged 18-45)were randomly assigned to either an intervention group receiving structured health education or a control group receiving general health information.Stratified randomization was used between the groups.A sample size of 340 participants was recruited to detect a 20%difference in outcomes with 80%power.Data were collected using prevalidated questionnaires at baseline,immediately after the intervention,and at a 3-month follow-up.The intervention consisted of three weekly 90-min educational sessions covering genetics,the benefits of screening,and practical guidance on accessing genetic services.The primary outcomes were changes in awareness and practices related to genetic screening,with secondary outcomes focusing on attitudes and intentions toward genetic counseling.Results:Findings revealed that awareness of genetic screening was higher in the intervention group,with 65.9%of participants aware of early detection,compared to 59.4%in the control group,although the difference was not statistically significant(P=0.23).In terms of practice,42.9%of the intervention group and 40.0%of the control group engaged in genetic screening programs,with no significant difference(P=0.57).Logistic regression analysis highlighted that age,educational level,and knowledge of teratogens were significant predictors of genetic screening awareness.Participants aged 36 years and above were 1.52 times more likely to be aware(odds ratio[OR]=1.52,P=0.003),and those with tertiary education had nearly double the likelihood of awareness(OR=1.96,P<0.001).Conclusion:The study underscores the importance of targeted education in improving genetic screening awareness.展开更多
The association between sugar-sweetened beverages(SSBs)intake and hair loss condition might give scientific support for better dietary practices to prevent hair loss.We aimed to explore the association of SSBs intake ...The association between sugar-sweetened beverages(SSBs)intake and hair loss condition might give scientific support for better dietary practices to prevent hair loss.We aimed to explore the association of SSBs intake with the hair loss condition in women.This online cross-sectional study,conducted from January 2022 to April 2022,recruited 1169 women aged 18-45 years from 31 provinces on mainland of China.We u sed the updated version of the 15-item Beverage Intake Questionnaire(BEVQ-15)to evaluate the usual beverage consumption over the past month and the Hair-Shedding Visual Scale for Asian Women(HSVS-A)to evaluate the extent of hair shedding.We utilized binary logistic regression to assess the association between SSBs intake and hair loss.Among 1169 female participants with an average age of 27.2,there were 211(18.0%)participants with hair loss.Compared with participants who never drank SSBs,those who drank m ore than 7 times/week or 1000 mL/week were more likely to have hair loss,with an adjusted odds ratio(OR)of 2.25(95%confidence interval(CI)=1.32,3.83)or 2.22(95%CI=1.28,3.85).Furthermore,the m ediation effect of anxiety status on the association between SSBs and female hair loss was observed,with a significant indirect effect(β_(indirect)=0.0199,95%CI=0.0032,0.0418).In conclusion,our study showed that w omen who consumed higher amounts of SSBs had an increased risk of hair loss,which might attract more attention from young women and benefit from reducing SSBs consumption.Further longitudinal and interventional studies are still needed to confirm the current association and provide evidenced-based health education.展开更多
As an emerging multifunctional metal with the lowest melting point except for mercury,gallium combines a wide range of metallic and non-metallic elements to form advanced semiconductors critically important in cutting...As an emerging multifunctional metal with the lowest melting point except for mercury,gallium combines a wide range of metallic and non-metallic elements to form advanced semiconductors critically important in cutting-edge technologies.However,due to its low melting point and poor machinability,it is quite difficult to simultaneously characterize gallium’s elastic properties and damping characteristics using conventional methods,which is es-sential in designing and evaluating gallium-based structures.Therefore,developing effective methods to achieve accurate and efficient measurements of Young’s modulus and corresponding internal friction of gallium is of great significance.This letter studies simultaneous measurements of the variations in Young’s modulus and internal friction of gallium at varying temperatures by employing the modified piezoelectric ultrasonic composite oscil-lator technique.Combining the explicit theoretical formulas with the measured resonance and anti-resonance frequencies,it has been discovered that Young’s modulus undergoes an approximately linear decrease as the temperature rises,declining from 83.84 GPa at -70℃ to 79.37 GPa at 20℃.Moreover,like aluminum in the same Group ⅢA of the Periodic Table of Elements and exhibits a grain-boundary internal friction peak,gallium displays a longitudinal internal friction peak at approximately-12°C,with the peak value reaching 1.77×10^(-3).This basic research on gallium’s elastic properties and damping characteristics under low-temperature condi-tions will inspire further explorations of the mechanical properties of a diverse spectrum of low-melting-point functional materials and facilitate applications of gallium-based structures under complex conditions.展开更多
BACKGROUND Breast cancer(BC)is the second most common malignancy globally.Young and middle-aged patients face more pressures from diagnosis,treatment,costs,and psychological issues like self-image concerns,social barr...BACKGROUND Breast cancer(BC)is the second most common malignancy globally.Young and middle-aged patients face more pressures from diagnosis,treatment,costs,and psychological issues like self-image concerns,social barriers,and professional challenges.Compared to other age groups,they have higher recurrence rates,lower survival rates,and increased risk of depression.Research is lacking on factors influencing depressive symptoms and predictive models for this age group.AIM To analyze factors influencing depressive symptoms in young/middle-aged BC patients and construct a depression risk predictive model.METHODS A total of 360 patients undergoing BC treatment at two tertiary hospitals in Jiangsu Province,China from November 2023 to April 2024 were included in the study.Participants were surveyed using a general information questionnaire,the patient health questionnaire depression scale,the visual analog scale for pain,the revised family support scale,and the long form of the international physical activity questionnaire.Univariate and multivariate analyses were conducted to identify the factors affecting depression in middle-aged and young BC patients,and a predictive model for depression risk was developed based on these findings.RESULTS Among the 360 middle-aged and young BC patients,the incidence rate of depressive symptoms was 38.61%(139/360).Multivariate analysis revealed that tumor grade,patient’s monthly income,pain score,family support score,and physical activity score were factors influencing depression in this patient group(P<0.05).The risk prediction model constructed based on these factors yielded an area under the receiver operating characteristic curve of 0.852,with a maximum Youden index of 0.973,sensitivity of 86.80%,specificity of 89.50%,and a diagnostic odds ratio of 0.552.The Hosmer-Lemeshow test for goodness of fit indicated an adequate model fit(χ^(2)=0.360,P=0.981).CONCLUSION The constructed predictive model demonstrates good predictive performance and can serve as a reference for medical professionals to early identify high-risk patients and implement corresponding preventive measures to decrease the incidence of depressive symptoms in this population.展开更多
AIM:To evaluate the prevalence of early post-traumatic stress disorder(PTSD)among young and middle-aged patients who have suffered open globe injuries,and to identify the psychosocial factors influencing PTSD in these...AIM:To evaluate the prevalence of early post-traumatic stress disorder(PTSD)among young and middle-aged patients who have suffered open globe injuries,and to identify the psychosocial factors influencing PTSD in these patients.METHODS:A total of 280 patients who underwent ocular trauma surgery between January 2023 and January 2024 were selected through convenience sampling.Data were collected using a custom-designed demographic questionnaire,the Connor-Davidson Resilience Scale(CDRISC),the Cognitive Emotion Regulation Questionnaire(C-ERRI),and the PTSD Checklist-Civilian Version(PCL-C).Univariate analysis and stepwise multiple linear regression analysis were performed to determine the factors affecting PTSD in these patients.RESULTS:The average PTSD score for the patients was 33.22±13.48.The scores for individual PTSD dimensions,ranked from highest to lowest,were recurrent traumatic experiences,heightened arousal,avoidance reactions,and social dysfunction.Positive PTSD symptoms were observed in 85 patients(30.36%).Univariate analysis indicated that gender,postoperative vision,marital status,psychological resilience,and rumination were significant factors affecting PTSD symptoms(χ^(2)/t=6.53,17.88,8.83,2.17,and 14.1,respectively;all P<0.05).Pearson correlation analysis showed a positive correlation between rumination and PTSD symptoms(r=0.73,P<0.01)and a negative correlation between psychological resilience and PTSD symptoms(r=-0.14,P<0.05).Stepwise multiple linear regression analysis identified postoperative vision(notably eye removal),rumination levels,and psychological resilience(optimism)as major factors influencing PTSD in these patients(R^(2)=0.57,P<0.001).CONCLUSION:Young and middle-aged patients with open globe injuries have a high incidence of PTSD.Significant risk factors for early PTSD include primary enucleation,high levels of rumination,and low psychological resilience(optimism).Conversely,patients with good postoperative vision recovery,low rumination levels,and high levels of optimism are less likely to develop PTSD.Healthcare providers should pay special attention to patients who undergo primary enucleation,strive to reduce their rumination levels,and enhance their psychological resilience,thereby promoting a positive and optimistic attitude towards their condition and reducing the incidence of PTSD.展开更多
BACKGROUND Acute myocardial infarction(AMI)is rare among patients aged≤40 years but imposes significant morbidity,psychological distress,and economic burden.App-roximately 10%of AMI hospitalizations involve patients ...BACKGROUND Acute myocardial infarction(AMI)is rare among patients aged≤40 years but imposes significant morbidity,psychological distress,and economic burden.App-roximately 10%of AMI hospitalizations involve patients under 45 years,under-scoring the need to study this group.Compared to older patients,young AMI pa-tients exhibit fewer traditional risk factors(e.g.,hypertension,diabetes)but higher rates of smoking,obesity,and non-atherosclerotic causes like spontaneous coro-nary artery dissection or coronary spasm,often linked to substance use.Global trends show rising obesity and dyslipidemia in young populations,with smoking contributing to 62%–90%of AMI cases in this age group.Family history of coro-nary artery disease also elevates risk,particularly in acute coronary syndrome.Studies like Bhardwaj et al report that young AMI patients are predominantly male with single-vessel disease,unlike the multi-vessel disease typical in older cohorts.This study characterizes AMI in young adults(≤40 years)at a single center,focusing on presentation,risk factors,angiographic findings,and manage-ment to guide preventive strategies.AIM To describe the characteristics of AMI in young patients,including presentation,risk factors,coronary angiography(CAG)findings,and management strategies.METHODS This retrospective cross-sectional study analyzed 91 patients aged 20–40 years diagnosed with AMI at Mouwasat Hospital Dammam,from June 2020 to May 2023.Data on clinical presentation,cardiovascular risk factors,CAG findings,and treatments were collected from medical records.Descriptive statistics were used to summarize findings.RESULTS Of 91 patients(96.7%male,mean age 35.9 years±3.4 years),43.9%were obese(body mass index>30 kg/m^(2)).Hyperlipidemia was the most prevalent risk factor(69.2%),followed by smoking(49.5%),diabetes mellitus(33.0%),and hypertension(26.4%).ST-elevation myocardial infarction(STEMI)was the most common presentation(57.1%).The left anterior descending artery was frequently affected(78.0%),with single-vessel disease predominant(72.5%).Most patients underwent percutaneous coronary intervention(PCI)(74.7%),while 8.8%required surgery.CONCLUSION Young AMI patients are predominantly obese males with hyperlipidemia and smoking as key risk factors,pre-senting with STEMI and single-vessel disease amenable to PCI.展开更多
[Objectives]To systematically evaluate the impact of interventions based on the Common Sense Model of Self-Regulation(CSM)on the psychosocial adaptation of young and middle-aged patients with acute coronary syndrome(A...[Objectives]To systematically evaluate the impact of interventions based on the Common Sense Model of Self-Regulation(CSM)on the psychosocial adaptation of young and middle-aged patients with acute coronary syndrome(ACS),providing evidence-based support for clinical practice.[Methods]A systematic review was conducted using a literature search method,systematically searching through Chinese and English databases such as PubMed,Embase,Cochrane Library,CINAHL,China National Knowledge Infrastructure(CNKI),Wanfang Database,and VIP Database,from the database inception to December 31,2024.The search focused on studies related to the impact of the CSM on the psychosocial adaptation of young and middle-aged ACS patients.Two researchers independently performed literature screening,quality assessment,and data extraction.[Results]A total of 18 studies were included,comprising 12 randomized controlled trials,4 quasi-experimental studies,and 2 cohort studies,involving 2847 young and middle-aged ACS patients.Interventions based on the CSM significantly improved patients disease perception,emotional regulation,self-efficacy,and quality of life.Patients in the intervention group showed significant reductions in anxiety and depression levels,cardiac-related fear,and improvements in disease perception accuracy,treatment adherence,and social function recovery.[Conclusions]Interventions based on the CSM can effectively promote the psychosocial adaptation of young and middle-aged ACS patients,improve their disease perception and emotional state,and enhance their quality of life.It is recommended that this model be widely applied in the clinical care of young and middle-aged ACS patients.展开更多
With the development of the international education environment and the continuous reform of higher education in China,the working pace in universities is accelerating,with higher requirements for university work and ...With the development of the international education environment and the continuous reform of higher education in China,the working pace in universities is accelerating,with higher requirements for university work and increasingly apparent pressure on teachers.Young teachers in Chinese universities are prone to occupational stress.In addition to undertaking teaching,research,and other tasks,they feel anxious and at a loss when facing personal issues such as job promotion and taking care of their families.This article selects young teachers from some universities in China as research subjects and uses a questionnaire survey method to understand the current situation and sources of pressure on young teachers in universities,so as to focus on and alleviate their stress in a targeted manner.展开更多
Different from the current measurement methods for Young’s modulus of metal materials,the Young’s modulus of intermetallic compounds(IMCs)was obtained by a non-destructive method based on Brillouin light scattering(...Different from the current measurement methods for Young’s modulus of metal materials,the Young’s modulus of intermetallic compounds(IMCs)was obtained by a non-destructive method based on Brillouin light scattering(BLS)in this paper.The single-phase regions of CoSn,CoSn_(2),Cu_(3)Sn and Cu_(6)Sn_(5) phases required for BLS test were obtained by applying long-term thermal stabilization through adjusting temperature gradient.The volume fractions of the corresponding phases near the solid-liquid interfaces of the samples were 98.3%,94.2%,99.6% and 95.9%,respectively.All the independent elastic coefficients and Young’s moduli of IMCs were obtained by Brillouin scatterometer.The Young’s moduli of CoSn,CoSn_(2) and Cu_(3)Sn and Cu_(6)Sn_(5) phases obtained through the present method are 115.0,101.7,129.9 and 125.6 GPa,respectively,which are in a good agreement with the previous experimental results.Thus,the effectiveness of BLS in measuring the Young’s moduli of IMCs in bulk alloys is confirmed.展开更多
Under the blazing sun of Kamuli District in Uganda’s Eastern Region,a group of young farmers gathered around a patch of freshly turned red soil.Cameras rolled as Uganda’s First Deputy Prime Minister Rebecca Kadaga j...Under the blazing sun of Kamuli District in Uganda’s Eastern Region,a group of young farmers gathered around a patch of freshly turned red soil.Cameras rolled as Uganda’s First Deputy Prime Minister Rebecca Kadaga joined local youth to plant the first chilli seedlings on a 10-acre(4.05 hectares)demonstration farm.The live broadcast,aired on the national agricultural television programme Kungula,marked not only the launch of a digital farming project led by AMPA Media,but also symbolised Africa’s growing ambition to unite tradition with technology.展开更多
Objective:To analyze the impact and mechanism of the SOC model intervention on improving health literacy and reducing disease uncertainty among young and middle-aged patients with coronary heart disease.Methods:A hund...Objective:To analyze the impact and mechanism of the SOC model intervention on improving health literacy and reducing disease uncertainty among young and middle-aged patients with coronary heart disease.Methods:A hundred young and middle-aged patients with coronary heart disease from our hospital between March and October 2024 were randomly divided into an observation group and a control group,with 50 patients in each group.Both groups received routine nursing intervention,while the observation group also received intervention based on the Stages of Change(SOC)model.The intervention period was 30 days.Changes in self-efficacy,health literacy,and disease uncertainty were compared between the two groups before and after the intervention.Results:After the intervention,the self-efficacy scores of both groups increased significantly,and the observation group had higher self-efficacy scores than the control group,with a significant difference(P<0.05).Additionally,the observation group showed significantly higher levels of health literacy than the control group(P<0.001).Furthermore,the observation group had significantly lower scores for disease uncertainty compared to the control group(P<0.001).Conclusion:The SOC model,in addition to routine nursing,significantly affects self-efficacy,disease uncertainty,and health literacy among young and middle-aged patients with coronary heart disease.It helps to enhance patients’knowledge of coronary heart disease,improve health literacy levels,and reduce disease uncertainty,making it worthy of clinical promotion and application.展开更多
Objective:To explore the current status of social alienation and its influencing factors among young and middle-aged stroke patients in Dali.Methods:A convenience sampling method was used to survey 385 young and middl...Objective:To explore the current status of social alienation and its influencing factors among young and middle-aged stroke patients in Dali.Methods:A convenience sampling method was used to survey 385 young and middle-aged stroke patients in a tertiary hospital in Dali from December 2024 to July 2025.Questionnaires including general demographic information,the General Alienation Scale,the Athens insomnia scale,and others were administered.Results:The social alienation score of young and middle-aged stroke patients in Dali was(35.67±3.46).Univariate analysis showed that general demographic factors[education level,monthly household income,whether it was the first onset,presence of sequelae,disease duration,activities of daily living(ADL,Barthel Index)],social support,stigma,self-perceived burden,anxiety and depression,and sleep status were influencing factors of social alienation(P<0.05).Regression analysis indicated that social support,anxiety and depression,disease duration,stigma,presence of sequelae,and self-care ability were significant influencing factors of social alienation(P<0.01),explaining 65.3%of the total variance.Conclusion:The level of social alienation among young and middle-aged stroke patients in Dali is relatively low.Special attention should be paid to patients with a disease duration of<7 days,those with sequelae,moderate-to-severe dependence in self-care,low social support,high stigma,and high levels of anxiety and depression,to effectively reduce their social alienation.展开更多
The single-point bending method,based on atomic force microscopy(AFM),has been extensively validated for characterizing the structural mechanical properties of micro-and nanobeams.Nevertheless,the influence of AFM pro...The single-point bending method,based on atomic force microscopy(AFM),has been extensively validated for characterizing the structural mechanical properties of micro-and nanobeams.Nevertheless,the influence of AFM probe loading and positioning has yet to be subjected to comprehensive investigation.This paper proposes a novel bending-test method based on sequential loading points,in which a series of evenly distributed loads are applied along the length of the central axis on the upper surface of the cantilever.The preliminary measured values of Young’s modulus for an unknown alloy material were 193,178,and 176 GPa,exhibiting a considerable degree of dispersion.An algorithm for self-correction of the positioning error was developed,and this resulted in a positioning error of 53 nm and a final converged Young’s modulus of 161 GPa.展开更多
BACKGROUND Maturity-onset diabetes of the young(MODY)is a monogenic form of diabetes often misdiagnosed as type 1 or type 2.The MODY7 subtype,attributed to variants in the Kruppel-like factor 11(KLF11)gene,is exceedin...BACKGROUND Maturity-onset diabetes of the young(MODY)is a monogenic form of diabetes often misdiagnosed as type 1 or type 2.The MODY7 subtype,attributed to variants in the Kruppel-like factor 11(KLF11)gene,is exceedingly rare,and its clinical spectrum is not fully characterized.Precise genetic diagnosis is essential for appropriate management but is challenging due to phenotypic overlap with other diabetes types.This case report describes a patient with a novel KLF11 variant,contributing to the understanding of this rare condition and its clinical implications.CASE SUMMARY A 50-year-old female with a family history of MODY in her son was initially diagnosed with type 2 diabetes.Due to the family history and a non-obese phenotype,a comprehensive genetic panel for monogenic diabetes was performed.The analysis identified a novel heterozygous missense variant,p.Cys105Phe,in the KLF11 gene,establishing a definitive diagnosis of MODY7.Following this diagnosis,the patient’s treatment was adjusted to include lifestyle modifications,resulting in adequate glycemic control.The patient has since maintained target glycated hemoglobin levels.CONCLUSION Monogenic diabetes type MODY7,caused by a mutation in the KLF11 gene,is extremely rare.Although some studies question its existence,compatible cases continue to be diagnosed,given its inclusion in genetic panels for MODY.展开更多
文摘Welcome to the Special Issue highlighting the latest innovative research conducted by young scientists who have received the 2023 or the 2024 Innovative Young Scientist Awards.Established in 2023 by the University of Science and Technology Beijing,the Innovative Young Scientist Award recognizes exceptional young scientists who have demonstrated sustained engagement in frontier research across mineral science,metallurgy,and materials science,with significant scientific contributions.Committed to fostering the next generation of scientific leaders,the award supports researchers aged under 45.Since its inception,the honor has been bestowed upon 20 recipients,with 10 outstanding researchers selected annually from a competitive pool of approximately 100 applicants.
文摘The global issue of climate change presents young entrepreneurs with opportunities to explore new business models.FACED with the severe challenges presented by global climate change,pursuing a green lifestyle is a way to achieve sustainable development.Many countries are exploring ways to reach a balance between economic development and environmental protection.
文摘Introduction: Considering a disease of postmenopausal women, there is a noted trend of increasing breast cancer cases among premenopausal women. Our study aimed to determine the main risk factors for breast cancer in women aged 40 and under. Materials and Methods: This was a case-control study with exhaustive sampling of all respondents with histological proof over a 12-month period, matched by age. For all statistical tests, we used a significance threshold of 5%. Additionally provided are the ORs and their 95% confidence intervals, the mean, and standard deviation. Results: We collected 65 cases and 130 controls. The frequency of breast cancer in women aged 40 and under was 35.5%. The mean age was 35.6 ± 4.5 years among cases compared to 32.1 ± 7.9 years among controls. A significantly positive association was detected in both univariate and multivariate analysis between age and breast cancer [(OR) = 10.30;95% CI (1.99 - 53.23)] and [(OR) = 7.53;95% CI (1.82 - 31.23)];family history of breast cancer and breast cancer [(OR) = 9.99;95% CI (1.43 - 69.58)];smoking and breast cancer [OR = 13.11;95% CI (1.05 - 163.30)];sedentary lifestyle and breast cancer [OR = 3.36;95% CI (1.01 - 11.17)];and night work and breast cancer [(OR) = 72.05;95% CI (8.15 - 637.25)]. Conclusion: Earlier systematic screening and regular follow-up should be conducted in young women in our context.
基金supported by the Postgraduate Supervision Fund within the School of Nursing at Fujian Medical University(No.110013)。
文摘Objectives:This study aimed to generate a theoretical framework based on empirical data to explain the behavioral patterns closely related to young and middle-aged patients with lymphoma throughout the disease.Methods:This study followed the classic grounded theory methodology,involving procedures such as theoretical sampling,substantive coding,theoretical coding,constant comparison,and memo writing and sorting.Multiple data types were used based on the principle of“all is data,”including 34 participants providing interview data along with observation notes and 40 relevant secondary texts from the“Lymphoma House”network platform and the“Lymphoma House 086”public account.Two autobiographical books written by lymphoma patients were also selected as data resources.Data collection and analysis were conducted in an iterative process until theoretical saturation was reached.The COREQ checklist was followed to report this study.Results:The main concern of middle-aged and young patients with lymphoma was identifiedas restoring normality,while managing uncertainty was the main behavioral pattern for restoring normality.Uncertainty consists of two interrelated types:inherent uncertainty of illness and perceived uncertainty of patients.Four strategies are used to manage uncertainty:reconstructing certainty,adaptive coping,defensive buffering,and compensatory changing.Managing uncertainty is influenced by disease characteristics and perceptions,social resources,and cultural concepts.The consequence of managing uncertainty is reaching a new normality.Conclusions:Pervasive uncertainty significantly affects the daily lives of young and middle-aged patients with lymphoma.Consequently,strategies for managing disease-related uncertainty to sustain normality are commonly observed in this population.This theoretical framework for addressing uncertainty can serve as a foundation for understanding and developing tailored interventions to manage uncertainty.Future research should focus on managing uncertainty to help patients restore normality.
基金funded by Tianjin Key Medical Discipline(Specialty)Construction Project,China(Grant No.TJYXZDXK-011A)Tianjin Medical University Cancer Institute&Hospital Nursing Special Fund Project(H2304)。
文摘Objectives:This study aimed to classify young breast cancer patients into distinct ambivalence over emotional expression and to explore the factors influencingthe level of ambivalence over emotional expression.Methods:A total of 217 young breast cancer patients were enrolled from a tertiary Grade A oncology hospital in Tianjin,China,using the convenience sampling method.All participants completed the general questionnaire,Ambivalence over Emotion Expression Questionnaire(AEQ),and Family Adapt-Ability and Cohesion Evaluation Scales-Chinese Version(FACES-CV).We employed exploratory latent profileanalysis for ambivalence over emotional expression profilingand logistic regression analysis to identify the influentialfactors Results:The results of the latent profileanalysis supported the models of four latent profiles,which were definedas“low conflict-lowexpression reflection”(19.2%),“high conflict-high inhibition expression”(43.9%),“moderate conflict-highregret expression”(18.1%),and“moderate conflict-desire understand”(18.8%).Logistic regression revealed that family cohesion,marital status,residence,per capita monthly income,and cancer stage were the influencingfactors of ambivalence over emotional expression in young breast cancer patients(P<0.05)Conclusions:Levels of ambivalence over emotional expression ameast cancer patients with breast cancer were highly heterogeneous.Medical staff should provide psychological counseling and health education tailored to the unique characteristics of emotional expression ambivalence in different patient groups to promote healthy emotional expression among patients.
文摘Objective:This randomized controlled trial aimed to assess the impact of a targeted educational intervention on the awareness and practice of genetic screening and counseling among young adults in Calabar Municipality,Cross River State.Materials and Methods:Participants(aged 18-45)were randomly assigned to either an intervention group receiving structured health education or a control group receiving general health information.Stratified randomization was used between the groups.A sample size of 340 participants was recruited to detect a 20%difference in outcomes with 80%power.Data were collected using prevalidated questionnaires at baseline,immediately after the intervention,and at a 3-month follow-up.The intervention consisted of three weekly 90-min educational sessions covering genetics,the benefits of screening,and practical guidance on accessing genetic services.The primary outcomes were changes in awareness and practices related to genetic screening,with secondary outcomes focusing on attitudes and intentions toward genetic counseling.Results:Findings revealed that awareness of genetic screening was higher in the intervention group,with 65.9%of participants aware of early detection,compared to 59.4%in the control group,although the difference was not statistically significant(P=0.23).In terms of practice,42.9%of the intervention group and 40.0%of the control group engaged in genetic screening programs,with no significant difference(P=0.57).Logistic regression analysis highlighted that age,educational level,and knowledge of teratogens were significant predictors of genetic screening awareness.Participants aged 36 years and above were 1.52 times more likely to be aware(odds ratio[OR]=1.52,P=0.003),and those with tertiary education had nearly double the likelihood of awareness(OR=1.96,P<0.001).Conclusion:The study underscores the importance of targeted education in improving genetic screening awareness.
文摘The association between sugar-sweetened beverages(SSBs)intake and hair loss condition might give scientific support for better dietary practices to prevent hair loss.We aimed to explore the association of SSBs intake with the hair loss condition in women.This online cross-sectional study,conducted from January 2022 to April 2022,recruited 1169 women aged 18-45 years from 31 provinces on mainland of China.We u sed the updated version of the 15-item Beverage Intake Questionnaire(BEVQ-15)to evaluate the usual beverage consumption over the past month and the Hair-Shedding Visual Scale for Asian Women(HSVS-A)to evaluate the extent of hair shedding.We utilized binary logistic regression to assess the association between SSBs intake and hair loss.Among 1169 female participants with an average age of 27.2,there were 211(18.0%)participants with hair loss.Compared with participants who never drank SSBs,those who drank m ore than 7 times/week or 1000 mL/week were more likely to have hair loss,with an adjusted odds ratio(OR)of 2.25(95%confidence interval(CI)=1.32,3.83)or 2.22(95%CI=1.28,3.85).Furthermore,the m ediation effect of anxiety status on the association between SSBs and female hair loss was observed,with a significant indirect effect(β_(indirect)=0.0199,95%CI=0.0032,0.0418).In conclusion,our study showed that w omen who consumed higher amounts of SSBs had an increased risk of hair loss,which might attract more attention from young women and benefit from reducing SSBs consumption.Further longitudinal and interventional studies are still needed to confirm the current association and provide evidenced-based health education.
基金financially supported by the National Key R&D Program of China(Grant No.2023YFF0716800)the National Natural Science Foundation of China(Grant No.12074160)the Natural Science Foundation of Liaoning Province of China(Grant No.2024-MS-181).
文摘As an emerging multifunctional metal with the lowest melting point except for mercury,gallium combines a wide range of metallic and non-metallic elements to form advanced semiconductors critically important in cutting-edge technologies.However,due to its low melting point and poor machinability,it is quite difficult to simultaneously characterize gallium’s elastic properties and damping characteristics using conventional methods,which is es-sential in designing and evaluating gallium-based structures.Therefore,developing effective methods to achieve accurate and efficient measurements of Young’s modulus and corresponding internal friction of gallium is of great significance.This letter studies simultaneous measurements of the variations in Young’s modulus and internal friction of gallium at varying temperatures by employing the modified piezoelectric ultrasonic composite oscil-lator technique.Combining the explicit theoretical formulas with the measured resonance and anti-resonance frequencies,it has been discovered that Young’s modulus undergoes an approximately linear decrease as the temperature rises,declining from 83.84 GPa at -70℃ to 79.37 GPa at 20℃.Moreover,like aluminum in the same Group ⅢA of the Periodic Table of Elements and exhibits a grain-boundary internal friction peak,gallium displays a longitudinal internal friction peak at approximately-12°C,with the peak value reaching 1.77×10^(-3).This basic research on gallium’s elastic properties and damping characteristics under low-temperature condi-tions will inspire further explorations of the mechanical properties of a diverse spectrum of low-melting-point functional materials and facilitate applications of gallium-based structures under complex conditions.
基金Supported by Jiangsu Provincial Cadre Healthcare Scientific Research Grant Project,No.BJ23019Jiangsu Provincial Association of Maternal and Child Healthcare Scientific Research Grant Project,No.FYX202350+2 种基金Special Fund for the Project of Enhancing Academic Capability of Integrative Nursing,No.ZXYJHHL-K-2023-M20Jiangsu Provincial Graduate Student Practice and Innovation Program Project,No.SJCX24_0833the Training Project for Backbone Talents in Traditional Chinese Medicine Nursing in Nanjing Region,No.Ningwei Zhongyi[2023]No.8.
文摘BACKGROUND Breast cancer(BC)is the second most common malignancy globally.Young and middle-aged patients face more pressures from diagnosis,treatment,costs,and psychological issues like self-image concerns,social barriers,and professional challenges.Compared to other age groups,they have higher recurrence rates,lower survival rates,and increased risk of depression.Research is lacking on factors influencing depressive symptoms and predictive models for this age group.AIM To analyze factors influencing depressive symptoms in young/middle-aged BC patients and construct a depression risk predictive model.METHODS A total of 360 patients undergoing BC treatment at two tertiary hospitals in Jiangsu Province,China from November 2023 to April 2024 were included in the study.Participants were surveyed using a general information questionnaire,the patient health questionnaire depression scale,the visual analog scale for pain,the revised family support scale,and the long form of the international physical activity questionnaire.Univariate and multivariate analyses were conducted to identify the factors affecting depression in middle-aged and young BC patients,and a predictive model for depression risk was developed based on these findings.RESULTS Among the 360 middle-aged and young BC patients,the incidence rate of depressive symptoms was 38.61%(139/360).Multivariate analysis revealed that tumor grade,patient’s monthly income,pain score,family support score,and physical activity score were factors influencing depression in this patient group(P<0.05).The risk prediction model constructed based on these factors yielded an area under the receiver operating characteristic curve of 0.852,with a maximum Youden index of 0.973,sensitivity of 86.80%,specificity of 89.50%,and a diagnostic odds ratio of 0.552.The Hosmer-Lemeshow test for goodness of fit indicated an adequate model fit(χ^(2)=0.360,P=0.981).CONCLUSION The constructed predictive model demonstrates good predictive performance and can serve as a reference for medical professionals to early identify high-risk patients and implement corresponding preventive measures to decrease the incidence of depressive symptoms in this population.
文摘AIM:To evaluate the prevalence of early post-traumatic stress disorder(PTSD)among young and middle-aged patients who have suffered open globe injuries,and to identify the psychosocial factors influencing PTSD in these patients.METHODS:A total of 280 patients who underwent ocular trauma surgery between January 2023 and January 2024 were selected through convenience sampling.Data were collected using a custom-designed demographic questionnaire,the Connor-Davidson Resilience Scale(CDRISC),the Cognitive Emotion Regulation Questionnaire(C-ERRI),and the PTSD Checklist-Civilian Version(PCL-C).Univariate analysis and stepwise multiple linear regression analysis were performed to determine the factors affecting PTSD in these patients.RESULTS:The average PTSD score for the patients was 33.22±13.48.The scores for individual PTSD dimensions,ranked from highest to lowest,were recurrent traumatic experiences,heightened arousal,avoidance reactions,and social dysfunction.Positive PTSD symptoms were observed in 85 patients(30.36%).Univariate analysis indicated that gender,postoperative vision,marital status,psychological resilience,and rumination were significant factors affecting PTSD symptoms(χ^(2)/t=6.53,17.88,8.83,2.17,and 14.1,respectively;all P<0.05).Pearson correlation analysis showed a positive correlation between rumination and PTSD symptoms(r=0.73,P<0.01)and a negative correlation between psychological resilience and PTSD symptoms(r=-0.14,P<0.05).Stepwise multiple linear regression analysis identified postoperative vision(notably eye removal),rumination levels,and psychological resilience(optimism)as major factors influencing PTSD in these patients(R^(2)=0.57,P<0.001).CONCLUSION:Young and middle-aged patients with open globe injuries have a high incidence of PTSD.Significant risk factors for early PTSD include primary enucleation,high levels of rumination,and low psychological resilience(optimism).Conversely,patients with good postoperative vision recovery,low rumination levels,and high levels of optimism are less likely to develop PTSD.Healthcare providers should pay special attention to patients who undergo primary enucleation,strive to reduce their rumination levels,and enhance their psychological resilience,thereby promoting a positive and optimistic attitude towards their condition and reducing the incidence of PTSD.
文摘BACKGROUND Acute myocardial infarction(AMI)is rare among patients aged≤40 years but imposes significant morbidity,psychological distress,and economic burden.App-roximately 10%of AMI hospitalizations involve patients under 45 years,under-scoring the need to study this group.Compared to older patients,young AMI pa-tients exhibit fewer traditional risk factors(e.g.,hypertension,diabetes)but higher rates of smoking,obesity,and non-atherosclerotic causes like spontaneous coro-nary artery dissection or coronary spasm,often linked to substance use.Global trends show rising obesity and dyslipidemia in young populations,with smoking contributing to 62%–90%of AMI cases in this age group.Family history of coro-nary artery disease also elevates risk,particularly in acute coronary syndrome.Studies like Bhardwaj et al report that young AMI patients are predominantly male with single-vessel disease,unlike the multi-vessel disease typical in older cohorts.This study characterizes AMI in young adults(≤40 years)at a single center,focusing on presentation,risk factors,angiographic findings,and manage-ment to guide preventive strategies.AIM To describe the characteristics of AMI in young patients,including presentation,risk factors,coronary angiography(CAG)findings,and management strategies.METHODS This retrospective cross-sectional study analyzed 91 patients aged 20–40 years diagnosed with AMI at Mouwasat Hospital Dammam,from June 2020 to May 2023.Data on clinical presentation,cardiovascular risk factors,CAG findings,and treatments were collected from medical records.Descriptive statistics were used to summarize findings.RESULTS Of 91 patients(96.7%male,mean age 35.9 years±3.4 years),43.9%were obese(body mass index>30 kg/m^(2)).Hyperlipidemia was the most prevalent risk factor(69.2%),followed by smoking(49.5%),diabetes mellitus(33.0%),and hypertension(26.4%).ST-elevation myocardial infarction(STEMI)was the most common presentation(57.1%).The left anterior descending artery was frequently affected(78.0%),with single-vessel disease predominant(72.5%).Most patients underwent percutaneous coronary intervention(PCI)(74.7%),while 8.8%required surgery.CONCLUSION Young AMI patients are predominantly obese males with hyperlipidemia and smoking as key risk factors,pre-senting with STEMI and single-vessel disease amenable to PCI.
基金Supported by Philosophy and Social Sciences Research Project of Hubei Provincial Department of Education(22Q149,19Y090).
文摘[Objectives]To systematically evaluate the impact of interventions based on the Common Sense Model of Self-Regulation(CSM)on the psychosocial adaptation of young and middle-aged patients with acute coronary syndrome(ACS),providing evidence-based support for clinical practice.[Methods]A systematic review was conducted using a literature search method,systematically searching through Chinese and English databases such as PubMed,Embase,Cochrane Library,CINAHL,China National Knowledge Infrastructure(CNKI),Wanfang Database,and VIP Database,from the database inception to December 31,2024.The search focused on studies related to the impact of the CSM on the psychosocial adaptation of young and middle-aged ACS patients.Two researchers independently performed literature screening,quality assessment,and data extraction.[Results]A total of 18 studies were included,comprising 12 randomized controlled trials,4 quasi-experimental studies,and 2 cohort studies,involving 2847 young and middle-aged ACS patients.Interventions based on the CSM significantly improved patients disease perception,emotional regulation,self-efficacy,and quality of life.Patients in the intervention group showed significant reductions in anxiety and depression levels,cardiac-related fear,and improvements in disease perception accuracy,treatment adherence,and social function recovery.[Conclusions]Interventions based on the CSM can effectively promote the psychosocial adaptation of young and middle-aged ACS patients,improve their disease perception and emotional state,and enhance their quality of life.It is recommended that this model be widely applied in the clinical care of young and middle-aged ACS patients.
基金Key Project of Education Science Planning in Jiangsu Province in 2024“Research on Risk Generation and Governance of Education Intelligence from the Perspective of Social Narrative”(B-b/2024/01/192)。
文摘With the development of the international education environment and the continuous reform of higher education in China,the working pace in universities is accelerating,with higher requirements for university work and increasingly apparent pressure on teachers.Young teachers in Chinese universities are prone to occupational stress.In addition to undertaking teaching,research,and other tasks,they feel anxious and at a loss when facing personal issues such as job promotion and taking care of their families.This article selects young teachers from some universities in China as research subjects and uses a questionnaire survey method to understand the current situation and sources of pressure on young teachers in universities,so as to focus on and alleviate their stress in a targeted manner.
基金supported by the Gansu Key Research and Development Project,China(No.23YFGA0003)the Key Science and Technology Projects of Gansu Province,China(No.22ZD6GB019)+2 种基金Gansu Provincial Joint Research Fund,China(No.23JRRC0004)the Industry Support Plan of Gansu Universities,China(No.2024CYZC-01)the Fundamental Research Funds for the Central Universities,China(No.lzujbky-2022-ey15).
文摘Different from the current measurement methods for Young’s modulus of metal materials,the Young’s modulus of intermetallic compounds(IMCs)was obtained by a non-destructive method based on Brillouin light scattering(BLS)in this paper.The single-phase regions of CoSn,CoSn_(2),Cu_(3)Sn and Cu_(6)Sn_(5) phases required for BLS test were obtained by applying long-term thermal stabilization through adjusting temperature gradient.The volume fractions of the corresponding phases near the solid-liquid interfaces of the samples were 98.3%,94.2%,99.6% and 95.9%,respectively.All the independent elastic coefficients and Young’s moduli of IMCs were obtained by Brillouin scatterometer.The Young’s moduli of CoSn,CoSn_(2) and Cu_(3)Sn and Cu_(6)Sn_(5) phases obtained through the present method are 115.0,101.7,129.9 and 125.6 GPa,respectively,which are in a good agreement with the previous experimental results.Thus,the effectiveness of BLS in measuring the Young’s moduli of IMCs in bulk alloys is confirmed.
文摘Under the blazing sun of Kamuli District in Uganda’s Eastern Region,a group of young farmers gathered around a patch of freshly turned red soil.Cameras rolled as Uganda’s First Deputy Prime Minister Rebecca Kadaga joined local youth to plant the first chilli seedlings on a 10-acre(4.05 hectares)demonstration farm.The live broadcast,aired on the national agricultural television programme Kungula,marked not only the launch of a digital farming project led by AMPA Media,but also symbolised Africa’s growing ambition to unite tradition with technology.
基金Handan City Science and Technology Research and Development Program Project Application(Project No.:23422083096ZC)。
文摘Objective:To analyze the impact and mechanism of the SOC model intervention on improving health literacy and reducing disease uncertainty among young and middle-aged patients with coronary heart disease.Methods:A hundred young and middle-aged patients with coronary heart disease from our hospital between March and October 2024 were randomly divided into an observation group and a control group,with 50 patients in each group.Both groups received routine nursing intervention,while the observation group also received intervention based on the Stages of Change(SOC)model.The intervention period was 30 days.Changes in self-efficacy,health literacy,and disease uncertainty were compared between the two groups before and after the intervention.Results:After the intervention,the self-efficacy scores of both groups increased significantly,and the observation group had higher self-efficacy scores than the control group,with a significant difference(P<0.05).Additionally,the observation group showed significantly higher levels of health literacy than the control group(P<0.001).Furthermore,the observation group had significantly lower scores for disease uncertainty compared to the control group(P<0.001).Conclusion:The SOC model,in addition to routine nursing,significantly affects self-efficacy,disease uncertainty,and health literacy among young and middle-aged patients with coronary heart disease.It helps to enhance patients’knowledge of coronary heart disease,improve health literacy levels,and reduce disease uncertainty,making it worthy of clinical promotion and application.
基金Scientific Research Fund Project of Yunnan Provincial Education Department(Project No.:2024J0832)。
文摘Objective:To explore the current status of social alienation and its influencing factors among young and middle-aged stroke patients in Dali.Methods:A convenience sampling method was used to survey 385 young and middle-aged stroke patients in a tertiary hospital in Dali from December 2024 to July 2025.Questionnaires including general demographic information,the General Alienation Scale,the Athens insomnia scale,and others were administered.Results:The social alienation score of young and middle-aged stroke patients in Dali was(35.67±3.46).Univariate analysis showed that general demographic factors[education level,monthly household income,whether it was the first onset,presence of sequelae,disease duration,activities of daily living(ADL,Barthel Index)],social support,stigma,self-perceived burden,anxiety and depression,and sleep status were influencing factors of social alienation(P<0.05).Regression analysis indicated that social support,anxiety and depression,disease duration,stigma,presence of sequelae,and self-care ability were significant influencing factors of social alienation(P<0.01),explaining 65.3%of the total variance.Conclusion:The level of social alienation among young and middle-aged stroke patients in Dali is relatively low.Special attention should be paid to patients with a disease duration of<7 days,those with sequelae,moderate-to-severe dependence in self-care,low social support,high stigma,and high levels of anxiety and depression,to effectively reduce their social alienation.
文摘The single-point bending method,based on atomic force microscopy(AFM),has been extensively validated for characterizing the structural mechanical properties of micro-and nanobeams.Nevertheless,the influence of AFM probe loading and positioning has yet to be subjected to comprehensive investigation.This paper proposes a novel bending-test method based on sequential loading points,in which a series of evenly distributed loads are applied along the length of the central axis on the upper surface of the cantilever.The preliminary measured values of Young’s modulus for an unknown alloy material were 193,178,and 176 GPa,exhibiting a considerable degree of dispersion.An algorithm for self-correction of the positioning error was developed,and this resulted in a positioning error of 53 nm and a final converged Young’s modulus of 161 GPa.
文摘BACKGROUND Maturity-onset diabetes of the young(MODY)is a monogenic form of diabetes often misdiagnosed as type 1 or type 2.The MODY7 subtype,attributed to variants in the Kruppel-like factor 11(KLF11)gene,is exceedingly rare,and its clinical spectrum is not fully characterized.Precise genetic diagnosis is essential for appropriate management but is challenging due to phenotypic overlap with other diabetes types.This case report describes a patient with a novel KLF11 variant,contributing to the understanding of this rare condition and its clinical implications.CASE SUMMARY A 50-year-old female with a family history of MODY in her son was initially diagnosed with type 2 diabetes.Due to the family history and a non-obese phenotype,a comprehensive genetic panel for monogenic diabetes was performed.The analysis identified a novel heterozygous missense variant,p.Cys105Phe,in the KLF11 gene,establishing a definitive diagnosis of MODY7.Following this diagnosis,the patient’s treatment was adjusted to include lifestyle modifications,resulting in adequate glycemic control.The patient has since maintained target glycated hemoglobin levels.CONCLUSION Monogenic diabetes type MODY7,caused by a mutation in the KLF11 gene,is extremely rare.Although some studies question its existence,compatible cases continue to be diagnosed,given its inclusion in genetic panels for MODY.
