Professor Qian Baogong, member of Academia Sinica, associate editor-in-chief of this journal, passed away on March 17,1992 at Wuhan. He was born on March 18, 1916 in Jiangyin, Jiangsu Province and graduated from the D...Professor Qian Baogong, member of Academia Sinica, associate editor-in-chief of this journal, passed away on March 17,1992 at Wuhan. He was born on March 18, 1916 in Jiangyin, Jiangsu Province and graduated from the Department of Chemistry, Wuhan University in Luoshan, Sichuan Province in 1940. He took his graduate study in 1947 at the Broo, klyn Polytechnic Institute in New York, and received M .S. degree from there.展开更多
Objective: to explore the value of Baogong Zhixue Granule combined with hysteroscopic electrotomy in the treatment of perimenopausal abnormal uterine bleeding. Methods: 323 patients with perimenopausal abnormal uterin...Objective: to explore the value of Baogong Zhixue Granule combined with hysteroscopic electrotomy in the treatment of perimenopausal abnormal uterine bleeding. Methods: 323 patients with perimenopausal abnormal uterine bleeding admitted by the department of gynecology in our hospital were selected for the study, which lasted from 2008 to 2021. The patients were divided into control group (n161) and observation group (n162). The control group was treated with routine hysteroscopic electrotomy, while the observation group was treated with Baogong Zhixue Granule. The clinical efficacy, postoperative complication rate, anemia status, sex hormone level and menstrual blood loss graph score were compared between the two groups. Results: the clinical effective rate of the observation group was 98.77%, higher than that of the control group (P0.05). The postoperative complication rate in the observation group was 1.85%, lower than that in the control group (P0.05). The anemia rate and repeated bleeding rate in the observation group were 12.35% and 0.62%, respectively, lower than those in the control group (P0.05). The bleeding stop time in the observation group was (4.52 ± 1.54) days, which was shorter than that in the control group (P0.05). After treatment, the menstrual blood loss graph score, LH level, FSH level and E2 level in the observation group were (3.04 ± 0.65) points, (8.89 ± 2.13) IU/L, (7.26 ± 2.55) IU/L and (208.65 ± 26.13) poml/L, respectively, compared with the control group (P0.05). Conclusion: Baogong Zhixue Granule combined with hysteroscopic electrotomy is effective in the treatment of perimenopausal abnormal uterine bleeding, which can improve the sex hormone level of patients, reduce postoperative complications, prevent anemia, and promote rehabilitation. It is worth popularizing.展开更多
目的:建立一种分析葆宫止血颗粒中13个成分的高效液相色谱法,并结合化学计量学及灰色关联度分析对葆宫止血颗粒进行质量评价。方法:采用50%甲醇超声提取样品,CAPCELL PAK C_(18)色谱柱,乙腈-0.2%磷酸水溶液为流动相梯度洗脱,同时测定葆...目的:建立一种分析葆宫止血颗粒中13个成分的高效液相色谱法,并结合化学计量学及灰色关联度分析对葆宫止血颗粒进行质量评价。方法:采用50%甲醇超声提取样品,CAPCELL PAK C_(18)色谱柱,乙腈-0.2%磷酸水溶液为流动相梯度洗脱,同时测定葆宫止血颗粒中梓醇、地黄苷D、地黄苷A、益母草苷、三七皂苷R_(1)、人参皂苷Rg_(1)、人参皂苷Rb_(1)、柴胡皂苷a、柴胡皂苷d、芍药内酯苷、芍药苷、苯甲酰芍药苷和鹤草酚的含量。采用化学计量学挖掘影响葆宫止血颗粒产品质量的差异标志物,结合灰色关联度法计算各指标的关联度并对13批葆宫止血颗粒的质量进行排序。结果:13个成分的线性范围分别为2.68~134.00、1.64~82.00、0.88~44.00、0.57~28.50、2.35~117.50、11.93~596.50、9.71~485.50、2.05~102.50、1.86~93.00、9.62~481.00、19.05~952.50、1.78~89.00、0.66~33.00µg·mL^(–1)(r>0.999),3个质量浓度水平加样回收率为96.78%~100.12%(RSD<2.0%)。化学计量学分析显示,芍药苷、人参皂苷Rg_(1)、芍药内酯苷、人参皂苷Rb_(1)、梓醇、柴胡皂苷a和三七皂苷R_(1)是影响葆宫止血颗粒产品质量的主要标志物。灰色关联度分析相对关联度为0.3446~0.5742。结论:该方法揭示了影响葆宫止血颗粒质量的主要潜在标志物,综合评价了葆宫止血颗粒的质量,可为其内在整体质量控制提供参考。展开更多
文摘Professor Qian Baogong, member of Academia Sinica, associate editor-in-chief of this journal, passed away on March 17,1992 at Wuhan. He was born on March 18, 1916 in Jiangyin, Jiangsu Province and graduated from the Department of Chemistry, Wuhan University in Luoshan, Sichuan Province in 1940. He took his graduate study in 1947 at the Broo, klyn Polytechnic Institute in New York, and received M .S. degree from there.
文摘Objective: to explore the value of Baogong Zhixue Granule combined with hysteroscopic electrotomy in the treatment of perimenopausal abnormal uterine bleeding. Methods: 323 patients with perimenopausal abnormal uterine bleeding admitted by the department of gynecology in our hospital were selected for the study, which lasted from 2008 to 2021. The patients were divided into control group (n161) and observation group (n162). The control group was treated with routine hysteroscopic electrotomy, while the observation group was treated with Baogong Zhixue Granule. The clinical efficacy, postoperative complication rate, anemia status, sex hormone level and menstrual blood loss graph score were compared between the two groups. Results: the clinical effective rate of the observation group was 98.77%, higher than that of the control group (P0.05). The postoperative complication rate in the observation group was 1.85%, lower than that in the control group (P0.05). The anemia rate and repeated bleeding rate in the observation group were 12.35% and 0.62%, respectively, lower than those in the control group (P0.05). The bleeding stop time in the observation group was (4.52 ± 1.54) days, which was shorter than that in the control group (P0.05). After treatment, the menstrual blood loss graph score, LH level, FSH level and E2 level in the observation group were (3.04 ± 0.65) points, (8.89 ± 2.13) IU/L, (7.26 ± 2.55) IU/L and (208.65 ± 26.13) poml/L, respectively, compared with the control group (P0.05). Conclusion: Baogong Zhixue Granule combined with hysteroscopic electrotomy is effective in the treatment of perimenopausal abnormal uterine bleeding, which can improve the sex hormone level of patients, reduce postoperative complications, prevent anemia, and promote rehabilitation. It is worth popularizing.
文摘目的:建立一种分析葆宫止血颗粒中13个成分的高效液相色谱法,并结合化学计量学及灰色关联度分析对葆宫止血颗粒进行质量评价。方法:采用50%甲醇超声提取样品,CAPCELL PAK C_(18)色谱柱,乙腈-0.2%磷酸水溶液为流动相梯度洗脱,同时测定葆宫止血颗粒中梓醇、地黄苷D、地黄苷A、益母草苷、三七皂苷R_(1)、人参皂苷Rg_(1)、人参皂苷Rb_(1)、柴胡皂苷a、柴胡皂苷d、芍药内酯苷、芍药苷、苯甲酰芍药苷和鹤草酚的含量。采用化学计量学挖掘影响葆宫止血颗粒产品质量的差异标志物,结合灰色关联度法计算各指标的关联度并对13批葆宫止血颗粒的质量进行排序。结果:13个成分的线性范围分别为2.68~134.00、1.64~82.00、0.88~44.00、0.57~28.50、2.35~117.50、11.93~596.50、9.71~485.50、2.05~102.50、1.86~93.00、9.62~481.00、19.05~952.50、1.78~89.00、0.66~33.00µg·mL^(–1)(r>0.999),3个质量浓度水平加样回收率为96.78%~100.12%(RSD<2.0%)。化学计量学分析显示,芍药苷、人参皂苷Rg_(1)、芍药内酯苷、人参皂苷Rb_(1)、梓醇、柴胡皂苷a和三七皂苷R_(1)是影响葆宫止血颗粒产品质量的主要标志物。灰色关联度分析相对关联度为0.3446~0.5742。结论:该方法揭示了影响葆宫止血颗粒质量的主要潜在标志物,综合评价了葆宫止血颗粒的质量,可为其内在整体质量控制提供参考。
