摘要
目的：测定锁骨上臂丛神经阻滞罗哌卡因的半数有效浓度（half-effective concentration,EC50）。方法：选择ASAⅠ－Ⅱ级上肢手术患者50例,采用神经刺激仪引导定位锁骨上臂丛神经阻滞。30 m in内评定麻醉效果,以VAS评分≤4分作为麻醉阳性（有效）指标。罗哌卡因总量30 m l,初始浓度为0.30%,其后浓度采用双盲根据前一患者的麻醉效果序贯递增或递减,间隔浓度为0.025%。通过SPSS13.0统计软件,prob it回归确定EC50及95%可信区间。结果：在本研究条件下罗哌卡因用于锁骨上臂丛神经阻滞的EC50为0.295%,95%可信区间为0.276%－0.316%。结论：罗哌卡因用于神经刺激仪引导下的锁骨上臂丛阻滞的EC50为0.295%。术中辅助用药可能对其EC50的影响尚需进一步研究。
Objective： To determine the half-effective concentration（EC50） of ropivacaine in nerve stimulator-guided supraclavicular brachial nerve block.Methods： Surpaclavicular brachial nerve block guided by nerve stimulator was performed in 50 patients with ASAⅠtoⅡ requiring scheduled elective upper-limb surgery.Each participant received 30 ml bolus of ropivacaine,and the concentration of ropivacaine was given by the response of the previous patient to a higher or lower concentration using double-blind,up-and-down sequential allocation.The initial concentration of ropivacaine was 0.30%,and the variety of two close concentrations was 0.025%.The anesthetic efficacy was assessed with visual analogue scale（VAS） within 30 min after anesthesia,and the effectiveness was defined as having a VAS≤4.The EC50 was obtained by probit analysis.Results： Among the 50 patients,one was excluded from the study because of uncertain anesthetic efficacy.The EC50 of ropivacaine in nerve stimulator-guided supraclavicular brachial nerve block was 0.295%,and 95% confidence interval was 0.276-0.316%.Conclusion： The EC50 of ropivacaine in nerve stimulator-guided supraclavicular brachial nerve block is 0.295%.The possible effects of assisted drug during operation needed further study.
出处
《西北国防医学杂志》
CAS
2010年第2期111-113,共3页
Medical Journal of National Defending Forces in Northwest China
关键词
麻醉学
罗哌卡因
半数有效浓度
锁骨上臂丛神经阻滞
神经刺激仪
Anesthesiology
Ropivacaine
Half-effective concentration
Supraclavicular brachial nerve block
Nerve stimulator
