目的探讨微小RNA(miRNA)在股骨头坏死(ONFH)中的治疗潜力。方法以"微小RNA""股骨头坏死""治疗"及"miRNA""osteonecrosis of the femoral head""treatment"等为中、英文关...目的探讨微小RNA(miRNA)在股骨头坏死(ONFH)中的治疗潜力。方法以"微小RNA""股骨头坏死""治疗"及"miRNA""osteonecrosis of the femoral head""treatment"等为中、英文关键词,分别在中华医学期刊全文数据库、中国知网、万方数据、PubMed等数据库中检索2025年3月之前公开发表的相关文献。排除研究主题不符、重复、质量不高及无法获取全文的文献,最终纳入52篇文献(中文文献5篇、英文文献47篇)进行归纳总结。结果miRNA通过多靶点、多通路作用于ONFH:miR-27a、miR-214、miR-29a等调控成骨-破骨细胞平衡,miR-27a、miR-26a、外泌体miR-150等抑制骨细胞及成骨细胞凋亡,miR-122-5p、外泌体miR-210等促进血管新生,miR-200b-3p、miR-206等调控细胞自噬,巨噬细胞来源,外泌体miR-122、miR-1a-3p等调节免疫微环境。基于miRNA的靶向策略(如外泌体递送、抗miRNA寡核苷酸、纳米载体)在ONFH治疗中展现出潜力,但面临递送效率、靶向性及个体化差异等临床转化瓶颈。结论miRNA通过多靶点调控骨代谢、血管生成、细胞凋亡、自噬及免疫反应,为ONFH的精准靶向治疗提供了新思路。克服递送技术瓶颈、优化靶向策略并推进个体化治疗是未来研究的关键方向。展开更多
In order to estimate the sound intensity level of vertical transmit array(VTA)from that of single transducer,a fast estimation method of transmit array gain(TAG)in Pekeris waveguide is studied.At first,the average sou...In order to estimate the sound intensity level of vertical transmit array(VTA)from that of single transducer,a fast estimation method of transmit array gain(TAG)in Pekeris waveguide is studied.At first,the average sound intensity of VTA is calculated on the basis of normal mode theory with the effective depth,and the TAG expressed by the summation of modes is derived.Then by using integral,instead of summation,of modes order,the fast estimation expression of TAG in 3/2 power field is derived along with error correction.Because only the first mode exists in effective shadow zone(ESZ),the fast estimation expression of TAG in ESZ is derived by directly simplifying the former expression.All of the fast estimation errors of computer simulations and experiment in shallow water are less than 1 dB,which can verify the validity of the fast estimation method.This fast estimation method of TAG can provide references for practical application.展开更多
Prom investigation of the advantages and disadvantages of conventional tri-voltage method,a method for the measurement of the transmitting transducer＇s impedance was presented to solve the difficult problem of examin...Prom investigation of the advantages and disadvantages of conventional tri-voltage method,a method for the measurement of the transmitting transducer＇s impedance was presented to solve the difficult problem of examining the consistency of the transmitting phased array on the single-mode excitation sea spot.In the method based on the system function, the circuit structure of tri-voltage method was used but new parameters were measured.The principle of the method was given first.Then when resistors with different nominal values were used in the circuit,the measured results for the impedance of transducers were reported.The results were compared with the higher precision impedance analyzer.Finally,the error analysis was performed according to the impedance formula and the equivalent circuit parameters were fitted.Under the condition of guaranteeing the sampling precision,by performance analyzing, the resistor value in series was chosen relatively smaller than the impedance of transducer,the measurement of impedance could achieve the same precision as the higher precision impedance analyzer.Finally,the least squares curve-fitting of measured curves indicated that the transducer equivalent electrical parameters could be extracted accurately and used to design the matching network.展开更多
文摘目的探讨微小RNA(miRNA)在股骨头坏死(ONFH)中的治疗潜力。方法以"微小RNA""股骨头坏死""治疗"及"miRNA""osteonecrosis of the femoral head""treatment"等为中、英文关键词,分别在中华医学期刊全文数据库、中国知网、万方数据、PubMed等数据库中检索2025年3月之前公开发表的相关文献。排除研究主题不符、重复、质量不高及无法获取全文的文献,最终纳入52篇文献(中文文献5篇、英文文献47篇)进行归纳总结。结果miRNA通过多靶点、多通路作用于ONFH:miR-27a、miR-214、miR-29a等调控成骨-破骨细胞平衡,miR-27a、miR-26a、外泌体miR-150等抑制骨细胞及成骨细胞凋亡,miR-122-5p、外泌体miR-210等促进血管新生,miR-200b-3p、miR-206等调控细胞自噬,巨噬细胞来源,外泌体miR-122、miR-1a-3p等调节免疫微环境。基于miRNA的靶向策略(如外泌体递送、抗miRNA寡核苷酸、纳米载体)在ONFH治疗中展现出潜力,但面临递送效率、靶向性及个体化差异等临床转化瓶颈。结论miRNA通过多靶点调控骨代谢、血管生成、细胞凋亡、自噬及免疫反应,为ONFH的精准靶向治疗提供了新思路。克服递送技术瓶颈、优化靶向策略并推进个体化治疗是未来研究的关键方向。
基金supported by the National Natural Science Foundation of China(Y211071131,11704396)。
文摘In order to estimate the sound intensity level of vertical transmit array(VTA)from that of single transducer,a fast estimation method of transmit array gain(TAG)in Pekeris waveguide is studied.At first,the average sound intensity of VTA is calculated on the basis of normal mode theory with the effective depth,and the TAG expressed by the summation of modes is derived.Then by using integral,instead of summation,of modes order,the fast estimation expression of TAG in 3/2 power field is derived along with error correction.Because only the first mode exists in effective shadow zone(ESZ),the fast estimation expression of TAG in ESZ is derived by directly simplifying the former expression.All of the fast estimation errors of computer simulations and experiment in shallow water are less than 1 dB,which can verify the validity of the fast estimation method.This fast estimation method of TAG can provide references for practical application.
基金supported by the National Natural Science Foundation of China(11004214,10574137)
文摘Prom investigation of the advantages and disadvantages of conventional tri-voltage method,a method for the measurement of the transmitting transducer＇s impedance was presented to solve the difficult problem of examining the consistency of the transmitting phased array on the single-mode excitation sea spot.In the method based on the system function, the circuit structure of tri-voltage method was used but new parameters were measured.The principle of the method was given first.Then when resistors with different nominal values were used in the circuit,the measured results for the impedance of transducers were reported.The results were compared with the higher precision impedance analyzer.Finally,the error analysis was performed according to the impedance formula and the equivalent circuit parameters were fitted.Under the condition of guaranteeing the sampling precision,by performance analyzing, the resistor value in series was chosen relatively smaller than the impedance of transducer,the measurement of impedance could achieve the same precision as the higher precision impedance analyzer.Finally,the least squares curve-fitting of measured curves indicated that the transducer equivalent electrical parameters could be extracted accurately and used to design the matching network.
