Chiral pyridyl alcohols are a type of synthetically versatile building block for natural products,functional materials and bioactive molecules.Herein,a highly efficient Ir/f-amphox-catalyzed asymmetric hydrogenation o...Chiral pyridyl alcohols are a type of synthetically versatile building block for natural products,functional materials and bioactive molecules.Herein,a highly efficient Ir/f-amphox-catalyzed asymmetric hydrogenation of 1-(pyridin-2-yl)ketone derivatives to access chiral pyridyl alcohols was reported.The reaction proceeds smoothly under mild conditions,delivering excellent yields and enantioselectivities(up to>99%ee,turnover number(TON)up to 2000).A broad range of pyridyl alkyl and aryl ketones were successfully transformed,demonstrating the generality and synthetic utility of this methodology.展开更多
The Ti-supported lead dioxide electrode（Ti/PdO2） consisted of a Sb2O3/SnO2 semiconductive interlayer and electrodeposited PbO2 films was prepared. The optimum ratio of Sb2O3 to SnO2 was 15%25%. Addition of NaF（0.40...The Ti-supported lead dioxide electrode（Ti/PdO2） consisted of a Sb2O3/SnO2 semiconductive interlayer and electrodeposited PbO2 films was prepared. The optimum ratio of Sb2O3 to SnO2 was 15%25%. Addition of NaF（0.40 g/L） in electroplating solution could decrease the rate of PbO2 deposition, which resulted in the formation of small crystal particles and compact PbO2 films. XRD study showed the β-form crystal of electrode. The electrode was tested in synthesis of 4-picoline acid by electro-oxidation of 4-picoline, showing good electroconductivity and stable life.展开更多
文摘Chiral pyridyl alcohols are a type of synthetically versatile building block for natural products,functional materials and bioactive molecules.Herein,a highly efficient Ir/f-amphox-catalyzed asymmetric hydrogenation of 1-(pyridin-2-yl)ketone derivatives to access chiral pyridyl alcohols was reported.The reaction proceeds smoothly under mild conditions,delivering excellent yields and enantioselectivities(up to>99%ee,turnover number(TON)up to 2000).A broad range of pyridyl alkyl and aryl ketones were successfully transformed,demonstrating the generality and synthetic utility of this methodology.
文摘The Ti-supported lead dioxide electrode（Ti/PdO2） consisted of a Sb2O3/SnO2 semiconductive interlayer and electrodeposited PbO2 films was prepared. The optimum ratio of Sb2O3 to SnO2 was 15%25%. Addition of NaF（0.40 g/L） in electroplating solution could decrease the rate of PbO2 deposition, which resulted in the formation of small crystal particles and compact PbO2 films. XRD study showed the β-form crystal of electrode. The electrode was tested in synthesis of 4-picoline acid by electro-oxidation of 4-picoline, showing good electroconductivity and stable life.
