目的:分析重症监护室(ICU)谵妄干预的研究现状、研究热点与发展趋势。方法:检索2012年1月1日—2022年5月31日中国知网(CNKI)和Web of Science中关于ICU谵妄干预的相关文献,基于CiteSpace软件进行数据分析与统计。结果:纳入近10年关于IC...目的:分析重症监护室(ICU)谵妄干预的研究现状、研究热点与发展趋势。方法:检索2012年1月1日—2022年5月31日中国知网(CNKI)和Web of Science中关于ICU谵妄干预的相关文献,基于CiteSpace软件进行数据分析与统计。结果:纳入近10年关于ICU谵妄干预的文献共334篇,包括中文文献162篇、英文文献172篇。纳入分析的ICU谵妄干预研究的中文文献发文量自2016年后呈大幅度上升趋势,发文量主要分布在华东地区,研究方向主要聚焦在早期活动、集束化干预和分级护理。英文文献关于ICU谵妄干预研究的发文量整体变化幅度较平稳,国家分布以美国为主,研究方向主要聚焦在认知功能训练和非药物集束化干预。结论:纳入分析的ICU谵妄干预的中文文献研究整体水平较英文文献低、干预策略单一且缺乏循证依据,建议护士借鉴英文文献经验,构建适合我国谵妄现状的基于循证的干预策略,降低ICU谵妄的发生率。展开更多
Alzheimer’s disease(AD)has become an important public health issue worldwide.p-Coumaric acid(CA)and lactoferrin(Lf)possessed antioxidant,anti-inflammatory,and anti-AD activities.Herein,we hypothesized that a combinat...Alzheimer’s disease(AD)has become an important public health issue worldwide.p-Coumaric acid(CA)and lactoferrin(Lf)possessed antioxidant,anti-inflammatory,and anti-AD activities.Herein,we hypothesized that a combination treatment of CA and Lf would synergistically improve AD symptoms and studied its mechanisms.Twelve-week-old amyloid precursor protein(APP)/presenilin 1(PS1)mice were treated with CA,Lf,or both CA and Lf for 8 weeks.Results showed that individual and combined treatments could ameliorate cognitive deficits to varying degrees,with stronger effects for combined intervention than for CA or Lf alone.Specifically,combined treatment was most effective in improving nesting ability and reducing amyloidββ_(1-42)(Aβ_(1-42))deposition in mice.Moreover,combined treatment was more effective in suppressing APP,β-site APP cleavage enzyme 1,and inflammation;it inhibited the CCAAT-enhancer-binding protein(C/EBPβ)/asparagine endopeptidase(AEP)signaling pathway in the hippocampus and colon and upregulated the expression of tight junction protein zonula occludens-1 in the colon;it also decreased the Firmicutes/Bacteroidetes ratio at the phylum level and increased the relative abundance of Prevotellaceae,Lachnospira,and Eubacterium at the genus level.Overall,the combination of CA and Lf may ameliorate cognitive deficits in APP/PS1 mice by improving inflammation and inhibiting the C/EBPβ/AEP signaling pathway via modulating gut microbiome.展开更多
文摘目的:分析重症监护室(ICU)谵妄干预的研究现状、研究热点与发展趋势。方法:检索2012年1月1日—2022年5月31日中国知网(CNKI)和Web of Science中关于ICU谵妄干预的相关文献,基于CiteSpace软件进行数据分析与统计。结果:纳入近10年关于ICU谵妄干预的文献共334篇,包括中文文献162篇、英文文献172篇。纳入分析的ICU谵妄干预研究的中文文献发文量自2016年后呈大幅度上升趋势,发文量主要分布在华东地区,研究方向主要聚焦在早期活动、集束化干预和分级护理。英文文献关于ICU谵妄干预研究的发文量整体变化幅度较平稳,国家分布以美国为主,研究方向主要聚焦在认知功能训练和非药物集束化干预。结论:纳入分析的ICU谵妄干预的中文文献研究整体水平较英文文献低、干预策略单一且缺乏循证依据,建议护士借鉴英文文献经验,构建适合我国谵妄现状的基于循证的干预策略,降低ICU谵妄的发生率。
基金funded by the National Natural Science Foundation of China(82103818)the Suzhou Applied Basic Research(Medical and Health)Science and Technology Innovation Project(SYW2024179)+1 种基金Jiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non-communicable Diseases,Soochow University(KJS2437)the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD).
文摘Alzheimer’s disease(AD)has become an important public health issue worldwide.p-Coumaric acid(CA)and lactoferrin(Lf)possessed antioxidant,anti-inflammatory,and anti-AD activities.Herein,we hypothesized that a combination treatment of CA and Lf would synergistically improve AD symptoms and studied its mechanisms.Twelve-week-old amyloid precursor protein(APP)/presenilin 1(PS1)mice were treated with CA,Lf,or both CA and Lf for 8 weeks.Results showed that individual and combined treatments could ameliorate cognitive deficits to varying degrees,with stronger effects for combined intervention than for CA or Lf alone.Specifically,combined treatment was most effective in improving nesting ability and reducing amyloidββ_(1-42)(Aβ_(1-42))deposition in mice.Moreover,combined treatment was more effective in suppressing APP,β-site APP cleavage enzyme 1,and inflammation;it inhibited the CCAAT-enhancer-binding protein(C/EBPβ)/asparagine endopeptidase(AEP)signaling pathway in the hippocampus and colon and upregulated the expression of tight junction protein zonula occludens-1 in the colon;it also decreased the Firmicutes/Bacteroidetes ratio at the phylum level and increased the relative abundance of Prevotellaceae,Lachnospira,and Eubacterium at the genus level.Overall,the combination of CA and Lf may ameliorate cognitive deficits in APP/PS1 mice by improving inflammation and inhibiting the C/EBPβ/AEP signaling pathway via modulating gut microbiome.
