Autism spectrum disorder(ASD)is a range of neurodevelopmental diseases characterized by social dysfunction and stereotypic behaviors.The etiology of ASD remains largely unexplored,resulting in a diverse array of descr...Autism spectrum disorder(ASD)is a range of neurodevelopmental diseases characterized by social dysfunction and stereotypic behaviors.The etiology of ASD remains largely unexplored,resulting in a diverse array of described clinical manifestations and varying degrees of severity.Currently,there are no drugs approved by a supervisory organization that can effectively treat the core symptoms of ASD.Childhood and adolescence are crucial stages for making significant achievements in ASD treatment,necessitating the development of drugs specifically for these periods.Based on the drug targets and mechanisms of action,it can be found that atypical psychotropic medications,anti-inflammatory and antioxidant medications,hormonal medications,ion channel medications,and gastrointestinal medications have shown significant improvement in treating the core symptoms of ASD in both children and adolescents.In addition,comparisons of drugs within the same category regarding efficacy and safety have been made to identify better alternatives and promote drug development.While further evaluation of the effectiveness and safety of these medications is needed,they hold great potential for widespread application in the clinical treatment of the principal symptoms of ASD.展开更多
目的通过网络分析探究老年脑卒中患者多维症状网络,识别核心症状并分析多维症状的影响因素,为制订精准症状管理提供依据。方法2024年1-5月,采用便利抽样法选取安徽省4所三级甲等医院收治的500例老年脑卒中患者为研究对象,采用一般资料...目的通过网络分析探究老年脑卒中患者多维症状网络,识别核心症状并分析多维症状的影响因素,为制订精准症状管理提供依据。方法2024年1-5月,采用便利抽样法选取安徽省4所三级甲等医院收治的500例老年脑卒中患者为研究对象,采用一般资料调查表、脑卒中症状体验量表(stroke patients’symptom experience scale,Stroke-SES)、多维健康心理控制源量表(multidimensional health locus of control,MHLC)、简易疾病感知问卷(brief illness perception questionnaire,BIPQ)对其进行调查。通过R语言构建症状网络并分析中心性指标,采用单因素分析、相关分析及多元线性回归分析探讨多维症状的影响因素。结果老年脑卒中患者多维症状发生率为19.00%~94.60%。症状网络分析显示,“自理能力下降”强度中心性和预期影响均最高。多元线性回归分析显示,身体活动水平、健康内部控制、健康机遇控制、疾病感知是症状严重程度的影响因素(均P<0.01),解释总变异的63.24%。结论自理能力下降是老年脑卒中患者多维症状网络中的核心症状,受多重因素影响;医护人员可基于核心症状及其相关影响因素制订精准干预措施,以提升症状管理效能。展开更多
基金supported by the Key-Area Research and Development Program of Guangdong Province(No.2019B030335001)the National Natural Science Foundation of China(No.32200815)+1 种基金the National Social Science Foundation of China(No.20&ZD296)the China Postdoctoral Science Foundation(No.2022M721218)。
文摘Autism spectrum disorder(ASD)is a range of neurodevelopmental diseases characterized by social dysfunction and stereotypic behaviors.The etiology of ASD remains largely unexplored,resulting in a diverse array of described clinical manifestations and varying degrees of severity.Currently,there are no drugs approved by a supervisory organization that can effectively treat the core symptoms of ASD.Childhood and adolescence are crucial stages for making significant achievements in ASD treatment,necessitating the development of drugs specifically for these periods.Based on the drug targets and mechanisms of action,it can be found that atypical psychotropic medications,anti-inflammatory and antioxidant medications,hormonal medications,ion channel medications,and gastrointestinal medications have shown significant improvement in treating the core symptoms of ASD in both children and adolescents.In addition,comparisons of drugs within the same category regarding efficacy and safety have been made to identify better alternatives and promote drug development.While further evaluation of the effectiveness and safety of these medications is needed,they hold great potential for widespread application in the clinical treatment of the principal symptoms of ASD.
文摘目的通过网络分析探究老年脑卒中患者多维症状网络,识别核心症状并分析多维症状的影响因素,为制订精准症状管理提供依据。方法2024年1-5月,采用便利抽样法选取安徽省4所三级甲等医院收治的500例老年脑卒中患者为研究对象,采用一般资料调查表、脑卒中症状体验量表(stroke patients’symptom experience scale,Stroke-SES)、多维健康心理控制源量表(multidimensional health locus of control,MHLC)、简易疾病感知问卷(brief illness perception questionnaire,BIPQ)对其进行调查。通过R语言构建症状网络并分析中心性指标,采用单因素分析、相关分析及多元线性回归分析探讨多维症状的影响因素。结果老年脑卒中患者多维症状发生率为19.00%~94.60%。症状网络分析显示,“自理能力下降”强度中心性和预期影响均最高。多元线性回归分析显示,身体活动水平、健康内部控制、健康机遇控制、疾病感知是症状严重程度的影响因素(均P<0.01),解释总变异的63.24%。结论自理能力下降是老年脑卒中患者多维症状网络中的核心症状,受多重因素影响;医护人员可基于核心症状及其相关影响因素制订精准干预措施,以提升症状管理效能。
