To clarify the densification behavior,deformation response and strengthening mechanisms of selective laser melted(SLM)Mg-RE alloys,this study systematically investigates a representative WE43 alloy via advanced materi...To clarify the densification behavior,deformation response and strengthening mechanisms of selective laser melted(SLM)Mg-RE alloys,this study systematically investigates a representative WE43 alloy via advanced material characterization techniques.A suitable laser output mode fell into the transition mode,allowing for the fabrication of nearly full-density samples(porosity=0.85±0.021%)with favorable mechanical properties(yield strength=351 MPa,ultimate tensile strength=417 MPa,the elongation at break=6.5%and microhardness=137.9±6.15 HV_(0.1))using optimal processing parameters(P=80 W,v=250 mm/s and d=50μm).Viscoplastic self-consistent analysis and transmission electron microscopy observations reveal that the plastic deformation response of the SLM Mg-RE alloys is primarily driven by basal and prismatic slips.Starting from a random texture before deformation(maximum multiple of ultimate density,Max.MUD=3.95),plastic stretching led the grains to align with the Z-axis,finally resulting in a{0001}<1010>texture orientation after fracture(Max.MUD=8.755).Main phases of the SLM state are mainly composed ofα-Mg,Mg_(24)Y_(5) andβ'-Mg_(41)Nd_(5),with an average grain size of only 4.27μm(about a quarter of that in the extruded state),resulting in a favorable strength-toughness ratio.Except for the nano-β'phase and semi-coherent Mg_(24)Y_(5) phase(mismatch=16.12%)around the grain boundaries,a small amount of nano-ZrO_(2) and Y_(2)O_(3) particles also play a role in dispersion strengthening.The high mechanical properties of the SLM state are chiefly attributed to precipitation hardening(44.41%),solid solution strengthening(34.06%)and grain boundary strengthening(21.53%),with precipitation hardening being predominantly driven by dislocation strengthening(67.77%).High-performance SLM Mg-RE alloy components were manufactured and showcased at TCT Asia 2024,receiving favorable attention.This work underscores the significant application potential of SLM Mg-RE alloys and establishes a strong foundation for advancing their use in the biomedical fields.展开更多
This study aimed to compare the eff ectiveness and safety of diff erent tidal volumes combined with breath-holding during inhalation for clearing airway retention,and to explore optimized strategies for preventing ven...This study aimed to compare the eff ectiveness and safety of diff erent tidal volumes combined with breath-holding during inhalation for clearing airway retention,and to explore optimized strategies for preventing ventilator-associated pneumonia(VAP).The study enrolled 105 adult patients receiving mechanical ventilation at the Emergency ICU of Dalian University of Technology Affiliated Central Hospital from April 2023 to June 2024.Using a randomized digital table method,patients were divided into three groups(A,B,C)with tidal volumes of 8ml/kg,10ml/kg,and 12ml/kg respectively.Standardized VAP prevention measures were implemented alongside daily four-time-point airway clearance through ventilator-assisted breath-holding.Results showed that Group C demonstrated significantly higher post-operation airway clearance(p<0.001)and more frequent coughing(median 3 vs.2 times)compared to Groups A and B,indicating that higher tidal volumes enhance secretions expulsion.No signifi cant diff erences were observed in airway retention characteristics(color,viscosity)among groups(p>0.05).Regarding safety,all groups maintained normal heart rate and blood pressure fl uctuations before and after procedures,with oxygenation index briefly declining but rapidly recovering without severe hypoxemia.However,Group C exhibited a higher proportion of peak airway pressure>35 cmH₂O(8.6%)compared to Groups A and B(2.9%).Clinically,Group C had a lower VAP incidence(14.2%)than Group A(22.9%)but higher than Group B(11.4%),though statistically insignifi cant(p=0.32).ICU length of stay was shorter in Group C,but this diff erence was not statistically signifi cant(p=0.15).No aspiration or suff ocation occurred across all groups.This study demonstrates that the combination of 12ml/kg tidal volume and breath-holding during inhalation can more eff ectively clear airway retention without signifi cantly increasing safety risks.We recommend prioritizing this approach for mechanically ventilated patients with adequate lung function,while adjusting tidal volume through individualized assessment.Future research should further validate long-term outcomes and evaluate its effi cacy across multiple centers.展开更多
目的分析一体式蜗内耳蜗电图在人工耳蜗植入(CI)术中的应用情况,讨论其优势及局限,总结该技术的标准化流程。方法收集2023年3月~2025年8月于本团队实施人工耳蜗术中一体式蜗内耳蜗电图的全部临床资料及术中监测数据,对监测成功率、监测...目的分析一体式蜗内耳蜗电图在人工耳蜗植入(CI)术中的应用情况,讨论其优势及局限,总结该技术的标准化流程。方法收集2023年3月~2025年8月于本团队实施人工耳蜗术中一体式蜗内耳蜗电图的全部临床资料及术中监测数据,对监测成功率、监测指标变化规律等进行分析,建立术中监测三阶段分型(植入早期、中期和晚期;上升型、下降型、稳定型、波动型)。结果共有44例(45耳)患者应用该技术(男24,女20),平均年龄27.3±19.2岁,术前低频平均听力为86.6±21.1 dB HL,无明显的耳蜗畸形,均完成全部电极植入。15耳成功在术中引出CM波形,9耳于术毕或术后第2天引出波形,21耳未引出波形(其中9耳术中干扰严重,2耳术中耳机脱落)。在去除术中干扰严重的9耳和术中耳机脱落的2耳后,34耳的术中CM波形引出率与术前低频平均听力之间无统计学意义(n=34,χ^(2)=1.145,P=0.451),且该34耳以及术中成功引出15耳耳蜗微音电位(cochlear microphonics,CM)波形最大幅值与术前低频平均听力无明显相关(n=34,r=-0.015,P=0.931;n=15,r=0.237,P=0.395)。15耳中,植入早期最常见为波动型[7耳(46.7%)],其中4耳依据波形变化采用优化植入干预方案;在中期为稳定型和波动型居多[均为5耳(33.3%)];在晚期,各类型比例相近,且波形下降趋势难以通过干预方案得到恢复。在本院完成术后开机随访且具有术前可测听力的12例(12耳)患者,术后低频听力完全保留率为75%,部分保留率为25%。术毕/术中最高幅值比与术后低频听力阈移呈显著负相关(r=-0.707,P=0.01)。结论术中应用ECochG技术可实时反馈电极植入对内耳的创伤,及时在损伤可逆期内进行微创化调整,有助于术后残余听力的保留。术中标准化流程的建立有助于提升该技术的术中引出率。术中监测三阶段分型的建立有助于电极植入对内耳创伤的机制分析。术中CM波形引出率、引出幅值与术前低频平均听力的关系仍待进一步探讨分析。展开更多
BACKGROUND: Bone metastases (BMs) from hepatocellular carcinoma (HCC) is an increasingly common disease in Asia. We assessed the clinical features, prognostic factors, and differences in outcomes related to BMs among ...BACKGROUND: Bone metastases (BMs) from hepatocellular carcinoma (HCC) is an increasingly common disease in Asia. We assessed the clinical features, prognostic factors, and differences in outcomes related to BMs among patients with different treatments for HCC. METHODS: Forty-three consecutive patients who were diagnosed with BMs from HCC between January 2010 and December 2014 were retrospectively enrolled. The clinical features were identified, the impacts of prognostic factors on survival were statistically analyzed, and clinical data were compared. RESULTS: The median patient age was 54 years; 38 patients were male and 5 female. The most common site for BMs was the trunk (69.3%). BMs with extension to the soft tissue were found in 14 patients (32.5%). Most (90.7%) of the lesions were mixed osteolytic and osteoblastic, and most (69.8%) patients presented with multiple BMs. The median survival after BMs diagnosis was 11 months. In multivariate analyses, survival after BM diagnosis was correlated with Karnofsky performance status (P=0.008) and the Child-Pugh classification (P<0.001); BM-free survival was correlated with progression beyond the University of California San Francisco criteria (P<0.001) and treatment of primary tumors (P<0.001). BMs with extension to soft tissue were less common in liver transplantation patients. During metastasis, the control of intrahepatic tumors was improved in liver transplantation and hepatectomy patients, compared to conservatively treated patients. CONCLUSIONS: The independent prognostic factors of survival after diagnosis of BMs were the Karnofsky performance status and Child-Pugh classification. HCC patients developed BMs may also benefit from liver transplantation or hepatectomy.展开更多
3D printing-based supercapacitors have been extensively explored,yet the rigid rheological requirement for corresponding ink preparation significantly limits the manufacturing of true 3D architecture in achieving supe...3D printing-based supercapacitors have been extensively explored,yet the rigid rheological requirement for corresponding ink preparation significantly limits the manufacturing of true 3D architecture in achieving superior energy storage.We proposed the stereolithographic technique to fabricate the metallic composite lattices with octet-truss arrangement by using electroless plating and engineering the 3D hierarchically porous graphene onto the scaffolds to build the hierarchically cellular lattices in quasi-solid supercapacitor application.The supercapacitor device that is composed of composite lattices span several pore size orders from nm to mm holds promising behavior on the areal capacitance(57.75 mF cm-2),rate capability(70% retention,2-40 mA cm-2),and long lifespan(96% after 5000 cycles),as well as superior energy density of 0.008 mWh cm-2,which are comparable to the state-of-the-art carbon-based supercapacitor.By synergistically combining this facile stereolithographic 3D printing technology with the hierarchically porous graphene architecture,we provide a novel route of manufacturing energy storage device as well as new insight into building other high-performance functional electronics.展开更多
Pharmaceutical salt formation is the most preferred and effective method to enhance the physicochemical properties of APIs. The aim of the study was to design and synthesize a series of new salts to improve the solubi...Pharmaceutical salt formation is the most preferred and effective method to enhance the physicochemical properties of APIs. The aim of the study was to design and synthesize a series of new salts to improve the solubility of Imatinib(IM). Two stable salts with malonic acid(S1) and citric acid(S5), one metastable salt with fumaric acid(S2), two unstable salts with citric acid(S3, S4) were obtained for the first time.Single crystal and powder X-ray diffraction, Fourier transform infrared, differential scanning calorimetry,and thermogravimetric analysis were used to characterize the novel salts. The solubility and stability of the solid were also evaluated, and three salts(S1, S2, S5) had a more than 20 folds of solubility and a faster dissolution rate improved as compared to the pure drug in water and p H 6.8 buffer, respectively.展开更多
This study investigated the anticancer effect of Shenqi Fuzheng （SQFZ） injection combined with docetaxel on lung cancer cell lines ofA549 and Lewis lung cancer （LLC）. SQFZ injection alone cannot inhibit the vitali...This study investigated the anticancer effect of Shenqi Fuzheng （SQFZ） injection combined with docetaxel on lung cancer cell lines ofA549 and Lewis lung cancer （LLC）. SQFZ injection alone cannot inhibit the vitality of lung cancer cells, but the anti- tumor activity of SQFZ combined with docetaxel was significantly higher than that using docetaxel alone展开更多
A cocrystal of diosgenin with piperazine in 2:1 stoichiometry was successfully synthesized.The solid form was prepared by liquid assisted grinding,slurry and crystallization methods.The cocrystal was characterized by ...A cocrystal of diosgenin with piperazine in 2:1 stoichiometry was successfully synthesized.The solid form was prepared by liquid assisted grinding,slurry and crystallization methods.The cocrystal was characterized by powder X-ray diffraction,differential scanning calorimetry,thermogravimetric analysis,Fourier transform infrared spectroscopy,and structure determined by single crystal X-ray diffraction,the hydrogen bonds formed into fish bone structure along the[010]direction and all the molecules packed into 3D layer structure along a axis.After formation of cocrystal,the solubility of diosgenin was improved,and the solubility value in 0.2%SDS solution was approximately 1.5 times as large as that of the parent material.展开更多
Objective:In this study,the influence of puerarin,paeoniflorin,and menthol on the structure and barrier function of tight junctions(TJs)in MadineDarby canine kidney epithelial(MDCK)and MDCK-multi-drug resistance 1(MDR...Objective:In this study,the influence of puerarin,paeoniflorin,and menthol on the structure and barrier function of tight junctions(TJs)in MadineDarby canine kidney epithelial(MDCK)and MDCK-multi-drug resistance 1(MDR1)cells was evaluated to determine the mechanisms by which the drugs cross the bloodebrain barrier(BBB).Method:Cells were treated with puerarin,paeoniflorin,and menthol followed by immunohistochemical staining with occludin,claudin-1,and F-actin.The cells were then observed using laser-scanning confocal microscopy.Average optical density(AOD)of the immunofluorescence images of the proteins were analyzed using ImageJ software while Transepithelial electrical resistance(TEER)was measured using an epithelial voltohmmeter.Results:Confocal microscopy revealed that puerarin-and paeoniflorin-treated tight junction proteins were conspicuous while menthol suppressed their expression.Correspondingly,AOD values of cells treated with puerarin or paeoniflorin,or both showed no difference compared to the control group(P>.05)while the menthol group value was downregulated.In 3 h,TEER of cells not treated with menthol were similar to the control group,while treatment with menthol significantly decreased TEER value(P<.05).In addition,application of menthol decreased TEER in MDCK cells earlier than in MDCK-MDR1 cells.Conclusion:Menthol but not puerarin and paeoniflorin may enhance paracellular transport and improve drug penetration of the BBB by disrupting the structure and,thereby,weakening the barrier function of TJs.展开更多
Garnet-type Li_(7)La_(3)Zr_(2)O_(12)(LLZO) has been recognized as a candidate solid electrolyte for high-safety Lianode based solid-state batteries because of its electro-chemical stability against Li-metal and high i...Garnet-type Li_(7)La_(3)Zr_(2)O_(12)(LLZO) has been recognized as a candidate solid electrolyte for high-safety Lianode based solid-state batteries because of its electro-chemical stability against Li-metal and high ionic conductivity. Solvent(e.g., isopropanol(IPA)) has been commonly applied for preparing LLZO powders and ceramics. However, the deterioration of the proton-exchange between LLZO and IPA/absorbed moisture during the mixing and tailoring route has aroused less attention. In this study, a solvent-free dry milling route was developed for preparing the LLZO powders and ceramics. For orthogonal four categories of samples prepared using solvent-free and IPA-assisted routes in the mixing and tailoring processes, the critical evaluation was conducted on the crystallinity, surficial morphology, and contamination of ascalcinated and as-tailored particles, the cross-sectional microstructure of green and sintered pellets,the morphology and electro-chemical properties of grain boundaries in ceramics, as well as the interfacial resistance and performance of Li anode based symmetric batteries. The wet route introduced Li-rich contaminations(e.g., Li OH·H)_(2)O and Li)_(2)CO)_(3)) onto the surfaces of LLZO particles and Li-Ta-O segregations at the adjacent and triangular grain boundaries. The LLZO solid electrolytes prepared through dry mixing in combination with the dry tailoring route without the use of any solvent were found to the optimal performance. The fundamental material properties in the whole LLZO preparation process were found, which are of guiding significance to the development of LLZO powder and ceramic production craft.展开更多
目的 比较韶音后挂式骨导助听器对不同类型听力损失患者的听力干预短期效果,探讨其临床应用前景。方法 55例听力损失患者(年龄18~82岁;传导性听力损失9例,感音神经性听力损失15例,混合性听力损失31例;左右耳0.5、1、2、4 kHz四个频率的...目的 比较韶音后挂式骨导助听器对不同类型听力损失患者的听力干预短期效果,探讨其临床应用前景。方法 55例听力损失患者(年龄18~82岁;传导性听力损失9例,感音神经性听力损失15例,混合性听力损失31例;左右耳0.5、1、2、4 kHz四个频率的骨导纯音听阈均≤60 dB HL)配戴韶音后挂式骨导助听器,分别于配戴助听器前和配戴第14±2 d行声场总体听阈、单音节识别率及安静环境语句识别阈测试,比较配戴助听器前后的结果差异。并于配戴第14±2 d使用IOI-HA问卷对助听器使用效果进行评估。结果 患者配戴后挂式骨导式助听器后声场四个频率平均听阈(39.3±4.9 dB HL)较配戴前(56.5±8.2 dB HL)显著改善,差异有统计学意义(P<0.001)。患者助听前单音节识别率(给声强度:患者助听前双音节言语识别阈减5 dB)为29.8%±11.4%,配戴第14±2 d为72.4%±14.4%,配戴后单音节识别率显著提高,差异有统计学意义(P<0.001)。患者语句识别阈由配戴前的48.6±9.7 dB HL降至34.3±5.6 dB HL,差异有统计学意义(P<0.001)。配戴14±2 d时IOI-HA问卷评估总分平均值为29.0±3.8分。结论 后挂式骨导助听器可显著提高传导性、0.5~4 kHz骨导纯音听阈不超过60 dB HL的混合性及感音神经性听力损失患者的听力及言语识别能力。展开更多
Diesel hydrotreatment removes heteroatoms and polycyclic aromatics in diesel in the presence of highpressure hydrogen gas.The hydrogen solubility is the basis for hydrogen consumption prediction and process design/opt...Diesel hydrotreatment removes heteroatoms and polycyclic aromatics in diesel in the presence of highpressure hydrogen gas.The hydrogen solubility is the basis for hydrogen consumption prediction and process design/optimization.In the presented study,we established a method to predict the hydrogen solubility of diesel molecules and mixture.A modified Henry equation was proposed to illustrate the hydrogen solubility variation among the temperature and pressure.The parameters of the modified Henry equation for typical molecules were regressed from literature data.Then we established an empirical correlation between the parameter and the structure and property of molecules.The method was then combined with a molecular-level compositional model to accurately predict the hydrogen solubility in diesel,illustrating the validity of the method.展开更多
Personal daytime radiative cooling(PDRC)materials have high sunlight reflection and high selective emis-sivity to outer space in the main atmospheric window,demonstrating huge potential in energy-saving for sustainabl...Personal daytime radiative cooling(PDRC)materials have high sunlight reflection and high selective emis-sivity to outer space in the main atmospheric window,demonstrating huge potential in energy-saving for sustainable development.Recently,polymer-based membranes for radiative cooling have been widely re-ported,due to their easy processing,low cost,and unique optical performance.However,the desired high sunlight reflectance of PDRC materials is easily dampened by environmental aging,high temperature,and ultraviolet(UV)irradiation,resulting in reduced cooling performance for most polymers,adverse to large-scale practical applications.In this work,we demonstrate a novel polyimide nanofiber(PINF)membrane with a fluorine-containing structure via typical electrospinning technology.The resultant PINF membrane exhibits high sunlight reflectance,UV resistance,and excellent thermal stability,rendering anti-aging day-time radiative cooling.The sunlight reflectance of PINF membranes could maintain constant in the aging test for continuous 720 h under outdoor solar irradiation,exhibiting durable and long-term personal day-time radiative cooling performance.展开更多
基金supported by the National Key Research and Development Program of China(No.2022YFC2406000)the Guangdong Basic and Applied Basic Research Foundation(2024A1515011024)+5 种基金the Guangzhou Science and Technology Project(2024A04J4943)the Guangdong Academy of Sciences Development Special Fund Project(2022GDASZH-2022010107)the Guangdong province Science and Technology Plan Projects(2023B1212120008,2023B1212060045)the GDAS Projects of International cooperation platform of Science and Technology(2022GDASZH-2022010203-003)Special Support Foundation of Guangdong Province(2023TQ07Z559)Shenzhen Basic Research Project(JCYJ20210324120001003 and JCYJ20220531091802006)。
文摘To clarify the densification behavior,deformation response and strengthening mechanisms of selective laser melted(SLM)Mg-RE alloys,this study systematically investigates a representative WE43 alloy via advanced material characterization techniques.A suitable laser output mode fell into the transition mode,allowing for the fabrication of nearly full-density samples(porosity=0.85±0.021%)with favorable mechanical properties(yield strength=351 MPa,ultimate tensile strength=417 MPa,the elongation at break=6.5%and microhardness=137.9±6.15 HV_(0.1))using optimal processing parameters(P=80 W,v=250 mm/s and d=50μm).Viscoplastic self-consistent analysis and transmission electron microscopy observations reveal that the plastic deformation response of the SLM Mg-RE alloys is primarily driven by basal and prismatic slips.Starting from a random texture before deformation(maximum multiple of ultimate density,Max.MUD=3.95),plastic stretching led the grains to align with the Z-axis,finally resulting in a{0001}<1010>texture orientation after fracture(Max.MUD=8.755).Main phases of the SLM state are mainly composed ofα-Mg,Mg_(24)Y_(5) andβ'-Mg_(41)Nd_(5),with an average grain size of only 4.27μm(about a quarter of that in the extruded state),resulting in a favorable strength-toughness ratio.Except for the nano-β'phase and semi-coherent Mg_(24)Y_(5) phase(mismatch=16.12%)around the grain boundaries,a small amount of nano-ZrO_(2) and Y_(2)O_(3) particles also play a role in dispersion strengthening.The high mechanical properties of the SLM state are chiefly attributed to precipitation hardening(44.41%),solid solution strengthening(34.06%)and grain boundary strengthening(21.53%),with precipitation hardening being predominantly driven by dislocation strengthening(67.77%).High-performance SLM Mg-RE alloy components were manufactured and showcased at TCT Asia 2024,receiving favorable attention.This work underscores the significant application potential of SLM Mg-RE alloys and establishes a strong foundation for advancing their use in the biomedical fields.
文摘This study aimed to compare the eff ectiveness and safety of diff erent tidal volumes combined with breath-holding during inhalation for clearing airway retention,and to explore optimized strategies for preventing ventilator-associated pneumonia(VAP).The study enrolled 105 adult patients receiving mechanical ventilation at the Emergency ICU of Dalian University of Technology Affiliated Central Hospital from April 2023 to June 2024.Using a randomized digital table method,patients were divided into three groups(A,B,C)with tidal volumes of 8ml/kg,10ml/kg,and 12ml/kg respectively.Standardized VAP prevention measures were implemented alongside daily four-time-point airway clearance through ventilator-assisted breath-holding.Results showed that Group C demonstrated significantly higher post-operation airway clearance(p<0.001)and more frequent coughing(median 3 vs.2 times)compared to Groups A and B,indicating that higher tidal volumes enhance secretions expulsion.No signifi cant diff erences were observed in airway retention characteristics(color,viscosity)among groups(p>0.05).Regarding safety,all groups maintained normal heart rate and blood pressure fl uctuations before and after procedures,with oxygenation index briefly declining but rapidly recovering without severe hypoxemia.However,Group C exhibited a higher proportion of peak airway pressure>35 cmH₂O(8.6%)compared to Groups A and B(2.9%).Clinically,Group C had a lower VAP incidence(14.2%)than Group A(22.9%)but higher than Group B(11.4%),though statistically insignifi cant(p=0.32).ICU length of stay was shorter in Group C,but this diff erence was not statistically signifi cant(p=0.15).No aspiration or suff ocation occurred across all groups.This study demonstrates that the combination of 12ml/kg tidal volume and breath-holding during inhalation can more eff ectively clear airway retention without signifi cantly increasing safety risks.We recommend prioritizing this approach for mechanically ventilated patients with adequate lung function,while adjusting tidal volume through individualized assessment.Future research should further validate long-term outcomes and evaluate its effi cacy across multiple centers.
文摘目的分析一体式蜗内耳蜗电图在人工耳蜗植入(CI)术中的应用情况,讨论其优势及局限,总结该技术的标准化流程。方法收集2023年3月~2025年8月于本团队实施人工耳蜗术中一体式蜗内耳蜗电图的全部临床资料及术中监测数据,对监测成功率、监测指标变化规律等进行分析,建立术中监测三阶段分型(植入早期、中期和晚期;上升型、下降型、稳定型、波动型)。结果共有44例(45耳)患者应用该技术(男24,女20),平均年龄27.3±19.2岁,术前低频平均听力为86.6±21.1 dB HL,无明显的耳蜗畸形,均完成全部电极植入。15耳成功在术中引出CM波形,9耳于术毕或术后第2天引出波形,21耳未引出波形(其中9耳术中干扰严重,2耳术中耳机脱落)。在去除术中干扰严重的9耳和术中耳机脱落的2耳后,34耳的术中CM波形引出率与术前低频平均听力之间无统计学意义(n=34,χ^(2)=1.145,P=0.451),且该34耳以及术中成功引出15耳耳蜗微音电位(cochlear microphonics,CM)波形最大幅值与术前低频平均听力无明显相关(n=34,r=-0.015,P=0.931;n=15,r=0.237,P=0.395)。15耳中,植入早期最常见为波动型[7耳(46.7%)],其中4耳依据波形变化采用优化植入干预方案;在中期为稳定型和波动型居多[均为5耳(33.3%)];在晚期,各类型比例相近,且波形下降趋势难以通过干预方案得到恢复。在本院完成术后开机随访且具有术前可测听力的12例(12耳)患者,术后低频听力完全保留率为75%,部分保留率为25%。术毕/术中最高幅值比与术后低频听力阈移呈显著负相关(r=-0.707,P=0.01)。结论术中应用ECochG技术可实时反馈电极植入对内耳的创伤,及时在损伤可逆期内进行微创化调整,有助于术后残余听力的保留。术中标准化流程的建立有助于提升该技术的术中引出率。术中监测三阶段分型的建立有助于电极植入对内耳创伤的机制分析。术中CM波形引出率、引出幅值与术前低频平均听力的关系仍待进一步探讨分析。
基金supported by grants from Zhejiang Provincial Clinical Scientific Research Foundation of China(2013ZYC-A17)Ministry of Health of China(WKJ-ZJ-12)Health Bureau of Zhejiang Province(2013KYB098)
文摘BACKGROUND: Bone metastases (BMs) from hepatocellular carcinoma (HCC) is an increasingly common disease in Asia. We assessed the clinical features, prognostic factors, and differences in outcomes related to BMs among patients with different treatments for HCC. METHODS: Forty-three consecutive patients who were diagnosed with BMs from HCC between January 2010 and December 2014 were retrospectively enrolled. The clinical features were identified, the impacts of prognostic factors on survival were statistically analyzed, and clinical data were compared. RESULTS: The median patient age was 54 years; 38 patients were male and 5 female. The most common site for BMs was the trunk (69.3%). BMs with extension to the soft tissue were found in 14 patients (32.5%). Most (90.7%) of the lesions were mixed osteolytic and osteoblastic, and most (69.8%) patients presented with multiple BMs. The median survival after BMs diagnosis was 11 months. In multivariate analyses, survival after BM diagnosis was correlated with Karnofsky performance status (P=0.008) and the Child-Pugh classification (P<0.001); BM-free survival was correlated with progression beyond the University of California San Francisco criteria (P<0.001) and treatment of primary tumors (P<0.001). BMs with extension to soft tissue were less common in liver transplantation patients. During metastasis, the control of intrahepatic tumors was improved in liver transplantation and hepatectomy patients, compared to conservatively treated patients. CONCLUSIONS: The independent prognostic factors of survival after diagnosis of BMs were the Karnofsky performance status and Child-Pugh classification. HCC patients developed BMs may also benefit from liver transplantation or hepatectomy.
基金the Research Grants Council of the Hong Kong Special Administrative Region of China (GRF No. CityU11216515)City University of Hong Kong (Nos. 7005070 and 9667153)+1 种基金Shenzhen Science and Technology Innovation Committee under the grant JCYJ20170818103206501the Natural Science Basic Research Plan in Shaanxi Province of China (No. 2017JM5003)
文摘3D printing-based supercapacitors have been extensively explored,yet the rigid rheological requirement for corresponding ink preparation significantly limits the manufacturing of true 3D architecture in achieving superior energy storage.We proposed the stereolithographic technique to fabricate the metallic composite lattices with octet-truss arrangement by using electroless plating and engineering the 3D hierarchically porous graphene onto the scaffolds to build the hierarchically cellular lattices in quasi-solid supercapacitor application.The supercapacitor device that is composed of composite lattices span several pore size orders from nm to mm holds promising behavior on the areal capacitance(57.75 mF cm-2),rate capability(70% retention,2-40 mA cm-2),and long lifespan(96% after 5000 cycles),as well as superior energy density of 0.008 mWh cm-2,which are comparable to the state-of-the-art carbon-based supercapacitor.By synergistically combining this facile stereolithographic 3D printing technology with the hierarchically porous graphene architecture,we provide a novel route of manufacturing energy storage device as well as new insight into building other high-performance functional electronics.
基金CAMS Innovation Fund for Medical Sciences(Nos. 2017-I2M-1–010, 2020-I2M-1–003)Key National Research and Development Program (No. 2016YFC1000901)+1 种基金Construction and Application of Technology Integration System for Efficient Identification of Natural/Effective Active Small Molecules (No.2018ZX09711001–001)National Science and Technology Major Project:Resource Library of Traditional Chinese Medicine Component (No. 2019ZX09735002) for the financial support。
文摘Pharmaceutical salt formation is the most preferred and effective method to enhance the physicochemical properties of APIs. The aim of the study was to design and synthesize a series of new salts to improve the solubility of Imatinib(IM). Two stable salts with malonic acid(S1) and citric acid(S5), one metastable salt with fumaric acid(S2), two unstable salts with citric acid(S3, S4) were obtained for the first time.Single crystal and powder X-ray diffraction, Fourier transform infrared, differential scanning calorimetry,and thermogravimetric analysis were used to characterize the novel salts. The solubility and stability of the solid were also evaluated, and three salts(S1, S2, S5) had a more than 20 folds of solubility and a faster dissolution rate improved as compared to the pure drug in water and p H 6.8 buffer, respectively.
基金Project supported by the Beijing Science and Technology Star Project(No.xx2015A048),China
文摘This study investigated the anticancer effect of Shenqi Fuzheng （SQFZ） injection combined with docetaxel on lung cancer cell lines ofA549 and Lewis lung cancer （LLC）. SQFZ injection alone cannot inhibit the vitality of lung cancer cells, but the anti- tumor activity of SQFZ combined with docetaxel was significantly higher than that using docetaxel alone
基金support by National Key research and development Program of China(Grant No.2016YFC1000900)CAMS Innovation Found for Medical Sciences(Grant No.2017-I2M-1-010)+1 种基金Construction and application of technology integration system for efficient identification of natural/effective active small molecules(Grant No.2018ZX09711001-001)National Science and Technology Major Project of China(Grant No.2018ZX09711001-010).
文摘A cocrystal of diosgenin with piperazine in 2:1 stoichiometry was successfully synthesized.The solid form was prepared by liquid assisted grinding,slurry and crystallization methods.The cocrystal was characterized by powder X-ray diffraction,differential scanning calorimetry,thermogravimetric analysis,Fourier transform infrared spectroscopy,and structure determined by single crystal X-ray diffraction,the hydrogen bonds formed into fish bone structure along the[010]direction and all the molecules packed into 3D layer structure along a axis.After formation of cocrystal,the solubility of diosgenin was improved,and the solubility value in 0.2%SDS solution was approximately 1.5 times as large as that of the parent material.
文摘Objective:In this study,the influence of puerarin,paeoniflorin,and menthol on the structure and barrier function of tight junctions(TJs)in MadineDarby canine kidney epithelial(MDCK)and MDCK-multi-drug resistance 1(MDR1)cells was evaluated to determine the mechanisms by which the drugs cross the bloodebrain barrier(BBB).Method:Cells were treated with puerarin,paeoniflorin,and menthol followed by immunohistochemical staining with occludin,claudin-1,and F-actin.The cells were then observed using laser-scanning confocal microscopy.Average optical density(AOD)of the immunofluorescence images of the proteins were analyzed using ImageJ software while Transepithelial electrical resistance(TEER)was measured using an epithelial voltohmmeter.Results:Confocal microscopy revealed that puerarin-and paeoniflorin-treated tight junction proteins were conspicuous while menthol suppressed their expression.Correspondingly,AOD values of cells treated with puerarin or paeoniflorin,or both showed no difference compared to the control group(P>.05)while the menthol group value was downregulated.In 3 h,TEER of cells not treated with menthol were similar to the control group,while treatment with menthol significantly decreased TEER value(P<.05).In addition,application of menthol decreased TEER in MDCK cells earlier than in MDCK-MDR1 cells.Conclusion:Menthol but not puerarin and paeoniflorin may enhance paracellular transport and improve drug penetration of the BBB by disrupting the structure and,thereby,weakening the barrier function of TJs.
基金the financial support from the National Key R&D Project (2018YFE0181300)the National Natural Science Foundation of China (Grant No. 52102284)+2 种基金the China Postdoctoral Science Foundation (2020M682871)the Guangdong Natural Science Funds (2019A1515010675)the Science and Technology Project of Shenzhen (JCYJ20190808142209376 and JCYJ20210324094206019)。
文摘Garnet-type Li_(7)La_(3)Zr_(2)O_(12)(LLZO) has been recognized as a candidate solid electrolyte for high-safety Lianode based solid-state batteries because of its electro-chemical stability against Li-metal and high ionic conductivity. Solvent(e.g., isopropanol(IPA)) has been commonly applied for preparing LLZO powders and ceramics. However, the deterioration of the proton-exchange between LLZO and IPA/absorbed moisture during the mixing and tailoring route has aroused less attention. In this study, a solvent-free dry milling route was developed for preparing the LLZO powders and ceramics. For orthogonal four categories of samples prepared using solvent-free and IPA-assisted routes in the mixing and tailoring processes, the critical evaluation was conducted on the crystallinity, surficial morphology, and contamination of ascalcinated and as-tailored particles, the cross-sectional microstructure of green and sintered pellets,the morphology and electro-chemical properties of grain boundaries in ceramics, as well as the interfacial resistance and performance of Li anode based symmetric batteries. The wet route introduced Li-rich contaminations(e.g., Li OH·H)_(2)O and Li)_(2)CO)_(3)) onto the surfaces of LLZO particles and Li-Ta-O segregations at the adjacent and triangular grain boundaries. The LLZO solid electrolytes prepared through dry mixing in combination with the dry tailoring route without the use of any solvent were found to the optimal performance. The fundamental material properties in the whole LLZO preparation process were found, which are of guiding significance to the development of LLZO powder and ceramic production craft.
文摘目的 比较韶音后挂式骨导助听器对不同类型听力损失患者的听力干预短期效果,探讨其临床应用前景。方法 55例听力损失患者(年龄18~82岁;传导性听力损失9例,感音神经性听力损失15例,混合性听力损失31例;左右耳0.5、1、2、4 kHz四个频率的骨导纯音听阈均≤60 dB HL)配戴韶音后挂式骨导助听器,分别于配戴助听器前和配戴第14±2 d行声场总体听阈、单音节识别率及安静环境语句识别阈测试,比较配戴助听器前后的结果差异。并于配戴第14±2 d使用IOI-HA问卷对助听器使用效果进行评估。结果 患者配戴后挂式骨导式助听器后声场四个频率平均听阈(39.3±4.9 dB HL)较配戴前(56.5±8.2 dB HL)显著改善,差异有统计学意义(P<0.001)。患者助听前单音节识别率(给声强度:患者助听前双音节言语识别阈减5 dB)为29.8%±11.4%,配戴第14±2 d为72.4%±14.4%,配戴后单音节识别率显著提高,差异有统计学意义(P<0.001)。患者语句识别阈由配戴前的48.6±9.7 dB HL降至34.3±5.6 dB HL,差异有统计学意义(P<0.001)。配戴14±2 d时IOI-HA问卷评估总分平均值为29.0±3.8分。结论 后挂式骨导助听器可显著提高传导性、0.5~4 kHz骨导纯音听阈不超过60 dB HL的混合性及感音神经性听力损失患者的听力及言语识别能力。
基金supported by the National Key Research and Development Program of China(No.2018YFA0702400)the Science Foundation of China University of Petroleum,Beijing(Nos.2462018BJC003 and 2462018QZDX04)。
文摘Diesel hydrotreatment removes heteroatoms and polycyclic aromatics in diesel in the presence of highpressure hydrogen gas.The hydrogen solubility is the basis for hydrogen consumption prediction and process design/optimization.In the presented study,we established a method to predict the hydrogen solubility of diesel molecules and mixture.A modified Henry equation was proposed to illustrate the hydrogen solubility variation among the temperature and pressure.The parameters of the modified Henry equation for typical molecules were regressed from literature data.Then we established an empirical correlation between the parameter and the structure and property of molecules.The method was then combined with a molecular-level compositional model to accurately predict the hydrogen solubility in diesel,illustrating the validity of the method.
基金National Natural Science Foundation of China(No.52073053)Young Elite Scientists Sponsorship Program by CAST(No.2021QNRC001)+2 种基金Shanghai Rising-Star Program(No.21QA1400300)Innovation Program of Shanghai Municipal Education Commission(No.2021–01–07–00–03-E00108)Fundamental Research Funds for the Central Universities(No.JUSRP123014).
文摘Personal daytime radiative cooling(PDRC)materials have high sunlight reflection and high selective emis-sivity to outer space in the main atmospheric window,demonstrating huge potential in energy-saving for sustainable development.Recently,polymer-based membranes for radiative cooling have been widely re-ported,due to their easy processing,low cost,and unique optical performance.However,the desired high sunlight reflectance of PDRC materials is easily dampened by environmental aging,high temperature,and ultraviolet(UV)irradiation,resulting in reduced cooling performance for most polymers,adverse to large-scale practical applications.In this work,we demonstrate a novel polyimide nanofiber(PINF)membrane with a fluorine-containing structure via typical electrospinning technology.The resultant PINF membrane exhibits high sunlight reflectance,UV resistance,and excellent thermal stability,rendering anti-aging day-time radiative cooling.The sunlight reflectance of PINF membranes could maintain constant in the aging test for continuous 720 h under outdoor solar irradiation,exhibiting durable and long-term personal day-time radiative cooling performance.
