目的:探讨血清Hsa_circ_0053881水平对类风湿关节炎(RA)患者的诊断价值及其与疾病严重程度的相关性。方法:选取RA患者117例(RA组)、骨关节炎(OA)患者60例(OA组)和健康对照者50例(对照组)作为研究对象。117例RA患者根据CRP的28个关节疾...目的:探讨血清Hsa_circ_0053881水平对类风湿关节炎(RA)患者的诊断价值及其与疾病严重程度的相关性。方法:选取RA患者117例(RA组)、骨关节炎(OA)患者60例(OA组)和健康对照者50例(对照组)作为研究对象。117例RA患者根据CRP的28个关节疾病活动性评分(DAS28-CRP)分为低活动组53例(DAS28评分≤3.2)、中度活动组34例(3.25.1)。根据RA患者骨侵蚀和骨破坏的程度分为非骨侵蚀组75例和骨侵蚀组42例。比较各组血清Hsa_circ_0053881及类风湿因子(RF)、抗环瓜氨酸肽(CCP)抗体水平。应用ROC曲线分析Hsa_circ_0053881联合RF及抗CCP抗体对RA的诊断价值,相关性分析采用Spearman相关。结果:RA组血清Hsa_circ_0053881(2.35±0.83 vs 0.93±0.18,0.84±0.10)及RF(106.40 vs 22.17,15.83) U/ml、抗CCP抗体(116.58 vs 5.82,2.50) RU/ml、ESR(40.27±12.41 vs13.92±4.63,11.47±2.50) mm/h、CRP(21.36±7.90 vs 7.10±2.38,4.82±1.26) mg/L、TNF-α(130.65±48.20 vs 88.92±21.75,52.60±14.53) ng/L、IL-6(49.84±13.90 vs 20.36±7.81,5.70±1.61) ng/L水平均明显高于OA组和对照组(P<0.001)。RA患者活动度越高,血清Hsa_circ_0053881及RF、抗CCP抗体水平越高,高活动组>中活动组>低活动组(P<0.001)。骨侵蚀组血清Hsa_circ_0053881(3.08±0.91 vs 1.69±0.42)及RF(151.20 vs 71.34) U/ml、抗CCP抗体(169.42 vs 68.35) RU/ml水平均明显高于非骨侵蚀组(P<0.001)。ROC曲线分析显示,血清Hsa_circ_0053881水平≥1.65诊断RA的特异度最高(83.8%),Hsa_circ_0053881联合RF及抗CCP抗体诊断RA的曲线下面积(AUC)最大(0.905,95%CI:0.842~0.968),准确度为91.0%。相关性分析显示,RA患者血清Hsa_circ_0053881水平与RF、抗CCP抗体、CRP、TNF-α、IL-6、肿胀关节数、压痛关节数、Sharp评分及DAS28评分均呈正相关(P<0.05)。结论:血清Hsa_circ_0053881水平在RA患者中明显升高,其高表达与疾病活动度及进展有关,Hsa_circ_0053881联合RF及抗CCP抗体对RA诊断有较好的价值。展开更多
Based on the previous research on the model of rainstorm weather with low-level jet in Xiangtan,using the classification result of radar echo characteristics,the wind profile data provided by new generation of weather...Based on the previous research on the model of rainstorm weather with low-level jet in Xiangtan,using the classification result of radar echo characteristics,the wind profile data provided by new generation of weather radar in Changsha and hourly rainfall data,a thorough study of the heavy rainfall from 2 to 5 July 2016 in Xiangtan was conducted. It was concluded that heavy precipitation had the characteristics of the WPSH pattern of rainstorm with low-level jet at early stage,and then it converted to cold shear jet pattern in latter stage. When low-level southwest jet began to have momentum download,that is to say,there was more than 12 m/s of southwest jet below 1 km,and it rapidly strengthened and expanded downward,it was conducive to the occurrence of short-term rainstorm. The low-level jet would not immediately cause a strong precipitation when it reached the station,with a certain lag. A positive correlation existed between the increase of low-level jet index and precipitation intensity,and low-level jet index could predict the occurrence of heavy rainfall and rain intensity.展开更多
文摘目的:探讨血清Hsa_circ_0053881水平对类风湿关节炎(RA)患者的诊断价值及其与疾病严重程度的相关性。方法:选取RA患者117例(RA组)、骨关节炎(OA)患者60例(OA组)和健康对照者50例(对照组)作为研究对象。117例RA患者根据CRP的28个关节疾病活动性评分(DAS28-CRP)分为低活动组53例(DAS28评分≤3.2)、中度活动组34例(3.25.1)。根据RA患者骨侵蚀和骨破坏的程度分为非骨侵蚀组75例和骨侵蚀组42例。比较各组血清Hsa_circ_0053881及类风湿因子(RF)、抗环瓜氨酸肽(CCP)抗体水平。应用ROC曲线分析Hsa_circ_0053881联合RF及抗CCP抗体对RA的诊断价值,相关性分析采用Spearman相关。结果:RA组血清Hsa_circ_0053881(2.35±0.83 vs 0.93±0.18,0.84±0.10)及RF(106.40 vs 22.17,15.83) U/ml、抗CCP抗体(116.58 vs 5.82,2.50) RU/ml、ESR(40.27±12.41 vs13.92±4.63,11.47±2.50) mm/h、CRP(21.36±7.90 vs 7.10±2.38,4.82±1.26) mg/L、TNF-α(130.65±48.20 vs 88.92±21.75,52.60±14.53) ng/L、IL-6(49.84±13.90 vs 20.36±7.81,5.70±1.61) ng/L水平均明显高于OA组和对照组(P<0.001)。RA患者活动度越高,血清Hsa_circ_0053881及RF、抗CCP抗体水平越高,高活动组>中活动组>低活动组(P<0.001)。骨侵蚀组血清Hsa_circ_0053881(3.08±0.91 vs 1.69±0.42)及RF(151.20 vs 71.34) U/ml、抗CCP抗体(169.42 vs 68.35) RU/ml水平均明显高于非骨侵蚀组(P<0.001)。ROC曲线分析显示,血清Hsa_circ_0053881水平≥1.65诊断RA的特异度最高(83.8%),Hsa_circ_0053881联合RF及抗CCP抗体诊断RA的曲线下面积(AUC)最大(0.905,95%CI:0.842~0.968),准确度为91.0%。相关性分析显示,RA患者血清Hsa_circ_0053881水平与RF、抗CCP抗体、CRP、TNF-α、IL-6、肿胀关节数、压痛关节数、Sharp评分及DAS28评分均呈正相关(P<0.05)。结论:血清Hsa_circ_0053881水平在RA患者中明显升高,其高表达与疾病活动度及进展有关,Hsa_circ_0053881联合RF及抗CCP抗体对RA诊断有较好的价值。
基金Supported by Forecasters' Special Project of Hunan Meteorological Bureau in 2016(XQKJ16C003)
文摘Based on the previous research on the model of rainstorm weather with low-level jet in Xiangtan,using the classification result of radar echo characteristics,the wind profile data provided by new generation of weather radar in Changsha and hourly rainfall data,a thorough study of the heavy rainfall from 2 to 5 July 2016 in Xiangtan was conducted. It was concluded that heavy precipitation had the characteristics of the WPSH pattern of rainstorm with low-level jet at early stage,and then it converted to cold shear jet pattern in latter stage. When low-level southwest jet began to have momentum download,that is to say,there was more than 12 m/s of southwest jet below 1 km,and it rapidly strengthened and expanded downward,it was conducive to the occurrence of short-term rainstorm. The low-level jet would not immediately cause a strong precipitation when it reached the station,with a certain lag. A positive correlation existed between the increase of low-level jet index and precipitation intensity,and low-level jet index could predict the occurrence of heavy rainfall and rain intensity.
