Electroacupuncture at Shangjuxu （ST37） and Tianshu （ST25） was reported to improve visceral hypersensitivity in rats, Colorectal distension was utilized to generate a rat model of chronic visceral hypersensitivity ...Electroacupuncture at Shangjuxu （ST37） and Tianshu （ST25） was reported to improve visceral hypersensitivity in rats, Colorectal distension was utilized to generate a rat model of chronic visceral hypersensitivity in irritable bowel syndrome, Results showed that abdominal withdrawal reflex scores noticeably increased after model establishment. Simultaneously, P2X4 receptor immunore- activity significantly increased in the colon and spinal cord. Electroacupuncture and pinaverium bromide therapy both markedly decreased abdominal withdrawal reflex scores in rats with visceral hypersensitivity, and significantly decreased P2X4 receptor immunoreactivity in the colon and spinal cord. These data suggest that electroacupuncture treatment can improve visceral hypersensitivity in rats with irritable bowel syndrome by diminishing P2X4 receptor immunoreactivity in the colon and spinal cord,展开更多
基金supported by the National Natural Science Foundation of China,No.30973783the Open Research Fund of Zhejiang First-foremost Key Subject--Acupuncture & Moxibustion,No.ZTK2010A01the scientific research grants of Shanghai Health Bureau,No.2009209
文摘Electroacupuncture at Shangjuxu （ST37） and Tianshu （ST25） was reported to improve visceral hypersensitivity in rats, Colorectal distension was utilized to generate a rat model of chronic visceral hypersensitivity in irritable bowel syndrome, Results showed that abdominal withdrawal reflex scores noticeably increased after model establishment. Simultaneously, P2X4 receptor immunore- activity significantly increased in the colon and spinal cord. Electroacupuncture and pinaverium bromide therapy both markedly decreased abdominal withdrawal reflex scores in rats with visceral hypersensitivity, and significantly decreased P2X4 receptor immunoreactivity in the colon and spinal cord. These data suggest that electroacupuncture treatment can improve visceral hypersensitivity in rats with irritable bowel syndrome by diminishing P2X4 receptor immunoreactivity in the colon and spinal cord,
