目的 分析2023—2024年安徽省报告猴痘突发公共卫生事件及相关病例的流行病学及临床特征,为猴痘疫情防控工作提供参考。方法 通过“中国疾病预防控制信息系统”获取创建时间为2023—2024年、报告地区为安徽省的猴痘突发公共卫生事件信...目的 分析2023—2024年安徽省报告猴痘突发公共卫生事件及相关病例的流行病学及临床特征,为猴痘疫情防控工作提供参考。方法 通过“中国疾病预防控制信息系统”获取创建时间为2023—2024年、报告地区为安徽省的猴痘突发公共卫生事件信息及相关病例的个案信息。采用描述性流行病学方法分析事件基本情况及病例的三间分布、就诊情况和临床特征等。结果 2023年安徽省9个地市19个县(区)报告19起猴痘突发公共卫生事件,共涉及病例22例;2024年未报告。突发事件主要发生在6—8月(73.7%,14/19),合肥市占比最高(26.3%,5/19)。2起为聚集性疫情,共报告5例病例,感染来源可能为与省外人员通过男男性行为接触传播。突发事件涉及病例均为男男性行为者(men who have sex with men, MSM)人群,77.3%(17/22)病例自述既往感染HIV;潜伏期中位数为6 d;86.4%(19/22)病例为主动就诊发现;9例为首次就诊确诊,其中8例就诊医院为艾滋病抗病毒治疗定点医疗机构;就诊科室以皮肤科/感染科为主(63.2%,12/19);确诊前就诊次数与首次就诊科室和首次就诊医院是否为艾滋病抗病毒治疗定点医疗机构均存在相关性(P<0.05)。病例首发症状以皮疹(50.0%,11/22)和发热(22.7%,5/22)为主。结论 安徽省猴痘疫情处于低流行散发态势,病例首发症状以皮疹为主。鉴于猴痘在MSM人群中存在隐匿性传播风险,需加强重点人群宣教干预。展开更多
The recent mpox outbreak(in 2022e2023)has different clinical and epidemiological features compared with previous outbreaks of the disease.During this outbreak,sexual contact was believed to be the primary transmission...The recent mpox outbreak(in 2022e2023)has different clinical and epidemiological features compared with previous outbreaks of the disease.During this outbreak,sexual contact was believed to be the primary transmission route of the disease.In addition,the community of men having sex with men(MSM)was disproportionately affected by the outbreak.This population is also disproportionately affected by HIV infection.Given that both diseases can be transmitted sexually,the endemicity of HIV,and the high sexual behavior associated with the MSM community,it is essential to understand the effect of the two diseases spreading simultaneously in an MSM population.Particularly,we aim to understand the potential effects of HIV on an mpox outbreak in the MSM population.We develop a mechanistic mathematical model of HIV and mpox co-infection.Our model incorporates the dynamics of both diseases and considers HIV treatment with antiretroviral therapy(ART).In addition,we consider a potential scenario where HIV infection increases susceptibility to mpox,and investigate the potential impact of this mechanism on mpox dynamics.Our analysis shows that HIV can facilitate the spread of mpox in an MSM population,and that HIV treatment with ART may not be sufficient to control the spread of mpox in the population.However,we showed that a moderate use of condoms or reduction in sexual contact in the population combined with ART is beneficial in controlling mpox transmission.Based on our analysis,it is evident that effective control of HIV,specifically through substantial ART use,moderate condom compliance,and reduction in sexual contact,is imperative for curtailing the transmission of mpox in an MSM population and mitigating the compounding impact of these intertwined epidemics.展开更多
文摘目的 分析2023—2024年安徽省报告猴痘突发公共卫生事件及相关病例的流行病学及临床特征,为猴痘疫情防控工作提供参考。方法 通过“中国疾病预防控制信息系统”获取创建时间为2023—2024年、报告地区为安徽省的猴痘突发公共卫生事件信息及相关病例的个案信息。采用描述性流行病学方法分析事件基本情况及病例的三间分布、就诊情况和临床特征等。结果 2023年安徽省9个地市19个县(区)报告19起猴痘突发公共卫生事件,共涉及病例22例;2024年未报告。突发事件主要发生在6—8月(73.7%,14/19),合肥市占比最高(26.3%,5/19)。2起为聚集性疫情,共报告5例病例,感染来源可能为与省外人员通过男男性行为接触传播。突发事件涉及病例均为男男性行为者(men who have sex with men, MSM)人群,77.3%(17/22)病例自述既往感染HIV;潜伏期中位数为6 d;86.4%(19/22)病例为主动就诊发现;9例为首次就诊确诊,其中8例就诊医院为艾滋病抗病毒治疗定点医疗机构;就诊科室以皮肤科/感染科为主(63.2%,12/19);确诊前就诊次数与首次就诊科室和首次就诊医院是否为艾滋病抗病毒治疗定点医疗机构均存在相关性(P<0.05)。病例首发症状以皮疹(50.0%,11/22)和发热(22.7%,5/22)为主。结论 安徽省猴痘疫情处于低流行散发态势,病例首发症状以皮疹为主。鉴于猴痘在MSM人群中存在隐匿性传播风险,需加强重点人群宣教干预。
基金funded by the Canadian Institute for Health Research(CIHR)under the Mpox and other zoonotic threats Team Grant(FRN.187246)financial support from the NSERC Discovery Grant(Appl No.:RGPIN-2023-05100)+2 种基金support from IDRC(Grant No.109981)support from NSERC Discovery Grant(Grant No.RGPIN-2022-04559),NSERC Discovery Launch Supplement(Grant No:DGECR-2022-00454)New Frontier in Research Fund-Exploratory(Grant No.NFRFE-2021-00879).
文摘The recent mpox outbreak(in 2022e2023)has different clinical and epidemiological features compared with previous outbreaks of the disease.During this outbreak,sexual contact was believed to be the primary transmission route of the disease.In addition,the community of men having sex with men(MSM)was disproportionately affected by the outbreak.This population is also disproportionately affected by HIV infection.Given that both diseases can be transmitted sexually,the endemicity of HIV,and the high sexual behavior associated with the MSM community,it is essential to understand the effect of the two diseases spreading simultaneously in an MSM population.Particularly,we aim to understand the potential effects of HIV on an mpox outbreak in the MSM population.We develop a mechanistic mathematical model of HIV and mpox co-infection.Our model incorporates the dynamics of both diseases and considers HIV treatment with antiretroviral therapy(ART).In addition,we consider a potential scenario where HIV infection increases susceptibility to mpox,and investigate the potential impact of this mechanism on mpox dynamics.Our analysis shows that HIV can facilitate the spread of mpox in an MSM population,and that HIV treatment with ART may not be sufficient to control the spread of mpox in the population.However,we showed that a moderate use of condoms or reduction in sexual contact in the population combined with ART is beneficial in controlling mpox transmission.Based on our analysis,it is evident that effective control of HIV,specifically through substantial ART use,moderate condom compliance,and reduction in sexual contact,is imperative for curtailing the transmission of mpox in an MSM population and mitigating the compounding impact of these intertwined epidemics.
