为提升chirplet变换(chirplet transform,CT)估算瞬时频率的精度,在CT基础上结合花斑翠鸟优化(pied kingfisher optimizer,PKO)和径向基移动最小二乘(radial basis function moving least squares,RBFMLS)算法提出了一种识别结构瞬时频...为提升chirplet变换(chirplet transform,CT)估算瞬时频率的精度,在CT基础上结合花斑翠鸟优化(pied kingfisher optimizer,PKO)和径向基移动最小二乘(radial basis function moving least squares,RBFMLS)算法提出了一种识别结构瞬时频率的新方法。该方法采用正定紧支径向基函数作为移动最小二乘近似的权函数,对CT的能量脊线进行估算,同时应用PKO对RBFMLS节点支撑半径和CT窗函数宽度进行优化。通过一组解析信号数值算例和一个时变拉索试验验证了所提方法的有效性。研究结果表明,该方法能有效改善信号分析的能量聚集性,提高瞬时频率的识别精度。展开更多
Aim: To compare serum gelsolin levels of women with androgenetic alopecia with PCOS and patients with non-PCOS alopecia. Materials and Methods: A total of 30 PCOS patients who applied to our dermatology clinic with th...Aim: To compare serum gelsolin levels of women with androgenetic alopecia with PCOS and patients with non-PCOS alopecia. Materials and Methods: A total of 30 PCOS patients who applied to our dermatology clinic with the complaint of hair loss and were diagnosed with androgenetic alopecia (AGA) were included in the study. Thirty patients who were not diagnosed with PCOS but were diagnosed with AGA were considered as the control group. Patients in the control group were matched with PCOS in terms of age. AGA was diagnosed in cases of widespread thinning of the hair on the scalp and preservation of the frontal hairline. All participants underwent a complete clinical examination and blood examination. Serum gelsolin levels of both groups were measured by ELISA. Results: The number, age, and BMI values of the participants in both groups were recorded as similar. Serum total testosterone, insulin, HOMA-IR and LH values were significantly higher in the PCOS with AGA compared to the AGA without PCOS. There is no significant difference between groups in terms of serum FSH levels. Serum gelsolin levels of the PCOS group were significantly lower than the control group (160.1 ± 34.2 ng/mL vs. 188.6 ± 46.7 ng/mL, p Conclusions: Serum gelsolin levels in PCOS patients with androgenetic alopecia were found to be significantly lower than in non-PCOS alopecia patient groups.展开更多
A murine maorophage-like cell line, J774, acquri ed, in response to LPS, an ability to kill tumor necrosis factor (TNF)-insensitive target P815 mastocytoma cells, whereas another cell line, P388D1, did not. LPS-trigge...A murine maorophage-like cell line, J774, acquri ed, in response to LPS, an ability to kill tumor necrosis factor (TNF)-insensitive target P815 mastocytoma cells, whereas another cell line, P388D1, did not. LPS-triggered signaling mechanisms between the two cell lines were compared with an aim to inquire about the possible nature of the above-mentioned difference. The results showed that two cell lines respond to LPS-treatment by parallel activation of both phospholipases C and A2 (PLC and PLA2) to approximately the same extent. The maximum response of both enzymes of J774 cells was noted within 10 min of the treatment, whereas that of P388D1 cells required more than 20 min. The other properties of LPS-responsive enzymes studied were similar between two cell lines, includingAotivation of PLC and PLA2 and PKC in macrophages by LPSGa2+ augmentation of enzyme activation, participation of guanine nuoleotide binding (G) proteins in the initial activation processes, and inhibition of enzyme activation by the prior treatment of cells with cholera or pertussis toxins etc. Moreover, LPS-triggered activation of PLC and PLA2 was found to be followed by the increase of PKC activities in both cell lines. In spite of these similarities, J774 cells possessed both basic and acidic forms of PKC activities, while P 388D1 cells owned only PKC of basic form. Nevertheless, the question why J774 cells, but not P388D1 cells, can acquire the tumorioidal activity, aganist P815 cells following LPS-treatment remains to be answered.展开更多
文摘为提升chirplet变换(chirplet transform,CT)估算瞬时频率的精度,在CT基础上结合花斑翠鸟优化(pied kingfisher optimizer,PKO)和径向基移动最小二乘(radial basis function moving least squares,RBFMLS)算法提出了一种识别结构瞬时频率的新方法。该方法采用正定紧支径向基函数作为移动最小二乘近似的权函数,对CT的能量脊线进行估算,同时应用PKO对RBFMLS节点支撑半径和CT窗函数宽度进行优化。通过一组解析信号数值算例和一个时变拉索试验验证了所提方法的有效性。研究结果表明,该方法能有效改善信号分析的能量聚集性,提高瞬时频率的识别精度。
文摘Aim: To compare serum gelsolin levels of women with androgenetic alopecia with PCOS and patients with non-PCOS alopecia. Materials and Methods: A total of 30 PCOS patients who applied to our dermatology clinic with the complaint of hair loss and were diagnosed with androgenetic alopecia (AGA) were included in the study. Thirty patients who were not diagnosed with PCOS but were diagnosed with AGA were considered as the control group. Patients in the control group were matched with PCOS in terms of age. AGA was diagnosed in cases of widespread thinning of the hair on the scalp and preservation of the frontal hairline. All participants underwent a complete clinical examination and blood examination. Serum gelsolin levels of both groups were measured by ELISA. Results: The number, age, and BMI values of the participants in both groups were recorded as similar. Serum total testosterone, insulin, HOMA-IR and LH values were significantly higher in the PCOS with AGA compared to the AGA without PCOS. There is no significant difference between groups in terms of serum FSH levels. Serum gelsolin levels of the PCOS group were significantly lower than the control group (160.1 ± 34.2 ng/mL vs. 188.6 ± 46.7 ng/mL, p Conclusions: Serum gelsolin levels in PCOS patients with androgenetic alopecia were found to be significantly lower than in non-PCOS alopecia patient groups.
基金This work was supportod in part by grants (CA35977 and AL 22742)form the National institute of cancer and the national instituty of allerge and infections disease ,and by a grant form wesley foundation ,wichita ,kansas
文摘A murine maorophage-like cell line, J774, acquri ed, in response to LPS, an ability to kill tumor necrosis factor (TNF)-insensitive target P815 mastocytoma cells, whereas another cell line, P388D1, did not. LPS-triggered signaling mechanisms between the two cell lines were compared with an aim to inquire about the possible nature of the above-mentioned difference. The results showed that two cell lines respond to LPS-treatment by parallel activation of both phospholipases C and A2 (PLC and PLA2) to approximately the same extent. The maximum response of both enzymes of J774 cells was noted within 10 min of the treatment, whereas that of P388D1 cells required more than 20 min. The other properties of LPS-responsive enzymes studied were similar between two cell lines, includingAotivation of PLC and PLA2 and PKC in macrophages by LPSGa2+ augmentation of enzyme activation, participation of guanine nuoleotide binding (G) proteins in the initial activation processes, and inhibition of enzyme activation by the prior treatment of cells with cholera or pertussis toxins etc. Moreover, LPS-triggered activation of PLC and PLA2 was found to be followed by the increase of PKC activities in both cell lines. In spite of these similarities, J774 cells possessed both basic and acidic forms of PKC activities, while P 388D1 cells owned only PKC of basic form. Nevertheless, the question why J774 cells, but not P388D1 cells, can acquire the tumorioidal activity, aganist P815 cells following LPS-treatment remains to be answered.
