Background:Cyperi Rhizoma,derived from Cyperus rotundus L.,is a widely used medicinal herb in traditional Chinese medicine(TCM),with Shandong Province recognized as its geo-authentic habitat.However,the quality of Cyp...Background:Cyperi Rhizoma,derived from Cyperus rotundus L.,is a widely used medicinal herb in traditional Chinese medicine(TCM),with Shandong Province recognized as its geo-authentic habitat.However,the quality of Cyperi Rhizoma varies significantly across different regions,potentially influencing its therapeutic efficacy.This study investigates the influence of geographic origin on the chemical composition and overall quality of Cyperi Rhizoma.Methods:A comprehensive approach,including traditional quality assessment,GC-MS(g as c hromatography-m ass s pectrometry),RP-HPLC(r everse p hase h igh-p erformance l iquid c hromatography),and FT-IR(f ourier t ransform i nfrared s pectroscopy)techniques,was employed to analyze Cyperi Rhizoma samples from Shandong Province.These methods examined the physical appearance,chemical profile,and content variations,particularly focusing onα-cyperone.Results:Traditional quality assessments revealed noticeable differences in the external characteristics of the samples.GC-MS analysis identified a variety of unique chemical constituents,while RP-HPLC and FT-IR showed significant variations inα-cyperone content,with higher levels found in Shandong samples.Conclusion:These results demonstrate that geographic origin is a critical determinant of Cyperi Rhizoma quality,with Shandong specimens exhibiting superiorα-cyperone levels and characteristic phytochemical profiles.This validates the geo-authenticity concept in TCM and provides actionable data for developing evidence-based quality standards,suggesting that provenance should be prioritized in medicinal material selection and pharmacopeial specifications.展开更多
[Objectives]This study was conducted to perform visual analysis of the research hotspots and development trends of Cyperi Rhizoma in the field of antidepressant based on CiteSpace,so as to explore the application and ...[Objectives]This study was conducted to perform visual analysis of the research hotspots and development trends of Cyperi Rhizoma in the field of antidepressant based on CiteSpace,so as to explore the application and development direction of Cyperi Rhizoma in the field of antidepressant.[Methods]Highly-relevant literatures were selected from the core database of China National Knowledge Infrastructure(CNKI),and CiteSpace and WPS office software were employed to visually analyze relevant contents such as publishing institutions,scholars,keywords,publishing time,and citation frequency.[Results]A total of 297 domestic relevant literatures were selected.Most of the publications,institutions and authors were concentrated in universities,affiliated institutions and scientific research institutes of traditional Chinese medicine in China,and no relatively novel applied research direction has emerged.At present,the hot spots and frontiers of application were mostly concentrated in its role in treating depression,anxiety,gynecological diseases and other disorders.[Conclusions]The research on Cyperi Rhizoma for its antidepressant effects in China originated in the late 20 th century.From 2004 to 2024,studies have primarily focused on its pharmacological principles,mechanisms of action,and classification,while the exploration of its application in specific depressive disorders was limited.Overall,research progress has been relatively slow.Currently,further efforts are needed to optimize the active antidepressant components of Cyperi Rhizoma and clarify its mechanisms of action,which will facilitate its broader application in treating various stages of depressive disorders.展开更多
This study aimed to evaluate the antidepressant effects of the combined administration of total saikosaponins(SSA)and volatile oil of Cyperi Rhizoma(VO)using a mouse depression model induced by chronic restraint plus ...This study aimed to evaluate the antidepressant effects of the combined administration of total saikosaponins(SSA)and volatile oil of Cyperi Rhizoma(VO)using a mouse depression model induced by chronic restraint plus mild stress(CRMS),and to compare the effects with the traditional antidepressant fluoxetine.Male Kunming mice were subjected to 14-day CRMS modeling and then randomly divided into four groups:the combined treatment group(intraperitoneal injection of SSA 3.5 mg·kg^(-1)+VO 35 mg·kg^(-1)),the fluoxetine treatment group(20 mg·kg^(-1)),the normal saline treatment group,and the non-model group.Drugs were administered continuously for 14 days.Depressive-like behaviors were assessed using the Forced Swimming Test(FST),Tail Suspension Test(TST),and Open-Field Test(OFT).The results showed that the absolute immobility time of mice in the CRMS model group was significantly prolonged in FST and TST.Combined administration of SSA and VO significantly improved depressive-like behaviors,restoring the absolute immobility time in FST and TST to levels close to the control group,with efficacy comparable to fluoxetine.This study confirms that the combination of SSA and VO exhibits antidepressant effects equivalent to fluoxetine in the CRMS model,providing experimental evidence for the further clinical development of this traditional Chinese medicine(TCM)compatibility.展开更多
It is well-known that odor has a good influence on a human mind and body. In this study, we investigated the effect of the essential oil inhalation of Cyperi rhizoma and Perillae herba which were main aromatic herbs i...It is well-known that odor has a good influence on a human mind and body. In this study, we investigated the effect of the essential oil inhalation of Cyperi rhizoma and Perillae herba which were main aromatic herbs ingredient of the Kososan, to psychological condition, autonomic nerve activity and salivary biomarker. In addition, we examined influence by the favorite difference in odor. 25 healthy female volunteers (control group: 5 people;Cyperi rhizoma group: 10 people;Perillae herba group: 10 people) were examined. POMS was examined at PRE and POST the experiment. Pulse analyser was examined and saliva samples were collected before the inhalation, just after the inhalation, 10 minutes and 20 minutes later, respectively. Saliva samples analyzed for levels of α-amylase and cortisol. At the examination for POMS after the experiment, the preference for the odor was confirmed. About both Cyperi rhizoma and Perillae herba, by the essential oil inhalation, mental stability and relaxation effect were provided in psychological and psysiological evaluation. In the “like” group, relaxation was greater than “unlike” group. However, about Cyperi rhizoma, the stress was relaxed regardless of the favorite difference in odor, and a physical relaxation effect was shown. In addition, about the autonomic nerve activity, the parasympathetic nerve was not activated, and it was suggested that it was made and stabilized the balance of the autonomic nerve.展开更多
目的运用CiteSpace软件对香附Cyperi Rhizoma的研究文献进行可视化分析,旨在全面梳理近年来的研究动态,揭示研究热点和未来可能的发展趋势,为香附的深入研究和应用提供参考依据。方法分别检索中国知网、万方数据和Web of Science核心数...目的运用CiteSpace软件对香附Cyperi Rhizoma的研究文献进行可视化分析,旨在全面梳理近年来的研究动态,揭示研究热点和未来可能的发展趋势,为香附的深入研究和应用提供参考依据。方法分别检索中国知网、万方数据和Web of Science核心数据库中收录的香附在中医药领域的中英文文献,时间设定为2004年1月1日—2024年7月31日。采用Note Express软件剔除重复以及不符合要求的文献,再利用CiteSpace对发文量、发文作者、研究机构、关键词共现、关键词突现等内容进行可视化图谱分析。结果筛选后共纳入1107篇中文文献,31篇英文文献;其中,年发文量呈波动上升趋势,发文量最多的作者是李大剑、Zhu Yue(朱悦),作者合作网络显示团队内部合作较多,团队间合作不足;研究机构中以山东中医药大学和Nanjing University of Chinese Medicine(南京中医药大学)的发文量最多,核心机构来自中医药类的高校与附属医院;关键词分析显示中文文献的研究热点主要为数据挖掘、临床研究等方面,英文文献更加偏向于药理作用、分子机制等方面。结论香附在中医药领域的相关研究仍不断上升,其在肝脏疾病、乳腺疾病、抑郁症等疾病的临床研究和数据挖掘是现阶段的研究热点,今后应采用多种现代技术手段不断深入挖掘香附潜力,扩大香附临床使用范围,推动香附的多元化发展,为香附的研究提供新思路。展开更多
基金supported by the National Natural Science Foundation of China(No.82204610)Qihang Talent Program(L2022046)+1 种基金the Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences(CI2021A04013)Fundamental Research Funds for the Central Public Welfare Research Institutes(ZZ15-YQ-041 and L2021029).
文摘Background:Cyperi Rhizoma,derived from Cyperus rotundus L.,is a widely used medicinal herb in traditional Chinese medicine(TCM),with Shandong Province recognized as its geo-authentic habitat.However,the quality of Cyperi Rhizoma varies significantly across different regions,potentially influencing its therapeutic efficacy.This study investigates the influence of geographic origin on the chemical composition and overall quality of Cyperi Rhizoma.Methods:A comprehensive approach,including traditional quality assessment,GC-MS(g as c hromatography-m ass s pectrometry),RP-HPLC(r everse p hase h igh-p erformance l iquid c hromatography),and FT-IR(f ourier t ransform i nfrared s pectroscopy)techniques,was employed to analyze Cyperi Rhizoma samples from Shandong Province.These methods examined the physical appearance,chemical profile,and content variations,particularly focusing onα-cyperone.Results:Traditional quality assessments revealed noticeable differences in the external characteristics of the samples.GC-MS analysis identified a variety of unique chemical constituents,while RP-HPLC and FT-IR showed significant variations inα-cyperone content,with higher levels found in Shandong samples.Conclusion:These results demonstrate that geographic origin is a critical determinant of Cyperi Rhizoma quality,with Shandong specimens exhibiting superiorα-cyperone levels and characteristic phytochemical profiles.This validates the geo-authenticity concept in TCM and provides actionable data for developing evidence-based quality standards,suggesting that provenance should be prioritized in medicinal material selection and pharmacopeial specifications.
基金Supported by Undergraduate Innovation and Enterpreneurship Training Program of Guangxi(S202310600067)Guangxi First-class Discipline Construction Project(GJKY[2022]1).
文摘[Objectives]This study was conducted to perform visual analysis of the research hotspots and development trends of Cyperi Rhizoma in the field of antidepressant based on CiteSpace,so as to explore the application and development direction of Cyperi Rhizoma in the field of antidepressant.[Methods]Highly-relevant literatures were selected from the core database of China National Knowledge Infrastructure(CNKI),and CiteSpace and WPS office software were employed to visually analyze relevant contents such as publishing institutions,scholars,keywords,publishing time,and citation frequency.[Results]A total of 297 domestic relevant literatures were selected.Most of the publications,institutions and authors were concentrated in universities,affiliated institutions and scientific research institutes of traditional Chinese medicine in China,and no relatively novel applied research direction has emerged.At present,the hot spots and frontiers of application were mostly concentrated in its role in treating depression,anxiety,gynecological diseases and other disorders.[Conclusions]The research on Cyperi Rhizoma for its antidepressant effects in China originated in the late 20 th century.From 2004 to 2024,studies have primarily focused on its pharmacological principles,mechanisms of action,and classification,while the exploration of its application in specific depressive disorders was limited.Overall,research progress has been relatively slow.Currently,further efforts are needed to optimize the active antidepressant components of Cyperi Rhizoma and clarify its mechanisms of action,which will facilitate its broader application in treating various stages of depressive disorders.
基金Guangdong Provincial Natural Science Foundation General Project[2214050002848]Jiaying University College Students’Innovation Projects(S202410582051,S202310582053,202310582018)。
文摘This study aimed to evaluate the antidepressant effects of the combined administration of total saikosaponins(SSA)and volatile oil of Cyperi Rhizoma(VO)using a mouse depression model induced by chronic restraint plus mild stress(CRMS),and to compare the effects with the traditional antidepressant fluoxetine.Male Kunming mice were subjected to 14-day CRMS modeling and then randomly divided into four groups:the combined treatment group(intraperitoneal injection of SSA 3.5 mg·kg^(-1)+VO 35 mg·kg^(-1)),the fluoxetine treatment group(20 mg·kg^(-1)),the normal saline treatment group,and the non-model group.Drugs were administered continuously for 14 days.Depressive-like behaviors were assessed using the Forced Swimming Test(FST),Tail Suspension Test(TST),and Open-Field Test(OFT).The results showed that the absolute immobility time of mice in the CRMS model group was significantly prolonged in FST and TST.Combined administration of SSA and VO significantly improved depressive-like behaviors,restoring the absolute immobility time in FST and TST to levels close to the control group,with efficacy comparable to fluoxetine.This study confirms that the combination of SSA and VO exhibits antidepressant effects equivalent to fluoxetine in the CRMS model,providing experimental evidence for the further clinical development of this traditional Chinese medicine(TCM)compatibility.
文摘It is well-known that odor has a good influence on a human mind and body. In this study, we investigated the effect of the essential oil inhalation of Cyperi rhizoma and Perillae herba which were main aromatic herbs ingredient of the Kososan, to psychological condition, autonomic nerve activity and salivary biomarker. In addition, we examined influence by the favorite difference in odor. 25 healthy female volunteers (control group: 5 people;Cyperi rhizoma group: 10 people;Perillae herba group: 10 people) were examined. POMS was examined at PRE and POST the experiment. Pulse analyser was examined and saliva samples were collected before the inhalation, just after the inhalation, 10 minutes and 20 minutes later, respectively. Saliva samples analyzed for levels of α-amylase and cortisol. At the examination for POMS after the experiment, the preference for the odor was confirmed. About both Cyperi rhizoma and Perillae herba, by the essential oil inhalation, mental stability and relaxation effect were provided in psychological and psysiological evaluation. In the “like” group, relaxation was greater than “unlike” group. However, about Cyperi rhizoma, the stress was relaxed regardless of the favorite difference in odor, and a physical relaxation effect was shown. In addition, about the autonomic nerve activity, the parasympathetic nerve was not activated, and it was suggested that it was made and stabilized the balance of the autonomic nerve.
文摘目的运用CiteSpace软件对香附Cyperi Rhizoma的研究文献进行可视化分析,旨在全面梳理近年来的研究动态,揭示研究热点和未来可能的发展趋势,为香附的深入研究和应用提供参考依据。方法分别检索中国知网、万方数据和Web of Science核心数据库中收录的香附在中医药领域的中英文文献,时间设定为2004年1月1日—2024年7月31日。采用Note Express软件剔除重复以及不符合要求的文献,再利用CiteSpace对发文量、发文作者、研究机构、关键词共现、关键词突现等内容进行可视化图谱分析。结果筛选后共纳入1107篇中文文献,31篇英文文献;其中,年发文量呈波动上升趋势,发文量最多的作者是李大剑、Zhu Yue(朱悦),作者合作网络显示团队内部合作较多,团队间合作不足;研究机构中以山东中医药大学和Nanjing University of Chinese Medicine(南京中医药大学)的发文量最多,核心机构来自中医药类的高校与附属医院;关键词分析显示中文文献的研究热点主要为数据挖掘、临床研究等方面,英文文献更加偏向于药理作用、分子机制等方面。结论香附在中医药领域的相关研究仍不断上升,其在肝脏疾病、乳腺疾病、抑郁症等疾病的临床研究和数据挖掘是现阶段的研究热点,今后应采用多种现代技术手段不断深入挖掘香附潜力,扩大香附临床使用范围,推动香附的多元化发展,为香附的研究提供新思路。
