In this paper, we developed a new continuous block method using the approach of collocation of the differential system and interpolation of the power series approximate solution. A constant step length within a half s...In this paper, we developed a new continuous block method using the approach of collocation of the differential system and interpolation of the power series approximate solution. A constant step length within a half step interval of integration was adopted. We evaluated at grid and off grid points to get a continuous linear multistep method. The continuous linear multistep method is solved for the independent solution to yield a continuous block method which is evaluated at selected points to yield a discrete block method. The basic properties of the block method were investigated and found to be consistent and zero stable hence convergent. The new method was tested on real life problems namely: SIR model, Growth model and Mixture Model. The results were found to compete favorably with the existing methods in terms of accuracy and error bound.展开更多
目的：测定锁骨上臂丛神经阻滞罗哌卡因的半数有效浓度（half-effective concentration,EC50）。方法：选择ASAⅠ－Ⅱ级上肢手术患者50例,采用神经刺激仪引导定位锁骨上臂丛神经阻滞。30 m in内评定麻醉效果,以VAS评分≤4分作为麻醉阳...目的：测定锁骨上臂丛神经阻滞罗哌卡因的半数有效浓度（half-effective concentration,EC50）。方法：选择ASAⅠ－Ⅱ级上肢手术患者50例,采用神经刺激仪引导定位锁骨上臂丛神经阻滞。30 m in内评定麻醉效果,以VAS评分≤4分作为麻醉阳性（有效）指标。罗哌卡因总量30 m l,初始浓度为0.30%,其后浓度采用双盲根据前一患者的麻醉效果序贯递增或递减,间隔浓度为0.025%。通过SPSS13.0统计软件,prob it回归确定EC50及95%可信区间。结果：在本研究条件下罗哌卡因用于锁骨上臂丛神经阻滞的EC50为0.295%,95%可信区间为0.276%－0.316%。结论：罗哌卡因用于神经刺激仪引导下的锁骨上臂丛阻滞的EC50为0.295%。术中辅助用药可能对其EC50的影响尚需进一步研究。展开更多
文摘In this paper, we developed a new continuous block method using the approach of collocation of the differential system and interpolation of the power series approximate solution. A constant step length within a half step interval of integration was adopted. We evaluated at grid and off grid points to get a continuous linear multistep method. The continuous linear multistep method is solved for the independent solution to yield a continuous block method which is evaluated at selected points to yield a discrete block method. The basic properties of the block method were investigated and found to be consistent and zero stable hence convergent. The new method was tested on real life problems namely: SIR model, Growth model and Mixture Model. The results were found to compete favorably with the existing methods in terms of accuracy and error bound.
文摘目的：测定锁骨上臂丛神经阻滞罗哌卡因的半数有效浓度（half-effective concentration,EC50）。方法：选择ASAⅠ－Ⅱ级上肢手术患者50例,采用神经刺激仪引导定位锁骨上臂丛神经阻滞。30 m in内评定麻醉效果,以VAS评分≤4分作为麻醉阳性（有效）指标。罗哌卡因总量30 m l,初始浓度为0.30%,其后浓度采用双盲根据前一患者的麻醉效果序贯递增或递减,间隔浓度为0.025%。通过SPSS13.0统计软件,prob it回归确定EC50及95%可信区间。结果：在本研究条件下罗哌卡因用于锁骨上臂丛神经阻滞的EC50为0.295%,95%可信区间为0.276%－0.316%。结论：罗哌卡因用于神经刺激仪引导下的锁骨上臂丛阻滞的EC50为0.295%。术中辅助用药可能对其EC50的影响尚需进一步研究。
