Varicella (chickenpox) is a generalized, self-limiting viral infection that is caused by varicella zoster virus (VZV). Chickenpox commonly infects children from 2 - 8 years without severe outcomes, but is particularly...Varicella (chickenpox) is a generalized, self-limiting viral infection that is caused by varicella zoster virus (VZV). Chickenpox commonly infects children from 2 - 8 years without severe outcomes, but is particularly severe when affecting adults.展开更多
Objective The occurrence of chickenpox in rapidly developing areas poses substantial seasonal risk to children.However,certain factors influencing local chickenpox outbreaks have not been studied.Here,we examined the ...Objective The occurrence of chickenpox in rapidly developing areas poses substantial seasonal risk to children.However,certain factors influencing local chickenpox outbreaks have not been studied.Here,we examined the relationship between spatial clustering,heterogeneity of chickenpox outbreaks,and socioeconomic factors in Southern China.Methods We assessed chickenpox outbreak data from Southern China between 2006 and 2021,comprising both relatively fast-growing parts and slower sub-regions,and provides a representative sample of many developing regions.We analyzed the spatial clustering attributes associated with chickenpox outbreaks using Moran’s I and local indicators of spatial association and quantified their socioeconomic determinants using Geodetector q statistics.Results There were significant spatial heterogeneity in the risk of chickenpox outbreaks,with strong correlations between chickenpox risk and various factors,particularly demographics and living environment.Furthermore,interactive effects among specific are factors,such as population density and per capita residential building area,percentage of households with toilets,percentage of rental housing,exhibited q statistics of 0.28,0.25,and 0.24,respectively.Conclusion This study provides valuable insights into the spatial dynamics of chickenpox outbreaks in rapidly developing regions,revealing the socioeconomic factors affecting disease transmission.These implications extend the formulation of effective public health strategies and interventions to prevent and control chickenpox outbreaks in similar global contexts.展开更多
A previously well 5-year-old boy presented with a 4-day his-tory of fever (39.2 °C) and spreading rash. His elder sister was diagnosed with a typical chickenpox two weeks ear-lier. The rash consisting of vesicles...A previously well 5-year-old boy presented with a 4-day his-tory of fever (39.2 °C) and spreading rash. His elder sister was diagnosed with a typical chickenpox two weeks ear-lier. The rash consisting of vesicles initially started on his head and spreaded to his body and limbs. On the third day of this illness, large erythematous maculopapular elements appeared on his left ear and lower legs and progressed into bullae 3–4 cm in diameter. Over the night, large eroded bul-lae were found on his inner thighs (Fig. 1a), body and upper limbs. Enzyme-linked immunosorbent essay performed on day 4 after the rash onset was positive for specific type 3 Varicella Zoster antibodies. Bacteriological examination of the bullae contents was negative. The patient was started on acyclovir. Healing of skin lesions occurred by day 11 of the disease (Fig. 1b). Bullous forms most frequently result from co-infection with S. pyogenes and S. aureus. (1)In the pre-sent case, no evidence of bacterial co-infection was found.展开更多
文摘Varicella (chickenpox) is a generalized, self-limiting viral infection that is caused by varicella zoster virus (VZV). Chickenpox commonly infects children from 2 - 8 years without severe outcomes, but is particularly severe when affecting adults.
基金supported by the Natural Science Foundation of Henan Province(242300421361)National Science Foundation of China(42371223,41901331)Innovation Project of LREIS(O88RA205YA,O88RA200YA).
文摘Objective The occurrence of chickenpox in rapidly developing areas poses substantial seasonal risk to children.However,certain factors influencing local chickenpox outbreaks have not been studied.Here,we examined the relationship between spatial clustering,heterogeneity of chickenpox outbreaks,and socioeconomic factors in Southern China.Methods We assessed chickenpox outbreak data from Southern China between 2006 and 2021,comprising both relatively fast-growing parts and slower sub-regions,and provides a representative sample of many developing regions.We analyzed the spatial clustering attributes associated with chickenpox outbreaks using Moran’s I and local indicators of spatial association and quantified their socioeconomic determinants using Geodetector q statistics.Results There were significant spatial heterogeneity in the risk of chickenpox outbreaks,with strong correlations between chickenpox risk and various factors,particularly demographics and living environment.Furthermore,interactive effects among specific are factors,such as population density and per capita residential building area,percentage of households with toilets,percentage of rental housing,exhibited q statistics of 0.28,0.25,and 0.24,respectively.Conclusion This study provides valuable insights into the spatial dynamics of chickenpox outbreaks in rapidly developing regions,revealing the socioeconomic factors affecting disease transmission.These implications extend the formulation of effective public health strategies and interventions to prevent and control chickenpox outbreaks in similar global contexts.
文摘A previously well 5-year-old boy presented with a 4-day his-tory of fever (39.2 °C) and spreading rash. His elder sister was diagnosed with a typical chickenpox two weeks ear-lier. The rash consisting of vesicles initially started on his head and spreaded to his body and limbs. On the third day of this illness, large erythematous maculopapular elements appeared on his left ear and lower legs and progressed into bullae 3–4 cm in diameter. Over the night, large eroded bul-lae were found on his inner thighs (Fig. 1a), body and upper limbs. Enzyme-linked immunosorbent essay performed on day 4 after the rash onset was positive for specific type 3 Varicella Zoster antibodies. Bacteriological examination of the bullae contents was negative. The patient was started on acyclovir. Healing of skin lesions occurred by day 11 of the disease (Fig. 1b). Bullous forms most frequently result from co-infection with S. pyogenes and S. aureus. (1)In the pre-sent case, no evidence of bacterial co-infection was found.
