摘要
本文建立同时检测3种4(3H)-喹唑啉酮滥用物质甲喹酮、依他喹酮和甲氧喹酮的GC-MS与GCMS/MS分析方法,并分别应用于实际案件中对疑似毒品与滥用人员毛发进行分析。使用选择离子监测模式(selected ion monitoring,SIM)和多反应监测模式(multiple reaction monitoring,MRM)分别对甲喹酮、依他喹酮和甲氧喹酮的标准品溶液进行分析,确定三种物质的特征碎片离子和特征离子对,并利用所建立的两种方法分别对实际案例中的疑似毒品和毛发样本进行检验。建立的GC-MS分析方法在送检的疑似毒品中检出甲喹酮、依他喹酮和甲氧喹酮成分且含量分别为11、4.3、2.5μg/mg,建立的GC-MS/MS分析方法在送检的毛发中检出甲喹酮、依他喹酮和甲氧喹酮成分且含量分别为148 ng/mg、565 pg/mg、58.2 ng/mg。本研究建立的GC-MS及GC-MS/MS检测方法具有简单、快速、准确的特点,可为疑似毒品与滥用人员毛发中甲喹酮、依他喹酮和甲氧喹酮的检测提供可靠的科学依据。
GC-MS and GC-MS/MS analytical methods were developed for the simultaneous detection of three 4(3H)-quinazolinone abused substances,including methaqualone,etaqualone,and 2-methoxyqualone,and applied to the analysis of suspected drugs and the hair of abusers,respectively.The standard solutions of methaqualone,etaqualone,and 2-methoxyqualone were analyzed by using the selected ion monitoring(SIM)and multiple reaction monitoring(MRM)modes,respectively,to determine the characteristic fragment ions and characteristic ion pairs of the three substances.The so established two methods were used to test the suspected drugs and hair samples in the actual cases.The established GC-MS analytical method detected components of methaqualone,etaqualone,and 2-methoxyqualone in the suspected drugs at levels of 11μg/mg,4.3μg/mg,and 2.5μg/mg,respectively.The established GC-MS/MS analytical method detected methaqualone,etaqualone,and 2-methoxyqualone in the hair at levels of 148 ng/mg,565 pg/mg,and 58.2 ng/mg,respectively.The detection methods of GC-MS and GC-MS/MS established in this study are simple,rapid,and accurate,which can provide a reliable scientific basis for the detection of methaqualone,etaqualone,and 2-methoxyqualone in the suspected drugs and the hair of abusers.
作者
王猛超
赵崐迪
代茵茵
张晓龙
陈雨轩
许文
阿民勿日他
刘金磊
张榆梓
奇海涛
WANG Mengchao;ZHAO Kundi;DAI Yinyin;ZHANG Xiaolong;CHEN Yuxuan;XU Wen;WURITA Amin;LIU Jinlei;ZHANG Yuzi;QI Haitao(College of Basic Medical Sciences,Inner Mongolia Medical University,Hohhot 010110,China;Criminal Science and Technology Office,Criminal Investigation Brigade,Qingshuihe Public Security Bureau,Hohhot 011600,China;Anti-Drug Corps of Inner Mongolia Autonomous Region Public Security Department,Hohhot 010051,China)
出处
《刑事技术》
2025年第5期489-495,共7页
Forensic Science and Technology
基金
国家自然科学基金项目(82360335)
内蒙古医科大学英才培育项目(YCPY2023114)。
