The fermented Chinese formula Shuan-Tong-Ling is composed of radix puerariae（Gegen）,salvia miltiorrhiza（Danshen）,radix curcuma（Jianghuang）,hawthorn（Shanzha）,salvia chinensis（Shijianchuan）,sinapis alba（Baiji...The fermented Chinese formula Shuan-Tong-Ling is composed of radix puerariae（Gegen）,salvia miltiorrhiza（Danshen）,radix curcuma（Jianghuang）,hawthorn（Shanzha）,salvia chinensis（Shijianchuan）,sinapis alba（Baijiezi）,astragalus（Huangqi）,panax japonicas（Zhujieshen）,atractylodes macrocephala koidz（Baizhu）,radix paeoniae alba（Baishao）,bupleurum（Chaihu）,chrysanthemum（Juhua）,rhizoma cyperi（Xiangfu） and gastrodin（Tianma）,whose aqueous extract was fermented with lactobacillus,bacillus aceticus and saccharomycetes.ShuanTong-Ling is a formula used to treat brain diseases including ischemic stroke,migraine,and vascular dementia.Shuan-Tong-Ling attenuated H_2O_2-induced oxidative stress in rat microvascular endothelial cells.However,the potential mechanism involved in these effects is poorly understood.Rats were intragastrically treated with 5.7 or 17.2 m L/kg Shuan-Tong-Ling for 7 days before middle cerebral artery occlusion was induced.The results indicated Shuan-Tong-Ling had a cerebral protective effect by reducing infarct volume and increasing neurological scores.Shuan-Tong-Ling also decreased tumor necrosis factor-α and interleukin-1β levels in the hippocampus on the ischemic side.In addition,Shuan-Tong-Ling upregulated the expression of SIRT1 and Bcl-2 and downregulated the expression of acetylated-protein 53 and Bax.Injection of 5 mg/kg silent information regulator 1（SIRT1） inhibitor EX527 into the subarachnoid space once every 2 days,four times,reversed the above changes.These results demonstrate that Shuan-Tong-Ling might benefit cerebral ischemia/reperfusion injury by reducing inflammation and apoptosis through activation of the SIRT1 signaling pathway.展开更多
To evaluate the therapeutic effects of Rong Shuan Jiao Nang(RSJN)on treatment of acute mountain sickness(AMS)and high altitude myocardial ischemic syndrome in workers in Yushu,three groups were studied:group A(60 pati...To evaluate the therapeutic effects of Rong Shuan Jiao Nang(RSJN)on treatment of acute mountain sickness(AMS)and high altitude myocardial ischemic syndrome in workers in Yushu,three groups were studied:group A(60 patients with AMS,given RSJN),group B(15 patients with altitude myocardial ischemic syndrome,given RSJN),and group C(control,without drugs).All studied subjects were lowland workers who were first time entry to Yushu for work at an altitude of 4250 m.During the course of treatment,a routing physical examina-tion was performed,AMS Lake Louise Scores were estimated,arterial oxygen saturation(SaO2),electrocardiography and hemoglobin concentration were measured before and after using RSJN for 10 days.In group A,the effective rate was 68%,symptomatic improvement in 54 cases(90%)within 5 days.In group B,the effective rate was 93%,episodes of angina pectoris stopped in 12 patients within 3-7 days,one lasted 8 days.After treatment,the level of SaO2 increased 15.5%,21.8%and 5.6%in group A,group B and group C,respectively.RSJN tak-en at the start of the arrival at Yushu can decrease AMS scores and facilitate cure.If taken after the illness has begun,RSJN may help lessen symptoms,especially effectively improved angina pectoris of the high altitude myocardial ischemic syndrome.Symptoms usually subside after 3-8 days.RSJN should be continually used lbr at least 7 days after ascent.展开更多
基金supported by the National Natural Science Foundation of China,No.81202625Open Fund of Key Laboratory of Cardiovascular and Cerebrovascular Diseases Translational Medicine of China Three Gorges University of China,No.2016xnxg101
文摘The fermented Chinese formula Shuan-Tong-Ling is composed of radix puerariae（Gegen）,salvia miltiorrhiza（Danshen）,radix curcuma（Jianghuang）,hawthorn（Shanzha）,salvia chinensis（Shijianchuan）,sinapis alba（Baijiezi）,astragalus（Huangqi）,panax japonicas（Zhujieshen）,atractylodes macrocephala koidz（Baizhu）,radix paeoniae alba（Baishao）,bupleurum（Chaihu）,chrysanthemum（Juhua）,rhizoma cyperi（Xiangfu） and gastrodin（Tianma）,whose aqueous extract was fermented with lactobacillus,bacillus aceticus and saccharomycetes.ShuanTong-Ling is a formula used to treat brain diseases including ischemic stroke,migraine,and vascular dementia.Shuan-Tong-Ling attenuated H_2O_2-induced oxidative stress in rat microvascular endothelial cells.However,the potential mechanism involved in these effects is poorly understood.Rats were intragastrically treated with 5.7 or 17.2 m L/kg Shuan-Tong-Ling for 7 days before middle cerebral artery occlusion was induced.The results indicated Shuan-Tong-Ling had a cerebral protective effect by reducing infarct volume and increasing neurological scores.Shuan-Tong-Ling also decreased tumor necrosis factor-α and interleukin-1β levels in the hippocampus on the ischemic side.In addition,Shuan-Tong-Ling upregulated the expression of SIRT1 and Bcl-2 and downregulated the expression of acetylated-protein 53 and Bax.Injection of 5 mg/kg silent information regulator 1（SIRT1） inhibitor EX527 into the subarachnoid space once every 2 days,four times,reversed the above changes.These results demonstrate that Shuan-Tong-Ling might benefit cerebral ischemia/reperfusion injury by reducing inflammation and apoptosis through activation of the SIRT1 signaling pathway.
基金"973"National Key Basic Research and Development Program(No.2012CB518202)Project of Qinghai Development of Science and Technology(No.2011-N-150)
文摘To evaluate the therapeutic effects of Rong Shuan Jiao Nang(RSJN)on treatment of acute mountain sickness(AMS)and high altitude myocardial ischemic syndrome in workers in Yushu,three groups were studied:group A(60 patients with AMS,given RSJN),group B(15 patients with altitude myocardial ischemic syndrome,given RSJN),and group C(control,without drugs).All studied subjects were lowland workers who were first time entry to Yushu for work at an altitude of 4250 m.During the course of treatment,a routing physical examina-tion was performed,AMS Lake Louise Scores were estimated,arterial oxygen saturation(SaO2),electrocardiography and hemoglobin concentration were measured before and after using RSJN for 10 days.In group A,the effective rate was 68%,symptomatic improvement in 54 cases(90%)within 5 days.In group B,the effective rate was 93%,episodes of angina pectoris stopped in 12 patients within 3-7 days,one lasted 8 days.After treatment,the level of SaO2 increased 15.5%,21.8%and 5.6%in group A,group B and group C,respectively.RSJN tak-en at the start of the arrival at Yushu can decrease AMS scores and facilitate cure.If taken after the illness has begun,RSJN may help lessen symptoms,especially effectively improved angina pectoris of the high altitude myocardial ischemic syndrome.Symptoms usually subside after 3-8 days.RSJN should be continually used lbr at least 7 days after ascent.
