摘要
Chiral pyridyl alcohols are a type of synthetically versatile building block for natural products,functional materials and bioactive molecules.Herein,a highly efficient Ir/f-amphox-catalyzed asymmetric hydrogenation of 1-(pyridin-2-yl)ketone derivatives to access chiral pyridyl alcohols was reported.The reaction proceeds smoothly under mild conditions,delivering excellent yields and enantioselectivities(up to>99%ee,turnover number(TON)up to 2000).A broad range of pyridyl alkyl and aryl ketones were successfully transformed,demonstrating the generality and synthetic utility of this methodology.
手性吡啶醇是一类合成用途广泛的砌块,可用于构建天然产物、功能材料和生物活性分子.报道了一种高效铱/手性双噁唑啉催化体系,通过吡啶酮衍生物的不对称氢化反应合成手性吡啶醇类化合物.该反应在温和条件下顺利进行,能获得优异产率和对映选择性[最高>99%ee,转化数(TON)值达2000].多种吡啶基烷基/芳基酮类底物均能成功转化,证明了该方法的普适性和合成价值.
出处
《有机化学》
北大核心
2025年第9期3326-3334,共9页
Chinese Journal of Organic Chemistry
基金
国家重点研发计划(No.2021YFA1500200)
深圳市基础研究重点(No.JCYJ20241202125305008)资助项目。
