Objective To explore anxiety and impulsivity in adult female patients with anorexia nervosa(AN),and the relationship with different dimensions of the core clinical symptoms.Methods From June 2014 to October 2022,96 pa...Objective To explore anxiety and impulsivity in adult female patients with anorexia nervosa(AN),and the relationship with different dimensions of the core clinical symptoms.Methods From June 2014 to October 2022,96 patients with AN,from both outpatient clinics andinpatienttwards,wereenrolled from Peking UniversitySixthHospital.Additionally,51 control participants were recruited from the community.Statetrait Anxiety Inventory(STAI)and Barratt Impulsiveness Scale(BIS-11))were used to evaluate the anxiety and impulsivityofeachggroup.TheEatingDisorder Inventory-1(EDI-1)was used to assess clinical and other psychological characteristics of ED.Correlation and regression analysis were employedtoexplore the relationship between anxiety,impulsivity,and core clinical symptoms of eating disorders.Results(1)The total EDI-1 score for the AN group((233.7±48.4)vs.(184.2±30.4),t=7.58,P<0.001)and scores in 7 subscales(Drive for Thinness:t=5.25,P<0.001;Bulimia:t=6.05,P<0.001;Ineffectiveness:t=7.91,P<0.001;Perfectionism:t=3.05,P=0.003;Interpersonal Distrust:t=5.50,P<0.001;Interoceptive Awareness:t=7.00,P<0.001;Maturity Fears:t=2.46,P=0.015)were significantly higher than the control group.(2)The AN group had significantly higher levels of state anxiety(t=8.60,P<0.001),trait anxiety(t=7.40,P<0.001),total impulsivity(t=3.55,P<0.001),attentional impulsiveness(t=2.43,P=0.017)and motor impulsiveness(t=4.29,P<0.001)compared to the control group.(3)Correlation analysis showed that state anxiety,trait anxiety,attentional impulsiveness,motor impulsiveness,and non-planning impulsiveness were positively correlated with the drive for thinness(r=0.522,0.577,0.272,0.387,0.209,allP<0.05);State anxiety,trait anxiety,attentional impulsiveness,motor impulsiveness,and non-planning impulsiveness were also positively correlated with bulimia(r=0.402,0.471,0.304,0.514,0.466,all P<0.01);Attentional impulsiveness,state anxiety,and trait anxiety were positively correlated with body dissatisfaction(r=0.333,0.448,0.409,all P<0.01).Further ridge regression analysis indicated that trait anxiety in AN patients was an influencing factor of the drive for thinness(t=3.13,P=0.002),state anxiety was an influencing factor of body dissatisfaction(t=1.99,P=0.050),and motor impulsiveness and non-planning impulsiveness were the influencing factors of bulimia(t=2.92,2.79,all P<005).Conclusion Patients with anorexia nervosa have higher anxiety and impulsivity,and the levels of anxiety and impulsivity in different dimensions are related to the core clinical symptoms of AN patients.展开更多
Objective： To observe the impacts of electro-acupuncture（EA） and psychological intervention（PI） on impulsive behavior among internet addiction（IA） adolescents. Methods： Thirty-two IA adolescents were allocated...Objective： To observe the impacts of electro-acupuncture（EA） and psychological intervention（PI） on impulsive behavior among internet addiction（IA） adolescents. Methods： Thirty-two IA adolescents were allocated to either EA（16 cases） or PI（16 cases） group by a randomized digital table. Subjects in the EA group received EA treatment and subjects in the PI group received cognition and behavior therapy. All adolescents underwent 45-d intervention. Sixteen healthy volunteers were recruited into a control group. Barratt Impulsiveness Scale（BIS-11） scores, Young＇s Internet Addiction Test（IAT） as well as the ratio of brain N-acetyl aspartate（NAA） to creatine（NAA/Cr） and choline（Cho） to creatine（Cho/Cr） were recorded by magnetic resonance spectroscopy before and after intervention respectively. Results： The IAT scores and BIS-11 total scores in both EA and PI group were remarkably decreased after treatment（P〈0.05）, while EA group showed more significant decrease in certain BIS-11 sub-factors（P〈0.05）. Both NAA/Cr and Cho/Cr were significantly improved in EA group after treatment（P〈0.05）; however, there were no significant changes of NAA/Cr or Cho/Cr in PI group after treatment（P〉0.05）. Conclusions： Both EA and PI had significantly positive effect on IA adolescents, especially in the aspects of psychological experiences and behavioral expressions, EA might have an advantage over PI in terms of impulsivity control and brain neuron protection. The mechanism underlying this advantage might be related to the increased NAA and Cho levels in prefrontal and anterior cingulate cortices.展开更多
文摘Objective To explore anxiety and impulsivity in adult female patients with anorexia nervosa(AN),and the relationship with different dimensions of the core clinical symptoms.Methods From June 2014 to October 2022,96 patients with AN,from both outpatient clinics andinpatienttwards,wereenrolled from Peking UniversitySixthHospital.Additionally,51 control participants were recruited from the community.Statetrait Anxiety Inventory(STAI)and Barratt Impulsiveness Scale(BIS-11))were used to evaluate the anxiety and impulsivityofeachggroup.TheEatingDisorder Inventory-1(EDI-1)was used to assess clinical and other psychological characteristics of ED.Correlation and regression analysis were employedtoexplore the relationship between anxiety,impulsivity,and core clinical symptoms of eating disorders.Results(1)The total EDI-1 score for the AN group((233.7±48.4)vs.(184.2±30.4),t=7.58,P<0.001)and scores in 7 subscales(Drive for Thinness:t=5.25,P<0.001;Bulimia:t=6.05,P<0.001;Ineffectiveness:t=7.91,P<0.001;Perfectionism:t=3.05,P=0.003;Interpersonal Distrust:t=5.50,P<0.001;Interoceptive Awareness:t=7.00,P<0.001;Maturity Fears:t=2.46,P=0.015)were significantly higher than the control group.(2)The AN group had significantly higher levels of state anxiety(t=8.60,P<0.001),trait anxiety(t=7.40,P<0.001),total impulsivity(t=3.55,P<0.001),attentional impulsiveness(t=2.43,P=0.017)and motor impulsiveness(t=4.29,P<0.001)compared to the control group.(3)Correlation analysis showed that state anxiety,trait anxiety,attentional impulsiveness,motor impulsiveness,and non-planning impulsiveness were positively correlated with the drive for thinness(r=0.522,0.577,0.272,0.387,0.209,allP<0.05);State anxiety,trait anxiety,attentional impulsiveness,motor impulsiveness,and non-planning impulsiveness were also positively correlated with bulimia(r=0.402,0.471,0.304,0.514,0.466,all P<0.01);Attentional impulsiveness,state anxiety,and trait anxiety were positively correlated with body dissatisfaction(r=0.333,0.448,0.409,all P<0.01).Further ridge regression analysis indicated that trait anxiety in AN patients was an influencing factor of the drive for thinness(t=3.13,P=0.002),state anxiety was an influencing factor of body dissatisfaction(t=1.99,P=0.050),and motor impulsiveness and non-planning impulsiveness were the influencing factors of bulimia(t=2.92,2.79,all P<005).Conclusion Patients with anorexia nervosa have higher anxiety and impulsivity,and the levels of anxiety and impulsivity in different dimensions are related to the core clinical symptoms of AN patients.
基金Supported by the National Natural Science Foundation of China(No.81072852,No.81574047)The Training Funds of Academic and Technical Leader in Sichuan Province+1 种基金Fok Ying-dong Education Foundation on Basic Research Project(No.131106)People-Benefiting Technology Research and Development Project of Chengdu Science and Technology Bureau(No.2014-HM01-00180-SF)
文摘Objective： To observe the impacts of electro-acupuncture（EA） and psychological intervention（PI） on impulsive behavior among internet addiction（IA） adolescents. Methods： Thirty-two IA adolescents were allocated to either EA（16 cases） or PI（16 cases） group by a randomized digital table. Subjects in the EA group received EA treatment and subjects in the PI group received cognition and behavior therapy. All adolescents underwent 45-d intervention. Sixteen healthy volunteers were recruited into a control group. Barratt Impulsiveness Scale（BIS-11） scores, Young＇s Internet Addiction Test（IAT） as well as the ratio of brain N-acetyl aspartate（NAA） to creatine（NAA/Cr） and choline（Cho） to creatine（Cho/Cr） were recorded by magnetic resonance spectroscopy before and after intervention respectively. Results： The IAT scores and BIS-11 total scores in both EA and PI group were remarkably decreased after treatment（P〈0.05）, while EA group showed more significant decrease in certain BIS-11 sub-factors（P〈0.05）. Both NAA/Cr and Cho/Cr were significantly improved in EA group after treatment（P〈0.05）; however, there were no significant changes of NAA/Cr or Cho/Cr in PI group after treatment（P〉0.05）. Conclusions： Both EA and PI had significantly positive effect on IA adolescents, especially in the aspects of psychological experiences and behavioral expressions, EA might have an advantage over PI in terms of impulsivity control and brain neuron protection. The mechanism underlying this advantage might be related to the increased NAA and Cho levels in prefrontal and anterior cingulate cortices.
