摘要
目的 分析孕早期血清学筛查指标妊娠相关血浆蛋白A(pregnancy associated plasma protein-A,PAPP-A)、游离β-人绒毛膜促性腺激素(free beta-human chorionic gonadotrophin,free-hCGβ)、孕期体质量增长(gestational weight gain,GWG)与胎儿生长受限(fetal growth restriction,FGR)的关系,探索其对FGR的预测价值。方法 回顾性选取2021年1月至2024年1月于内蒙古自治区妇幼保健院规律孕检、孕早期于该院行血清学筛查、确诊并分娩FGR的孕妇作为FGR组(n=426),随机选择同期胎儿体质量正常的单胎妊娠孕妇作为对照组(n=520)。采用SPSS 24.0统计学软件分析两组孕妇的基本资料、血清学筛查资料,通过受试者操作特征曲线分析血清学筛查指标、GWG对FGR的预测价值。结果 FGR组孕妇的年龄高于对照组(P<0.05),FGR组孕妇的GWG、PAPP-A、free-hCGβ低于对照组(P<0.05)。年龄、PAPP-A降低、free-hCGβ降低、GWG降低是FGR发生的独立危险因素。PAPP-A、free-hCGβ、年龄、GWG联合预测FGR的曲线下面积为0.806(95%CI:0.778~0.834)。结论 FGR发生的影响因素包括PAPP-A、free-hCGβ、年龄、GWG;其联合预测FGR的价值较高。
Objective To analyze the relationship between first-trimester serological screening markers pregnancy associated plasma protein-A(PAPP-A),free beta-human chorionic gonadotrophin(free-hCGβ),gestational weight gain(GWG),and fetal growth restriction(FGR),and to explore their predictive value for FGR.Methods A retrospective study was conducted FGR cases(n=426)were selected from women who received regular prenatal care,first-trimester serological screening,and delivered at Inner Mongolia Maternal and Child Health Care Hospital from January,2021,to January 2024.Control group of 520 normal-weight singleton pregnancies from the same period was randomly selected.SPSS 24.0 was used to analyze maternal characteristics and serological data.Receiver operating characteristic curve were generated to evaluate the predictive value of serological markers and GWG for FGR.Results Maternal age in FGR group was higher than that in control group(P<0.05).GWG,PAPP-A,and free-hCGβlevels were significantly lower in FGR group(P<0.05).Advanced maternal age,decreased PAPP-A,reduced free-hCGβ,and insufficient GWG were identified as independent risk factors for FGR.The combined predictive model(PAPP-A,free-hCGβ,maternal age,and GWG)achieved an area under the curve of 0.806(95%CI:0.778-0.834)for FGR prediction.Conclusion Factors influencing FGR include PAPP-A,free-hCGβ,maternal age,and GWG.The combination of these markers demonstrates high predictive value for FGR.
作者
杨文颖
杨晓彦
YANG Wenying;YANG Xiaoyan(Graduate School of Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014060,Inner Mongolia,China;Department of Obstetrics,Inner Mongolia Maternal and Child Health Care Hospital,Hohhot 010020,Inner Mongolia,China)
出处
《中国现代医生》
2025年第24期35-38,62,共5页
China Modern Doctor
基金
内蒙古自治区妇幼保健院院内科研项目(2024FYYNC035)。
