We examined the changes of the plasma NE concentration and 24 hours urinaryMHPG. SO<sub>4</sub> excretion in patients with endogenous depression after six weeks of electroacupuncture（EA） treatment. The b...We examined the changes of the plasma NE concentration and 24 hours urinaryMHPG. SO<sub>4</sub> excretion in patients with endogenous depression after six weeks of electroacupuncture（EA） treatment. The base-line plasma NE concentration of our endogenous depressed patients wassignificantly higher than that of their age- and sex-matched healthy controls （P【0. 05）. The plasmaNE concentration and 24 hours urinary MHPG. SO<sub>4</sub> excretion of our endogenous depressed patientswere not changed after six weeks of EA treatment. The variation of the base-line plasma NE concen-tration in depression was higher than that of in healthy controls （P【0.01） . Variation of plasma NEconcentration of depressed patients was significantly reduced after six weeks of EA treatment. Bothhase-line plasma NE concentration and 24 hours urinary MHPG. SO<sub>4</sub> excretion was lower in EA re-sponsive patients than that in EA non-responsive patients. After six weeks of EA treatment, plasmaNE concentration was significantly raised in EA responsive patients展开更多
Objective: The present study sought to determine changes in plasma levels of catecholamine metabolites and serum levels of brain-derived neurotorophic factor (BDNF) among smokers with schizophrenia who were treated wi...Objective: The present study sought to determine changes in plasma levels of catecholamine metabolites and serum levels of brain-derived neurotorophic factor (BDNF) among smokers with schizophrenia who were treated with varenicline. Methods: We compared plasma homovanillic acid (HVA) and 3-methoxy-4-hydroxyphenylglycol (MHPG) levels and serum BDNF levels across 4 groups, divided as follows: smokers with schizophrenia (S-Sc), nonsmokers with schizophrenia (NS-Sc), smokers who were otherwise healthy (S-HC) and nonsmokers who were otherwise healthy (NS-HC). In addition, we also examined plasma HVA and MHPG levels and serum BDNF levels prior to study initiation (T0) and 8 weeks after varenicline treatment (T8) in the S-Sc and S-HC groups. Results: Plasma HVA levels in the S-Sc group at T0 were significantly higher than in the NS-Sc, S-HC and NS-HC groups at the same time point (S-Sc at T0;7.6 ± 1.6 ng/mL, NS-Sc;4.8 ± 1.0 ng/mL, S-HC;4.3 ± 0.9 ng/mL, NS-HC;3.4 ± 1.4 ng/mL, p < 0.0001). Plasma MHPG levels in the S-Sc group at T0 were significantly higher than in the NS-Sc and S-HC groups;in addition, plasma MHPG levels in the NS-HC group were significantly higher than in the S-HC group (S-Sc at T0;5.2 ± 0.7 ng/mL, NS-Sc;2.8 ± 1.2 ng/mL, S-HC;1.9 ± 0.8 ng/mL, NS-HC;3.6 ± 1.3 ng/mL, p < 0.0002). Serum BDNF levels did not differ between the S-Sc and NS-Sc groups. In contrast, no difference in plasma HVA levels, plasma MHPG levels or serum BDNF levels was observed between T0 and T8. Conclusions: In conclusion, plasma levels of HVA and MHPG in the S-Sc group were significantly higher than in the NS-Sc group. Serum BDNF levels did not differ between the S-Sc and NS-Sc groups. Plasma HVA and MHPG levels and serum BDNF levels did not change after treatment with varenicline.展开更多
文摘We examined the changes of the plasma NE concentration and 24 hours urinaryMHPG. SO<sub>4</sub> excretion in patients with endogenous depression after six weeks of electroacupuncture（EA） treatment. The base-line plasma NE concentration of our endogenous depressed patients wassignificantly higher than that of their age- and sex-matched healthy controls （P【0. 05）. The plasmaNE concentration and 24 hours urinary MHPG. SO<sub>4</sub> excretion of our endogenous depressed patientswere not changed after six weeks of EA treatment. The variation of the base-line plasma NE concen-tration in depression was higher than that of in healthy controls （P【0.01） . Variation of plasma NEconcentration of depressed patients was significantly reduced after six weeks of EA treatment. Bothhase-line plasma NE concentration and 24 hours urinary MHPG. SO<sub>4</sub> excretion was lower in EA re-sponsive patients than that in EA non-responsive patients. After six weeks of EA treatment, plasmaNE concentration was significantly raised in EA responsive patients
文摘Objective: The present study sought to determine changes in plasma levels of catecholamine metabolites and serum levels of brain-derived neurotorophic factor (BDNF) among smokers with schizophrenia who were treated with varenicline. Methods: We compared plasma homovanillic acid (HVA) and 3-methoxy-4-hydroxyphenylglycol (MHPG) levels and serum BDNF levels across 4 groups, divided as follows: smokers with schizophrenia (S-Sc), nonsmokers with schizophrenia (NS-Sc), smokers who were otherwise healthy (S-HC) and nonsmokers who were otherwise healthy (NS-HC). In addition, we also examined plasma HVA and MHPG levels and serum BDNF levels prior to study initiation (T0) and 8 weeks after varenicline treatment (T8) in the S-Sc and S-HC groups. Results: Plasma HVA levels in the S-Sc group at T0 were significantly higher than in the NS-Sc, S-HC and NS-HC groups at the same time point (S-Sc at T0;7.6 ± 1.6 ng/mL, NS-Sc;4.8 ± 1.0 ng/mL, S-HC;4.3 ± 0.9 ng/mL, NS-HC;3.4 ± 1.4 ng/mL, p < 0.0001). Plasma MHPG levels in the S-Sc group at T0 were significantly higher than in the NS-Sc and S-HC groups;in addition, plasma MHPG levels in the NS-HC group were significantly higher than in the S-HC group (S-Sc at T0;5.2 ± 0.7 ng/mL, NS-Sc;2.8 ± 1.2 ng/mL, S-HC;1.9 ± 0.8 ng/mL, NS-HC;3.6 ± 1.3 ng/mL, p < 0.0002). Serum BDNF levels did not differ between the S-Sc and NS-Sc groups. In contrast, no difference in plasma HVA levels, plasma MHPG levels or serum BDNF levels was observed between T0 and T8. Conclusions: In conclusion, plasma levels of HVA and MHPG in the S-Sc group were significantly higher than in the NS-Sc group. Serum BDNF levels did not differ between the S-Sc and NS-Sc groups. Plasma HVA and MHPG levels and serum BDNF levels did not change after treatment with varenicline.
