目的 整合接纳与承诺疗法(acceptance and commitment therapy,ACT)在癌症患者中的应用现状,明确其干预策略、实施特征及效果。方法 基于JBI范围综述框架,检索中国知网、中国生物医学文献数据库、万方、维普、PubMed、Web of science、E...目的 整合接纳与承诺疗法(acceptance and commitment therapy,ACT)在癌症患者中的应用现状,明确其干预策略、实施特征及效果。方法 基于JBI范围综述框架,检索中国知网、中国生物医学文献数据库、万方、维普、PubMed、Web of science、Embase、PsycINFO、The Cochrane Library等中英文数据库,并补充手工检索相关期刊与会议论文,时限为建库至2025年4月30日,提取纳入研究的干预特征及结局指标。结果 共纳入25篇文献,涵盖乳腺癌、肺癌等多种癌症类型。干预以护士主导的多学科团队实施,整合正念、隐喻等核心技术,联合虚拟现实等创新形式(频次:6~10次/周;时长:25~120 min/次)。ACT可提升心理灵活性、减轻负性情绪、改善生活质量,但对罕见癌种及老年患者研究不足。结论 ACT在癌症患者中应用效果显著,可适应不同癌症类型及疾病阶段,未来需解决干预方案异质性大、特殊人群研究薄弱等问题,并开展多中心研究,拓展应用范围,提升其临床转化价值。展开更多
The last research focuses on the role of exosomes in cancer treatment.Exosomes are extracellular vesicles.They can be secreted by cancer cells,and they can modulate chemotherapy sensitivity.Determining exosomal conten...The last research focuses on the role of exosomes in cancer treatment.Exosomes are extracellular vesicles.They can be secreted by cancer cells,and they can modulate chemotherapy sensitivity.Determining exosomal content opens the possibility for guiding treatment strategies for cancer diseases.Exosomal microRNA are considered one of the prime candidates for exosomal biomarkers.Exosomal circular RNAs represent excellent biomarkers for liquid biopsy because of their stability in many types of cancer.Exosomal proteins remain reliable biomarkers also.Exosomes have emerged as promising therapeutic candidates.Their biological properties render them ideal vectors for drug delivery.Genetic modification of exosomes is an effective way to deliver material capable of modulating cellular pathways involved in drug resistance.Furthermore,exosomes have been explored as carriers for metal-chelating agents.Integrating exosome-based therapies with traditional anticancer agents aims to exploit the natural targeting abilities of exosomes to enhance drug delivery.Despite the dynamic development of this field,many mechanisms of exosome action remain incompletely understood.Therefore,it is necessary to conduct further studies that will allow for a better understanding of their role in the process of resistance and will enable the development of effective therapeutic strategies.展开更多
文摘The last research focuses on the role of exosomes in cancer treatment.Exosomes are extracellular vesicles.They can be secreted by cancer cells,and they can modulate chemotherapy sensitivity.Determining exosomal content opens the possibility for guiding treatment strategies for cancer diseases.Exosomal microRNA are considered one of the prime candidates for exosomal biomarkers.Exosomal circular RNAs represent excellent biomarkers for liquid biopsy because of their stability in many types of cancer.Exosomal proteins remain reliable biomarkers also.Exosomes have emerged as promising therapeutic candidates.Their biological properties render them ideal vectors for drug delivery.Genetic modification of exosomes is an effective way to deliver material capable of modulating cellular pathways involved in drug resistance.Furthermore,exosomes have been explored as carriers for metal-chelating agents.Integrating exosome-based therapies with traditional anticancer agents aims to exploit the natural targeting abilities of exosomes to enhance drug delivery.Despite the dynamic development of this field,many mechanisms of exosome action remain incompletely understood.Therefore,it is necessary to conduct further studies that will allow for a better understanding of their role in the process of resistance and will enable the development of effective therapeutic strategies.
