摘要
目的探讨小细胞肺癌(SCLC)患者血清乳酸脱氢酶(LDH)和白细胞介素1β(IL-1β)、IL-6、IL-8水平与临床特征之间的关系。方法前瞻性纳入42例初诊、不可手术治疗的SCLC患者,采用全自动生化仪检测其血清LDH水平,采用ELISA法检测其血清IL-1β、IL-6和IL-8水平,分析上述指标与患者年龄、性别、疾病分期、吸烟史、转移部位及数量等临床特征的关系。结果≥60岁、广泛期、有肝转移和淋巴结转移的患者血清LDH水平高于<60岁、局限期、无肝转移和淋巴结转移的患者(P均<0.05),且血清LDH水平与转移部位数量呈正相关(r=0.468,P=0.002)。女性患者血清IL-1β水平高于男性患者(P<0.05)。广泛期SCLC患者血清IL-6水平高于局限期患者(P<0.05)。血清IL-8水平在不同临床特征SCLC患者间无统计学意义(P均>0.05)。不同血清LDH水平患者间血清IL-1β、IL-6和IL-8水平差异无统计学意义,不同血清IL-1β、IL-6和IL-8水平患者间血清LDH水平差异无统计学意义(P均>0.05)。结论SCLC患者血清LDH水平在广泛期、肝转移及淋巴结转移患者中升高,且随转移部位增多而上升;血清IL-6在广泛期患者中升高,血清IL-1β水平在不同性别患者中存在差异;上述指标可反映SCLC的疾病进展程度,为疾病评估提供一定参考。
Objective To investigate the relationships between serum levels of lactate dehydrogenase(LDH),inter⁃leukin-1β(IL-1β),IL-6,IL-8 and clinical characteristics in patients with small cell lung cancer(SCLC).Methods For⁃ty-two newly diagnosed SCLC patients unsuitable for surgical treatment were prospectively enrolled.The serum LDH level was measured using an automatic biochemical analyzer.Serum levels of IL-1β,IL-6,and IL-8 were determined by en⁃zyme-linked immunosorbent assay(ELISA).The relationships between these serum markers and clinical characteristics(age,gender,disease stage,smoking history,sites and number of metastases)were analyzed.Results Serum LDH lev⁃els were significantly higher in patients aged≥60 years,those with extensive-stage disease,those with liver metastases,and those with lymph node metastases than in patients aged<60 years,those with limited-stage disease,those without liver metastases,and those without lymph node metastases,respectively(all P<0.05).A positive correlation was observed be⁃tween the serum LDH level and the number of metastatic sites(r=0.468,P=0.002).Female patients exhibited signifi⁃cantly higher serum IL-1βlevels than male patients(P<0.05).The serum IL-6 level was significantly higher in patients with extensive-stage disease than in those with limited-stage disease(P<0.05).No statistically significant difference was found in serum IL-8 levels among patients of different clinical characteristics(P>0.05).No significant differences were found in serum IL-1β,IL-6,or IL-8 levels among patients with different serum LDH levels.Similarly,no significant dif⁃ference was found in serum LDH level among patients with different serum levels of IL-1β,IL-6,and IL-8(all P>0.05).Conclusions The serum LDH levels increase in patients with extensive disease,liver metastasis,and lymph node metas⁃tasis,and rise with the increase of metastatic sites.The serum IL-6 level is elevated in patients with extensive disease,and the serum IL-1βlevel varies among patients of different genders.These indicators can reflect the disease progression of SCLC and provide certain references for disease assessment.
作者
肖菡
沈存芳
史雪霞
唐玉平
乔晓敏
XIAO Han;SHEN Cunfang;SHI Xuexia;TANG Yuping;QIAO Xiaomin(Clinical Pharmacy Department,Qinghai University Affiliated Hospital,Xining 810001,China;不详)
出处
《山东医药》
2026年第1期24-28,共5页
Shandong Medical Journal
基金
青海省卫健委指导性计划课题(2022-wjzdx-79)
青海省“昆仑英才·高原名医”项目。
