Objective To investigate the reproductive and sexual health situation, including knowledge, attitudes, and behaviors, among a population-based sample of internal migrant workers in China. Methods A cross-sectional sur...Objective To investigate the reproductive and sexual health situation, including knowledge, attitudes, and behaviors, among a population-based sample of internal migrant workers in China. Methods A cross-sectional survey of 4 900 rural-to-urban migrants in 6 provinces of China was conducted. Participants completed a 30-min semi-structured questionnaire about contraceptive practices, sexual behavior, and HIV-related knowledge. Results Migrants lacked knowledge of reproductive and sexual health issues. Among those who had heard any sexually transmitted infections （STIs）, only 79.1%, 46.2%, 86.1%, 14.5% and 82.2%, respectively, knew that gonorrhea, condyloma, syphilis, chancroid, and AIDS were STIs. About three-quarters of participants had not used any contraceptive method at sexual debut. Among current users of contraceptive methods, 85.5% indicated that they were satisfied with the method. Before adoption of a contraceptive method, 46.6% of the migrant workers were unaware of the advantages/ disadvantages of the method and 75.3% had no knowledge of emergency contraception. Nearly one-quarter （23.4%） reported that they had premarital sex. Among migrants who were sexually active one month prior to the survey, only 14.0% reported that they had used condoms. Conclusion The limited sexual and reproductive health knowledge and unmet reproductive health services of migrant workers in China underscore the need for a comprehensive package of sexual and reproductive health interventions that combine cognitive and behavioral skills training and target both migrants and health care providers.展开更多
目的:对ATP6V1H内含子区域的4个目标SNPs(rs2376011,rs4738884,rs10435587,rs41321146)等位基因进行深度分析,并探讨这些SNPs的生物学意义。方法:运用3DSNP数据库、LncSNP 2.0数据库、LNCipedia version 5.2、NCBI网站信息及RPIseq数据...目的:对ATP6V1H内含子区域的4个目标SNPs(rs2376011,rs4738884,rs10435587,rs41321146)等位基因进行深度分析,并探讨这些SNPs的生物学意义。方法:运用3DSNP数据库、LncSNP 2.0数据库、LNCipedia version 5.2、NCBI网站信息及RPIseq数据库等多种信息分析方法对4个SNPs的生物学信息及相关lncRNA的功能进行预测。结果:该4个SNPs位于8号染色体,其等位基因频率在亚洲人群约0.35,高于国际平均水平(约0.18)。染色质状态预测发现其中3个SNPs在不同组织或细胞的ATP6V1H中定位于增强子区域,可通过形成约800 kb的染色质环与NPBWR1进行三维交互作用。采用LncSNP2.0预测分析发现,rs4738884和rs10435587位于lncRNA编码基因NONHSAG050234和lnc-TCEA1-3之上,而lnc-TCEA1-3与ATP6V1H存在较强的相互作用,与自闭症和冠状动脉疾病的发生发展相关。结论:4个内含子区域SNPs通过增强子效应与lncRNA影响基因表达及相关功能。展开更多
文摘Objective To investigate the reproductive and sexual health situation, including knowledge, attitudes, and behaviors, among a population-based sample of internal migrant workers in China. Methods A cross-sectional survey of 4 900 rural-to-urban migrants in 6 provinces of China was conducted. Participants completed a 30-min semi-structured questionnaire about contraceptive practices, sexual behavior, and HIV-related knowledge. Results Migrants lacked knowledge of reproductive and sexual health issues. Among those who had heard any sexually transmitted infections （STIs）, only 79.1%, 46.2%, 86.1%, 14.5% and 82.2%, respectively, knew that gonorrhea, condyloma, syphilis, chancroid, and AIDS were STIs. About three-quarters of participants had not used any contraceptive method at sexual debut. Among current users of contraceptive methods, 85.5% indicated that they were satisfied with the method. Before adoption of a contraceptive method, 46.6% of the migrant workers were unaware of the advantages/ disadvantages of the method and 75.3% had no knowledge of emergency contraception. Nearly one-quarter （23.4%） reported that they had premarital sex. Among migrants who were sexually active one month prior to the survey, only 14.0% reported that they had used condoms. Conclusion The limited sexual and reproductive health knowledge and unmet reproductive health services of migrant workers in China underscore the need for a comprehensive package of sexual and reproductive health interventions that combine cognitive and behavioral skills training and target both migrants and health care providers.
文摘目的:对ATP6V1H内含子区域的4个目标SNPs(rs2376011,rs4738884,rs10435587,rs41321146)等位基因进行深度分析,并探讨这些SNPs的生物学意义。方法:运用3DSNP数据库、LncSNP 2.0数据库、LNCipedia version 5.2、NCBI网站信息及RPIseq数据库等多种信息分析方法对4个SNPs的生物学信息及相关lncRNA的功能进行预测。结果:该4个SNPs位于8号染色体,其等位基因频率在亚洲人群约0.35,高于国际平均水平(约0.18)。染色质状态预测发现其中3个SNPs在不同组织或细胞的ATP6V1H中定位于增强子区域,可通过形成约800 kb的染色质环与NPBWR1进行三维交互作用。采用LncSNP2.0预测分析发现,rs4738884和rs10435587位于lncRNA编码基因NONHSAG050234和lnc-TCEA1-3之上,而lnc-TCEA1-3与ATP6V1H存在较强的相互作用,与自闭症和冠状动脉疾病的发生发展相关。结论:4个内含子区域SNPs通过增强子效应与lncRNA影响基因表达及相关功能。
