We study an exclusion process with multiple dynamic roadblocks.Each roadblock can move diffusively forward or backward with different rates,as well as unbind from/rebind to a free site.By Monte Carlo simulations,the t...We study an exclusion process with multiple dynamic roadblocks.Each roadblock can move diffusively forward or backward with different rates,as well as unbind from/rebind to a free site.By Monte Carlo simulations,the two moving types are investigated in combination of roadblock number.The case of only diffusive roadblocks shows an asymmetric current-density relation.The case of only long-range jumping roadblocks presents that flux decreases with increasing roadblock number.展开更多
Baculoviruses infect insects in nature by targeting their larvae.They can also pass on genes into mammalian cells(including human cells)without producing progeny viruses via a process termed transduction.For that,they...Baculoviruses infect insects in nature by targeting their larvae.They can also pass on genes into mammalian cells(including human cells)without producing progeny viruses via a process termed transduction.For that,they are promising vectors for human gene therapy.There is,however,an unsolved obstacle that the mammalian transduction is very inefficient.To address that,scientists from the CAS Wuhan Institute of Virology(WHIOV)sought to figure out the major roadblock to mammalian cell entry of baculovirus and find out a solution to overcome it.展开更多
基金Project supported by the National Basic Research Program of China(Grant No.2012CB725404)the National Natural Science Foundation of China(Grant Nos.11422221,71171185,and 71371175)
文摘We study an exclusion process with multiple dynamic roadblocks.Each roadblock can move diffusively forward or backward with different rates,as well as unbind from/rebind to a free site.By Monte Carlo simulations,the two moving types are investigated in combination of roadblock number.The case of only diffusive roadblocks shows an asymmetric current-density relation.The case of only long-range jumping roadblocks presents that flux decreases with increasing roadblock number.
文摘Baculoviruses infect insects in nature by targeting their larvae.They can also pass on genes into mammalian cells(including human cells)without producing progeny viruses via a process termed transduction.For that,they are promising vectors for human gene therapy.There is,however,an unsolved obstacle that the mammalian transduction is very inefficient.To address that,scientists from the CAS Wuhan Institute of Virology(WHIOV)sought to figure out the major roadblock to mammalian cell entry of baculovirus and find out a solution to overcome it.
