背景妊娠期肝内胆汁淤积症(intrahepatic cholestasis of pregnancy,ICP)可导致胎儿生长发育不良,早期预测至关重要,现有指标预警存在滞后性,本研究假设游离雌三醇(unconjugated estriol,UE3)、妊娠相关血清蛋白A(pregnancy-associated ...背景妊娠期肝内胆汁淤积症(intrahepatic cholestasis of pregnancy,ICP)可导致胎儿生长发育不良,早期预测至关重要,现有指标预警存在滞后性,本研究假设游离雌三醇(unconjugated estriol,UE3)、妊娠相关血清蛋白A(pregnancy-associated plasma protein-A,PAPP-A)及游离β绒毛膜促性腺激素(free beta-subunit of human chorionic gonadotropin,free-hcgβ)与胎儿生长发育相关,联合检测可提高预测效能.目的探讨外周血UE3、PAPP-A及free-hcgβ与ICP患者胎儿生长发育的相关性及其预测价值,以期为临床防治工作提供参考.方法选取2023-05/2025-04杭州市临平区妇幼保健院收治300例ICP患者,统计胎儿生长发育情况,并据此分为不良组(62例)、良好组(238例).比较两组患者的临床资料及外周血UE3、PAPP-A及free-hcgβ表达,Logistic回归分析ICP患者胎儿生长发育不良的影响因素,限制性立方样条(restricted cubic spline,RCS)曲线进一步探索UE3、PAPP-A、free-hcgβ与胎儿发育不良之间的剂量-反应关系,并采用受试者工作特征(receiver operating characteristic,ROC)曲线分析UE3、PAPP-A、free-hcgβ单独及联合检测对胎儿发育不良预测效能.结果300例ICP患者胎儿发育不良62例(20.67%);不良组重度/极重度ICP占比及总胆汁酸、谷草转氨酶、谷丙转氨酶、UE3、free-hcgβ表达高于良好组,PAPP-A表达低于好组,差异有统计学意义(P<0.05);Logistic回归分析结果显示,校正ICP混杂因素后,UE3、PAPP-A及free-hcgβ仍是胎儿生长发育情况的影响因素(P<0.05);RCS分析结果显示,UE3、PAPP-A、free-hcgβ均与胎儿生长发育不良呈线性关系(Pnonlinear>0.05);ROC分析结果显示,UE3、PAPP-A、free-hcgβ联合预测胎儿生长发育不良的曲线下面积(area under curve,AUC)为0.923(95%CI:0.887-0.951),明显大于各指标单独预测价值的AUC(Z=3.018、3.583、3.355,均P<0.05).结论外周血UE3、PAPP-A及free-hcgβ均是ICP患者胎儿生长发育的影响因素,联合检测对胎儿生长发育不良具有一定预测价值,可作为临床预测胎儿生长发育情况的辅助指标,并可指导临床防治.展开更多
We examine possible funding sources for constructing Climate Change Haven Communities on a global basis. Areas of the planet that have the potential to house persons migrating to “safe havens” in their own or other ...We examine possible funding sources for constructing Climate Change Haven Communities on a global basis. Areas of the planet that have the potential to house persons migrating to “safe havens” in their own or other countries will require the rapid construction of communities capable of supporting them, their families, businesses and farms. However, different political-economic conditions are found across the areas which can serve as locations for these Climate Change Haven Communities. We develop funding and construction strategies for the United States (free-market capitalism), France and Spain (European Union supported economies), and Taiwan region (state-directed economy). The proposals for the Taiwan region should also be applicable to the rest of China.展开更多
文摘背景妊娠期肝内胆汁淤积症(intrahepatic cholestasis of pregnancy,ICP)可导致胎儿生长发育不良,早期预测至关重要,现有指标预警存在滞后性,本研究假设游离雌三醇(unconjugated estriol,UE3)、妊娠相关血清蛋白A(pregnancy-associated plasma protein-A,PAPP-A)及游离β绒毛膜促性腺激素(free beta-subunit of human chorionic gonadotropin,free-hcgβ)与胎儿生长发育相关,联合检测可提高预测效能.目的探讨外周血UE3、PAPP-A及free-hcgβ与ICP患者胎儿生长发育的相关性及其预测价值,以期为临床防治工作提供参考.方法选取2023-05/2025-04杭州市临平区妇幼保健院收治300例ICP患者,统计胎儿生长发育情况,并据此分为不良组(62例)、良好组(238例).比较两组患者的临床资料及外周血UE3、PAPP-A及free-hcgβ表达,Logistic回归分析ICP患者胎儿生长发育不良的影响因素,限制性立方样条(restricted cubic spline,RCS)曲线进一步探索UE3、PAPP-A、free-hcgβ与胎儿发育不良之间的剂量-反应关系,并采用受试者工作特征(receiver operating characteristic,ROC)曲线分析UE3、PAPP-A、free-hcgβ单独及联合检测对胎儿发育不良预测效能.结果300例ICP患者胎儿发育不良62例(20.67%);不良组重度/极重度ICP占比及总胆汁酸、谷草转氨酶、谷丙转氨酶、UE3、free-hcgβ表达高于良好组,PAPP-A表达低于好组,差异有统计学意义(P<0.05);Logistic回归分析结果显示,校正ICP混杂因素后,UE3、PAPP-A及free-hcgβ仍是胎儿生长发育情况的影响因素(P<0.05);RCS分析结果显示,UE3、PAPP-A、free-hcgβ均与胎儿生长发育不良呈线性关系(Pnonlinear>0.05);ROC分析结果显示,UE3、PAPP-A、free-hcgβ联合预测胎儿生长发育不良的曲线下面积(area under curve,AUC)为0.923(95%CI:0.887-0.951),明显大于各指标单独预测价值的AUC(Z=3.018、3.583、3.355,均P<0.05).结论外周血UE3、PAPP-A及free-hcgβ均是ICP患者胎儿生长发育的影响因素,联合检测对胎儿生长发育不良具有一定预测价值,可作为临床预测胎儿生长发育情况的辅助指标,并可指导临床防治.
文摘We examine possible funding sources for constructing Climate Change Haven Communities on a global basis. Areas of the planet that have the potential to house persons migrating to “safe havens” in their own or other countries will require the rapid construction of communities capable of supporting them, their families, businesses and farms. However, different political-economic conditions are found across the areas which can serve as locations for these Climate Change Haven Communities. We develop funding and construction strategies for the United States (free-market capitalism), France and Spain (European Union supported economies), and Taiwan region (state-directed economy). The proposals for the Taiwan region should also be applicable to the rest of China.
