We investigated sarcopenia, focusing on the dose of loop diuretics used in 70 patients with refractory hepatic ascites treated with tolvaptan. Bloating improved in 68.5% of patients, as determined using the Japanese v...We investigated sarcopenia, focusing on the dose of loop diuretics used in 70 patients with refractory hepatic ascites treated with tolvaptan. Bloating improved in 68.5% of patients, as determined using the Japanese version of the Support Team Assessment Schedule. The psoas muscle index (PMI) was used to define sarcopenia. A statistically significant difference was observed in the PMI between patients receiving low-dose (3.6 ± 1.2 cm2/m2) and high-dose furosemide (3.1 ± 1.2 cm2/m2) before tolvaptan treatment (P = 0.048). The PMI increased from 3.2 ± 1.1 cm2/m2 to 3.5 ± 1.3 cm2/m2 (P = 0.002) in responders, but decreased from 3.4 ± 1.2 cm2/m2 to 3.0 ± 1.0 cm2/m2 (P = 0.106) in non-responders before and after tolvaptan treatment, respectively. The long-term prognosis improved in responders compared with non-responders (mean survival time: 646 days vs. 228 days, P < 0.001). Early introduction of tolvaptan treatment is necessary to prevent the progression of sarcopenia.展开更多
为了更好地保护和利用坝上长尾鸡的品种资源,且从母系遗传的角度探明坝上长尾鸡的遗传多样性与起源分化,试验采用PCR直接测序法,测定了30只坝上长尾鸡线粒体DNA(mt DNA)D-loop区1 491bp片段序列。结果显示:在所测定的mt DNA D-loop序列...为了更好地保护和利用坝上长尾鸡的品种资源,且从母系遗传的角度探明坝上长尾鸡的遗传多样性与起源分化,试验采用PCR直接测序法,测定了30只坝上长尾鸡线粒体DNA(mt DNA)D-loop区1 491bp片段序列。结果显示:在所测定的mt DNA D-loop序列中,A、G、T和C碱基的平均含量分别为28.02%、13.91%、30.97%、27.10%。共检测到1个插入/缺失和32个变异位点,组成17个单倍型。单倍型多样度为0.945±0.025,群体内序列间核苷酸平均差异数为8.536,核苷酸多样度为0.00573,平均遗传距离为0.006。由最大似然法构建的NJ系统进化树将坝上长尾鸡聚为3大支,划分为与A、B、C 3个类群。与其它家鸡品种类比,显示其独特性。与原鸡亚种类比,发现A类群起源于原鸡海南亚种,B类群起源于原鸡印度亚种,C类群起源于原鸡滇南亚种。结果表明:坝上长尾鸡遗传多样性丰富,并具有独特性;坝上长尾鸡存在3个区分明显的母系来源。展开更多
In this paper we investigate spatiotemporal pattern formation in excitable media with only a long-range link. Besides the trivial solutions of spiral patterns, we find the asymptotic self-sustained target waves in the...In this paper we investigate spatiotemporal pattern formation in excitable media with only a long-range link. Besides the trivial solutions of spiral patterns, we find the asymptotic self-sustained target waves in the autonomous tissues. The wave source supporting this kind of new pattern is the oscillatory one-dimensional Winfree-loop self- organized under the presence of a long-range link, which is explored by the dominant phase-advanced driving method. Based on this understanding we can effectively regulate the oscillations of excitable media by suitably arranging the long-range link, including construction of self-sustained target waves with controllable period and wave length, or manipulation of system states between different patterns.展开更多
We investigated Tolvaptan efficacy and long-term prognosis with focus on nutrition in 20 patients with refractory hepatic ascites in hepatocellular carcinoma (HCC). Bloating improved in 55% of patients, as determined ...We investigated Tolvaptan efficacy and long-term prognosis with focus on nutrition in 20 patients with refractory hepatic ascites in hepatocellular carcinoma (HCC). Bloating improved in 55% of patients, as determined using a Japanese version of the Support Team Assessment Schedule. Nutritional status improved with Tolvaptan treatment, based on the Controlling Nutritional Status score and Onodera’s prognostic nutritional index. Long-term prognosis was better in responders than in non-responders (mean survival time: 308 days vs. 97 days, p = 0.031). Tolvaptan was even effective in many patients with HCC, with additional improvement in long-term prognosis expected with improvement in the nutritional status.展开更多
Curcumin has been shown to significantly improve spatial memory impairment induced by HIV-1 gp 120 V3 in rats, but the electrophysiological mechanism remains unknown. Using extracellular microelectrode recording techn...Curcumin has been shown to significantly improve spatial memory impairment induced by HIV-1 gp 120 V3 in rats, but the electrophysiological mechanism remains unknown. Using extracellular microelectrode recording techniques, this study confirmed that the gp120 V3 loop could suppress long-term potentiation in the rat hippocampal CA1 region and synaptic plasticity, and that curcumin could antagonize these inhibitory effects. Using a Fura-2/AM calcium ion probe, we found that curcumin resisted the effects of the gp120 V3 loop on hippocampal synaptosomes and decreased Ca2＋ concentration in synaptosomes. This effect of curcumin was identical to nimodipine, suggesting that curcumin improved the inhibitory effects of gpl20 on synaptic plasticity, ameliorated damage caused to the central nervous system, and might be a potential neuroprotective drug.展开更多
2001-2009年,在全国范围内采集了14个地理种群总计126个样本,以线粒体控制区作为分子标记,分析大卫鼠耳蝠种群系统发育关系和殖民历史.根据线粒体控制区序列构建的TCS网络图,将大卫鼠耳蝠的14个地理种群划分成3个地理区域,分别为中东部...2001-2009年,在全国范围内采集了14个地理种群总计126个样本,以线粒体控制区作为分子标记,分析大卫鼠耳蝠种群系统发育关系和殖民历史.根据线粒体控制区序列构建的TCS网络图,将大卫鼠耳蝠的14个地理种群划分成3个地理区域,分别为中东部平原区、西南高原区和南方丘陵区.在53个单倍型中,浙江的单倍型14、贵州的单倍型47、广东的单倍型50分别为3个地理区域的祖先单倍型.Geodis、错配分布和中性检验的分析结果表明,中东部平原区(76.12和79.17 ka BP)和西南高原区(69.12 ka BP)曾发生过种群扩张事件,并于61.24 ka BP发生了一次由西南高原向中东部平原区的长距离殖民事件.分子生物学、仿生学、解剖学和空气动力学的证据,共同揭示了大卫鼠耳蝠具有长距离的迁移能力.展开更多
文摘We investigated sarcopenia, focusing on the dose of loop diuretics used in 70 patients with refractory hepatic ascites treated with tolvaptan. Bloating improved in 68.5% of patients, as determined using the Japanese version of the Support Team Assessment Schedule. The psoas muscle index (PMI) was used to define sarcopenia. A statistically significant difference was observed in the PMI between patients receiving low-dose (3.6 ± 1.2 cm2/m2) and high-dose furosemide (3.1 ± 1.2 cm2/m2) before tolvaptan treatment (P = 0.048). The PMI increased from 3.2 ± 1.1 cm2/m2 to 3.5 ± 1.3 cm2/m2 (P = 0.002) in responders, but decreased from 3.4 ± 1.2 cm2/m2 to 3.0 ± 1.0 cm2/m2 (P = 0.106) in non-responders before and after tolvaptan treatment, respectively. The long-term prognosis improved in responders compared with non-responders (mean survival time: 646 days vs. 228 days, P < 0.001). Early introduction of tolvaptan treatment is necessary to prevent the progression of sarcopenia.
基金supported by the National Natural Science Foundation of China (Grant No. 11047146)the Science Foundation of the Education Bureau of Shaanxi Province of China (Grant No. 11JK0544)+1 种基金the Natural Science Foundation of Shaanxi Province of China (Grant No. 2010JQ1014)the Science Foundation of Baoji University of Arts and Sciences (Grant Nos. ZK1048 andZK1049)
文摘In this paper we investigate spatiotemporal pattern formation in excitable media with only a long-range link. Besides the trivial solutions of spiral patterns, we find the asymptotic self-sustained target waves in the autonomous tissues. The wave source supporting this kind of new pattern is the oscillatory one-dimensional Winfree-loop self- organized under the presence of a long-range link, which is explored by the dominant phase-advanced driving method. Based on this understanding we can effectively regulate the oscillations of excitable media by suitably arranging the long-range link, including construction of self-sustained target waves with controllable period and wave length, or manipulation of system states between different patterns.
文摘We investigated Tolvaptan efficacy and long-term prognosis with focus on nutrition in 20 patients with refractory hepatic ascites in hepatocellular carcinoma (HCC). Bloating improved in 55% of patients, as determined using a Japanese version of the Support Team Assessment Schedule. Nutritional status improved with Tolvaptan treatment, based on the Controlling Nutritional Status score and Onodera’s prognostic nutritional index. Long-term prognosis was better in responders than in non-responders (mean survival time: 308 days vs. 97 days, p = 0.031). Tolvaptan was even effective in many patients with HCC, with additional improvement in long-term prognosis expected with improvement in the nutritional status.
基金supported by the National Natural Science Foundation of China,No.81171134 and 81471235a grant from the Introducing Talents of Discipline to Universities,No.B14036+4 种基金a grant from the College Students’Extracurricular Scientific Innovation and Entrepreneurial Activity Research Topic of Jinan University Challenge Cup,No.(2013)27 and (2014)16a grant from the College Students’Extracurricular Scientific Innovation and Entrepreneurial Activity Research Topic of Jinan University in China,No.201410559079,1055914162 and CX14261a grant from the National Basic Research Program of China(973 Program),No.2011CB707501the Science and Technology Foundation of Guangdong Province in China,No.2010B030700016the Natural Science Foundation of Guangdong Province in China,No.2014A030313360
文摘Curcumin has been shown to significantly improve spatial memory impairment induced by HIV-1 gp 120 V3 in rats, but the electrophysiological mechanism remains unknown. Using extracellular microelectrode recording techniques, this study confirmed that the gp120 V3 loop could suppress long-term potentiation in the rat hippocampal CA1 region and synaptic plasticity, and that curcumin could antagonize these inhibitory effects. Using a Fura-2/AM calcium ion probe, we found that curcumin resisted the effects of the gp120 V3 loop on hippocampal synaptosomes and decreased Ca2＋ concentration in synaptosomes. This effect of curcumin was identical to nimodipine, suggesting that curcumin improved the inhibitory effects of gpl20 on synaptic plasticity, ameliorated damage caused to the central nervous system, and might be a potential neuroprotective drug.
文摘2001-2009年,在全国范围内采集了14个地理种群总计126个样本,以线粒体控制区作为分子标记,分析大卫鼠耳蝠种群系统发育关系和殖民历史.根据线粒体控制区序列构建的TCS网络图,将大卫鼠耳蝠的14个地理种群划分成3个地理区域,分别为中东部平原区、西南高原区和南方丘陵区.在53个单倍型中,浙江的单倍型14、贵州的单倍型47、广东的单倍型50分别为3个地理区域的祖先单倍型.Geodis、错配分布和中性检验的分析结果表明,中东部平原区(76.12和79.17 ka BP)和西南高原区(69.12 ka BP)曾发生过种群扩张事件,并于61.24 ka BP发生了一次由西南高原向中东部平原区的长距离殖民事件.分子生物学、仿生学、解剖学和空气动力学的证据,共同揭示了大卫鼠耳蝠具有长距离的迁移能力.
