摘要
难治性肾病综合征（ＲＮＳ）的治疗是临床医师经常遇到的棘手问题。本文以四联双冲击疗法，予地塞米松和环磷酰胺冲击，配合蛇毒抗栓酶、中药治疗，２周为一个疗程。一个疗程的完全缓解率为３１．８％，基本缓解率为３３．３％，部分缓解率为１９．０％，总有效率为８４．１％，无效１５．９％。无效的１０例予第二个疗程，其中５例达完全经解和基本缓解；３例予第三个疗程，结果２例基本经解，１例部分经解。血清Ｃ３、肌酐、血沉、尿Ｃ３、尿ＦＤＰ、尿圆盘电泳对疗效的预测有一定的价值。本疗法疗程短、收效快、疗效高、副作用少，但必须严格掌握适应证，注意有无隐性感染、白细胞减少和电解质紊乱等，以免发生严重的并发症。
ixty-three patients with refractorynephropathy syndrome were treated by doublepulse
therapy of dexaniethasone andcyclophosphamide combined with Fu She KangShuan Mei and
Chinese herb medicine. Onecourse of treatment lasted four two weeks. Afterone course of
treatment the results showed thatthe complete remission rate was 31. 8%, basalremission rate
33. 3% , partly remission rate19%, invalid rate 15. 9% and total effectiverate 84. 1%. Of ten
invalid petients receivingtwo courses of treatment, five patients reachedstandard of complete
remission and basalremission. Of three invalid patients receivingthree courese of trcatment,
two patients obtainedbasal remission, one partly remission. The levelof serum C3, serum
creainine, erythrocytesedimentation rate, urine C3 and urine SDS-PAGE in patients may
suggest curative effect.The treatnient has many advantages such asshorter couroe of
treatment, more excellentcurative effect, less side effects. Howerer, thedoctors must know well
indications and avoidpatients sufferins from infection , leukopenia anddialectric disturbance.
出处
《肾脏病与透析肾移植杂志》
CAS
CSCD
1994年第4期276-280,共5页
Chinese Journal of Nephrology,Dialysis & Transplantation
关键词
难治性
肾病综合征
中西医结合治疗
dexamethasone
cyclo-phosphamide
Fu She Kans Shuan Mei
Chinese herb
medicine
refractory nephropethysyndrome
