The proliferation of robot accounts on social media platforms has posed a significant negative impact,necessitating robust measures to counter network anomalies and safeguard content integrity.Social robot detection h...The proliferation of robot accounts on social media platforms has posed a significant negative impact,necessitating robust measures to counter network anomalies and safeguard content integrity.Social robot detection has emerged as a pivotal yet intricate task,aimed at mitigating the dissemination of misleading information.While graphbased approaches have attained remarkable performance in this realm,they grapple with a fundamental limitation:the homogeneity assumption in graph convolution allows social robots to stealthily evade detection by mingling with genuine human profiles.To unravel this challenge and thwart the camouflage tactics,this work proposed an innovative social robot detection framework based on enhanced HOmogeneity and Random Forest(HORFBot).At the core of HORFBot lies a homogeneous graph enhancement strategy,intricately woven with edge-removal techniques,tometiculously dissect the graph intomultiple revealing subgraphs.Subsequently,leveraging the power of contrastive learning,the proposed methodology meticulously trains multiple graph convolutional networks,each honed to discern nuances within these tailored subgraphs.The culminating stage involves the fusion of these feature-rich base classifiers,harmoniously aggregating their insights to produce a comprehensive detection outcome.Extensive experiments on three social robot detection datasets have shown that this method effectively improves the accuracy of social robot detection and outperforms comparative methods.展开更多
A single-phase anti-perovskite medium-entropy alloy nitride foams(MEANFs),as innovative materials for electromagnetic wave(EMW)absorption,have been successfully synthesized through the lattice expansion induced by nit...A single-phase anti-perovskite medium-entropy alloy nitride foams(MEANFs),as innovative materials for electromagnetic wave(EMW)absorption,have been successfully synthesized through the lattice expansion induced by nitrogen doping.This achievement notably overcomes the inherent constraints of conventional metal-based absorbers,including low resonance frequency,high conductivity,and elevated density,for the synergistic advantages provided by multimetallic alloys and foams.Microstructural analysis with comprehensive theoretical calculations provides in-depth insights into the formation mechanism,electronic structure,and magnetic moment of MEANFs.Furthermore,deliberate component design along with the foam structure proves to be an effective strategy for enhancing impedance matching and absorption.The results show that the MEANFs exhibit a minimum reflection loss(RL_(min))value of-60.32 dB and a maximum effective absorption bandwidth(EAB_(max))of 5.28 GHz at 1.69 mm.This augmentation of energy dissipation in EMW is predominantly attributed to factors such as porous structure,interfacial polarization,defect-induced polarization,and magnetic resonance.This study demonstrates a facile and efficient approach for synthesizing single-phase medium-entropy alloys,emphasizing their potential as materials for electromagnetic wave absorption due to their adjustable magnetic-dielectric properties.展开更多
When immersed in sand and dust environment,aero-engine blades are exposed to harsh erosion which may lead to failure if erosion is severe.Using Physical Vapor Deposition(PVD)to prepare hard ceramic coatings can greatl...When immersed in sand and dust environment,aero-engine blades are exposed to harsh erosion which may lead to failure if erosion is severe.Using Physical Vapor Deposition(PVD)to prepare hard ceramic coatings can greatly enhance the operational capabilities of aero-engine.However,due to the“line-of-sight”processing characteristic of PVD process,uneven coating deposition rates occur when preparing coatings on obstructed areas such as blisks.Quantitative research on such phenomena is few,and it is even rarer in the study of aero-engine coatings.Based on the analyses and considerations of the geometric shape of blade surfaces and the influence of both deposition and re-sputtering effect,an ideal model is established to analyze the deposition rate variation along blocked region in complex self-shadowing boundaries.The relative deposition rates at various locations on the blade surface within the inter-blade gaps are quantitatively calculated and experimentally validated.Furthermore,differences in erosion resistance of the coatings are tested.The conclusions are drawn as follows:the geometric configuration of the obstructed shape and resputtering phenomenon significantly influence the deposition rates within the inner wall of blade gaps.Taking the structural configuration as an example,in a 25 mm×60 mm×15 mm gap,the coating thickness can vary more than 252%from the thickest to the thinnest location.The deposition rates of various locations are proportional to the solid angle of incident ion in more obstructed regions,and the re-sputtering is more prominent in open regions.Obstructive boundaries directly affect the erosion resistance at various locations within the gaps,with erosion failure time decreasing by 40%in heavily blocked region compared to open region.展开更多
Bioinspired nacre-like structured high-density soft magnetic composites(SMCs)have been successfully constructed using flaky-Fe_(73.8)Si_(13.5)B_(8.7)Cu_(1)Nb_(3) powders in the supercooled liquid region(SCLR).These de...Bioinspired nacre-like structured high-density soft magnetic composites(SMCs)have been successfully constructed using flaky-Fe_(73.8)Si_(13.5)B_(8.7)Cu_(1)Nb_(3) powders in the supercooled liquid region(SCLR).These densely arranged particles with a consistent planar orientation significantly enhance the soft magnetic properties of SMCs,including high permeability and low magnetic losses.The internal structures of the composites and microstructure evolution of the flaky nanocrystalline particles during the hot-pressing process have been thoroughly studied.Moreover,systematic investigations into the effects of coatings and particle sizes on the maximum permeability and magnetic losses of the composites are conducted.The SMC prepared using the coated particles with a size of 0-100μm exhibits a high maximum perme-ability of 2170(at 1000 Hz)and low magnetic loss of 41.61 W kg^(-1)(at 1000 Hz and 1.0 T).The losses and permeability analysis reveal that the superior performance of these soft magnetic materials is attributed to their laminated structure,insulation coating,and the reduced planar demagnetizing factor.Compared to the traditional silicon steel,this novel SMCs exhibits high magnetic permeability and reduced magnetic losses at frequencies above 1000 Hz,which possess immense application potential within high-frequency electric machines.展开更多
Undesired ice accumulation on infrastructure and transportation systems leads to catastrophic events and significant economic losses.Although various anti-icing surfaces with photothermal effects can initially prevent...Undesired ice accumulation on infrastructure and transportation systems leads to catastrophic events and significant economic losses.Although various anti-icing surfaces with photothermal effects can initially prevent icing,any thawy droplets remaining on the horizontal surface can quickly re-freezing once the light diminishes.To address these challenges,we have developed a self-draining slippery surface(SDSS)that enables the thawy droplets to self-remove on the horizontal surface,thereby facilitating real-time anti-icing with the aid of sunlight(100 m W cm^(-2)).This is achieved by sandwiching a thin pyroelectric layer between slippery surface and photothermal film.Due to the synergy between the photothermal and pyroelectric layers,the SDSS not only maintains a high surface temperature of 19.8±2.2℃at the low temperature(-20.0±1.0℃),but also generates amount of charge through thermoelectric coupling.Thus,as cold droplets dropped on the SDSS,electrostatic force pushes the droplets off the charged surface because of the charge transfer mechanism.Even if the surface freezes overnight,the ice can melt and drain off the SDSS within 10 min of exposure to sunlight at-20.0±1.0℃,leaving a clean surface.This work provides a new perspective on the anti-icing system in the real-world environments.展开更多
Coupled nanogenerators have been a research hotspot due to their ability to harvest a variety of forms of energy such as light,mechanical and thermal energy and achieve a stable direct current output.Ferroelectric fil...Coupled nanogenerators have been a research hotspot due to their ability to harvest a variety of forms of energy such as light,mechanical and thermal energy and achieve a stable direct current output.Ferroelectric films are frequently investigated for photovoltaic applications due to their unique photovoltaic properties and bandgap-independent photovoltage,while the flexoelectric effect is an electromechanical property commonly found in solid dielectrics.Here,we effectively construct a new form of coupled nanogenerator based on a flexible BiFeO_(3) ferroelectric film that combines both flexoelectric and photovoltaic effects to successfully harvest both light and vibration energies.This device converts an alternating current into a direct current and achieves a 6.2% charge enhancement and a 19.3%energy enhancement to achieve a multi-dimensional"1+1>2"coupling enhancement in terms of current,charge and energy.This work proposes a new approach to the coupling of multiple energy harvesting mechanisms in ferroelectric nanogenerators and provides a new strategy to enhance the transduction efficiency of flexible functional devices.展开更多
The carbides and mechanical properties of as-cast high grade knives steel with and without cerium(Ce)addition were studied.The as-cast microstructure of the steel,the size of carbide precipitation,carbide morphology,a...The carbides and mechanical properties of as-cast high grade knives steel with and without cerium(Ce)addition were studied.The as-cast microstructure of the steel,the size of carbide precipitation,carbide morphology,and mechanical properties were systematically studied through optical microscopy,scanning electron microscopy,and X-ray diffraction.Besides,through the Equilib module of the FactSage thermodynamics software,the changes in the precipitation type of the inclusions with Ce during the solidification of the steel were calculated.The results indicate that the rare earth Ce is added into the steel to refine the as-cast microstructure of the steel.The types of inclusions in the steel are changed by the addition of Ce.The precipitated carbide morphology changes from a complex rod shape to a relatively single lamellar shape.The rare earth inclusions formed in steel by a moderate addition of Ce can be severed as the core of heterogeneous nucleation of carbides,which reduce the size of carbide precipitation,promote the uniform distribution of carbide in the as-cast steel,and improve the mechanical properties of the as-cast high grade knives steel.展开更多
Cross-ice acoustic information transmission is an effective means of communication in polar sea areas covered by ice.However,the channel is extremely complicated because of the combined influence of water,ice,and air....Cross-ice acoustic information transmission is an effective means of communication in polar sea areas covered by ice.However,the channel is extremely complicated because of the combined influence of water,ice,and air.Based on the normalmode theory,this paper establishes a cascade acoustic channel(CAC)model for the transmission of underwater acoustic waves across ice layer.The model can calculate the displacement response of the ice layer’s upper surface by separating the upward waves from normal modes in the water and multiplying it by a transmission coefficient matrix.The relationship between the displacement response of the upper surface of ice layer and the acoustic frequency is calculated by the finite-element method,and the calculation result was consistent with that of the CAC model.To verify the applicability of the model,a cross-ice acoustic communication experiment was conducted in Songhua River in January 2019.Experimental results show the energy of the acoustic signals received by geophones is closely related to sound frequency and crossice acoustic communication is feasible.The result of present research is important for understanding crossice acoustic channel characteristics and developing future cross-ice acoustic communication in polar sea areas.展开更多
Salinity is a severe abiotic stress that affects plant growth and yield.Salinity stress activates jasmonate(JA)signaling in Arabidopsis thaliana,but the underlying molecular mechanism remains to be elucidated.In this ...Salinity is a severe abiotic stress that affects plant growth and yield.Salinity stress activates jasmonate(JA)signaling in Arabidopsis thaliana,but the underlying molecular mechanism remains to be elucidated.In this study,we confirmed the activation of JA signaling under saline conditions and demonstrated the importance of the CORONATINE INSENSITIVE1(COI1)-mediated JA signaling for this process.Phenotypic analyses reflected the negative regulation of JASMONATE ZIM-DOMAIN(JAZ)repressors during salinity stress-enhanced JA signaling.Mechanistic analyses revealed that JAZ proteins physically interact with ABSCISIC ACID-RESPONSIVE ELEMENT BINDING FACTOR1(ABF1),AREB1/ABF2,ABF3,and AREB2/ABF4,which belong to the basic leucine zipper(bZIP)transcription factor family and respond to salinity stress.Analyses on the ABF3 overexpression plants and ABF mutants indicated the positive role of ABF3 in regulating JA signaling under saline condition.Furthermore,ABF3 overexpression partially recovered the JA-related phenotypes of JAZ1-D3A plants.Moreover,ABF3 was observed to indirectly activate ALLENE OXIDE SYNTHASE(AOS)transcription,but this activation was inhibited by JAZ1.In addition,ABF3 competitively bind to JAZ1,thereby decreasing the interaction between JAZ1 and MYC2,which is the master transcription factor controlling JA signaling.Collectively,our findings have clarified the regulatory effects of ABF3 on JA signaling and provide new insights into how JA signaling is enhanced following an exposure to salinity stress.展开更多
Radiotherapy(RT)is a widely used way for cancer treatment.However,the efficiency of RT may come with various challenges such as low specificity,limitation by resistance,high dose and so on.Nitric oxide(NO)is known a v...Radiotherapy(RT)is a widely used way for cancer treatment.However,the efficiency of RT may come with various challenges such as low specificity,limitation by resistance,high dose and so on.Nitric oxide(NO)is known a very effective radiosensitizer of hypoxic tumor.However,NO cannot circulate in body with high concentration.Herein,an NIR light-responsive NO delivery system is developed for controlled and precisely release of NO to hypoxic tumors during radiotherapy.Tert-Butyl nitrite,which is an efficient NO source,is coupled to Ag2S quantum dots(QDs).NO could be generated and released from the Ag2S QDs effectively under the NIR irradiation due to the thermal effect.In addition,Ag is also a type of heavy metal that can benefit the RT therapy.We demonstrate that Ag2S NO delivery platforms remarkably maximize radiotherapy effects to inhibit tumor growth in CT26 tumor model.Furthermore,immunosuppressive tumor microenvironment is improved by our NO delivery system,significantly enhancing the anti-PD-L1 immune checkpoint blockade therapy.100% survival rate is achieved by the radio-immune combined therapy strategy based on the Ag2S NO delivery platforms.Our results suggest the promise of Ag2S NO delivery platforms for multifunctional cancer radioimmunotherapy.展开更多
A designed visual geometry group(VGG)-based convolutional neural network(CNN)model with small computational cost and high accuracy is utilized to monitor pulse amplitude modulation-based intensity modulation and direc...A designed visual geometry group(VGG)-based convolutional neural network(CNN)model with small computational cost and high accuracy is utilized to monitor pulse amplitude modulation-based intensity modulation and direct detection channel performance using eye diagram measurements.Experimental results show that the proposed technique can achieve a high accuracy in jointly monitoring modulation format,probabilistic shaping,roll-off factor,baud rate,optical signal-to-noise ratio,and chromatic dispersion.The designed VGG-based CNN model outperforms the other four traditional machine-learning methods in different scenarios.Furthermore,the multitask learning model combined with MobileNet CNN is designed to improve the flexibility of the network.Compared with the designed VGG-based CNN,the MobileNet-based MTL does not need to train all the classes,and it can simultaneously monitor single parameter or multiple parameters without sacrificing accuracy,indicating great potential in various monitoring scenarios.展开更多
基金Funds for the Central Universities(grant number CUC24SG018).
文摘The proliferation of robot accounts on social media platforms has posed a significant negative impact,necessitating robust measures to counter network anomalies and safeguard content integrity.Social robot detection has emerged as a pivotal yet intricate task,aimed at mitigating the dissemination of misleading information.While graphbased approaches have attained remarkable performance in this realm,they grapple with a fundamental limitation:the homogeneity assumption in graph convolution allows social robots to stealthily evade detection by mingling with genuine human profiles.To unravel this challenge and thwart the camouflage tactics,this work proposed an innovative social robot detection framework based on enhanced HOmogeneity and Random Forest(HORFBot).At the core of HORFBot lies a homogeneous graph enhancement strategy,intricately woven with edge-removal techniques,tometiculously dissect the graph intomultiple revealing subgraphs.Subsequently,leveraging the power of contrastive learning,the proposed methodology meticulously trains multiple graph convolutional networks,each honed to discern nuances within these tailored subgraphs.The culminating stage involves the fusion of these feature-rich base classifiers,harmoniously aggregating their insights to produce a comprehensive detection outcome.Extensive experiments on three social robot detection datasets have shown that this method effectively improves the accuracy of social robot detection and outperforms comparative methods.
基金supported by the National Natural Science Foundation of China(Grant No.52071294)the National Key Research and Development Program(Grant No.2022YFE0109800)the Natural Science Foundation of Zhejiang Province(Grant No.LY20E020015).
文摘A single-phase anti-perovskite medium-entropy alloy nitride foams(MEANFs),as innovative materials for electromagnetic wave(EMW)absorption,have been successfully synthesized through the lattice expansion induced by nitrogen doping.This achievement notably overcomes the inherent constraints of conventional metal-based absorbers,including low resonance frequency,high conductivity,and elevated density,for the synergistic advantages provided by multimetallic alloys and foams.Microstructural analysis with comprehensive theoretical calculations provides in-depth insights into the formation mechanism,electronic structure,and magnetic moment of MEANFs.Furthermore,deliberate component design along with the foam structure proves to be an effective strategy for enhancing impedance matching and absorption.The results show that the MEANFs exhibit a minimum reflection loss(RL_(min))value of-60.32 dB and a maximum effective absorption bandwidth(EAB_(max))of 5.28 GHz at 1.69 mm.This augmentation of energy dissipation in EMW is predominantly attributed to factors such as porous structure,interfacial polarization,defect-induced polarization,and magnetic resonance.This study demonstrates a facile and efficient approach for synthesizing single-phase medium-entropy alloys,emphasizing their potential as materials for electromagnetic wave absorption due to their adjustable magnetic-dielectric properties.
基金financially supported by the Shaanxi Provincial Science and Technology Innovation Team,China(No.2024RS-CXTD-26)。
文摘When immersed in sand and dust environment,aero-engine blades are exposed to harsh erosion which may lead to failure if erosion is severe.Using Physical Vapor Deposition(PVD)to prepare hard ceramic coatings can greatly enhance the operational capabilities of aero-engine.However,due to the“line-of-sight”processing characteristic of PVD process,uneven coating deposition rates occur when preparing coatings on obstructed areas such as blisks.Quantitative research on such phenomena is few,and it is even rarer in the study of aero-engine coatings.Based on the analyses and considerations of the geometric shape of blade surfaces and the influence of both deposition and re-sputtering effect,an ideal model is established to analyze the deposition rate variation along blocked region in complex self-shadowing boundaries.The relative deposition rates at various locations on the blade surface within the inter-blade gaps are quantitatively calculated and experimentally validated.Furthermore,differences in erosion resistance of the coatings are tested.The conclusions are drawn as follows:the geometric configuration of the obstructed shape and resputtering phenomenon significantly influence the deposition rates within the inner wall of blade gaps.Taking the structural configuration as an example,in a 25 mm×60 mm×15 mm gap,the coating thickness can vary more than 252%from the thickest to the thinnest location.The deposition rates of various locations are proportional to the solid angle of incident ion in more obstructed regions,and the re-sputtering is more prominent in open regions.Obstructive boundaries directly affect the erosion resistance at various locations within the gaps,with erosion failure time decreasing by 40%in heavily blocked region compared to open region.
基金supported by the National Natural Science Foundation of China(Grant No.52071294)the National Key Research and Development Program(Grant No.2022YFE0109800)the Natural Science Foundation of Zhejiang Province(Grant No.LY20E020015).
文摘Bioinspired nacre-like structured high-density soft magnetic composites(SMCs)have been successfully constructed using flaky-Fe_(73.8)Si_(13.5)B_(8.7)Cu_(1)Nb_(3) powders in the supercooled liquid region(SCLR).These densely arranged particles with a consistent planar orientation significantly enhance the soft magnetic properties of SMCs,including high permeability and low magnetic losses.The internal structures of the composites and microstructure evolution of the flaky nanocrystalline particles during the hot-pressing process have been thoroughly studied.Moreover,systematic investigations into the effects of coatings and particle sizes on the maximum permeability and magnetic losses of the composites are conducted.The SMC prepared using the coated particles with a size of 0-100μm exhibits a high maximum perme-ability of 2170(at 1000 Hz)and low magnetic loss of 41.61 W kg^(-1)(at 1000 Hz and 1.0 T).The losses and permeability analysis reveal that the superior performance of these soft magnetic materials is attributed to their laminated structure,insulation coating,and the reduced planar demagnetizing factor.Compared to the traditional silicon steel,this novel SMCs exhibits high magnetic permeability and reduced magnetic losses at frequencies above 1000 Hz,which possess immense application potential within high-frequency electric machines.
基金supported by the National Natural Science Foundation of China(52273101,51922018,and 21875011)the Fundamental Research Funds for the Central Universities(KG21015201 and KG21020801)China Postdoctoral Science Foundation(2025M77422)。
文摘Undesired ice accumulation on infrastructure and transportation systems leads to catastrophic events and significant economic losses.Although various anti-icing surfaces with photothermal effects can initially prevent icing,any thawy droplets remaining on the horizontal surface can quickly re-freezing once the light diminishes.To address these challenges,we have developed a self-draining slippery surface(SDSS)that enables the thawy droplets to self-remove on the horizontal surface,thereby facilitating real-time anti-icing with the aid of sunlight(100 m W cm^(-2)).This is achieved by sandwiching a thin pyroelectric layer between slippery surface and photothermal film.Due to the synergy between the photothermal and pyroelectric layers,the SDSS not only maintains a high surface temperature of 19.8±2.2℃at the low temperature(-20.0±1.0℃),but also generates amount of charge through thermoelectric coupling.Thus,as cold droplets dropped on the SDSS,electrostatic force pushes the droplets off the charged surface because of the charge transfer mechanism.Even if the surface freezes overnight,the ice can melt and drain off the SDSS within 10 min of exposure to sunlight at-20.0±1.0℃,leaving a clean surface.This work provides a new perspective on the anti-icing system in the real-world environments.
基金This work was supported by the National Natural Science Foundation of China(No.52072041)the Beijing Natural Science Foundation(No.JQ21007)the University of Chinese Academy of Sciences(No.Y8540XX2D2).
文摘Coupled nanogenerators have been a research hotspot due to their ability to harvest a variety of forms of energy such as light,mechanical and thermal energy and achieve a stable direct current output.Ferroelectric films are frequently investigated for photovoltaic applications due to their unique photovoltaic properties and bandgap-independent photovoltage,while the flexoelectric effect is an electromechanical property commonly found in solid dielectrics.Here,we effectively construct a new form of coupled nanogenerator based on a flexible BiFeO_(3) ferroelectric film that combines both flexoelectric and photovoltaic effects to successfully harvest both light and vibration energies.This device converts an alternating current into a direct current and achieves a 6.2% charge enhancement and a 19.3%energy enhancement to achieve a multi-dimensional"1+1>2"coupling enhancement in terms of current,charge and energy.This work proposes a new approach to the coupling of multiple energy harvesting mechanisms in ferroelectric nanogenerators and provides a new strategy to enhance the transduction efficiency of flexible functional devices.
基金This work was financially supported by National Natural Science Foundation of China(51874171 and 51974154)supported by University of Science and Technology Liaoning talents program.
文摘The carbides and mechanical properties of as-cast high grade knives steel with and without cerium(Ce)addition were studied.The as-cast microstructure of the steel,the size of carbide precipitation,carbide morphology,and mechanical properties were systematically studied through optical microscopy,scanning electron microscopy,and X-ray diffraction.Besides,through the Equilib module of the FactSage thermodynamics software,the changes in the precipitation type of the inclusions with Ce during the solidification of the steel were calculated.The results indicate that the rare earth Ce is added into the steel to refine the as-cast microstructure of the steel.The types of inclusions in the steel are changed by the addition of Ce.The precipitated carbide morphology changes from a complex rod shape to a relatively single lamellar shape.The rare earth inclusions formed in steel by a moderate addition of Ce can be severed as the core of heterogeneous nucleation of carbides,which reduce the size of carbide precipitation,promote the uniform distribution of carbide in the as-cast steel,and improve the mechanical properties of the as-cast high grade knives steel.
基金This research was funded by the National Key R&D Program of China(2018YFC1405900)The National Natural Science Foundation of China(Grant No.61631008 and No.51779061)+2 种基金the Fok Ying-Tong Education Foundation,China(Grant,No.151007)The Heilongjiang Province Outstanding Youth Science Fund(JC2017017)and the Innovation Special Zone of National Defense Science and Technology.
文摘Cross-ice acoustic information transmission is an effective means of communication in polar sea areas covered by ice.However,the channel is extremely complicated because of the combined influence of water,ice,and air.Based on the normalmode theory,this paper establishes a cascade acoustic channel(CAC)model for the transmission of underwater acoustic waves across ice layer.The model can calculate the displacement response of the ice layer’s upper surface by separating the upward waves from normal modes in the water and multiplying it by a transmission coefficient matrix.The relationship between the displacement response of the upper surface of ice layer and the acoustic frequency is calculated by the finite-element method,and the calculation result was consistent with that of the CAC model.To verify the applicability of the model,a cross-ice acoustic communication experiment was conducted in Songhua River in January 2019.Experimental results show the energy of the acoustic signals received by geophones is closely related to sound frequency and crossice acoustic communication is feasible.The result of present research is important for understanding crossice acoustic channel characteristics and developing future cross-ice acoustic communication in polar sea areas.
基金supported by the Natural Science Foundation of China(32270613,31922009,and 31870259)the Yunnan Fundamental Research Projects(202201AS070051,202001AV070009,2019FI006,202001AT070118,and 202101AW070005,202401AT070220)+1 种基金the CAS“Light of West China”Program(to X.H.)the Youth Innovation Promotion Association of the of Chinese Academy of Sciences(Y201973 and 2022399).
文摘Salinity is a severe abiotic stress that affects plant growth and yield.Salinity stress activates jasmonate(JA)signaling in Arabidopsis thaliana,but the underlying molecular mechanism remains to be elucidated.In this study,we confirmed the activation of JA signaling under saline conditions and demonstrated the importance of the CORONATINE INSENSITIVE1(COI1)-mediated JA signaling for this process.Phenotypic analyses reflected the negative regulation of JASMONATE ZIM-DOMAIN(JAZ)repressors during salinity stress-enhanced JA signaling.Mechanistic analyses revealed that JAZ proteins physically interact with ABSCISIC ACID-RESPONSIVE ELEMENT BINDING FACTOR1(ABF1),AREB1/ABF2,ABF3,and AREB2/ABF4,which belong to the basic leucine zipper(bZIP)transcription factor family and respond to salinity stress.Analyses on the ABF3 overexpression plants and ABF mutants indicated the positive role of ABF3 in regulating JA signaling under saline condition.Furthermore,ABF3 overexpression partially recovered the JA-related phenotypes of JAZ1-D3A plants.Moreover,ABF3 was observed to indirectly activate ALLENE OXIDE SYNTHASE(AOS)transcription,but this activation was inhibited by JAZ1.In addition,ABF3 competitively bind to JAZ1,thereby decreasing the interaction between JAZ1 and MYC2,which is the master transcription factor controlling JA signaling.Collectively,our findings have clarified the regulatory effects of ABF3 on JA signaling and provide new insights into how JA signaling is enhanced following an exposure to salinity stress.
基金This work is supported by grants from startup supports of Soochow University and the Program for Jiangsu Specially Appointed Professors to C.WThis work is partly supported by Collaborative Innovation Center of Suzhou Nano Science&Technology,the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD),the 111 Project+2 种基金This work was also supported by the National Natural Science Foundation of China(No.31900988)the Natural Science Foundation of Jiangsu Province(No.SBK2019040088)Jiangsu Province Six Talent Peaks Project(No.SWYY-110).
文摘Radiotherapy(RT)is a widely used way for cancer treatment.However,the efficiency of RT may come with various challenges such as low specificity,limitation by resistance,high dose and so on.Nitric oxide(NO)is known a very effective radiosensitizer of hypoxic tumor.However,NO cannot circulate in body with high concentration.Herein,an NIR light-responsive NO delivery system is developed for controlled and precisely release of NO to hypoxic tumors during radiotherapy.Tert-Butyl nitrite,which is an efficient NO source,is coupled to Ag2S quantum dots(QDs).NO could be generated and released from the Ag2S QDs effectively under the NIR irradiation due to the thermal effect.In addition,Ag is also a type of heavy metal that can benefit the RT therapy.We demonstrate that Ag2S NO delivery platforms remarkably maximize radiotherapy effects to inhibit tumor growth in CT26 tumor model.Furthermore,immunosuppressive tumor microenvironment is improved by our NO delivery system,significantly enhancing the anti-PD-L1 immune checkpoint blockade therapy.100% survival rate is achieved by the radio-immune combined therapy strategy based on the Ag2S NO delivery platforms.Our results suggest the promise of Ag2S NO delivery platforms for multifunctional cancer radioimmunotherapy.
基金supported by the National Key Research and Development Program of China (Grant No.2019YFB1803700)the Key Technologies Research and Development Program of Tianjin (Grant No.20YFZCGX00440).
文摘A designed visual geometry group(VGG)-based convolutional neural network(CNN)model with small computational cost and high accuracy is utilized to monitor pulse amplitude modulation-based intensity modulation and direct detection channel performance using eye diagram measurements.Experimental results show that the proposed technique can achieve a high accuracy in jointly monitoring modulation format,probabilistic shaping,roll-off factor,baud rate,optical signal-to-noise ratio,and chromatic dispersion.The designed VGG-based CNN model outperforms the other four traditional machine-learning methods in different scenarios.Furthermore,the multitask learning model combined with MobileNet CNN is designed to improve the flexibility of the network.Compared with the designed VGG-based CNN,the MobileNet-based MTL does not need to train all the classes,and it can simultaneously monitor single parameter or multiple parameters without sacrificing accuracy,indicating great potential in various monitoring scenarios.
