Inborn errors of metabolism(IEMs)are a large group of disorders resulting from deficient activities in several metabolic pathways due to the dysfunction of a distinct enzyme associated with a biochemical pathway[1,2]....Inborn errors of metabolism(IEMs)are a large group of disorders resulting from deficient activities in several metabolic pathways due to the dysfunction of a distinct enzyme associated with a biochemical pathway[1,2].Toxic intermediates will be produced due to the dysfunction of biochemical pathways.The liver is responsible for many essential metabolic processes,therefore it becomes one of the most severely affected organ by metabolic diseases[3].Early onset of liver disorders in IEMs includes jaundice,hepatomegaly,splenomegaly,ascites,hepatic encephalopathy,and liver failure[4].In infants and young children under 3 years old with acute liver failure(ALF),IEMs account for 18.9%-43%[5].展开更多
Introduction,Breast cancer is the most common cancer type in adolescents and young adults<40 years of age,accounting for 30%of cancers in this age group1.Breast cancer in the young presents significant challenges f...Introduction,Breast cancer is the most common cancer type in adolescents and young adults<40 years of age,accounting for 30%of cancers in this age group1.Breast cancer in the young presents significant challenges for patients and society,including more aggressive tumor biology,poor prognosis,genetic susceptibility,fertility preservation,and complex psychosocial issues.Moreover,because of the markedly younger median age of breast cancer,the proportion of young breast cancer patients in China is significantly higher than Western countries2.The first Young Breast Cancer in China(YBCC)consensus meeting was held in Guangzhou,China in December 2021 to address exclusive challenges and requirements facing young patients with breast cancer.Chinese medical experts from multiple specialties had an extensive discussion and formulated a consensus over several hot topics in young patients with breast cancer.The“Expert Consensus on the Diagnosis and Treatment of Young Breast Cancer in China(2022 edition)”published in the Chinese Medical Journal has garnered significant attention3,highlighting enormous interest in the YBCC consensus in the medical community and public.展开更多
Nitrate pollution is a severe threat to the fragile ecosystems in karst regions.However,our knowledge of the sources and transformations of nitrate in karst cave groundwater is still limited.This study aimed to invest...Nitrate pollution is a severe threat to the fragile ecosystems in karst regions.However,our knowledge of the sources and transformations of nitrate in karst cave groundwater is still limited.This study aimed to investigate the temporal and spatial patterns of nitrate dynamics in the underground water of karst caves located on the south bank of the Qingjiang River in central China,through a comprehensive application of multiple approaches,such as hydrochemistry,nitrogen and oxygen isotope compositions of nitrate,and a Bayesian isotope mixing model(SIMMR).During the sampling period(from December 2018 to December 2019),the nitrate concentration did not show an apparent temporal variation;meanwhile,no water samples in this study had a nitrate concentration higher than the limit for drinking water,but the nitrate concentration in karst underground rivers is significantly higher than that in surface water.The results of the comprehensive analyses revealed that the predominant nitrate sources included nitrification in soil and chemical fertilizer,which had mean percentages of 43%and 32%,respectively.The source contribution varied in the outlet water among different caves.The soil-derived nitrate in the underground water from the Shizi Cave accounted for the highest proportion(49%),while chemical-fertilizer-derived nitrate in the underground water from the Mishui Cave accounted for the highest proportion(36%).The dualisotope signatures of nitrate supported a major influence on nitrogen dynamics in the cave underground from nitrification.These findings suggest that nitrate carried by underground rivers in karst caves should be alerted when making the nitrate balance in rivers flowing through karst areas.展开更多
Guggulsterone(GS)is a bioactive compound primarily extracted from the oleo-gum resin of plants in the Commiphora and Boswellia genera.Modern pharmacological studies have demonstrated that GS possesses a broad spectrum...Guggulsterone(GS)is a bioactive compound primarily extracted from the oleo-gum resin of plants in the Commiphora and Boswellia genera.Modern pharmacological studies have demonstrated that GS possesses a broad spectrum of biological activities,with notable therapeutic potential in inflammatory disorders,neurodegenerative conditions,diabetes mellitus,and various cancers.In this review,we systematically analyzed relevant literature published up to 2024 from the CNKI,Web of Science,ScienceDirect,and PubMed databases to summarize the current understanding of GS's pharmacological effects,toxicity profile,and pharmacokinetic properties.The findings indicate that GS exerts potent antioxidant,anti-inflammatory,anticancer,antiviral,antidepressant,lipid-lowering,and cardiovascular protective effects,primarily through modulation of key signaling pathways such as the Janus kinase(JAK)-signal transducer and activator of transcription 3(STAT3),nuclear factor erythroid 2-related factor 2(Nrf2)/heme oxygenase-1(HO-1),Nrf2/Keap1,nuclear factor kappa-B(NF-κB),AMPK,phosphoinositide 3-kinase(PI3K)/protein kinase B(Akt),and mitogen-activated protein kinase(MAPK)/activator protein-1(AP-1).Additionally,GS may help overcome limitations associated with conventional chemotherapy by modulating drug resistance via regulation of p-glycoprotein activity.Following hepatic metabolism mediated by cytochrome P450 enzymes,GS does not appear to cause significant adverse effects.This review provides a comprehensive synthesis of the sources,pharmacological actions,safety,pharmacokinetics,and potential applications of GS.Future research should focus on structural modification of GS,development of novel formulations,and exploration of synergistic combinations with other therapeutic agents to broaden its clinical utility.展开更多
The aim of the present study was to investigate the effect of lipoxin A4 （LXA4） pretreatment on cognitive function of aged rats after global cerebral ischemia reperfusion, and to explore its possible mechanism. Thir...The aim of the present study was to investigate the effect of lipoxin A4 （LXA4） pretreatment on cognitive function of aged rats after global cerebral ischemia reperfusion, and to explore its possible mechanism. Thirty-six aged male Sprague-Dawley rats were randomly divided into three groups （n=12 each）： sham-operation group （S group）, global cerebral ischemia reperfusion group （I/R group） and LXA4-pretreatment group （L group）. The rat model of global cerebral ischemia reperfusion was established by occlusion of the bilateral common carotid artery with hypotension. The cognitive function of rats was determined by a step-down type passive avoidance test and Morris Water Maze test on the third day after reperfusion. Rats were sacrificed after Water Maze test and the pathological changes ofhippocampal CA1 region were observed and the related inflammatory mediators were determined. As compared with S group, the escape latency in I/R group was prolonged from the first day to the fifth day, while that in L group was prolonged from the first day to the third day. The retention time in I/R group and L group in the first quadrant was shortened. The reaction time, frequency of reaction mistake and frequency of escape mistake in I/R group increased, and the latent period shortened. The frequency of escape mistake in L group increased, and the damage in the hippocampal CAI region of I/R group and L group was obvious. The levels of S-10013, TNF-α, IL-1β, IL-10 and NF-κB in I/R group and L group increased. As compared with I/R group, the escape latency in L group was shortened from the first day to the fifth day, and the retention time in the first quadrant prolonged. The reaction time, frequency of reaction mistake and frequency of escape mistake in L group decreased, and the latent period prolonged. The damage in the hippocampal CA1 region of L group was alleviated as well. The levels of S-10013, TNF-α, IL-1β and NF-κB in L group decreased, and those of IL-10 increased. It can be concluded that LXA4 pretreatment can improve the cognitive function in aged rats after global cerebral ischemia reperfusion probably by inhibiting the inflammatory reaction.展开更多
Physical and chemical properties of ambient aerosols at the single particle level were studied in Shanghai from December 22 to 28, 2009. A Cavity-Ring-Down Aerosol Extinction Spectrometer（CRD-AES） and a nephelometer...Physical and chemical properties of ambient aerosols at the single particle level were studied in Shanghai from December 22 to 28, 2009. A Cavity-Ring-Down Aerosol Extinction Spectrometer（CRD-AES） and a nephelometer were deployed to measure aerosol light extinction and scattering properties, respectively. An Aerosol Time-of-Flight Mass Spectrometer（ATOFMS）was used to detect single particle sizes and chemical composition. Seven particle types were detected. Air parcels arrived at the sampling site from the vicinity of Shanghai until mid-day of December 25, when they started to originate from North China. The aerosol extinction,scattering, and absorption coefficients all dropped sharply when this cold, clean air arrived.Aerosol particles changed from a highly aged type before this meteorological shift to a relatively fresh type afterwards. The aerosol optical properties were dependent on the wind direction.Aerosols with high extinction coefficient and scattering Angstrom exponent（SAE） were observed when the wind blew from the west and northwest, indicating that they were predominantly fine particles. Nitrate and ammonium correlated most strongly with the change in aerosol optical properties. In the elemental carbon/organic carbon（ECOC） particle type, the diurnal trends of single scattering albedo（SSA） and elemental carbon（EC） signal intensity had a negative correlation. We also found a negative correlation（r =-0.87） between high mass-OC particle number fraction and the SSA in a relatively clean period, suggesting that particulate aromatic components might play an important role in light absorption in urban areas.展开更多
Profound understanding on the diversity of local residents’willingness to pay(WTP)for ecosystem services(ESs)may aid evaluation of policy impacts by uncovering trade-offs and synergies for achieving sustainable envir...Profound understanding on the diversity of local residents’willingness to pay(WTP)for ecosystem services(ESs)may aid evaluation of policy impacts by uncovering trade-offs and synergies for achieving sustainable environmental resource management.However,the reasons for the spatial preference heterogeneity of WTP are still unclear.In this study,an extensive survey with 4,580 residents in the Yangtze River Middle Reaches Megalopolis(YRMRM),central China,was carried out to investigate the public’s WTP to maintain and improve ESs.We identified key influencing factors and explored how they shaped the preference heterogeneity in WTP by random forest model and surface fitting method.Our results showed that 81.4% of residents reported WTP for ESs greater than zero.Water supply,waste treatment,food supply and raw material supply were the preferred ESs for residents.Living environment factors(i.e.,extent of farmland,water and forest near the residence)were found as the key drivers of WTP.Proximity to farmland,water and forests resulted in high WTP values for a series of specific ESs.The reasons for the heterogeneity of WTP are(1)the difference in proximity to farmland,water and forest(i.e.,the contributor to ESs),(2)the divergence of local residents’preferences for ESs.This study disclosed the heterogeneity and causes of public preferences in YRMRM,which could help policy and decision makers to develop eco-compensation initiatives towards conservative and sustainable use of the environmental resources.展开更多
BACKGROUND Return to work(RTW)serves as an indication for young and middle-aged colorectal cancer(CRC)survivors to resume their normal social lives.However,these survivors encounter significant challenges during their...BACKGROUND Return to work(RTW)serves as an indication for young and middle-aged colorectal cancer(CRC)survivors to resume their normal social lives.However,these survivors encounter significant challenges during their RTW process.Hence,scientific research is necessary to explore the barriers and facilitating factors of returning to work for young and middle-aged CRC survivors.AIM To examine the current RTW status among young and middle-aged CRC survivors and to analyze the impact of RTW self-efficacy(RTW-SE),fear of progression(FoP),eHealth literacy(eHL),family resilience(FR),and financial toxicity(FT)on their RTW outcomes.METHODS A cross-sectional investigation was adopted in this study.From September 2022 to February 2023,a total of 209 participants were recruited through a convenience sampling method from the gastrointestinal surgery department of a class A tertiary hospital in Chongqing.The investigation utilized a general information questionnaire alongside scales assessing RTW-SE,FoP,eHL,FR,and FT.To analyze the factors that influence RTW outcomes among young and middle-aged CRC survivors,Cox regression modeling and Kaplan-Meier survival analysis were used.RESULTS A total of 43.54%of the participants successfully returned to work,with an average RTW time of 100 days.Cox regression univariate analysis revealed that RTW-SE,FoP,eHL,FR,and FT were significantly different between the non-RTW and RTW groups(P<0.05).Furthermore,Cox regression multivariate analysis identified per capita family monthly income,job type,RTW-SE,and FR as independent influencing factors for RTW(P<0.05).CONCLUSION The RTW rate requires further improvement.Elevated levels of RTW-SE and FR were found to significantly increase RTW among young and middle-aged CRC survivors.Health professionals should focus on modifiable factors,such as RTW-SE and FR,to design targeted RTW support programs,thereby facilitating their timely reintegration into mainstream society.展开更多
Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and memory.The activity-dependent release of brain-derived neurotrophic factor at...Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and memory.The activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term potentiation.Postsynaptically,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term potentiation.In this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and depression.Treatment with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 isoform.Although TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific functions.Targeting TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.展开更多
目的:探究火麻仁对SW620结肠癌细胞的抑制作用及其化学成分。方法:以RT-qPCR技术为检测手段,考察火麻仁乙醇提取液对结肠癌SW620细胞三磷酸腺苷家族蛋白2(ATPase family AAA domain-containing protein 2,ATAD2)基因表达水平的影响;采...目的:探究火麻仁对SW620结肠癌细胞的抑制作用及其化学成分。方法:以RT-qPCR技术为检测手段,考察火麻仁乙醇提取液对结肠癌SW620细胞三磷酸腺苷家族蛋白2(ATPase family AAA domain-containing protein 2,ATAD2)基因表达水平的影响;采用超高效液相色谱/四级杆-静电场轨道阱质谱,分别对液相色谱流动相种类、柱温、梯度洗脱条件,质谱分辨率、喷雾电压等条件进行优化,对火麻仁乙醇提取液中的化学成分进行定性检测。结果:火麻仁乙醇提取液可抑制结肠癌SW620细胞ATAD2的基因表达;在火麻仁提取液中共定性检测到22个化学成分。结论:火麻仁乙醇提取液具有潜在的抗结肠癌活性,其潜在活性成分包括脂肪酸类、黄酮类及生物碱类。展开更多
Background:The high recurrent rate after surgery hinders the survival of patients with hepatocellular carcinoma(HCC).This prospective cohort study aimed to evaluate the efficacy and safety of lenvatinib plus transarte...Background:The high recurrent rate after surgery hinders the survival of patients with hepatocellular carcinoma(HCC).This prospective cohort study aimed to evaluate the efficacy and safety of lenvatinib plus transarterial chemoembolization(TACE)as an adjuvant therapy in HCC patients with high risk of recurrence.Methods:Patients were enrolled from eight hepatobiliary centers in China.The primary endpoint was disease-free survival(DFS).The secondary endpoints were overall survival(OS)and safety.Additionally,propensity score matching(PSM)and other three propensity score analyses were performed to balance the potential baseline bias to validate the conclusion.The adverse events(AEs)were recorded throughout the study.The study was registered at Clinical Trials.gov(NCT03838796).Results:A total of 297 patients were enrolled,with 147 in the LEN+TACE group and 150 in the TACE group.Before PSM,the LEN+TACE group achieved significantly better DFS than the TACE group(19.0 vs.10.0 months,P=0.011).PSM analysis identified 111 matched pairs.After PSM,the LEN+TACE group also showed better DFS(19.0 vs.9.0 months,P=0.018).Other three propensity score analyses yielded similar DFS benefit tendency.Furthermore,favorable OS was also obtained in the LEN+TACE group before PSM.Lenvatinib related AEs of grade 3 or 4 occurred in 28.6%of the patients in the LEN+TACE group.Conclusions:Adjuvant lenvatinib plus TACE might be a promising adjuvant approach for HCC patients with high risk of recurrence,which could significantly prolong DFS and potentially OS with a manageable safety profile.展开更多
文摘Inborn errors of metabolism(IEMs)are a large group of disorders resulting from deficient activities in several metabolic pathways due to the dysfunction of a distinct enzyme associated with a biochemical pathway[1,2].Toxic intermediates will be produced due to the dysfunction of biochemical pathways.The liver is responsible for many essential metabolic processes,therefore it becomes one of the most severely affected organ by metabolic diseases[3].Early onset of liver disorders in IEMs includes jaundice,hepatomegaly,splenomegaly,ascites,hepatic encephalopathy,and liver failure[4].In infants and young children under 3 years old with acute liver failure(ALF),IEMs account for 18.9%-43%[5].
基金supported by the National Natural Science Foundation of China(Grant Nos.82230057 and 82272859)the National Key R&D Program of China(Grant No.2022YFC2505101).
文摘Introduction,Breast cancer is the most common cancer type in adolescents and young adults<40 years of age,accounting for 30%of cancers in this age group1.Breast cancer in the young presents significant challenges for patients and society,including more aggressive tumor biology,poor prognosis,genetic susceptibility,fertility preservation,and complex psychosocial issues.Moreover,because of the markedly younger median age of breast cancer,the proportion of young breast cancer patients in China is significantly higher than Western countries2.The first Young Breast Cancer in China(YBCC)consensus meeting was held in Guangzhou,China in December 2021 to address exclusive challenges and requirements facing young patients with breast cancer.Chinese medical experts from multiple specialties had an extensive discussion and formulated a consensus over several hot topics in young patients with breast cancer.The“Expert Consensus on the Diagnosis and Treatment of Young Breast Cancer in China(2022 edition)”published in the Chinese Medical Journal has garnered significant attention3,highlighting enormous interest in the YBCC consensus in the medical community and public.
基金supported by the National Natural Science Foundation of China(Nos.42372355,42530706)。
文摘Nitrate pollution is a severe threat to the fragile ecosystems in karst regions.However,our knowledge of the sources and transformations of nitrate in karst cave groundwater is still limited.This study aimed to investigate the temporal and spatial patterns of nitrate dynamics in the underground water of karst caves located on the south bank of the Qingjiang River in central China,through a comprehensive application of multiple approaches,such as hydrochemistry,nitrogen and oxygen isotope compositions of nitrate,and a Bayesian isotope mixing model(SIMMR).During the sampling period(from December 2018 to December 2019),the nitrate concentration did not show an apparent temporal variation;meanwhile,no water samples in this study had a nitrate concentration higher than the limit for drinking water,but the nitrate concentration in karst underground rivers is significantly higher than that in surface water.The results of the comprehensive analyses revealed that the predominant nitrate sources included nitrification in soil and chemical fertilizer,which had mean percentages of 43%and 32%,respectively.The source contribution varied in the outlet water among different caves.The soil-derived nitrate in the underground water from the Shizi Cave accounted for the highest proportion(49%),while chemical-fertilizer-derived nitrate in the underground water from the Mishui Cave accounted for the highest proportion(36%).The dualisotope signatures of nitrate supported a major influence on nitrogen dynamics in the cave underground from nitrification.These findings suggest that nitrate carried by underground rivers in karst caves should be alerted when making the nitrate balance in rivers flowing through karst areas.
基金supported by the National Natural Science Foundation of China(Nos.81873232 and 82074026)the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(No.ZYYCXTD-D-202209)。
文摘Guggulsterone(GS)is a bioactive compound primarily extracted from the oleo-gum resin of plants in the Commiphora and Boswellia genera.Modern pharmacological studies have demonstrated that GS possesses a broad spectrum of biological activities,with notable therapeutic potential in inflammatory disorders,neurodegenerative conditions,diabetes mellitus,and various cancers.In this review,we systematically analyzed relevant literature published up to 2024 from the CNKI,Web of Science,ScienceDirect,and PubMed databases to summarize the current understanding of GS's pharmacological effects,toxicity profile,and pharmacokinetic properties.The findings indicate that GS exerts potent antioxidant,anti-inflammatory,anticancer,antiviral,antidepressant,lipid-lowering,and cardiovascular protective effects,primarily through modulation of key signaling pathways such as the Janus kinase(JAK)-signal transducer and activator of transcription 3(STAT3),nuclear factor erythroid 2-related factor 2(Nrf2)/heme oxygenase-1(HO-1),Nrf2/Keap1,nuclear factor kappa-B(NF-κB),AMPK,phosphoinositide 3-kinase(PI3K)/protein kinase B(Akt),and mitogen-activated protein kinase(MAPK)/activator protein-1(AP-1).Additionally,GS may help overcome limitations associated with conventional chemotherapy by modulating drug resistance via regulation of p-glycoprotein activity.Following hepatic metabolism mediated by cytochrome P450 enzymes,GS does not appear to cause significant adverse effects.This review provides a comprehensive synthesis of the sources,pharmacological actions,safety,pharmacokinetics,and potential applications of GS.Future research should focus on structural modification of GS,development of novel formulations,and exploration of synergistic combinations with other therapeutic agents to broaden its clinical utility.
基金This study was supported by grants from the Innovation Foundation of Health and Family Planning Commission of Hubei Province （No. WJ2017M036） and the National Natural Science Foundation of China （No. 81471858）.
文摘The aim of the present study was to investigate the effect of lipoxin A4 （LXA4） pretreatment on cognitive function of aged rats after global cerebral ischemia reperfusion, and to explore its possible mechanism. Thirty-six aged male Sprague-Dawley rats were randomly divided into three groups （n=12 each）： sham-operation group （S group）, global cerebral ischemia reperfusion group （I/R group） and LXA4-pretreatment group （L group）. The rat model of global cerebral ischemia reperfusion was established by occlusion of the bilateral common carotid artery with hypotension. The cognitive function of rats was determined by a step-down type passive avoidance test and Morris Water Maze test on the third day after reperfusion. Rats were sacrificed after Water Maze test and the pathological changes ofhippocampal CA1 region were observed and the related inflammatory mediators were determined. As compared with S group, the escape latency in I/R group was prolonged from the first day to the fifth day, while that in L group was prolonged from the first day to the third day. The retention time in I/R group and L group in the first quadrant was shortened. The reaction time, frequency of reaction mistake and frequency of escape mistake in I/R group increased, and the latent period shortened. The frequency of escape mistake in L group increased, and the damage in the hippocampal CAI region of I/R group and L group was obvious. The levels of S-10013, TNF-α, IL-1β, IL-10 and NF-κB in I/R group and L group increased. As compared with I/R group, the escape latency in L group was shortened from the first day to the fifth day, and the retention time in the first quadrant prolonged. The reaction time, frequency of reaction mistake and frequency of escape mistake in L group decreased, and the latent period prolonged. The damage in the hippocampal CA1 region of L group was alleviated as well. The levels of S-10013, TNF-α, IL-1β and NF-κB in L group decreased, and those of IL-10 increased. It can be concluded that LXA4 pretreatment can improve the cognitive function in aged rats after global cerebral ischemia reperfusion probably by inhibiting the inflammatory reaction.
基金supported by the National Natural Science Foundation of China(Nos.21177027,41275126)the Science&Technology Commission of Shanghai Municipality(Nos.12DJ1400100,14XD1400600)the Jiangsu Provincial Collaborative Innovation Center of Climate Change
文摘Physical and chemical properties of ambient aerosols at the single particle level were studied in Shanghai from December 22 to 28, 2009. A Cavity-Ring-Down Aerosol Extinction Spectrometer（CRD-AES） and a nephelometer were deployed to measure aerosol light extinction and scattering properties, respectively. An Aerosol Time-of-Flight Mass Spectrometer（ATOFMS）was used to detect single particle sizes and chemical composition. Seven particle types were detected. Air parcels arrived at the sampling site from the vicinity of Shanghai until mid-day of December 25, when they started to originate from North China. The aerosol extinction,scattering, and absorption coefficients all dropped sharply when this cold, clean air arrived.Aerosol particles changed from a highly aged type before this meteorological shift to a relatively fresh type afterwards. The aerosol optical properties were dependent on the wind direction.Aerosols with high extinction coefficient and scattering Angstrom exponent（SAE） were observed when the wind blew from the west and northwest, indicating that they were predominantly fine particles. Nitrate and ammonium correlated most strongly with the change in aerosol optical properties. In the elemental carbon/organic carbon（ECOC） particle type, the diurnal trends of single scattering albedo（SSA） and elemental carbon（EC） signal intensity had a negative correlation. We also found a negative correlation（r =-0.87） between high mass-OC particle number fraction and the SSA in a relatively clean period, suggesting that particulate aromatic components might play an important role in light absorption in urban areas.
基金financially supported by the National Key Research and Development Plan,Ministry of Science and Technology of the People’s Republic of China(Grant No.2020YFC1908704)the Innovative Foundation of Huazhong University of Science and Technology(Grant No.2018KFYYXJJ133).
文摘Profound understanding on the diversity of local residents’willingness to pay(WTP)for ecosystem services(ESs)may aid evaluation of policy impacts by uncovering trade-offs and synergies for achieving sustainable environmental resource management.However,the reasons for the spatial preference heterogeneity of WTP are still unclear.In this study,an extensive survey with 4,580 residents in the Yangtze River Middle Reaches Megalopolis(YRMRM),central China,was carried out to investigate the public’s WTP to maintain and improve ESs.We identified key influencing factors and explored how they shaped the preference heterogeneity in WTP by random forest model and surface fitting method.Our results showed that 81.4% of residents reported WTP for ESs greater than zero.Water supply,waste treatment,food supply and raw material supply were the preferred ESs for residents.Living environment factors(i.e.,extent of farmland,water and forest near the residence)were found as the key drivers of WTP.Proximity to farmland,water and forests resulted in high WTP values for a series of specific ESs.The reasons for the heterogeneity of WTP are(1)the difference in proximity to farmland,water and forest(i.e.,the contributor to ESs),(2)the divergence of local residents’preferences for ESs.This study disclosed the heterogeneity and causes of public preferences in YRMRM,which could help policy and decision makers to develop eco-compensation initiatives towards conservative and sustainable use of the environmental resources.
基金Supported by the Chongqing Medical University Program for Youth Innovation in Future Medicine,No.W0019Chongqing Municipal Education Commission’s 14th Five-Year Key Discipline Support Project,No.20240101 and No.20240102。
文摘BACKGROUND Return to work(RTW)serves as an indication for young and middle-aged colorectal cancer(CRC)survivors to resume their normal social lives.However,these survivors encounter significant challenges during their RTW process.Hence,scientific research is necessary to explore the barriers and facilitating factors of returning to work for young and middle-aged CRC survivors.AIM To examine the current RTW status among young and middle-aged CRC survivors and to analyze the impact of RTW self-efficacy(RTW-SE),fear of progression(FoP),eHealth literacy(eHL),family resilience(FR),and financial toxicity(FT)on their RTW outcomes.METHODS A cross-sectional investigation was adopted in this study.From September 2022 to February 2023,a total of 209 participants were recruited through a convenience sampling method from the gastrointestinal surgery department of a class A tertiary hospital in Chongqing.The investigation utilized a general information questionnaire alongside scales assessing RTW-SE,FoP,eHL,FR,and FT.To analyze the factors that influence RTW outcomes among young and middle-aged CRC survivors,Cox regression modeling and Kaplan-Meier survival analysis were used.RESULTS A total of 43.54%of the participants successfully returned to work,with an average RTW time of 100 days.Cox regression univariate analysis revealed that RTW-SE,FoP,eHL,FR,and FT were significantly different between the non-RTW and RTW groups(P<0.05).Furthermore,Cox regression multivariate analysis identified per capita family monthly income,job type,RTW-SE,and FR as independent influencing factors for RTW(P<0.05).CONCLUSION The RTW rate requires further improvement.Elevated levels of RTW-SE and FR were found to significantly increase RTW among young and middle-aged CRC survivors.Health professionals should focus on modifiable factors,such as RTW-SE and FR,to design targeted RTW support programs,thereby facilitating their timely reintegration into mainstream society.
基金supported by Postdoc Fellowship from the Foundation for Angelman Syndrome Therapeutics(FT2022-005 to JM,PD2023-001 to XY,and FT2024-001 to YAH)STTR R41 MH118747(to JM)。
文摘Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and memory.The activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term potentiation.Postsynaptically,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term potentiation.In this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and depression.Treatment with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 isoform.Although TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific functions.Targeting TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.
文摘目的:探究火麻仁对SW620结肠癌细胞的抑制作用及其化学成分。方法:以RT-qPCR技术为检测手段,考察火麻仁乙醇提取液对结肠癌SW620细胞三磷酸腺苷家族蛋白2(ATPase family AAA domain-containing protein 2,ATAD2)基因表达水平的影响;采用超高效液相色谱/四级杆-静电场轨道阱质谱,分别对液相色谱流动相种类、柱温、梯度洗脱条件,质谱分辨率、喷雾电压等条件进行优化,对火麻仁乙醇提取液中的化学成分进行定性检测。结果:火麻仁乙醇提取液可抑制结肠癌SW620细胞ATAD2的基因表达;在火麻仁提取液中共定性检测到22个化学成分。结论:火麻仁乙醇提取液具有潜在的抗结肠癌活性,其潜在活性成分包括脂肪酸类、黄酮类及生物碱类。
基金supported by grants from the National Natural Science Foundation of China(91959203,82272836 and 82373017)。
文摘Background:The high recurrent rate after surgery hinders the survival of patients with hepatocellular carcinoma(HCC).This prospective cohort study aimed to evaluate the efficacy and safety of lenvatinib plus transarterial chemoembolization(TACE)as an adjuvant therapy in HCC patients with high risk of recurrence.Methods:Patients were enrolled from eight hepatobiliary centers in China.The primary endpoint was disease-free survival(DFS).The secondary endpoints were overall survival(OS)and safety.Additionally,propensity score matching(PSM)and other three propensity score analyses were performed to balance the potential baseline bias to validate the conclusion.The adverse events(AEs)were recorded throughout the study.The study was registered at Clinical Trials.gov(NCT03838796).Results:A total of 297 patients were enrolled,with 147 in the LEN+TACE group and 150 in the TACE group.Before PSM,the LEN+TACE group achieved significantly better DFS than the TACE group(19.0 vs.10.0 months,P=0.011).PSM analysis identified 111 matched pairs.After PSM,the LEN+TACE group also showed better DFS(19.0 vs.9.0 months,P=0.018).Other three propensity score analyses yielded similar DFS benefit tendency.Furthermore,favorable OS was also obtained in the LEN+TACE group before PSM.Lenvatinib related AEs of grade 3 or 4 occurred in 28.6%of the patients in the LEN+TACE group.Conclusions:Adjuvant lenvatinib plus TACE might be a promising adjuvant approach for HCC patients with high risk of recurrence,which could significantly prolong DFS and potentially OS with a manageable safety profile.
