[Objectives]To observe the effects of Huanglian Jiedu Decoction on pain behaviors in rat models of postherpetic neuralgia(PHN)and analyze potential mechanisms.[Methods]Twenty SD rats with PHN models induced by intrapl...[Objectives]To observe the effects of Huanglian Jiedu Decoction on pain behaviors in rat models of postherpetic neuralgia(PHN)and analyze potential mechanisms.[Methods]Twenty SD rats with PHN models induced by intraplantar injection of 50μL(6×106)varicella-zoster virus(VZV)into the left hind paw were randomly divided into two groups(n=10 each)using a random number table:the model group(PHN group)and the Huanglian Jiedu Decoction group.From day 7 after inoculation,the Huanglian Jiedu Decoction group received oral gavage of Huanglian Jiedu Decoction twice daily for 14 days,while the PHN group received an equal volume of 0.9%saline.Thermal withdrawal latency(TWL)and mechanical withdrawal threshold(MWT)were measured at 1,4,7,14,and 21 d after inoculation.Pain-related behaviors(vocalization,scratching,and licking/biting of the hind paw)were recorded.[Results]Compared with the PHN group,the Huanglian Jiedu Decoction group exhibited significantly prolonged TWL and increased MWT at days 14 and 21(P<0.05).At day 4 post-inoculation,both groups showed marked pain-related behaviors(e.g.,vocalization,scratching,licking/biting).These behaviors persisted until day 21 in the PHN group but significantly decreased in the Huanglian Jiedu Decoction group at days 14 and 21(P<0.05).[Conclusions]Huanglian Jiedu Decoction reduces pain sensitivity and alleviates pain-related behaviors in PHN model rats.The mechanism may involve elevating pain thresholds and decreasing pain conduction velocity.展开更多
In this paper,we study the orthogonal time frequency space signal transmission over multi-path channel in the presence of phase noise(PHN)at both sides of millimeter wave(mmWave)communication links.The statistics char...In this paper,we study the orthogonal time frequency space signal transmission over multi-path channel in the presence of phase noise(PHN)at both sides of millimeter wave(mmWave)communication links.The statistics characteristics of the PHN-induced common phase error and inter-Doppler interference are investigated.Then,a column-shaped pilot structure is designed,and training pilots are used to realize linear-complexity PHN tracking and compensation.Numerical results demonstrate that the proposed scheme enables the signal to noise ratio loss to be restrained within 1 dB in contrast to the no PHN case.展开更多
文摘[Objectives]To observe the effects of Huanglian Jiedu Decoction on pain behaviors in rat models of postherpetic neuralgia(PHN)and analyze potential mechanisms.[Methods]Twenty SD rats with PHN models induced by intraplantar injection of 50μL(6×106)varicella-zoster virus(VZV)into the left hind paw were randomly divided into two groups(n=10 each)using a random number table:the model group(PHN group)and the Huanglian Jiedu Decoction group.From day 7 after inoculation,the Huanglian Jiedu Decoction group received oral gavage of Huanglian Jiedu Decoction twice daily for 14 days,while the PHN group received an equal volume of 0.9%saline.Thermal withdrawal latency(TWL)and mechanical withdrawal threshold(MWT)were measured at 1,4,7,14,and 21 d after inoculation.Pain-related behaviors(vocalization,scratching,and licking/biting of the hind paw)were recorded.[Results]Compared with the PHN group,the Huanglian Jiedu Decoction group exhibited significantly prolonged TWL and increased MWT at days 14 and 21(P<0.05).At day 4 post-inoculation,both groups showed marked pain-related behaviors(e.g.,vocalization,scratching,licking/biting).These behaviors persisted until day 21 in the PHN group but significantly decreased in the Huanglian Jiedu Decoction group at days 14 and 21(P<0.05).[Conclusions]Huanglian Jiedu Decoction reduces pain sensitivity and alleviates pain-related behaviors in PHN model rats.The mechanism may involve elevating pain thresholds and decreasing pain conduction velocity.
基金supported by the National Natural Science Foundation of China(62071097)the Sichuan Science and Technology Program(2023NSFSC0458).
文摘In this paper,we study the orthogonal time frequency space signal transmission over multi-path channel in the presence of phase noise(PHN)at both sides of millimeter wave(mmWave)communication links.The statistics characteristics of the PHN-induced common phase error and inter-Doppler interference are investigated.Then,a column-shaped pilot structure is designed,and training pilots are used to realize linear-complexity PHN tracking and compensation.Numerical results demonstrate that the proposed scheme enables the signal to noise ratio loss to be restrained within 1 dB in contrast to the no PHN case.
