Current methods for nasal spray formulations have been elementary evaluating the dripping characteristics of a formulation and have not assessed the behavior of the nasal formulation in the presence of varying types o...Current methods for nasal spray formulations have been elementary evaluating the dripping characteristics of a formulation and have not assessed the behavior of the nasal formulation in the presence of varying types of mucus depending on the indication or diseased state. This research investigated the effects of nasal mucus on the dripping behavior of nasal formulations and focused on developing an improved in vitro analytical test method that is more physiologically relevant in characterizing nasal formulation dripping behavior. Method development was performed using simulated nasal mucus preparations for both healthy and diseased states as coatings for the dripping experiment representing a wide range of viscosity. Factors evaluated during development of this in vitro test method included amount of mucus, application of mucus, drying times, and compatibility of the mucus on a C18 Thin Layer Chromatography(TLC) substrate. The dripping behavior of nasal formulations containing a range of 1%Avicel to 3.5% Avicel was assessed by actuating the nasal spray on a perpendicular TLC plate coated with either healthy or diseased simulated nasal mucus. After actuation of the nasal spray, the dripping of the formulation on the coated TLC plate was measured after the plate was repositioned vertically. The method that was developed generated reproducible results on the dripping behavior of nasal formulations and provided critical information about the compatibility of the formulation with the nasal mucus for different diseased states, aiding in nasal spray formulation development and physical characterization of the nasal spray.展开更多
A direct electroless copper （Cu） coating on tungsten powders method requiring no surface treatment or stabilizing agent and using glyoxylic acid （C2H203） as a reducing agent was reported. The effects of copper sul...A direct electroless copper （Cu） coating on tungsten powders method requiring no surface treatment or stabilizing agent and using glyoxylic acid （C2H203） as a reducing agent was reported. The effects of copper sulfate concentration and the pH of the plating solution on the properties of the prepared W@Cu composite powders were assessed. The content of Cu in the composite powders was controlled by adjusting the concentration of copper sulfate in the electroless plating solution. A uniform, dense, and consistent Cu coating was obtained under the established optimum conditions （flow rate of C2H203 = 5.01 mL/min, solution pH = 12.25 and reaction temperature 45.35℃） by using central composite design method. In addition, the crystalline Cu coating was evenly dispersed within the W@Cu composite powders and Cu element in the coating existed as Cu~. The formation mechanism for the W@Cu composite powders by electroless plating in the absence of surface treatment and stabilizing agent was also proposed.展开更多
A capacity building program on drip irrigation (TNDRIP) was undertaken in certain regions of the Indian State of Tamil Nadu during 2009-2010. An assessment of the impact of the program in terms of effective use of dri...A capacity building program on drip irrigation (TNDRIP) was undertaken in certain regions of the Indian State of Tamil Nadu during 2009-2010. An assessment of the impact of the program in terms of effective use of drip irrigation and increased crop yields was made in 2011 by applying double difference method (a combination of both with and without and before and after approaches). The results had indicated that the drip capacity building program resulted in a yield increase of 2.5 t/ha for Banana 1, 1.9 t/ha for Banana 2, 3.3 t/ha for sugarcane and 0.3 t/ha for turmeric. The conventional method using the before and after situations had shown a yield increase of 4.3 t/ha for Banana 1, 12.1 t/ha for Banana 2, 40.6 t/ha for sugarcane and 2.6 t/ha for turmeric. The conventional approach is highly upward biased in estimating the impact of the drip capacity building program and thus the double difference method will be an appropriate method to evaluate the impact of the programs that involve both with and without as well as before and after situations.展开更多
文摘Current methods for nasal spray formulations have been elementary evaluating the dripping characteristics of a formulation and have not assessed the behavior of the nasal formulation in the presence of varying types of mucus depending on the indication or diseased state. This research investigated the effects of nasal mucus on the dripping behavior of nasal formulations and focused on developing an improved in vitro analytical test method that is more physiologically relevant in characterizing nasal formulation dripping behavior. Method development was performed using simulated nasal mucus preparations for both healthy and diseased states as coatings for the dripping experiment representing a wide range of viscosity. Factors evaluated during development of this in vitro test method included amount of mucus, application of mucus, drying times, and compatibility of the mucus on a C18 Thin Layer Chromatography(TLC) substrate. The dripping behavior of nasal formulations containing a range of 1%Avicel to 3.5% Avicel was assessed by actuating the nasal spray on a perpendicular TLC plate coated with either healthy or diseased simulated nasal mucus. After actuation of the nasal spray, the dripping of the formulation on the coated TLC plate was measured after the plate was repositioned vertically. The method that was developed generated reproducible results on the dripping behavior of nasal formulations and provided critical information about the compatibility of the formulation with the nasal mucus for different diseased states, aiding in nasal spray formulation development and physical characterization of the nasal spray.
基金Funded by the National Natural Science Foundation of China(Nos.51202175 and 11072228)the National 111 Project(No.B13035)
文摘A direct electroless copper （Cu） coating on tungsten powders method requiring no surface treatment or stabilizing agent and using glyoxylic acid （C2H203） as a reducing agent was reported. The effects of copper sulfate concentration and the pH of the plating solution on the properties of the prepared W@Cu composite powders were assessed. The content of Cu in the composite powders was controlled by adjusting the concentration of copper sulfate in the electroless plating solution. A uniform, dense, and consistent Cu coating was obtained under the established optimum conditions （flow rate of C2H203 = 5.01 mL/min, solution pH = 12.25 and reaction temperature 45.35℃） by using central composite design method. In addition, the crystalline Cu coating was evenly dispersed within the W@Cu composite powders and Cu element in the coating existed as Cu~. The formation mechanism for the W@Cu composite powders by electroless plating in the absence of surface treatment and stabilizing agent was also proposed.
文摘A capacity building program on drip irrigation (TNDRIP) was undertaken in certain regions of the Indian State of Tamil Nadu during 2009-2010. An assessment of the impact of the program in terms of effective use of drip irrigation and increased crop yields was made in 2011 by applying double difference method (a combination of both with and without and before and after approaches). The results had indicated that the drip capacity building program resulted in a yield increase of 2.5 t/ha for Banana 1, 1.9 t/ha for Banana 2, 3.3 t/ha for sugarcane and 0.3 t/ha for turmeric. The conventional method using the before and after situations had shown a yield increase of 4.3 t/ha for Banana 1, 12.1 t/ha for Banana 2, 40.6 t/ha for sugarcane and 2.6 t/ha for turmeric. The conventional approach is highly upward biased in estimating the impact of the drip capacity building program and thus the double difference method will be an appropriate method to evaluate the impact of the programs that involve both with and without as well as before and after situations.
