Each morning at Yangluo Port in Wuhan,Hubei Province,the all-electric cargo vessel Huahang Xinneng No.1 completes a battery swap in under 10 minutes before returning to service with nearly 8,000 kWh of power onboard。
To conduct marine surveys,multiple unmanned surface vessels(Multi-USV)with different capabilities perform collaborative mapping in multiple designated areas.This paper proposes a task allocation algorithm based on int...To conduct marine surveys,multiple unmanned surface vessels(Multi-USV)with different capabilities perform collaborative mapping in multiple designated areas.This paper proposes a task allocation algorithm based on integer linear programming(ILP)with flow balance constraints,ensuring the fair and efficient distribution of sub-areas among USVs and maintaining strong connectivity of assigned regions.In the established gridmap,a search-based path planning algorithm is performed on the sub-areas according to the allocation scheme.It uses the greedy algorithm and the A*algorithm to achieve complete coverage of the barrier-free area and obtain an efficient trajectory of each USV.The greedy algorithm enables fast local traversal of unvisited grids,while the A*algorithm ensures navigation to escape from deadlock areas and maintains global path continuity.The comparison of task allocation results proves that the task allocation algorithm based on ILP improves the mapping efficiency and task distribution fairness.The proposed allocation method and result analysis provide a certain reference for the practical application ofMulti-USV to perform survey tasks collaboratively.展开更多
Cardiovascular disease(CVD)is a major global health challenge,which causes significant illness and death worldwide.These include a range of conditions that affect the heart and blood vessels,including coro-nary artery...Cardiovascular disease(CVD)is a major global health challenge,which causes significant illness and death worldwide.These include a range of conditions that affect the heart and blood vessels,including coro-nary artery disease,stroke,peripheral artery disease,and heart failure.Despite advances in medicine and healthcare delivery,CVD continues to have a serious impact on individuals,families,and the healthcare system.This review begins by delineating the merits and demerits of commonly employed synthetic and natural materials for artificial blood vessels.It delves into various techniques commonly employed in the fabrication of artificial blood vessels,encompassing advanced textile technologies,electrospinning,ther-mally induced phase separation,and 3D printing.The review critically analyzes the attributes of different preparation methodologies alongside the latest advancements in research.The review also outlines the requisite performance requirements for artificial blood vessels,which encompass robust mechanical prop-erties,appropriate porosity,exceptional compatibility,and antibacterial attributes.It provides a succinct overview of ongoing effort s in vascular functionalization,particularly emphasizing thrombus mitigation,promotion of endothelialization,and enhancement of nitric oxide production.The review finally encap-sulates the primary challenges confronting vascular grafts and prospective avenues for future research.展开更多
Dear Editor,Underactuated autonomous surface vessels(ASVs)are increasingly attracting attention from researchers because of a wide range of applications[1].Consequently,path following,a typical functionality for ASVs,...Dear Editor,Underactuated autonomous surface vessels(ASVs)are increasingly attracting attention from researchers because of a wide range of applications[1].Consequently,path following,a typical functionality for ASVs,has become a research focus[2].Despite the abundant study results,some challenging issues are still worthy of exploration and resolution,two of which are addressed in this letter.The first one is related to the guidance law.Currently,common guidance methods in the ASV field include the line-of-sight(LOS)guidance[3]and vector field(VF)guidance[4].The response quality of LOS guidance is highly related to the lookahead distance;a constant lookahead distance may result in undesired phenomena such as the singularity problem and the reduction of trajectory smoothness of ASVs(see[5]).To this end,several works have proposed modified LOS guidance laws(see[6]).Although the above modifications,as pointed out by[7],the VF guidance exhibits smaller crosstrack errors and better performances than the LOS guidance.However,the existing VF guidance is only available for straight lines and orbits rather than curved paths,a considerable obstacle that limits its practical application(see[8],[9]).Thus,the VF guidance for curved path following deserves more in-depth study.展开更多
Objective:To study the application effect of bundle nursing strategy in the maintenance of difficult blood vessels for long-term hemodialysis patients.Methods:A prospective study was conducted on 40 long-term hemodial...Objective:To study the application effect of bundle nursing strategy in the maintenance of difficult blood vessels for long-term hemodialysis patients.Methods:A prospective study was conducted on 40 long-term hemodialysis patients admitted from January 2024 to January 2025.The patients were randomly divided into a control group(20 cases)and an observation group(20 cases)using computer random sampling.The control group received routine nursing for difficult blood vessels,while the observation group received a bundle nursing strategy for difficult blood vessels.The self-care ability,complication rate,and nursing satisfaction were compared between the two groups.Results:After nursing,the self-care ability score of the observation group was higher than that of the control group(P<0.05).The complication rate in the observation group was lower than that in the control group(P<0.05).The nursing satisfaction in the observation group was higher than that in the control group(P<0.05).Conclusion:The application of the bundle nursing strategy in the maintenance of difficult blood vessels for long-term hemodialysis patients is beneficial for improving self-care ability,reducing complications,and increasing patient satisfaction with nursing services.展开更多
Frequent flood disasters caused by climate change may lead to tremendous economic and human losses along inland waterways.Emergency response and rescue vessels(ERRVs)play an essential role in minimizing losses and pro...Frequent flood disasters caused by climate change may lead to tremendous economic and human losses along inland waterways.Emergency response and rescue vessels(ERRVs)play an essential role in minimizing losses and protecting lives and property.However,the path planning of ERRVs has mainly depended on expert experiences instead of rational decision making.This paper proposes an improved artificial potential field(APF)algorithm to optimize the shortest path for ERRVs in the rescue process.To verify the feasibility of the proposed model,eight tests were carried out in two water areas of the Yangtze River.The results showed that the improved APF algorithm was efficient with fewer iterations and that the response time of path planning was reduced to around eight seconds.The improved APF algorithm performed better in the ERRV’s goal achievement,compared with the traditional algorithm.The path planning method for ERRVs proposed in this paper has theoretical and practical value in flood relief.It can be applied in the emergency management of ERRVs to accelerate flood management efficiency and improve capacity to prevent,mitigate,and relieve flood disasters.展开更多
The mechanical properties,microstructure and second phase precipitation behavior of flange forgings for high-pressure hydrogen storage vessels at different tempering temperatures(620–700℃)were studied.The results sh...The mechanical properties,microstructure and second phase precipitation behavior of flange forgings for high-pressure hydrogen storage vessels at different tempering temperatures(620–700℃)were studied.The results showed that when tempered at 620–680°C,the main microstructure of the test steel was tempered sorbite,and the main microstructure of tempered steel changed to martensite at 700℃.At 700℃,the dislocation density increased and some retained austenite existed.With the tempering temperature increasing,the yield strength showed a decreasing trend,the formation of fresh martensite made the tensile strength first decrease and then increase slightly,the impact energy at−40℃increased first and then decreased,and the impact energy at 660℃had the maximum value.The precipitates of MC type were mainly(Mo,V,Ti)C.The test steel had excellent strength and toughness matching at 660℃tempering,the tensile strength at different cross section locations was above 750 MPa,the impact energy was above 200 J at−40℃,and the relative percentage reduction of area(ZH2/ZN2)was above 75%at hydrogen environment of 6.3 MPa.展开更多
Segmentation of the retinal vessels in the fundus is crucial for diagnosing ocular diseases.Retinal vessel images often suffer from category imbalance and large scale variations.This ultimately results in incomplete v...Segmentation of the retinal vessels in the fundus is crucial for diagnosing ocular diseases.Retinal vessel images often suffer from category imbalance and large scale variations.This ultimately results in incomplete vessel segmentation and poor continuity.In this study,we propose CT-MFENet to address the aforementioned issues.First,the use of context transformer(CT)allows for the integration of contextual feature information,which helps establish the connection between pixels and solve the problem of incomplete vessel continuity.Second,multi-scale dense residual networks are used instead of traditional CNN to address the issue of inadequate local feature extraction when the model encounters vessels at multiple scales.In the decoding stage,we introduce a local-global fusion module.It enhances the localization of vascular information and reduces the semantic gap between high-and low-level features.To address the class imbalance in retinal images,we propose a hybrid loss function that enhances the segmentation ability of the model for topological structures.We conducted experiments on the publicly available DRIVE,CHASEDB1,STARE,and IOSTAR datasets.The experimental results show that our CT-MFENet performs better than most existing methods,including the baseline U-Net.展开更多
[Objective] The aim of this study was to provide the theoretical basis for variety identification of carambola and pomiculture.[Method] The molecular structure of vessels in stem secondary xylem from three carambola v...[Objective] The aim of this study was to provide the theoretical basis for variety identification of carambola and pomiculture.[Method] The molecular structure of vessels in stem secondary xylem from three carambola varieties of Malaysia 8,Misi and Malaysia B17 were studied by cell image analysis system and microphotography.[Result] The molecular structure of vessels in stem secondary xylem from carambola was as follows:the first type had tails in two ends,the second type had tail in one end,and the third type had no tails in two ends.The average length of vessel elements was from 328.88 to 366.09 μm,while its average width was from 44.61 to 52.43 μm.Most of the end wall was simple perforation plates,while the alternate-opposite pitting was the major forms of pitting.[Conclusion] Most characteristics of vessel elements from carambola were evolutionary characters of vessel elements in the process of phylogeny,but there were more primitive characters,for example,both two ends of vessel had tails or just one end had tail,and end wall was inclined.The molecular structure of vessel from carambola was in accordance with its ecological adaptability,and the growth characteristics of different varieties were also in accordance with the difference of molecular structure of vessel.展开更多
Cerebral small vessel disease encompasses a group of neurological disorders characterized by injury to small blood vessels,often leading to stroke and dementia.Due to its diverse etiologies and complex pathological me...Cerebral small vessel disease encompasses a group of neurological disorders characterized by injury to small blood vessels,often leading to stroke and dementia.Due to its diverse etiologies and complex pathological mechanisms,preventing and treating cerebral small vessel vasculopathy is challenging.Recent studies have shown that the glymphatic system plays a crucial role in interstitial solute clearance and the maintenance of brain homeostasis.Increasing evidence also suggests that dysfunction in glymphatic clearance is a key factor in the progression of cerebral small vessel disease.This review begins with a comprehensive introduction to the structure,function,and driving factors of the glymphatic system,highlighting its essential role in brain waste clearance.Afterwards,cerebral small vessel disease was reviewed from the perspective of the glymphatic system,after which the mechanisms underlying their correlation were summarized.Glymphatic dysfunction may lead to the accumulation of metabolic waste in the brain,thereby exacerbating the pathological processes associated with cerebral small vessel disease.The review also discussed the direct evidence of glymphatic dysfunction in patients and animal models exhibiting two subtypes of cerebral small vessel disease:arteriolosclerosis-related cerebral small vessel disease and amyloid-related cerebral small vessel disease.Diffusion tensor image analysis along the perivascular space is an important non-invasive tool for assessing the clearance function of the glymphatic system.However,the effectiveness of its parameters needs to be enhanced.Among various nervous system diseases,including cerebral small vessel disease,glymphatic failure may be a common final pathway toward dementia.Overall,this review summarizes prevention and treatment strategies that target glymphatic drainage and will offer valuable insight for developing novel treatments for cerebral small vessel disease.展开更多
Objective To investigate the effects of histamine receptor antagonists on vasoconstriction induced by electrical stimulation （ES） on posterior auricular nerve,and to explore the pre-and post-synaptic effects of symp...Objective To investigate the effects of histamine receptor antagonists on vasoconstriction induced by electrical stimulation （ES） on posterior auricular nerve,and to explore the pre-and post-synaptic effects of sympathetic histamine on the vasomotor responses of vascular smooth muscle in rabbit ear.Methods ES was applied to posterior auricular nerves of the whole rabbit ear at 10 Hz,20 Hz and 40 Hz,respectively.Besides,the whole ear was perfused with different histamine receptor antagonists under constant perfusion pressure,and the changes in the flow rate of perfusate were observed.Results The flow rate of venous outflow was decreased by ES at all the 3 frequencies.The ES-induced vasoconstriction at 20 Hz and 40 Hz could be partly inhibited by H1 receptor antagonist chlorpheniramine （P0.05） .After exhaustion of histamine in mast cells by pretreatment with specific mast cell degranulator compound 48/80,chlorpheniramine could still inhibit the ES-induced flow rate reduction.In contrast,H2 receptor antagonist cimetidine could enhance the 40-Hz ES-induced flow rate reduction （P 0.05） .Moreover,ES-induced vasoconstriction at the 3 frequencies could all be enhanced by H3 receptor antagonist thioperamide （P0.05） .Conclusion Stimulation on the auricular nerve may evoke histamine release from sympathetic nerves rather than from mast cells.Moreover,the functions of sympathetic histamine vary from pre-synaptic modulation to post-synaptic vasoconstriction or vasodilatation,via activation of different histamine receptors.展开更多
Background:Limited data are available for sirolimus-eluting stent(SES,Cypher)implantation in patients with coronary artery disease in small vessels.The clinical longtermoutcomes of SES in patients with coronary artery...Background:Limited data are available for sirolimus-eluting stent(SES,Cypher)implantation in patients with coronary artery disease in small vessels.The clinical longtermoutcomes of SES in patients with coronary artery disease after intracoronary stenting in small vessels has not been yet evaluated.展开更多
Lymphatic vessel networks have been identified in the meninges of mice,non-human primates,and humans[1].Meningeal lymphatic vessels(mLVs),composed of meningeal lymphatic endothelial cells(mLECs),are present in both ze...Lymphatic vessel networks have been identified in the meninges of mice,non-human primates,and humans[1].Meningeal lymphatic vessels(mLVs),composed of meningeal lymphatic endothelial cells(mLECs),are present in both zebrafish and mammals,although their anatomical distributions differ;they reside in the dura mater in mice,but are situated within the meninges in zebrafish[2].Moreover,the lymphatic marker genes expressed in these vessels differ between species[2].展开更多
At Yangpu Port on the northwestern tip of Hainan Island,towering quay cranes are lined in neat rows, hoisting containers on and off cargo vessels in constant motion.“Today, half of the international ships we pilot ar...At Yangpu Port on the northwestern tip of Hainan Island,towering quay cranes are lined in neat rows, hoisting containers on and off cargo vessels in constant motion.“Today, half of the international ships we pilot are ultra-large vessels over 200meters in length,” said Lin Hongpin,head of the Yangpu branch of Hainan Provincial Ship Pilot Station. Since the launch of the island-wide special customs operations, port throughput has continued to climb, with pilotage services for such large ships rising by nearly 20 percent year on year.展开更多
Background:The traditional method of heterotopic abdominal heart transplantation(HTx)involves crossclamping the inferior vena cava,which inevitably leads to bilateral lower limb ischemia(LI).This study first aimed to ...Background:The traditional method of heterotopic abdominal heart transplantation(HTx)involves crossclamping the inferior vena cava,which inevitably leads to bilateral lower limb ischemia(LI).This study first aimed to investigate the impact of LI on renal function in rats subjected to unilateral nephrectomy(UNx).Second,a modified method utilizing renal vessel-assisted anastomosis in rats with left UNx was compared with the traditional method for abdominal HTx.Methods:Male Sprague-Dawley rats were utilized as subjects for both experimental phases.In experiment 1,the animals were divided into four groups:sham operation group;LI group-rats undergoing occlusion of the abdominal aorta and vena cava below the renal vessels;UNx group-rats with left UNx;and LI+UNx group.All operated animals were monitored for up to 7 days for biochemical markers,renal histopathology,and survival rates.In experiment 2,we introduced the renal vessel-assisted method as the experimental group and compared it against the traditional method as the control within rat heterotopic HTx models.We assessed operative characteristics,echocardiography results,histological findings,and graft survival.Results:First,LI resulted in acute kidney dysfunction characterized by a decrease in 7day survival rates and creatinine clearance rates in both the LI and LI+UNx groups compared to the sham operation and UNx groups.Particularly,histopathological damage in the kidney and liver did not exhibit significant effects during this period.Second,the implementation of the renal vessel-assisted method significantly reduced bleeding volume at suture sites and enhanced the 7day survival rate compared to the traditional method.Conclusion:Acute kidney injury was induced by LI postoperation in treated rats.The renal vessel-assisted method demonstrated its effectiveness as a superior alternative that mitigates complications associated with the traditional method.展开更多
Cells of the central nervous system(CNS)are privileged in lying behind the blood-brain barrier(BBB).Unlike blood vessels in other organs,CNS blood vessels are unique in displaying high electrical resistance and low pe...Cells of the central nervous system(CNS)are privileged in lying behind the blood-brain barrier(BBB).Unlike blood vessels in other organs,CNS blood vessels are unique in displaying high electrical resistance and low permeability.With this unique structure and function,the BBB prevents potentially harmful blood components such as serum proteins,inflammatory cytokines,and inflammatory leukocytes from entering the hallowed space of the CNS and wreaking havoc.In addition to these“tightness”properties,the BBB has an array of specialized transporters designed to import essential nutrients.展开更多
文摘Each morning at Yangluo Port in Wuhan,Hubei Province,the all-electric cargo vessel Huahang Xinneng No.1 completes a battery swap in under 10 minutes before returning to service with nearly 8,000 kWh of power onboard。
基金supported in part by the International Science and Technology Project of Guangzhou Development District under Grant 2023GH08the Science and Technology Development Fund,MSAR,under Grants 0029/2022/AGJ and 0029/2023/RIA1the Program of Guangdong under Grant 2023A0505020003.
文摘To conduct marine surveys,multiple unmanned surface vessels(Multi-USV)with different capabilities perform collaborative mapping in multiple designated areas.This paper proposes a task allocation algorithm based on integer linear programming(ILP)with flow balance constraints,ensuring the fair and efficient distribution of sub-areas among USVs and maintaining strong connectivity of assigned regions.In the established gridmap,a search-based path planning algorithm is performed on the sub-areas according to the allocation scheme.It uses the greedy algorithm and the A*algorithm to achieve complete coverage of the barrier-free area and obtain an efficient trajectory of each USV.The greedy algorithm enables fast local traversal of unvisited grids,while the A*algorithm ensures navigation to escape from deadlock areas and maintains global path continuity.The comparison of task allocation results proves that the task allocation algorithm based on ILP improves the mapping efficiency and task distribution fairness.The proposed allocation method and result analysis provide a certain reference for the practical application ofMulti-USV to perform survey tasks collaboratively.
基金the National Natural Science Foundation of China(No.82374295)the National Key R&D Program of China(No.2021YFE0111100)+1 种基金the Science and Technol-ogy Partnership Program by the Ministry of Science and Technol-ogy of China(No.KY202201002)the Jiangsu Provincial De-partment of Science and Technology(No.BZ2022017).
文摘Cardiovascular disease(CVD)is a major global health challenge,which causes significant illness and death worldwide.These include a range of conditions that affect the heart and blood vessels,including coro-nary artery disease,stroke,peripheral artery disease,and heart failure.Despite advances in medicine and healthcare delivery,CVD continues to have a serious impact on individuals,families,and the healthcare system.This review begins by delineating the merits and demerits of commonly employed synthetic and natural materials for artificial blood vessels.It delves into various techniques commonly employed in the fabrication of artificial blood vessels,encompassing advanced textile technologies,electrospinning,ther-mally induced phase separation,and 3D printing.The review critically analyzes the attributes of different preparation methodologies alongside the latest advancements in research.The review also outlines the requisite performance requirements for artificial blood vessels,which encompass robust mechanical prop-erties,appropriate porosity,exceptional compatibility,and antibacterial attributes.It provides a succinct overview of ongoing effort s in vascular functionalization,particularly emphasizing thrombus mitigation,promotion of endothelialization,and enhancement of nitric oxide production.The review finally encap-sulates the primary challenges confronting vascular grafts and prospective avenues for future research.
基金supported by the National Natural Science Foundation of China(62473243,62421004)the Fundamental Research Funds for the Provincial Universities(3072024 GH0404)+1 种基金the Key Research and Development Projects in Hainan Province(ZDYF2024GXJS009)the“Spring Wild Goose”Plan Project of Heilongjiang Province(CYQN24071).
文摘Dear Editor,Underactuated autonomous surface vessels(ASVs)are increasingly attracting attention from researchers because of a wide range of applications[1].Consequently,path following,a typical functionality for ASVs,has become a research focus[2].Despite the abundant study results,some challenging issues are still worthy of exploration and resolution,two of which are addressed in this letter.The first one is related to the guidance law.Currently,common guidance methods in the ASV field include the line-of-sight(LOS)guidance[3]and vector field(VF)guidance[4].The response quality of LOS guidance is highly related to the lookahead distance;a constant lookahead distance may result in undesired phenomena such as the singularity problem and the reduction of trajectory smoothness of ASVs(see[5]).To this end,several works have proposed modified LOS guidance laws(see[6]).Although the above modifications,as pointed out by[7],the VF guidance exhibits smaller crosstrack errors and better performances than the LOS guidance.However,the existing VF guidance is only available for straight lines and orbits rather than curved paths,a considerable obstacle that limits its practical application(see[8],[9]).Thus,the VF guidance for curved path following deserves more in-depth study.
文摘Objective:To study the application effect of bundle nursing strategy in the maintenance of difficult blood vessels for long-term hemodialysis patients.Methods:A prospective study was conducted on 40 long-term hemodialysis patients admitted from January 2024 to January 2025.The patients were randomly divided into a control group(20 cases)and an observation group(20 cases)using computer random sampling.The control group received routine nursing for difficult blood vessels,while the observation group received a bundle nursing strategy for difficult blood vessels.The self-care ability,complication rate,and nursing satisfaction were compared between the two groups.Results:After nursing,the self-care ability score of the observation group was higher than that of the control group(P<0.05).The complication rate in the observation group was lower than that in the control group(P<0.05).The nursing satisfaction in the observation group was higher than that in the control group(P<0.05).Conclusion:The application of the bundle nursing strategy in the maintenance of difficult blood vessels for long-term hemodialysis patients is beneficial for improving self-care ability,reducing complications,and increasing patient satisfaction with nursing services.
基金The National Natural Science Foundation of China(Grant No.72274052)the National Natural Science Foundation of China(Grant No.72174173).
文摘Frequent flood disasters caused by climate change may lead to tremendous economic and human losses along inland waterways.Emergency response and rescue vessels(ERRVs)play an essential role in minimizing losses and protecting lives and property.However,the path planning of ERRVs has mainly depended on expert experiences instead of rational decision making.This paper proposes an improved artificial potential field(APF)algorithm to optimize the shortest path for ERRVs in the rescue process.To verify the feasibility of the proposed model,eight tests were carried out in two water areas of the Yangtze River.The results showed that the improved APF algorithm was efficient with fewer iterations and that the response time of path planning was reduced to around eight seconds.The improved APF algorithm performed better in the ERRV’s goal achievement,compared with the traditional algorithm.The path planning method for ERRVs proposed in this paper has theoretical and practical value in flood relief.It can be applied in the emergency management of ERRVs to accelerate flood management efficiency and improve capacity to prevent,mitigate,and relieve flood disasters.
基金supported by the National Key research and Development Program of China(No.2022YFB4003001).
文摘The mechanical properties,microstructure and second phase precipitation behavior of flange forgings for high-pressure hydrogen storage vessels at different tempering temperatures(620–700℃)were studied.The results showed that when tempered at 620–680°C,the main microstructure of the test steel was tempered sorbite,and the main microstructure of tempered steel changed to martensite at 700℃.At 700℃,the dislocation density increased and some retained austenite existed.With the tempering temperature increasing,the yield strength showed a decreasing trend,the formation of fresh martensite made the tensile strength first decrease and then increase slightly,the impact energy at−40℃increased first and then decreased,and the impact energy at 660℃had the maximum value.The precipitates of MC type were mainly(Mo,V,Ti)C.The test steel had excellent strength and toughness matching at 660℃tempering,the tensile strength at different cross section locations was above 750 MPa,the impact energy was above 200 J at−40℃,and the relative percentage reduction of area(ZH2/ZN2)was above 75%at hydrogen environment of 6.3 MPa.
基金the National Natural Science Foundation of China(No.62266025)。
文摘Segmentation of the retinal vessels in the fundus is crucial for diagnosing ocular diseases.Retinal vessel images often suffer from category imbalance and large scale variations.This ultimately results in incomplete vessel segmentation and poor continuity.In this study,we propose CT-MFENet to address the aforementioned issues.First,the use of context transformer(CT)allows for the integration of contextual feature information,which helps establish the connection between pixels and solve the problem of incomplete vessel continuity.Second,multi-scale dense residual networks are used instead of traditional CNN to address the issue of inadequate local feature extraction when the model encounters vessels at multiple scales.In the decoding stage,we introduce a local-global fusion module.It enhances the localization of vascular information and reduces the semantic gap between high-and low-level features.To address the class imbalance in retinal images,we propose a hybrid loss function that enhances the segmentation ability of the model for topological structures.We conducted experiments on the publicly available DRIVE,CHASEDB1,STARE,and IOSTAR datasets.The experimental results show that our CT-MFENet performs better than most existing methods,including the baseline U-Net.
基金Supported by Guangdong Natural Science Foundation(04300850)~~
文摘[Objective] The aim of this study was to provide the theoretical basis for variety identification of carambola and pomiculture.[Method] The molecular structure of vessels in stem secondary xylem from three carambola varieties of Malaysia 8,Misi and Malaysia B17 were studied by cell image analysis system and microphotography.[Result] The molecular structure of vessels in stem secondary xylem from carambola was as follows:the first type had tails in two ends,the second type had tail in one end,and the third type had no tails in two ends.The average length of vessel elements was from 328.88 to 366.09 μm,while its average width was from 44.61 to 52.43 μm.Most of the end wall was simple perforation plates,while the alternate-opposite pitting was the major forms of pitting.[Conclusion] Most characteristics of vessel elements from carambola were evolutionary characters of vessel elements in the process of phylogeny,but there were more primitive characters,for example,both two ends of vessel had tails or just one end had tail,and end wall was inclined.The molecular structure of vessel from carambola was in accordance with its ecological adaptability,and the growth characteristics of different varieties were also in accordance with the difference of molecular structure of vessel.
基金supported by the National Natural Science Foundation of China,No.82274304(to YH)the Major Clinical Study Projects of Shanghai Shenkang Hospital Development Center,No.SHDC2020CR2046B(to YH)Shanghai Municipal Health Commission Talent Plan,No.2022LJ010(to YH).
文摘Cerebral small vessel disease encompasses a group of neurological disorders characterized by injury to small blood vessels,often leading to stroke and dementia.Due to its diverse etiologies and complex pathological mechanisms,preventing and treating cerebral small vessel vasculopathy is challenging.Recent studies have shown that the glymphatic system plays a crucial role in interstitial solute clearance and the maintenance of brain homeostasis.Increasing evidence also suggests that dysfunction in glymphatic clearance is a key factor in the progression of cerebral small vessel disease.This review begins with a comprehensive introduction to the structure,function,and driving factors of the glymphatic system,highlighting its essential role in brain waste clearance.Afterwards,cerebral small vessel disease was reviewed from the perspective of the glymphatic system,after which the mechanisms underlying their correlation were summarized.Glymphatic dysfunction may lead to the accumulation of metabolic waste in the brain,thereby exacerbating the pathological processes associated with cerebral small vessel disease.The review also discussed the direct evidence of glymphatic dysfunction in patients and animal models exhibiting two subtypes of cerebral small vessel disease:arteriolosclerosis-related cerebral small vessel disease and amyloid-related cerebral small vessel disease.Diffusion tensor image analysis along the perivascular space is an important non-invasive tool for assessing the clearance function of the glymphatic system.However,the effectiveness of its parameters needs to be enhanced.Among various nervous system diseases,including cerebral small vessel disease,glymphatic failure may be a common final pathway toward dementia.Overall,this review summarizes prevention and treatment strategies that target glymphatic drainage and will offer valuable insight for developing novel treatments for cerebral small vessel disease.
基金supported by the National Natural Science Foundation of China(No.30770669,30800310)
文摘Objective To investigate the effects of histamine receptor antagonists on vasoconstriction induced by electrical stimulation （ES） on posterior auricular nerve,and to explore the pre-and post-synaptic effects of sympathetic histamine on the vasomotor responses of vascular smooth muscle in rabbit ear.Methods ES was applied to posterior auricular nerves of the whole rabbit ear at 10 Hz,20 Hz and 40 Hz,respectively.Besides,the whole ear was perfused with different histamine receptor antagonists under constant perfusion pressure,and the changes in the flow rate of perfusate were observed.Results The flow rate of venous outflow was decreased by ES at all the 3 frequencies.The ES-induced vasoconstriction at 20 Hz and 40 Hz could be partly inhibited by H1 receptor antagonist chlorpheniramine （P0.05） .After exhaustion of histamine in mast cells by pretreatment with specific mast cell degranulator compound 48/80,chlorpheniramine could still inhibit the ES-induced flow rate reduction.In contrast,H2 receptor antagonist cimetidine could enhance the 40-Hz ES-induced flow rate reduction （P 0.05） .Moreover,ES-induced vasoconstriction at the 3 frequencies could all be enhanced by H3 receptor antagonist thioperamide （P0.05） .Conclusion Stimulation on the auricular nerve may evoke histamine release from sympathetic nerves rather than from mast cells.Moreover,the functions of sympathetic histamine vary from pre-synaptic modulation to post-synaptic vasoconstriction or vasodilatation,via activation of different histamine receptors.
文摘Background:Limited data are available for sirolimus-eluting stent(SES,Cypher)implantation in patients with coronary artery disease in small vessels.The clinical longtermoutcomes of SES in patients with coronary artery disease after intracoronary stenting in small vessels has not been yet evaluated.
基金supported by the National Natural Science Foundation of China(32220103006 and 82271524).
文摘Lymphatic vessel networks have been identified in the meninges of mice,non-human primates,and humans[1].Meningeal lymphatic vessels(mLVs),composed of meningeal lymphatic endothelial cells(mLECs),are present in both zebrafish and mammals,although their anatomical distributions differ;they reside in the dura mater in mice,but are situated within the meninges in zebrafish[2].Moreover,the lymphatic marker genes expressed in these vessels differ between species[2].
文摘At Yangpu Port on the northwestern tip of Hainan Island,towering quay cranes are lined in neat rows, hoisting containers on and off cargo vessels in constant motion.“Today, half of the international ships we pilot are ultra-large vessels over 200meters in length,” said Lin Hongpin,head of the Yangpu branch of Hainan Provincial Ship Pilot Station. Since the launch of the island-wide special customs operations, port throughput has continued to climb, with pilotage services for such large ships rising by nearly 20 percent year on year.
基金The Youth Project of Tianjin Natural Science Foundation,Grant/Award Number:23JCQNJC01380。
文摘Background:The traditional method of heterotopic abdominal heart transplantation(HTx)involves crossclamping the inferior vena cava,which inevitably leads to bilateral lower limb ischemia(LI).This study first aimed to investigate the impact of LI on renal function in rats subjected to unilateral nephrectomy(UNx).Second,a modified method utilizing renal vessel-assisted anastomosis in rats with left UNx was compared with the traditional method for abdominal HTx.Methods:Male Sprague-Dawley rats were utilized as subjects for both experimental phases.In experiment 1,the animals were divided into four groups:sham operation group;LI group-rats undergoing occlusion of the abdominal aorta and vena cava below the renal vessels;UNx group-rats with left UNx;and LI+UNx group.All operated animals were monitored for up to 7 days for biochemical markers,renal histopathology,and survival rates.In experiment 2,we introduced the renal vessel-assisted method as the experimental group and compared it against the traditional method as the control within rat heterotopic HTx models.We assessed operative characteristics,echocardiography results,histological findings,and graft survival.Results:First,LI resulted in acute kidney dysfunction characterized by a decrease in 7day survival rates and creatinine clearance rates in both the LI and LI+UNx groups compared to the sham operation and UNx groups.Particularly,histopathological damage in the kidney and liver did not exhibit significant effects during this period.Second,the implementation of the renal vessel-assisted method significantly reduced bleeding volume at suture sites and enhanced the 7day survival rate compared to the traditional method.Conclusion:Acute kidney injury was induced by LI postoperation in treated rats.The renal vessel-assisted method demonstrated its effectiveness as a superior alternative that mitigates complications associated with the traditional method.
基金supported by the NIH RF1 grant NS119477 jointly funded by NINDS and NIA(to RM).
文摘Cells of the central nervous system(CNS)are privileged in lying behind the blood-brain barrier(BBB).Unlike blood vessels in other organs,CNS blood vessels are unique in displaying high electrical resistance and low permeability.With this unique structure and function,the BBB prevents potentially harmful blood components such as serum proteins,inflammatory cytokines,and inflammatory leukocytes from entering the hallowed space of the CNS and wreaking havoc.In addition to these“tightness”properties,the BBB has an array of specialized transporters designed to import essential nutrients.
