Preliminary studies showed that the inducible form of heme exygenase-1 (HO-1) was induced and played a protective role in the process of inflammation. The present study aimed to investigate the possible role of HO-1 i...Preliminary studies showed that the inducible form of heme exygenase-1 (HO-1) was induced and played a protective role in the process of inflammation. The present study aimed to investigate the possible role of HO-1 in acetic acid-induced gastric mucosa damage in rats. HO-1 mRNA and protein expressions were determined at 1 day, 3 days, and 7 days after ulceration by RT-PCR and western blotting, respectively. The severity of ulcer was assessed by ulcer area. Inducible nitric oxide synthase (iNOS) which are involved in oxidative injury were also measured. HO-1 gene expression in gastric mucosa was markedly increased after luminal application of an acetic acid solution.展开更多
Sleep deprivation as a stress has been shown to induce gastric mucosal lesions and lowered the effectiveness of the mucosa as a barrier. The precise mechanism of how sleep deprivation to affect the gastric mucosa barr...Sleep deprivation as a stress has been shown to induce gastric mucosal lesions and lowered the effectiveness of the mucosa as a barrier. The precise mechanism of how sleep deprivation to affect the gastric mucosa barrier, especially at the molecular level, still remains unclear. To identify genes with relevance to sleep deprivation, a cDNA expression array analysis was performed on 588 cDNA clones on a filter to screen for genes with differential expression between the gastric mucosa of sleep deprivation and normal control rats.展开更多
文摘Preliminary studies showed that the inducible form of heme exygenase-1 (HO-1) was induced and played a protective role in the process of inflammation. The present study aimed to investigate the possible role of HO-1 in acetic acid-induced gastric mucosa damage in rats. HO-1 mRNA and protein expressions were determined at 1 day, 3 days, and 7 days after ulceration by RT-PCR and western blotting, respectively. The severity of ulcer was assessed by ulcer area. Inducible nitric oxide synthase (iNOS) which are involved in oxidative injury were also measured. HO-1 gene expression in gastric mucosa was markedly increased after luminal application of an acetic acid solution.
文摘Sleep deprivation as a stress has been shown to induce gastric mucosal lesions and lowered the effectiveness of the mucosa as a barrier. The precise mechanism of how sleep deprivation to affect the gastric mucosa barrier, especially at the molecular level, still remains unclear. To identify genes with relevance to sleep deprivation, a cDNA expression array analysis was performed on 588 cDNA clones on a filter to screen for genes with differential expression between the gastric mucosa of sleep deprivation and normal control rats.
