Protein kinases play an important role in every aspect of cellular life.In this study,we systemically identified protein kinases from the predicted proteomes of 59 representative fungi from Ascomycota and Basidiomycot...Protein kinases play an important role in every aspect of cellular life.In this study,we systemically identified protein kinases from the predicted proteomes of 59 representative fungi from Ascomycota and Basidiomycota.Comparative analysis revealed that fungi from Ascomycota and Basidiomycota differed in the number and variety of protein kinases.Some groups of protein kinases,such as calmodulin/calcium regulated kinases(CMGC) and those with the highest group percentages are the most prevalent protein kinases among all fungal species tested.In contrast,the STE group(homologs of the yeast STE7,STE11 and STE20 genes),was more abundant in Basidiomycetes than in Ascomycetes.Importantly,the distribution of some protein kinase families appeared to be subphylum-specific.The tyrosine kinase-like(TKL) group had a higher protein kinase density in Agaricomycotina fungi.In addition,the distribution of accessory domains,which could have functional implications,demonstrated that usage bias varied between the two phyla.Principal component analysis revealed a divergence between the main functional domains and associated domains in fungi.This study provides novel insights into the variety and expansion of fungal protein kinases between Ascomycota and Basidiomycota.展开更多
Diabetes is a chronic metabolic disease with an increasing incidence rate year by year.it severely diminishes the quality of life for individuals,reduces life expectancy,and poses a significant public health issue in ...Diabetes is a chronic metabolic disease with an increasing incidence rate year by year.it severely diminishes the quality of life for individuals,reduces life expectancy,and poses a significant public health issue in worldwide.Medicinal fungi,as a large group of microorganisms,possess abundant food and medicinal value,as well as vast research potential.This review describes the antidiabetic activities of seven medicinal fungi from subphylum Ascomycota,including Monascus purpureus,Cordyceps militaris,Ophiocordyceps sinensis,Cordyceps cicadae,Shiraia bambusicola,Claviceps purpurea,and Xylaria nigripes.it provides readers with evidence and information on the medicinal fungi(subphylum Ascomycota)with hypoglycemic effects,as well as their compounds for hypoglycemic properties.展开更多
采集湖南省新宁县崀山世界自然遗产风景名胜区和广西省乐业县雅长兰科植物自然保护区这两个生境中处于生长期的铁皮石斛(Dendrobium of ficinale)的营养根,并进行分离培养。通过对分离所得的41个菌株进行形态观察和ITS序列测定相结合的...采集湖南省新宁县崀山世界自然遗产风景名胜区和广西省乐业县雅长兰科植物自然保护区这两个生境中处于生长期的铁皮石斛(Dendrobium of ficinale)的营养根,并进行分离培养。通过对分离所得的41个菌株进行形态观察和ITS序列测定相结合的鉴定,共获得内生真菌34种。对担子菌和子囊菌分别进行了系统发育树构建结果显示,子囊菌为优势种类(31种),以炭角菌目(Xylariales)和肉座菌目(Hypocreales)的种类为主,担子菌则以胶膜菌科(Tulasnellaceae)为主。Simpson多样性指数分析结果表明,不同生境下野生铁皮石斛内生真菌的多样性都很高,且雅长的高于崀山的。展开更多
基金supported by the National Science & Technology Pillar Program of China during the Twelfth Five-Year Plan period (2012BAD19B04)the National Natural Science Foundation of China (31371924)+1 种基金the 111 Project from the Ministry of Education of China (B07049)the National Basic Research Program of China (2013CB127700)
文摘Protein kinases play an important role in every aspect of cellular life.In this study,we systemically identified protein kinases from the predicted proteomes of 59 representative fungi from Ascomycota and Basidiomycota.Comparative analysis revealed that fungi from Ascomycota and Basidiomycota differed in the number and variety of protein kinases.Some groups of protein kinases,such as calmodulin/calcium regulated kinases(CMGC) and those with the highest group percentages are the most prevalent protein kinases among all fungal species tested.In contrast,the STE group(homologs of the yeast STE7,STE11 and STE20 genes),was more abundant in Basidiomycetes than in Ascomycetes.Importantly,the distribution of some protein kinase families appeared to be subphylum-specific.The tyrosine kinase-like(TKL) group had a higher protein kinase density in Agaricomycotina fungi.In addition,the distribution of accessory domains,which could have functional implications,demonstrated that usage bias varied between the two phyla.Principal component analysis revealed a divergence between the main functional domains and associated domains in fungi.This study provides novel insights into the variety and expansion of fungal protein kinases between Ascomycota and Basidiomycota.
基金funded by Shandong Provincial Natural Science Foundation(Zr2023Mc099)National Natural Science Foundation of china(21877075)Key research and Development Program of Shandong Province(2022TZXD0033).
文摘Diabetes is a chronic metabolic disease with an increasing incidence rate year by year.it severely diminishes the quality of life for individuals,reduces life expectancy,and poses a significant public health issue in worldwide.Medicinal fungi,as a large group of microorganisms,possess abundant food and medicinal value,as well as vast research potential.This review describes the antidiabetic activities of seven medicinal fungi from subphylum Ascomycota,including Monascus purpureus,Cordyceps militaris,Ophiocordyceps sinensis,Cordyceps cicadae,Shiraia bambusicola,Claviceps purpurea,and Xylaria nigripes.it provides readers with evidence and information on the medicinal fungi(subphylum Ascomycota)with hypoglycemic effects,as well as their compounds for hypoglycemic properties.
文摘采集湖南省新宁县崀山世界自然遗产风景名胜区和广西省乐业县雅长兰科植物自然保护区这两个生境中处于生长期的铁皮石斛(Dendrobium of ficinale)的营养根,并进行分离培养。通过对分离所得的41个菌株进行形态观察和ITS序列测定相结合的鉴定,共获得内生真菌34种。对担子菌和子囊菌分别进行了系统发育树构建结果显示,子囊菌为优势种类(31种),以炭角菌目(Xylariales)和肉座菌目(Hypocreales)的种类为主,担子菌则以胶膜菌科(Tulasnellaceae)为主。Simpson多样性指数分析结果表明,不同生境下野生铁皮石斛内生真菌的多样性都很高,且雅长的高于崀山的。
基金Supported by the National Natural Science Foundation of China(No.31270073)Ministry of Science and Technology of China for Fundamental Research(No.2013FY110400)
基金Supported by National Natural Science Foundation of China(31270066＆31750001) the fund of Shandong Provincial Education Association for International Exchanges
