Continuous manufacturing is considered as one of the future trends of pharmaceutical engineering. In this work, continuous liquid-liquid extraction for sinomenine purification was realized with the usage of centrifuga...Continuous manufacturing is considered as one of the future trends of pharmaceutical engineering. In this work, continuous liquid-liquid extraction for sinomenine purification was realized with the usage of centrifugal extractors. Chloroform was used as the extractant because of the high distribution coefficient (>100). Higher extraction ratio can be obtained when using the centrifugal extractor of Model CWL50-N. The extraction ratio of the second-stage extraction was higher than that of the first-stage extraction. The extraction ratio of the second-stage countercurrent extraction was higher than that of second-stage cross-flow extraction. When chloroform phase was recycled for liquid-liquid extraction, the extraction ratio was also higher than 95%. This work can also be an example of continuous liquid-liquid extraction for the separation of other Chinese medicine components.展开更多
A novel extraction method of baicalin from radix scutellariae was explored in this study. Liquid-liquid continuous biphasic extraction was a new method, and showed the advantage of high extracting contents of total fl...A novel extraction method of baicalin from radix scutellariae was explored in this study. Liquid-liquid continuous biphasic extraction was a new method, and showed the advantage of high extracting contents of total flavone compared with one of the traditional methods. The novel extraction method which is easy to operate and has good reproducibility was much more effective than the traditional one.展开更多
High pure CO2 gas was tested in different intensity through MAT253&GasBench to determine the relationship between CO2 intensity and its isotope ratio under different extractions.10 points’ trend lines show that r...High pure CO2 gas was tested in different intensity through MAT253&GasBench to determine the relationship between CO2 intensity and its isotope ratio under different extractions.10 points’ trend lines show that relative variations of 4544 are-0.06‰,-0.03‰ and-0.005‰ respectively,corresponding to the extraction values of 15%,50% and 95%,with sensitivity’s slight decreasing.The results show that extraction forms main influence on the linearity of gas isotope mass spectrometer,and that the best linearity can be found when using high percent value of extraction.Emission,trap voltage and electron energy are indirect factors to slightly affect linearity,extraction should properly match them to acquire better linearity,because they influence the ions ratio to some extent during the ionization.展开更多
文摘Continuous manufacturing is considered as one of the future trends of pharmaceutical engineering. In this work, continuous liquid-liquid extraction for sinomenine purification was realized with the usage of centrifugal extractors. Chloroform was used as the extractant because of the high distribution coefficient (>100). Higher extraction ratio can be obtained when using the centrifugal extractor of Model CWL50-N. The extraction ratio of the second-stage extraction was higher than that of the first-stage extraction. The extraction ratio of the second-stage countercurrent extraction was higher than that of second-stage cross-flow extraction. When chloroform phase was recycled for liquid-liquid extraction, the extraction ratio was also higher than 95%. This work can also be an example of continuous liquid-liquid extraction for the separation of other Chinese medicine components.
文摘A novel extraction method of baicalin from radix scutellariae was explored in this study. Liquid-liquid continuous biphasic extraction was a new method, and showed the advantage of high extracting contents of total flavone compared with one of the traditional methods. The novel extraction method which is easy to operate and has good reproducibility was much more effective than the traditional one.
文摘High pure CO2 gas was tested in different intensity through MAT253&GasBench to determine the relationship between CO2 intensity and its isotope ratio under different extractions.10 points’ trend lines show that relative variations of 4544 are-0.06‰,-0.03‰ and-0.005‰ respectively,corresponding to the extraction values of 15%,50% and 95%,with sensitivity’s slight decreasing.The results show that extraction forms main influence on the linearity of gas isotope mass spectrometer,and that the best linearity can be found when using high percent value of extraction.Emission,trap voltage and electron energy are indirect factors to slightly affect linearity,extraction should properly match them to acquire better linearity,because they influence the ions ratio to some extent during the ionization.
