Analytical difficulties encountered in the determination of ethyl carbamate, a known cancinogen, in a wide variety of wines and spirits have been overcome by spe- cific, sensitive GC/GC and CC/CC/MS methods with a rel...Analytical difficulties encountered in the determination of ethyl carbamate, a known cancinogen, in a wide variety of wines and spirits have been overcome by spe- cific, sensitive GC/GC and CC/CC/MS methods with a relatively shorter extraction procedure. The lowest detection limits were estimated to be 0. 1 and 0. 01μg/L for GC/GC and GC/GC/MS respectively. The RSD of the GC/GC method was 2. 5%.展开更多
本文建立同时检测3种4(3H)-喹唑啉酮滥用物质甲喹酮、依他喹酮和甲氧喹酮的GC-MS与GCMS/MS分析方法,并分别应用于实际案件中对疑似毒品与滥用人员毛发进行分析。使用选择离子监测模式(selected ion monitoring,SIM)和多反应监测模式(mul...本文建立同时检测3种4(3H)-喹唑啉酮滥用物质甲喹酮、依他喹酮和甲氧喹酮的GC-MS与GCMS/MS分析方法,并分别应用于实际案件中对疑似毒品与滥用人员毛发进行分析。使用选择离子监测模式(selected ion monitoring,SIM)和多反应监测模式(multiple reaction monitoring,MRM)分别对甲喹酮、依他喹酮和甲氧喹酮的标准品溶液进行分析,确定三种物质的特征碎片离子和特征离子对,并利用所建立的两种方法分别对实际案例中的疑似毒品和毛发样本进行检验。建立的GC-MS分析方法在送检的疑似毒品中检出甲喹酮、依他喹酮和甲氧喹酮成分且含量分别为11、4.3、2.5μg/mg,建立的GC-MS/MS分析方法在送检的毛发中检出甲喹酮、依他喹酮和甲氧喹酮成分且含量分别为148 ng/mg、565 pg/mg、58.2 ng/mg。本研究建立的GC-MS及GC-MS/MS检测方法具有简单、快速、准确的特点,可为疑似毒品与滥用人员毛发中甲喹酮、依他喹酮和甲氧喹酮的检测提供可靠的科学依据。展开更多
文摘Analytical difficulties encountered in the determination of ethyl carbamate, a known cancinogen, in a wide variety of wines and spirits have been overcome by spe- cific, sensitive GC/GC and CC/CC/MS methods with a relatively shorter extraction procedure. The lowest detection limits were estimated to be 0. 1 and 0. 01μg/L for GC/GC and GC/GC/MS respectively. The RSD of the GC/GC method was 2. 5%.
