This paper described a novel method t hat is in alkaline protonic solvent (water or ethanol)to prepare sodium diselenide with a 8:1molar ratio of selenium to sodium borohydride,then to syn-thesize organic diselenides....This paper described a novel method t hat is in alkaline protonic solvent (water or ethanol)to prepare sodium diselenide with a 8:1molar ratio of selenium to sodium borohydride,then to syn-thesize organic diselenides.Compared with the reaction in neutral solu tion described in literature,this method has advantages as below.(1)To prepare same amount of diselenide,the amount of NaBH4in alkaline solution is only 1/8of th at in neutral solution.(2)The reaction proceeded mildly with no injurious gas forming.(3)The operation is convenient and safe.(4)The obtained Na 2Se2solution can be utilized directly to synthesize diselenides with higher yields.展开更多
在铁粉存在下,以商用N,N-二甲基甲酰胺(DMF)作溶剂,90℃、氮气保护下,二芳基二硒醚与α-溴代羰基化合物反应,得到一系列α-芳硒基羰基化合物.考察了温度、时间、溶剂及铁粉用量对反应的影响,其中,温度对反应的影响最为明显.α-溴代羰基...在铁粉存在下,以商用N,N-二甲基甲酰胺(DMF)作溶剂,90℃、氮气保护下,二芳基二硒醚与α-溴代羰基化合物反应,得到一系列α-芳硒基羰基化合物.考察了温度、时间、溶剂及铁粉用量对反应的影响,其中,温度对反应的影响最为明显.α-溴代羰基化合物中羰基上取代基对反应有很大影响,取代基为苯基时,转化率较甲基或烷氧基时低.反应机理可能是铁插入Se—Se键中形成亲核性Se Fe Se,随后与亲电底物α-溴代羰基化合物发生亲核取代.本方法使用铁粉促进断裂Se—Se键具有原料安全无毒、廉价易得、实验操作简便等优点.展开更多
Five selenium containing compounds are synthesized and their molecular structures are verified by IR, 1H NMR and MS. The action on escherichia coli are studied by microcalorimetry, the rate constant k and half inhibit...Five selenium containing compounds are synthesized and their molecular structures are verified by IR, 1H NMR and MS. The action on escherichia coli are studied by microcalorimetry, the rate constant k and half inhibitory concentration, IC 50 are calculated, the biological activity of the compounds is expressed quantitatively.展开更多
文摘This paper described a novel method t hat is in alkaline protonic solvent (water or ethanol)to prepare sodium diselenide with a 8:1molar ratio of selenium to sodium borohydride,then to syn-thesize organic diselenides.Compared with the reaction in neutral solu tion described in literature,this method has advantages as below.(1)To prepare same amount of diselenide,the amount of NaBH4in alkaline solution is only 1/8of th at in neutral solution.(2)The reaction proceeded mildly with no injurious gas forming.(3)The operation is convenient and safe.(4)The obtained Na 2Se2solution can be utilized directly to synthesize diselenides with higher yields.
文摘在铁粉存在下,以商用N,N-二甲基甲酰胺(DMF)作溶剂,90℃、氮气保护下,二芳基二硒醚与α-溴代羰基化合物反应,得到一系列α-芳硒基羰基化合物.考察了温度、时间、溶剂及铁粉用量对反应的影响,其中,温度对反应的影响最为明显.α-溴代羰基化合物中羰基上取代基对反应有很大影响,取代基为苯基时,转化率较甲基或烷氧基时低.反应机理可能是铁插入Se—Se键中形成亲核性Se Fe Se,随后与亲电底物α-溴代羰基化合物发生亲核取代.本方法使用铁粉促进断裂Se—Se键具有原料安全无毒、廉价易得、实验操作简便等优点.
文摘Five selenium containing compounds are synthesized and their molecular structures are verified by IR, 1H NMR and MS. The action on escherichia coli are studied by microcalorimetry, the rate constant k and half inhibitory concentration, IC 50 are calculated, the biological activity of the compounds is expressed quantitatively.
