A strategy for the green synthesis of heterocyclicβ-ketosulfides via nucleophilic substitution ofα-halogenated ketone with het-eroaryl thiols in water media is presented.Compared with the available literature report...A strategy for the green synthesis of heterocyclicβ-ketosulfides via nucleophilic substitution ofα-halogenated ketone with het-eroaryl thiols in water media is presented.Compared with the available literature reports,this new method had the advantages of base-free,additives-free,simple operation,mild condition,greenness,high efficiency,tolerance of a broad scope of substrates.Furth-more,the reaction could easily be scaled up in gram scale and the products also could easily transformed to other useful organic compounds.Mechanism investigation indicated that the tautomerism of pyrimidine-2-thiol to pyrimidine-2(1H)-thione and the hy-drogen bonds played important roles in the reaction.展开更多
In an attempt to search for novel compounds with agricultural bioactivity,a series of new polysubstituted pyridine derivatives,α-[2-methyl-5-cyano4-（furan-2-yl）-3-ethoxycarboxyl-pyridine-6-thio]acetamide 4a, 2-meth...In an attempt to search for novel compounds with agricultural bioactivity,a series of new polysubstituted pyridine derivatives,α-[2-methyl-5-cyano4-（furan-2-yl）-3-ethoxycarboxyl-pyridine-6-thio]acetamide 4a, 2-methyl-5-cyano-4-（furan-2-yl）-3-acetyl pyridine-6-thioethers [STHZ]5 and 6a were designed and synthesized by a three-step or one-step synthetic route.The structures of all the compounds prepared were confirmed by（elemental） analysis and 1H NMR.The preliminary bioassay results indicate that compound 4a possesses certain fungicidal and herbicidal activities.展开更多
文摘A strategy for the green synthesis of heterocyclicβ-ketosulfides via nucleophilic substitution ofα-halogenated ketone with het-eroaryl thiols in water media is presented.Compared with the available literature reports,this new method had the advantages of base-free,additives-free,simple operation,mild condition,greenness,high efficiency,tolerance of a broad scope of substrates.Furth-more,the reaction could easily be scaled up in gram scale and the products also could easily transformed to other useful organic compounds.Mechanism investigation indicated that the tautomerism of pyrimidine-2-thiol to pyrimidine-2(1H)-thione and the hy-drogen bonds played important roles in the reaction.
文摘In an attempt to search for novel compounds with agricultural bioactivity,a series of new polysubstituted pyridine derivatives,α-[2-methyl-5-cyano4-（furan-2-yl）-3-ethoxycarboxyl-pyridine-6-thio]acetamide 4a, 2-methyl-5-cyano-4-（furan-2-yl）-3-acetyl pyridine-6-thioethers [STHZ]5 and 6a were designed and synthesized by a three-step or one-step synthetic route.The structures of all the compounds prepared were confirmed by（elemental） analysis and 1H NMR.The preliminary bioassay results indicate that compound 4a possesses certain fungicidal and herbicidal activities.
