Objective:This study is conducted to investigate the effects differences of escitalopram with or without combined electroacupuncture(EA)among male inpatients with a diagnosis of alcohol dependence and comorbid protrac...Objective:This study is conducted to investigate the effects differences of escitalopram with or without combined electroacupuncture(EA)among male inpatients with a diagnosis of alcohol dependence and comorbid protracted alcohol withdrawal symptoms(PAWS).Methods:A total of 62 participants who met the inclusion criteria were enrolled in a two-arm randomized,placebo controlled,patients-blind trial and allocated to an escitalopram with real-EA group(realEA group,patients=31)and an escitalopram with sham-EA group(sham-EA group,patients=31),respectively.In addition to the oral administration of escitalopram for total four weeks,patients in each group received corresponding EA treatment five days per week and two days off for consecutive four weeks.Both serum homocysteine(Hcy)test and electrophysiological tests,including event-related potentials(ERPs)and exploratory eye movement(EEM)were performed at pre-and post-treatment.Additionally,the global scores of Penn Alcohol Craving Scale(PACS),17-items Hamilton Depression Rating Scale(HAMD-17),and Hamilton Anxiety Scale(HAMA)were used for assessing the subjective emotion experience of patients,respectively.Meanwhile,adverse effects were monitored and recorded.Results:After four-week treatment,the global scores of PACS and HAMD-17 declined significantly in both groups(both P<0.05).Furthermore,the decline in the real-EA group was superior to that in the shamEA group(P<0.05).Meanwhile,the total scores of HAMA only decreased in the real-EA group(P<0.05)but not in the sham-EA group(P>0.05).According to the parameters of ERPs,significant declines for N2PL,P3PL,and P3amp were observed in both two groups(all P<0.05),and the decreases for P3PL and P3amp in the real-EA group was much superior to that in the sham-EA group(both P<0.05).According to the parameters of EEM,significant increase for NEF was observed only in the real-EA group(P<0.05).Besides,there was a dramatic decline for serum Hcy level only in the real-EA group(P<0.05).One case in the sham-EA group withdrew from the trial due to self-reported nausea and bitter taste,and outcomes of the remaining 61 patients were adopted for analysis.Conclusion:(1)Escitalopram with EA may be a potential alternative therapy for mitigating PAWS among male inpatients with alcohol dependence.(2)Escitalopram with EA might improve the alcoholdependence induced cognitive dysfunctions via upregulating the expression of Hcy.展开更多
Handedness is a fundamental behavioral trait in humans,with the majority exhibiting right-hand dominance.While its origins remain elusive,it is considered an innate genetic trait.This study demonstrates pawedness in m...Handedness is a fundamental behavioral trait in humans,with the majority exhibiting right-hand dominance.While its origins remain elusive,it is considered an innate genetic trait.This study demonstrates pawedness in mice(n=473),comparable to human handedness,as an acquired trait rapidly emerging after limited unilateral paw training.Notably,acquired right-pawedness demonstrates greater conservativeness compared to left-pawedness,as evidenced by stronger stability and greater resistance to reversal.This results in a population right-paw dominance under random training conditions.Moreover,acquired pawedness also exhibits sex differences,with the initial preference proving more malleable in females.These findings unveil the acquired features of pawedness in mice.By illuminating possible behavioral laterality commonalities across species,the study proposes a postnatal hypothesis for the origins of human handedness:it is not an innate genetic trait as traditionally believed,but rather an environmentally acquired stable behavior whose development is actively guided by genetic predispositions.展开更多
基金Sponsored by Scientific Research Project,Shanghai Science and Technology Committee:No.16401902600Special Project for Clinical Research,Shanghai Municipal Health Commission:No.20174Y0009。
文摘Objective:This study is conducted to investigate the effects differences of escitalopram with or without combined electroacupuncture(EA)among male inpatients with a diagnosis of alcohol dependence and comorbid protracted alcohol withdrawal symptoms(PAWS).Methods:A total of 62 participants who met the inclusion criteria were enrolled in a two-arm randomized,placebo controlled,patients-blind trial and allocated to an escitalopram with real-EA group(realEA group,patients=31)and an escitalopram with sham-EA group(sham-EA group,patients=31),respectively.In addition to the oral administration of escitalopram for total four weeks,patients in each group received corresponding EA treatment five days per week and two days off for consecutive four weeks.Both serum homocysteine(Hcy)test and electrophysiological tests,including event-related potentials(ERPs)and exploratory eye movement(EEM)were performed at pre-and post-treatment.Additionally,the global scores of Penn Alcohol Craving Scale(PACS),17-items Hamilton Depression Rating Scale(HAMD-17),and Hamilton Anxiety Scale(HAMA)were used for assessing the subjective emotion experience of patients,respectively.Meanwhile,adverse effects were monitored and recorded.Results:After four-week treatment,the global scores of PACS and HAMD-17 declined significantly in both groups(both P<0.05).Furthermore,the decline in the real-EA group was superior to that in the shamEA group(P<0.05).Meanwhile,the total scores of HAMA only decreased in the real-EA group(P<0.05)but not in the sham-EA group(P>0.05).According to the parameters of ERPs,significant declines for N2PL,P3PL,and P3amp were observed in both two groups(all P<0.05),and the decreases for P3PL and P3amp in the real-EA group was much superior to that in the sham-EA group(both P<0.05).According to the parameters of EEM,significant increase for NEF was observed only in the real-EA group(P<0.05).Besides,there was a dramatic decline for serum Hcy level only in the real-EA group(P<0.05).One case in the sham-EA group withdrew from the trial due to self-reported nausea and bitter taste,and outcomes of the remaining 61 patients were adopted for analysis.Conclusion:(1)Escitalopram with EA may be a potential alternative therapy for mitigating PAWS among male inpatients with alcohol dependence.(2)Escitalopram with EA might improve the alcoholdependence induced cognitive dysfunctions via upregulating the expression of Hcy.
基金supported by grants from the National Natural Science Foundation of China,China(32470630 to Z.S.)the Scientific Foundation of the Institute of Psychology,Chinese Academy of Sciences,China(E2CX4115CX to J.W.)State Key Laboratory of Animal Biodiversity Conservation and Integrated Pest Management,China(SKLA2508 to Y.W.).
文摘Handedness is a fundamental behavioral trait in humans,with the majority exhibiting right-hand dominance.While its origins remain elusive,it is considered an innate genetic trait.This study demonstrates pawedness in mice(n=473),comparable to human handedness,as an acquired trait rapidly emerging after limited unilateral paw training.Notably,acquired right-pawedness demonstrates greater conservativeness compared to left-pawedness,as evidenced by stronger stability and greater resistance to reversal.This results in a population right-paw dominance under random training conditions.Moreover,acquired pawedness also exhibits sex differences,with the initial preference proving more malleable in females.These findings unveil the acquired features of pawedness in mice.By illuminating possible behavioral laterality commonalities across species,the study proposes a postnatal hypothesis for the origins of human handedness:it is not an innate genetic trait as traditionally believed,but rather an environmentally acquired stable behavior whose development is actively guided by genetic predispositions.
