The aim of this study was to clarify the response of sympathetic activity to antihypertensive drugs using a mental stress test in hypertensive patients and to determine the effects of antihypertensive drugs on the sym...The aim of this study was to clarify the response of sympathetic activity to antihypertensive drugs using a mental stress test in hypertensive patients and to determine the effects of antihypertensive drugs on the sympathetic activitymediated hemodynamic response to mental stress. Hypertensive patients were divided into three groups according to the type of drug(s) being taken: a calcium antagonist group, an angiotensin II receptor blocker group, and a combination therapy group of calcium antagonists and angiotensin II receptor blockers. The Stroop color-word conflict test was applied as a mental stress test and hemodynamic responses to mental stress were measured, including blood pressure, pulse rate, and skin blood flow. Elevation of blood pressure by mental stress was suppressed in the combination therapy group compared with the calcium antagonist group. Reduction of skin blood flow by mental stress was suppressed in both the angiotensin II blocker group and the combination therapy group compared with the calcium antagonist group. In conclusion, skin blood flow can be a useful tool to evaluate sympathetic activity and combination therapy with calcium antagonists and angiotensin II receptor blockers were the most useful therapy for suppressing the hemodynamic response to mental stress.展开更多
目的:探讨H2受体阻滞剂联合多潘立酮对肝硬化患者门静脉系统血流量的影响．方法:以20名健康人作为正常对照．60例肝硬化患者随机分成3组,分别给予口服高舒达、口服多潘立酮以及联合用药,治疗前后采用多普勒超声测定门静脉(PVF)、脾静脉(...目的:探讨H2受体阻滞剂联合多潘立酮对肝硬化患者门静脉系统血流量的影响．方法:以20名健康人作为正常对照．60例肝硬化患者随机分成3组,分别给予口服高舒达、口服多潘立酮以及联合用药,治疗前后采用多普勒超声测定门静脉(PVF)、脾静脉(SVF)和肠系膜上静脉(SMVF)血流量(mL/min)．结果:治疗后,H2受体阻滞剂组的PVF显著高于治疗前(850．23±140．78 vs 695．22±221．44, P＜0．01),SVF和SMVF低于治疗前,但无显著差异．多潘立酮组PVF较治疗前有增高,无显著差异,而SVF和SMVF显著低于治疗前(SVF: 598．13±272．33 vs 816．40±279．61,P＜0．05: SMVF:504．23±188．54 vs 640．30±200．12．P＜0．05)．联合用药组则PVF显著高于治疗前(876．76±178．65 vs 705．34±200．15,P＜0．05),而SVF、SMVF显著低于治疗前(SVF:605．33±252．86 vs 798．33±280．45,P＜0．01:SMVF: 503．43±175．25 vs 650．19±190．62,P＜0．01)．结论:H2受体阻滞剂组及多潘立酮都具有改善门静脉系统血流的作用,联合应用作用更为明显．展开更多
文摘The aim of this study was to clarify the response of sympathetic activity to antihypertensive drugs using a mental stress test in hypertensive patients and to determine the effects of antihypertensive drugs on the sympathetic activitymediated hemodynamic response to mental stress. Hypertensive patients were divided into three groups according to the type of drug(s) being taken: a calcium antagonist group, an angiotensin II receptor blocker group, and a combination therapy group of calcium antagonists and angiotensin II receptor blockers. The Stroop color-word conflict test was applied as a mental stress test and hemodynamic responses to mental stress were measured, including blood pressure, pulse rate, and skin blood flow. Elevation of blood pressure by mental stress was suppressed in the combination therapy group compared with the calcium antagonist group. Reduction of skin blood flow by mental stress was suppressed in both the angiotensin II blocker group and the combination therapy group compared with the calcium antagonist group. In conclusion, skin blood flow can be a useful tool to evaluate sympathetic activity and combination therapy with calcium antagonists and angiotensin II receptor blockers were the most useful therapy for suppressing the hemodynamic response to mental stress.
文摘目的:探讨H2受体阻滞剂联合多潘立酮对肝硬化患者门静脉系统血流量的影响．方法:以20名健康人作为正常对照．60例肝硬化患者随机分成3组,分别给予口服高舒达、口服多潘立酮以及联合用药,治疗前后采用多普勒超声测定门静脉(PVF)、脾静脉(SVF)和肠系膜上静脉(SMVF)血流量(mL/min)．结果:治疗后,H2受体阻滞剂组的PVF显著高于治疗前(850．23±140．78 vs 695．22±221．44, P＜0．01),SVF和SMVF低于治疗前,但无显著差异．多潘立酮组PVF较治疗前有增高,无显著差异,而SVF和SMVF显著低于治疗前(SVF: 598．13±272．33 vs 816．40±279．61,P＜0．05: SMVF:504．23±188．54 vs 640．30±200．12．P＜0．05)．联合用药组则PVF显著高于治疗前(876．76±178．65 vs 705．34±200．15,P＜0．05),而SVF、SMVF显著低于治疗前(SVF:605．33±252．86 vs 798．33±280．45,P＜0．01:SMVF: 503．43±175．25 vs 650．19±190．62,P＜0．01)．结论:H2受体阻滞剂组及多潘立酮都具有改善门静脉系统血流的作用,联合应用作用更为明显．
