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Citalopram increases the differentiation efficacy of bone marrow mesenchymal stem cells into neuronal-like cells 被引量：2

Citalopram increases the differentiation efficacy of bone marrow mesenchymal stem cells into neuronal-like cells
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摘要 Several studies have demonstrated that selective serotonin reuptake inhibitor antidepressants can promote neuronal cell proliferation and enhance neuroplasticity both in vitro and in vivo. It is hypothesized that citalopram, a selective serotonin reuptake inhibitor, can promote the neuronal differentiation of adult bone marrow mesenchymal stem cells. Citalopram strongly enhanced neuronal characteristics of the cells derived from bone marrow mesenchymal stem cells. The rate of cell death was decreased in citalopram-treated bone marrow mesenchymal stem cells than in control cells in neurobasal medium. In addition, the cumulative population doubling level of the citalopram-treated cells was signiifcantly increased compared to that of control cells. Also BrdU incorporation was elevated in citalopram-treated cells. These ifndings suggest that citalopram can improve the neuronal-like cell differentiation of bone marrow mesenchymal stem cells by increasing cell proliferation and survival while maintaining their neuronal characteristics. Several studies have demonstrated that selective serotonin reuptake inhibitor antidepressants can promote neuronal cell proliferation and enhance neuroplasticity both in vitro and in vivo. It is hypothesized that citalopram, a selective serotonin reuptake inhibitor, can promote the neuronal differentiation of adult bone marrow mesenchymal stem cells. Citalopram strongly enhanced neuronal characteristics of the cells derived from bone marrow mesenchymal stem cells. The rate of cell death was decreased in citalopram-treated bone marrow mesenchymal stem cells than in control cells in neurobasal medium. In addition, the cumulative population doubling level of the citalopram-treated cells was signiifcantly increased compared to that of control cells. Also BrdU incorporation was elevated in citalopram-treated cells. These ifndings suggest that citalopram can improve the neuronal-like cell differentiation of bone marrow mesenchymal stem cells by increasing cell proliferation and survival while maintaining their neuronal characteristics.
作者 Javad Verdi Seyed Abdolreza Mortazavi-Tabatabaei Shiva Sharif Hadi Verdi Alireza Shoae-Hassani
机构地区 Department of Applied Cell Sciences Department of Stem Cells and Tissue Engineering Department of Tissue Engineering
出处 《Neural Regeneration Research》 SCIE CAS CSCD 2014年第8期845-850,共6页 中国神经再生研究（英文版）
基金 funded by the Research Center for Science and Technology in Medicine(RCSTiM),Tehran University of Medical Sciences,Tehran(TUMS),Tehran,Iran
关键词 nerve regeneration CITALOPRAM stem cells bone marrow mesenchymal stem cells survival proliferation DIFFERENTIATION NEURONS neural regeneration nerve regeneration citalopram stem cells bone marrow mesenchymal stem cells survival proliferation differentiation neurons neural regeneration
分类号 R741 [医药卫生—神经病学与精神病学]
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参考文献38

  • 1Atkinson S, Lako M, Armstrong L (2012) Potential for pharmacological manipulation of embryonic stem cells. Br Pharmacol 169:269-289.
  • 2Bissonnette CJ, Lyass L, Bhattacharyya BJ, Belmadani A, Miller R, Kessler JA (2011) The controlled generation of functional basal fore- brain cholinergic neurons from human embryonic stem cells. Stem Cells 29:802-811.
  • 3Boldrini M, Underwood MD, Hen R, Rosoklija GB, Dwork AJ, John Mann J (2009) Antidepressants increase neural progenitor cells in the human hippocampus. Neuropsychopharmacology 34:2376-2389.
  • 4Chen SJ, Kao-CL, Clang YL, YenC, Shui JW, Chien CS, Chen IL, Tsai TH, Ku HH, Chiou SH (2007) Antidepressant administration mod- ulates neural stern cell survival and serotoninergic differentiation through bcl-2. Curr Neurovasc Res 4:19-29.
  • 5Chung S, Moon JI, Leung A, Aldrich D, Lukianov S, Kitayama Y (2011) ES cell-derived renewable and functional midbrain dopaminergic progenitors. Proc Natl Acad Sci USA 108 9703-9708.
  • 6Croce-N, Math6 AA, Gelfo F, Caltagirone C, Bernardini S, Angelucci F (2014) Effects of lithium and valproic acid on BDNF protein and gene expression in an in vitro human neuron-like model of degen- eration. J Psychopharmacol doi: 10.1177/0269881114529379.
  • 7Duman RS, Nakagawa S, Malberg (2001) Regulation of adult neu- rogenesis by antidepressant treatment. Neuropsychopharmacology 25:8.36-844.
  • 8Hashimt S, Inoue T, Muraki I, Koyama T (2009) Effects of acute citalopram on the expression of conditioned freezing in naive versus chronic citalopram-treated rats. Prog Neuropsychopharmacol Biol Psych 33:113-117.
  • 9Huang B, Li K, Yu J, Zhang M, Li Y, Li W, Wang W, Guan L, Zhang W, Lin S, Huang X, Lin L, Lin Y, Zhang Y, Song X, Wang Z, Ge J (2013) Generation of human epidermis-derived mesenchymal stem cell-like pluripotent ceils (hEMSCPCs). Sci Reports doi:10.1038/ srep01933.
  • 10Ilic Eli Stephenson E, Wood V, Jacquet L, Stevenson D, Petrova A (2011) Derivation and feeder-free propagation of human embryonic stem cells under xeno-free conditions. Cytotherapy 14:122-128.

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Neural Regeneration Research
2014年 第8期

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