Several studies have demonstrated that selective serotonin reuptake inhibitor antidepressants can promote neuronal cell proliferation and enhance neuroplasticity both in vitro and in vivo. It is hypothesized that cita...Several studies have demonstrated that selective serotonin reuptake inhibitor antidepressants can promote neuronal cell proliferation and enhance neuroplasticity both in vitro and in vivo. It is hypothesized that citalopram, a selective serotonin reuptake inhibitor, can promote the neuronal differentiation of adult bone marrow mesenchymal stem cells. Citalopram strongly enhanced neuronal characteristics of the cells derived from bone marrow mesenchymal stem cells. The rate of cell death was decreased in citalopram-treated bone marrow mesenchymal stem cells than in control cells in neurobasal medium. In addition, the cumulative population doubling level of the citalopram-treated cells was signiifcantly increased compared to that of control cells. Also BrdU incorporation was elevated in citalopram-treated cells. These ifndings suggest that citalopram can improve the neuronal-like cell differentiation of bone marrow mesenchymal stem cells by increasing cell proliferation and survival while maintaining their neuronal characteristics.展开更多
Background: Major depressive disorder(MDD) accompanied by anxious distress is a chronic and disabling disorder. Its conventional drug therapies often have low patient compliance due to drug-related side effects. In Pe...Background: Major depressive disorder(MDD) accompanied by anxious distress is a chronic and disabling disorder. Its conventional drug therapies often have low patient compliance due to drug-related side effects. In Persian medicine, lavender-dodder syrup is one formula often recommended for such disorders.Objective: This study compares the effects of lavender-dodder syrup to the standard drug, citalopram, for treating MDD with anxious distress.Design, setting, participants and intervention: This six-week, double-blind, randomized, clinical trial was carried out in a psychiatric outpatient clinic. During the six-week intervention period, patients in citalopram group received citalopram tablets 20 mg/d plus 5 mL placebo syrup every 12 h;patients in group B received placebo tablets once daily plus 5 mL of lavender-dodder herbal syrup every 12 h.Main outcome measures: Primary outcome measures, depression and anxiety, were evaluated using the Hamilton Depression/Anxiety Rating Scales, and were scored at the beginning of the study and at weeks three and six. Secondary outcome measures including response to treatment and remission rates were also compared between the two groups.Results: Fifty-six participants with MDD and anxious distress were randomly assigned to two groups.Mean depression scores significantly decreased in citalopram and herbal groups at weeks three and six(time effect: P < 0.001), although the observed changes were not significantly different between the groups(intervention effect: P = 0.61). Mean anxiety scores were not significantly different between the two groups at week three(P = 0.75). However, at the end of week six, the observed decrease was significantly higher in the herbal syrup group than the citalopram group(intervention effect: P = 0.007).Conclusion: The herbal syrup is an effective and tolerable supplement for treating MDD with anxious distress.Trial registration number: IRCT2016102430459 N1 on Iranian Registry of Clinical Trials.展开更多
目的:探讨对抑郁症睡眠障碍患者实施西酞普兰联合米氮平治疗对其睡眠调节、抑郁症状缓解的效果。方法:选取100例于2022年6月至2025年6月在北京市房山区精神卫生保健院治疗的抑郁症伴有睡眠障碍患者,按随机数表法分作两组,对照组(50例)...目的:探讨对抑郁症睡眠障碍患者实施西酞普兰联合米氮平治疗对其睡眠调节、抑郁症状缓解的效果。方法:选取100例于2022年6月至2025年6月在北京市房山区精神卫生保健院治疗的抑郁症伴有睡眠障碍患者,按随机数表法分作两组,对照组(50例)单独行草酸艾司西酞普兰治疗,观察组(50例)行草酸艾司西酞普兰合并米氮平治疗,对比两组的睡眠调节效果、抑郁症状缓解效果、总体疗效及不良反应。结果:观察组治疗后的匹兹堡睡眠质量指数量表(pittsburgh sleep quality index,PSQI)总分是(9.89±1.21)分,低于对照组的(12.68±1.08)分(P<0.05);观察组治疗后的17项汉密尔顿抑郁量表(17-item hamilton depression scale,HAMD-17)总分是(11.38±1.20)分,临床总体印象量表-病情严重程度(clinical global impressions scale,CGI-S)总分是(3.32±0.42)分,分别低于对照组的(13.49±1.12)分、(4.11±0.45)分;观察组的总有效率(94.00%)高于对照组(80.00%)(P<0.05);观察组的不良反应(6.00%)与对照组(4.00%)对比,差异无统计学意义(P>0.05)。结论:对抑郁症睡眠障碍展开治疗时,联用草酸艾司西酞普兰与米氮平可促进睡眠调节、抑郁症状缓解效果进一步提升,达到良好总体疗效,且具备理想安全性。展开更多
基金funded by the Research Center for Science and Technology in Medicine(RCSTiM),Tehran University of Medical Sciences,Tehran(TUMS),Tehran,Iran
文摘Several studies have demonstrated that selective serotonin reuptake inhibitor antidepressants can promote neuronal cell proliferation and enhance neuroplasticity both in vitro and in vivo. It is hypothesized that citalopram, a selective serotonin reuptake inhibitor, can promote the neuronal differentiation of adult bone marrow mesenchymal stem cells. Citalopram strongly enhanced neuronal characteristics of the cells derived from bone marrow mesenchymal stem cells. The rate of cell death was decreased in citalopram-treated bone marrow mesenchymal stem cells than in control cells in neurobasal medium. In addition, the cumulative population doubling level of the citalopram-treated cells was signiifcantly increased compared to that of control cells. Also BrdU incorporation was elevated in citalopram-treated cells. These ifndings suggest that citalopram can improve the neuronal-like cell differentiation of bone marrow mesenchymal stem cells by increasing cell proliferation and survival while maintaining their neuronal characteristics.
基金a part of a PhD thesis by Dr. Toktam Sadat Firoozeei,supported by Tehran University of Medical Sciences,in order to fulfil the requirements of a PhD degree in Persian medicine。
文摘Background: Major depressive disorder(MDD) accompanied by anxious distress is a chronic and disabling disorder. Its conventional drug therapies often have low patient compliance due to drug-related side effects. In Persian medicine, lavender-dodder syrup is one formula often recommended for such disorders.Objective: This study compares the effects of lavender-dodder syrup to the standard drug, citalopram, for treating MDD with anxious distress.Design, setting, participants and intervention: This six-week, double-blind, randomized, clinical trial was carried out in a psychiatric outpatient clinic. During the six-week intervention period, patients in citalopram group received citalopram tablets 20 mg/d plus 5 mL placebo syrup every 12 h;patients in group B received placebo tablets once daily plus 5 mL of lavender-dodder herbal syrup every 12 h.Main outcome measures: Primary outcome measures, depression and anxiety, were evaluated using the Hamilton Depression/Anxiety Rating Scales, and were scored at the beginning of the study and at weeks three and six. Secondary outcome measures including response to treatment and remission rates were also compared between the two groups.Results: Fifty-six participants with MDD and anxious distress were randomly assigned to two groups.Mean depression scores significantly decreased in citalopram and herbal groups at weeks three and six(time effect: P < 0.001), although the observed changes were not significantly different between the groups(intervention effect: P = 0.61). Mean anxiety scores were not significantly different between the two groups at week three(P = 0.75). However, at the end of week six, the observed decrease was significantly higher in the herbal syrup group than the citalopram group(intervention effect: P = 0.007).Conclusion: The herbal syrup is an effective and tolerable supplement for treating MDD with anxious distress.Trial registration number: IRCT2016102430459 N1 on Iranian Registry of Clinical Trials.
文摘目的:探讨对抑郁症睡眠障碍患者实施西酞普兰联合米氮平治疗对其睡眠调节、抑郁症状缓解的效果。方法:选取100例于2022年6月至2025年6月在北京市房山区精神卫生保健院治疗的抑郁症伴有睡眠障碍患者,按随机数表法分作两组,对照组(50例)单独行草酸艾司西酞普兰治疗,观察组(50例)行草酸艾司西酞普兰合并米氮平治疗,对比两组的睡眠调节效果、抑郁症状缓解效果、总体疗效及不良反应。结果:观察组治疗后的匹兹堡睡眠质量指数量表(pittsburgh sleep quality index,PSQI)总分是(9.89±1.21)分,低于对照组的(12.68±1.08)分(P<0.05);观察组治疗后的17项汉密尔顿抑郁量表(17-item hamilton depression scale,HAMD-17)总分是(11.38±1.20)分,临床总体印象量表-病情严重程度(clinical global impressions scale,CGI-S)总分是(3.32±0.42)分,分别低于对照组的(13.49±1.12)分、(4.11±0.45)分;观察组的总有效率(94.00%)高于对照组(80.00%)(P<0.05);观察组的不良反应(6.00%)与对照组(4.00%)对比,差异无统计学意义(P>0.05)。结论:对抑郁症睡眠障碍展开治疗时,联用草酸艾司西酞普兰与米氮平可促进睡眠调节、抑郁症状缓解效果进一步提升,达到良好总体疗效,且具备理想安全性。
