Two new glutarimide derivatives,2-hydroxy-3-[2-(2-hydroxy-3-methylphenyl-5-hydroxymethyl)-2-oxoethyl]glutarimide(1)and 2-hydroxy-3-[2-[2-hydroxy-3-hydroxymethyl-5-methylphenyl]-2-oxoethyl]glutarimide(2),along with 8 k...Two new glutarimide derivatives,2-hydroxy-3-[2-(2-hydroxy-3-methylphenyl-5-hydroxymethyl)-2-oxoethyl]glutarimide(1)and 2-hydroxy-3-[2-[2-hydroxy-3-hydroxymethyl-5-methylphenyl]-2-oxoethyl]glutarimide(2),along with 8 known compounds were isolated from the liquid fermentation broth of endophytic Streptomyces sp.YINM00048 obtained from Agrimonia pilosa.Their structures were elucidated through comprehensive spectroscopic analysis,including nuclear magnetic resonance,high-resolution mass spectrometry,and single-crystal X-ray diffraction,supported by time-dependent density functional theory(TDDFT)-electronic circular dichroism(ECD)calculations.Furthermore,compound 2 displayed weak cytotoxic activity against A549 and SMMC-7721 cell lines with IC50 values of 62.69 and 55.07μmol/L,respectively.展开更多
文摘Two new glutarimide derivatives,2-hydroxy-3-[2-(2-hydroxy-3-methylphenyl-5-hydroxymethyl)-2-oxoethyl]glutarimide(1)and 2-hydroxy-3-[2-[2-hydroxy-3-hydroxymethyl-5-methylphenyl]-2-oxoethyl]glutarimide(2),along with 8 known compounds were isolated from the liquid fermentation broth of endophytic Streptomyces sp.YINM00048 obtained from Agrimonia pilosa.Their structures were elucidated through comprehensive spectroscopic analysis,including nuclear magnetic resonance,high-resolution mass spectrometry,and single-crystal X-ray diffraction,supported by time-dependent density functional theory(TDDFT)-electronic circular dichroism(ECD)calculations.Furthermore,compound 2 displayed weak cytotoxic activity against A549 and SMMC-7721 cell lines with IC50 values of 62.69 and 55.07μmol/L,respectively.
