The realization of real-time thermal feedback for monitoring photothermal therapy(PTT)under near-infrared(NIR)light irradiation is of great interest and challenge for antitumor therapy.Herein,by assembling highly effi...The realization of real-time thermal feedback for monitoring photothermal therapy(PTT)under near-infrared(NIR)light irradiation is of great interest and challenge for antitumor therapy.Herein,by assembling highly efficient photothermal conversion gold nanorods and a temperature-responsive probe((E)-4-(4-(diethylamino)styryl)-1-methylpyridin-1-ium,PyS)within MOF-199,an intelligent nanoplatform(AMPP)was fabricated for simultaneous chemodynamic therapy and NIR light-induced temperature-feedback PTT.The fluorescence intensity and temperature of the PyS probe are linearly related due to the restriction of the rotation of the characteristic monomethine bridge.Moreover,the copper ions resulting from the degradation of MOF-199 in an acidic microenvironment can convert H_(2)O_(2)into•OH,resulting in tumor ablation through a Fenton-like reaction,and this process can be accelerated by increasing the temperature.This study establishes a feasible platform for fabricating highly sensitive temperature sensors for efficient temperature-feedback PTT.展开更多
针对实时系统负载动态变化的问题,提出一种面向软实时的基于资源预留的反馈调度模型(Feedback Scheduling M odel based on Resource Reservation,FSM-RR),当负载发生变化时调整服务器的CPU带宽.接着针对混合任务提出一种自适应分层调...针对实时系统负载动态变化的问题,提出一种面向软实时的基于资源预留的反馈调度模型(Feedback Scheduling M odel based on Resource Reservation,FSM-RR),当负载发生变化时调整服务器的CPU带宽.接着针对混合任务提出一种自适应分层调度框架(Adaptive Hierarchical Scheduling Framework,AHSF),对不同类型任务采用相应的调度算法,保证硬实时任务在其截止期之前完成,同时尽可能的降低软实时以及非实时任务的截止期错失率.在RTSim平台上进行仿真实验,并与传统调度算法进行对比分析,实验结果表明本文提出调度算法具有较好的性能.展开更多
基金supported by the National Natural Science Foundation of China(22171001,22305001,51972001,52372073)the Natural Science Foundation of Anhui Province of China(2108085MB49).
文摘The realization of real-time thermal feedback for monitoring photothermal therapy(PTT)under near-infrared(NIR)light irradiation is of great interest and challenge for antitumor therapy.Herein,by assembling highly efficient photothermal conversion gold nanorods and a temperature-responsive probe((E)-4-(4-(diethylamino)styryl)-1-methylpyridin-1-ium,PyS)within MOF-199,an intelligent nanoplatform(AMPP)was fabricated for simultaneous chemodynamic therapy and NIR light-induced temperature-feedback PTT.The fluorescence intensity and temperature of the PyS probe are linearly related due to the restriction of the rotation of the characteristic monomethine bridge.Moreover,the copper ions resulting from the degradation of MOF-199 in an acidic microenvironment can convert H_(2)O_(2)into•OH,resulting in tumor ablation through a Fenton-like reaction,and this process can be accelerated by increasing the temperature.This study establishes a feasible platform for fabricating highly sensitive temperature sensors for efficient temperature-feedback PTT.
文摘针对实时系统负载动态变化的问题,提出一种面向软实时的基于资源预留的反馈调度模型(Feedback Scheduling M odel based on Resource Reservation,FSM-RR),当负载发生变化时调整服务器的CPU带宽.接着针对混合任务提出一种自适应分层调度框架(Adaptive Hierarchical Scheduling Framework,AHSF),对不同类型任务采用相应的调度算法,保证硬实时任务在其截止期之前完成,同时尽可能的降低软实时以及非实时任务的截止期错失率.在RTSim平台上进行仿真实验,并与传统调度算法进行对比分析,实验结果表明本文提出调度算法具有较好的性能.
