Three copper(Ⅱ),nickel and cadmium(Ⅱ)complexes,namely[Cu_(2)(μ-H2dbda)2(phen)2]·2H_(2)O(1),[Ni(μ-H2dbda)(μ-bpb)(H_(2)O)2]n(2),and[Cd(μ-H2dbda)(μ-bpa)]n(3),have been constructed hydrothermally using H4dbda(...Three copper(Ⅱ),nickel and cadmium(Ⅱ)complexes,namely[Cu_(2)(μ-H2dbda)2(phen)2]·2H_(2)O(1),[Ni(μ-H2dbda)(μ-bpb)(H_(2)O)2]n(2),and[Cd(μ-H2dbda)(μ-bpa)]n(3),have been constructed hydrothermally using H4dbda(4,4'-dihydroxy-[1,1'-biphenyl]-3,3'-dicarboxylic acid),phen(1,10-phenanthroline),bpb(1,4-bis(pyrid-4-yl)benzene),bpa(bis(4-pyridyl)amine),and copper,nickel and cadmium chlorides at 160℃.The products were isolated as stable crystalline solids and were characterized by IR spectra,elemental analyses,thermogravimetric analyses,and singlecrystal X-ray diffraction analyses.Single-crystal X-ray diffraction analyses revealed that three complexes crystallize in the monoclinic P21/n,tetragonal I42d,and orthorhombic P21212 space groups.The complexes exhibit molecular dimers(1)or 2D metal-organic networks(2 and 3).The catalytic performances in the Knoevenagel reaction of these complexes were investigated.Complex 1 exhibits an effective catalytic activity and excellent reusability as a heterogeneous catalyst in the Knoevenagel reaction at room temperature.CCDC:2463800,1;2463801,2;2463802,3.展开更多
With the approval of more and more genetically modified(GM)crops in our country,GM safety management has become more important.Transgenic detection is a major approach for transgenic safety management.Nevertheless,a c...With the approval of more and more genetically modified(GM)crops in our country,GM safety management has become more important.Transgenic detection is a major approach for transgenic safety management.Nevertheless,a convenient and visual technique with low equipment requirements and high sensitivity for the field detection of GM plants is still lacking.On the basis of the existing recombinase polymerase amplification(RPA)technique,we developed a multiplex RPA(multi-RPA)method that can simultaneously detect three transgenic elements,including the cauliflower mosaic virus 35S gene(CaMV35S)promoter,neomycin phosphotransferaseⅡgene(NptⅡ)and hygromycin B phosphotransferase gene(Hyg),thus improving the detection rate.Moreover,we coupled this multi-RPA technique with the CRISPR/Cas12a reporter system,which enabled the detection results to be clearly observed by naked eyes under ultraviolet(UV)light(254 nm;which could be achieved by a portable UV flashlight),therefore establishing a multi-RPA visual detection technique.Compared with the traditional test strip detection method,this multi-RPA-CRISPR/Cas12a technique has the higher specificity,higher sensitivity,wider application range and lower cost.Compared with other polymerase chain reaction(PCR)techniques,it also has the advantages of low equipment requirements and visualization,making it a potentially feasible method for the field detection of GM plants.展开更多
The Upper Cretaceous of Tantou Basin in western Henan has yielded many vertebrate fossils,which are featured by several non-avian dinosaurs.Meanwhile,studies on their eggs were yet inadequate though many eggshells hav...The Upper Cretaceous of Tantou Basin in western Henan has yielded many vertebrate fossils,which are featured by several non-avian dinosaurs.Meanwhile,studies on their eggs were yet inadequate though many eggshells have been reported.The newly discovered material 41HⅤ0199 was excavated from the Upper Cretaceous Qiupa Formation in 2021.The block preserves eight complete eggs arranged in two partial rings that form a partial clutch,and there are some scattered eggshells preserved closely with the block,showing a concave-up to concave-down ratio of 54.5:45.5,which indicates that the scattered eggshells come from the clutch and the clutch had been partially broken before it was buried.Based on morphological and microstructural characteristics,the eggs and eggshells can be assigned to Macroolithus yaotunensis(Elongatoolithidae),an oospecies known to be related to oviraptorids,which leads Yulong mini to be its probable producer.Besides,some eggshells show microstructural signs indicating egg retention,which marks the second example of egg retention in the oofamily Elongatoolithidae.展开更多
During strike-slip fault dislocation,multiple fault planes are commonly observed.The resulting permanent ground deformation can lead to profound structural damage to tunnels.However,existing analytical models do not c...During strike-slip fault dislocation,multiple fault planes are commonly observed.The resulting permanent ground deformation can lead to profound structural damage to tunnels.However,existing analytical models do not consider multiple fault planes.Instead,they concentrate the entire fault displacement onto a single fault plane for analysis,thereby giving rise to notable errors in the calculated results.To address this issue,a refined nonlinear theoretical model was established to analyze the mechanical responses of the tunnels subjected to multiple strike-slip fault dislocations.The analytical model considers the number of fault planes,nonlinear soil‒tunnel interactions,geometric nonlinearity,and fault zone width,leading to a significant improvement in its range of applicability and calculation accuracy.The results of the analytical model are in agreement,both qualitatively and quantitatively,with the model test and numerical results.Then,based on the proposed theoretical model,a sensitivity analysis of parameters was conducted,focusing on the variables such as the number of fault planes,fault plane distance(d),fault displacement ratio(η),burial depth(C),crossing angle(β),tunnel diameter(D),fault zone width(Wf),and strike-slip fault displacement(Δfs).The results show that the peak shear force(Vmax),bending moment(Mmax),and axial force(Nmax)decrease with increasing d.The Vmax of the tunnel is found at the fault plane with the largest fault displacement.C,D,andΔfs contribute to the increases in Vmax,Mmax,and Nmax.Additionally,increasing the number of fault planes reduces Vmax and Mmax,whereas the variation in Nmax remains minimal.展开更多
Mercury ions(Hg^(2+))and bacteria are widely spread in water pollution and pose a great threat to human health and the environment.Herein,a multifunctional COF Dmta Tph with significant Hg^(2+)adsorption capability an...Mercury ions(Hg^(2+))and bacteria are widely spread in water pollution and pose a great threat to human health and the environment.Herein,a multifunctional COF Dmta Tph with significant Hg^(2+)adsorption capability and continuous sunlight-driven sterilization property is designed and synthesized by introducing thioether and photosensitive porphyrin in a single molecule.The obtained COF displays a high Hg^(2+)adsorption capacity of 657.9 mg/g at 298 K and a superior antibacterial effect toward Escherichia coli and Staphylococcus aureus under sunlight irradiation.Mechanistic studies reveal that the strong coordination between S species and Hg^(2+)is the main driving force for high Hg^(2+)adsorption capability.The sterilization mechanism clarifies that the inactivation of bacteria is caused by1O_(2)produced from Dmta Tph with the assistance of light irradiation.Noteworthy,when Dmta Tph is applied in the treatment of wastewater,it displays high Hg^(2+)removal efficiency and remarkable antibacterial effect under complex conditions.This study has demonstrated a promising strategy for designing multifunctional COF-based materials,offering great potential in tackling the problem of heavy metal ions and bacteria pollution in water.展开更多
The origins of peloidal micrites in reefal limestone are not yet well understood.Moscovian microbial reefs with abundant peloidal micrites from Guizhou,South China,provide an opportunity to study the peloids and their...The origins of peloidal micrites in reefal limestone are not yet well understood.Moscovian microbial reefs with abundant peloidal micrites from Guizhou,South China,provide an opportunity to study the peloids and their geological significance for this time interval.Three types of peloids are differentiated:microbial,lithic,and bioclastic peloids.Microbial peloids that are well-sorted and may form in situ by microbial activities.The poorly sorted lithic peloids are derived from erosion and redeposition of the micrite matrix caused by the bottom turbulence induced by periodic storms.Bioclastic peloids are completely micritized fragments of hard parts and shells.Microbial boring and encrustations promote the processes of micritization.Microbial peloids commonly develop in zones with low or normal energy levels,and contribute to the construction and stabilization of the framework.In contrast,the occurrence of lithic peloids reflects that the reefs are destroyed by bottom turbulence during growth.It is suggested that the microbial reefs were deposited under a dynamic balance between constructional versus destructive processes.By comparative analysis,the peloids as microbial in origin play a key role in the growth and stabilization of bioconstructions during Carboniferous,which should be paid more attention in the studies of Carboniferous buildups.展开更多
This study proposes a framework for the concept of“new quality productive forces”in the ice and snow economy(ISE)as a strategic response to global climate change and the demands of technological and industrial trans...This study proposes a framework for the concept of“new quality productive forces”in the ice and snow economy(ISE)as a strategic response to global climate change and the demands of technological and industrial transformation for high-quality development.These new quality productive forces in the ISE have developed alongside the zonal distribution of natural resources,strictly adhere to ecological principles,and integrate value transformation mechanisms specific to ice and snow resources.Their development is projected to generate multiple benefits across ecological,economic,and social dimensions.The new quality productive forces in the ISE are characterized by technology-driven resource development,synergistic integration across the entire ice and snow industry value chain,and a focus on high-quality,green growth.Grounded in geography and economics,the new quality productive forces in the ISE link scientific innovation,the reallocation of productive factors,and industrial upgrading within the context of resource constraints.Furthermore,they expand the growth potential of the ISE by fostering new production relations through digital,intelligent,and green integration,while advancing low-carbon,sustainable development under the guiding principle that“ice and snow landscapes are also mountains of gold and silver.”For China's ISE,these new quality productive forces emphasize rigorous resource protection,balanced human-environment relationships,a resilient integrated supply chain framework,and an efficient“dual circulation”economic model.Practical strategies include integrating production factors,optimizing spatial resource allocation,fostering industrial synergy,and adapting production relations,all aimed at advancing the sustainable and high-quality development of China's ISE.展开更多
Flax(Linum usitatissimum L.)is an important oil crop in the high-altitude arid regions of China.Flaxseed is rich in various nutrients.However,the nutritional qualities of flaxseeds from different producing areas are s...Flax(Linum usitatissimum L.)is an important oil crop in the high-altitude arid regions of China.Flaxseed is rich in various nutrients.However,the nutritional qualities of flaxseeds from different producing areas are still unclear.In this study,the nutritional characteristics of flaxseed from five producing areas in China were investigated.Twenty five nutritional quality indices in flaxseed were analyzed.Subsequently,chemometric methods,including cluster analysis,principal component analysis(PCA)and partial least square discriminant analysis(PLS-DA),were employed to discover the characteristics of nutritional qualities in flaxseeds.The results revealed there are significant differences in nutritional qualities among flaxseeds from different production areas.Six quality indices includingγ-tocopherol,vitamin E,phytosterols,oleic acid,α-linolenic acid,and cycloartenol were susceptible to producing area.In detail,the superiorcharacteristic nutrients of Ningxia flaxseed,Inner Mongolia flaxseed and Hebei flaxseed are vitamin E(17.3 mg/100g),α-linolenic acid(52.6%)and cycloartenol(1738.1 mg/kg),and phytosterols(3032.0 mg/kg),respectively.This study promotes the high-value development and utilization of local flaxseed industry.展开更多
Objective:To explore the application value of a machine learning-based prediction model in assessing the prognosis of septic children in the pediatric intensive care unit(PICU)and provide data support for clinical dec...Objective:To explore the application value of a machine learning-based prediction model in assessing the prognosis of septic children in the pediatric intensive care unit(PICU)and provide data support for clinical decision-making.Methods:A total of 180 septic children admitted to the PICU of a tertiary hospital from January 2020 to December 2024 were selected.They were divided into a control group(90 cases,using traditional scoring methods to predict prognosis)and an observation group(90 cases,using a multivariable model based on machine learning algorithms to predict prognosis)according to the random number table method.General information,laboratory indicators,and clinical interventions were collected.Various models such as Random Forest(RF),Support Vector Machine(SVM),and Logistic Regression(LR)were established.The model performance was evaluated using ROC curve,AUC value,accuracy,sensitivity,and specificity.Results:The machine learning models performed better than traditional scoring methods in predicting the 28-day mortality rate of septic children.Among them,the RF model achieved an AUC value of 0.921,a sensitivity of 85.6%,and a specificity of 88.1%,which were significantly higher than the PIM3 score(AUC 0.762).The prediction accuracy and timeliness of clinical intervention in the observation group were significantly improved,leading to a shortened hospital stay and reduced mortality rate(p<0.05).Conclusion:The prediction model based on machine learning can more accurately assess the prognostic risk of septic children in PICU,showing good clinical application prospects and providing references for individualized treatment and optimal resource allocation.展开更多
BACKGROUND Stroke is a leading cause of long-term disability worldwide,and limb motor dysfunction is one of the most common complications affecting the quality of life of patients.AIM To investigate the rehabilitation...BACKGROUND Stroke is a leading cause of long-term disability worldwide,and limb motor dysfunction is one of the most common complications affecting the quality of life of patients.AIM To investigate the rehabilitation effects of conventional rehabilitation training combined with electromyographic biofeedback therapy on limb motor dysfunction in stroke survivors.METHODS This observational retrospective cohort study included 60 stroke survivors who underwent post-stroke rehabilitation training in the rehabilitation department of Qilu Hospital of Shandong University(Qingdao)from May 2023 to July 2024.The medical records of the patients were assessed.Eligible patients(N=60)were divided into two groups on the basis of the type of rehabilitation training received:Conventional rehabilitation alone(control group,n=30)and conventional rehabilitation combined with electromyographic biofeedback therapy(biofeedback group,n=30).Upper and lower limb motor function,wrist extension,balance ability,and ankle dorsiflexion range of motion were evaluated before treatment and at 4 weeks and 8 weeks post-treatment by reviewing the patients’electronic medical records.RESULTS At 4 weeks and 8 weeks post-treatment,the biofeedback group showed significantly better Fugl-Meyer assessment scores,Hospital Anxiety and Depression Scale scores,Hamilton Depression Rating Scale scores,Hamilton Anxiety Rating Scale scores,and wrist and ankle active range of motion scores than the control group.CONCLUSION Electromyographic biofeedback therapy combined with conventional rehabilitation can effectively improve upper and lower limb motor function,balance ability,activities of daily living,wrist extension,and ankle dorsiflexion dysfunction in patients post-stroke,with better efficacy than conventional rehabilitation alone.展开更多
文摘Three copper(Ⅱ),nickel and cadmium(Ⅱ)complexes,namely[Cu_(2)(μ-H2dbda)2(phen)2]·2H_(2)O(1),[Ni(μ-H2dbda)(μ-bpb)(H_(2)O)2]n(2),and[Cd(μ-H2dbda)(μ-bpa)]n(3),have been constructed hydrothermally using H4dbda(4,4'-dihydroxy-[1,1'-biphenyl]-3,3'-dicarboxylic acid),phen(1,10-phenanthroline),bpb(1,4-bis(pyrid-4-yl)benzene),bpa(bis(4-pyridyl)amine),and copper,nickel and cadmium chlorides at 160℃.The products were isolated as stable crystalline solids and were characterized by IR spectra,elemental analyses,thermogravimetric analyses,and singlecrystal X-ray diffraction analyses.Single-crystal X-ray diffraction analyses revealed that three complexes crystallize in the monoclinic P21/n,tetragonal I42d,and orthorhombic P21212 space groups.The complexes exhibit molecular dimers(1)or 2D metal-organic networks(2 and 3).The catalytic performances in the Knoevenagel reaction of these complexes were investigated.Complex 1 exhibits an effective catalytic activity and excellent reusability as a heterogeneous catalyst in the Knoevenagel reaction at room temperature.CCDC:2463800,1;2463801,2;2463802,3.
基金the Experimental Technology Research Project of Zhejiang University(SYB202138)National Natural Science Foundation of China(32000195)。
文摘With the approval of more and more genetically modified(GM)crops in our country,GM safety management has become more important.Transgenic detection is a major approach for transgenic safety management.Nevertheless,a convenient and visual technique with low equipment requirements and high sensitivity for the field detection of GM plants is still lacking.On the basis of the existing recombinase polymerase amplification(RPA)technique,we developed a multiplex RPA(multi-RPA)method that can simultaneously detect three transgenic elements,including the cauliflower mosaic virus 35S gene(CaMV35S)promoter,neomycin phosphotransferaseⅡgene(NptⅡ)and hygromycin B phosphotransferase gene(Hyg),thus improving the detection rate.Moreover,we coupled this multi-RPA technique with the CRISPR/Cas12a reporter system,which enabled the detection results to be clearly observed by naked eyes under ultraviolet(UV)light(254 nm;which could be achieved by a portable UV flashlight),therefore establishing a multi-RPA visual detection technique.Compared with the traditional test strip detection method,this multi-RPA-CRISPR/Cas12a technique has the higher specificity,higher sensitivity,wider application range and lower cost.Compared with other polymerase chain reaction(PCR)techniques,it also has the advantages of low equipment requirements and visualization,making it a potentially feasible method for the field detection of GM plants.
文摘The Upper Cretaceous of Tantou Basin in western Henan has yielded many vertebrate fossils,which are featured by several non-avian dinosaurs.Meanwhile,studies on their eggs were yet inadequate though many eggshells have been reported.The newly discovered material 41HⅤ0199 was excavated from the Upper Cretaceous Qiupa Formation in 2021.The block preserves eight complete eggs arranged in two partial rings that form a partial clutch,and there are some scattered eggshells preserved closely with the block,showing a concave-up to concave-down ratio of 54.5:45.5,which indicates that the scattered eggshells come from the clutch and the clutch had been partially broken before it was buried.Based on morphological and microstructural characteristics,the eggs and eggshells can be assigned to Macroolithus yaotunensis(Elongatoolithidae),an oospecies known to be related to oviraptorids,which leads Yulong mini to be its probable producer.Besides,some eggshells show microstructural signs indicating egg retention,which marks the second example of egg retention in the oofamily Elongatoolithidae.
基金support from the National Natural Science Foundation of China(Grant Nos.52378411,52208404)China National Railway Group Limited Science and Technology Research and Development Program(Grant No.K2023G041).
文摘During strike-slip fault dislocation,multiple fault planes are commonly observed.The resulting permanent ground deformation can lead to profound structural damage to tunnels.However,existing analytical models do not consider multiple fault planes.Instead,they concentrate the entire fault displacement onto a single fault plane for analysis,thereby giving rise to notable errors in the calculated results.To address this issue,a refined nonlinear theoretical model was established to analyze the mechanical responses of the tunnels subjected to multiple strike-slip fault dislocations.The analytical model considers the number of fault planes,nonlinear soil‒tunnel interactions,geometric nonlinearity,and fault zone width,leading to a significant improvement in its range of applicability and calculation accuracy.The results of the analytical model are in agreement,both qualitatively and quantitatively,with the model test and numerical results.Then,based on the proposed theoretical model,a sensitivity analysis of parameters was conducted,focusing on the variables such as the number of fault planes,fault plane distance(d),fault displacement ratio(η),burial depth(C),crossing angle(β),tunnel diameter(D),fault zone width(Wf),and strike-slip fault displacement(Δfs).The results show that the peak shear force(Vmax),bending moment(Mmax),and axial force(Nmax)decrease with increasing d.The Vmax of the tunnel is found at the fault plane with the largest fault displacement.C,D,andΔfs contribute to the increases in Vmax,Mmax,and Nmax.Additionally,increasing the number of fault planes reduces Vmax and Mmax,whereas the variation in Nmax remains minimal.
基金financially supported by the National Natural Science Foundation of China(Nos.22106078,62105175)High-end Foreign Experts Recruitment Plan(No.G2023024007L)+1 种基金Shandong Provincial Natural Science Foundation(Nos.ZR2022YQ12,ZR2021QB031,ZR2021QF058)the Science,Education,and Industry Integration Pilot Project for Talent Research at Qilu University of Technology(Shandong Academy of Sciences)(No.2024RCKY028)。
文摘Mercury ions(Hg^(2+))and bacteria are widely spread in water pollution and pose a great threat to human health and the environment.Herein,a multifunctional COF Dmta Tph with significant Hg^(2+)adsorption capability and continuous sunlight-driven sterilization property is designed and synthesized by introducing thioether and photosensitive porphyrin in a single molecule.The obtained COF displays a high Hg^(2+)adsorption capacity of 657.9 mg/g at 298 K and a superior antibacterial effect toward Escherichia coli and Staphylococcus aureus under sunlight irradiation.Mechanistic studies reveal that the strong coordination between S species and Hg^(2+)is the main driving force for high Hg^(2+)adsorption capability.The sterilization mechanism clarifies that the inactivation of bacteria is caused by1O_(2)produced from Dmta Tph with the assistance of light irradiation.Noteworthy,when Dmta Tph is applied in the treatment of wastewater,it displays high Hg^(2+)removal efficiency and remarkable antibacterial effect under complex conditions.This study has demonstrated a promising strategy for designing multifunctional COF-based materials,offering great potential in tackling the problem of heavy metal ions and bacteria pollution in water.
基金supported by the National Natural Science Foundation of China(Grant Nos.42272008 and 41972002).
文摘The origins of peloidal micrites in reefal limestone are not yet well understood.Moscovian microbial reefs with abundant peloidal micrites from Guizhou,South China,provide an opportunity to study the peloids and their geological significance for this time interval.Three types of peloids are differentiated:microbial,lithic,and bioclastic peloids.Microbial peloids that are well-sorted and may form in situ by microbial activities.The poorly sorted lithic peloids are derived from erosion and redeposition of the micrite matrix caused by the bottom turbulence induced by periodic storms.Bioclastic peloids are completely micritized fragments of hard parts and shells.Microbial boring and encrustations promote the processes of micritization.Microbial peloids commonly develop in zones with low or normal energy levels,and contribute to the construction and stabilization of the framework.In contrast,the occurrence of lithic peloids reflects that the reefs are destroyed by bottom turbulence during growth.It is suggested that the microbial reefs were deposited under a dynamic balance between constructional versus destructive processes.By comparative analysis,the peloids as microbial in origin play a key role in the growth and stabilization of bioconstructions during Carboniferous,which should be paid more attention in the studies of Carboniferous buildups.
基金The Third Scientific Expedition Project in Xinjiang,No.2022xjkk0905Project Commissioned by the General Administration of Sport of ChinaProject Commissioned by the Ministry of Culture and Tourism of the People’s Republic of China。
文摘This study proposes a framework for the concept of“new quality productive forces”in the ice and snow economy(ISE)as a strategic response to global climate change and the demands of technological and industrial transformation for high-quality development.These new quality productive forces in the ISE have developed alongside the zonal distribution of natural resources,strictly adhere to ecological principles,and integrate value transformation mechanisms specific to ice and snow resources.Their development is projected to generate multiple benefits across ecological,economic,and social dimensions.The new quality productive forces in the ISE are characterized by technology-driven resource development,synergistic integration across the entire ice and snow industry value chain,and a focus on high-quality,green growth.Grounded in geography and economics,the new quality productive forces in the ISE link scientific innovation,the reallocation of productive factors,and industrial upgrading within the context of resource constraints.Furthermore,they expand the growth potential of the ISE by fostering new production relations through digital,intelligent,and green integration,while advancing low-carbon,sustainable development under the guiding principle that“ice and snow landscapes are also mountains of gold and silver.”For China's ISE,these new quality productive forces emphasize rigorous resource protection,balanced human-environment relationships,a resilient integrated supply chain framework,and an efficient“dual circulation”economic model.Practical strategies include integrating production factors,optimizing spatial resource allocation,fostering industrial synergy,and adapting production relations,all aimed at advancing the sustainable and high-quality development of China's ISE.
基金supported by the National Key Research and Devel-opment Project of China(2021YFD1600101)the earmarked fund for the China Agriculture Research System(CARS-12,CARS-13 and CARS-14)the Agricultural Science and Technology Innovation Program of Chinese Academy of Agricultural Sciences(CAAS-ASTIP-2024-OCRI).
文摘Flax(Linum usitatissimum L.)is an important oil crop in the high-altitude arid regions of China.Flaxseed is rich in various nutrients.However,the nutritional qualities of flaxseeds from different producing areas are still unclear.In this study,the nutritional characteristics of flaxseed from five producing areas in China were investigated.Twenty five nutritional quality indices in flaxseed were analyzed.Subsequently,chemometric methods,including cluster analysis,principal component analysis(PCA)and partial least square discriminant analysis(PLS-DA),were employed to discover the characteristics of nutritional qualities in flaxseeds.The results revealed there are significant differences in nutritional qualities among flaxseeds from different production areas.Six quality indices includingγ-tocopherol,vitamin E,phytosterols,oleic acid,α-linolenic acid,and cycloartenol were susceptible to producing area.In detail,the superiorcharacteristic nutrients of Ningxia flaxseed,Inner Mongolia flaxseed and Hebei flaxseed are vitamin E(17.3 mg/100g),α-linolenic acid(52.6%)and cycloartenol(1738.1 mg/kg),and phytosterols(3032.0 mg/kg),respectively.This study promotes the high-value development and utilization of local flaxseed industry.
文摘Objective:To explore the application value of a machine learning-based prediction model in assessing the prognosis of septic children in the pediatric intensive care unit(PICU)and provide data support for clinical decision-making.Methods:A total of 180 septic children admitted to the PICU of a tertiary hospital from January 2020 to December 2024 were selected.They were divided into a control group(90 cases,using traditional scoring methods to predict prognosis)and an observation group(90 cases,using a multivariable model based on machine learning algorithms to predict prognosis)according to the random number table method.General information,laboratory indicators,and clinical interventions were collected.Various models such as Random Forest(RF),Support Vector Machine(SVM),and Logistic Regression(LR)were established.The model performance was evaluated using ROC curve,AUC value,accuracy,sensitivity,and specificity.Results:The machine learning models performed better than traditional scoring methods in predicting the 28-day mortality rate of septic children.Among them,the RF model achieved an AUC value of 0.921,a sensitivity of 85.6%,and a specificity of 88.1%,which were significantly higher than the PIM3 score(AUC 0.762).The prediction accuracy and timeliness of clinical intervention in the observation group were significantly improved,leading to a shortened hospital stay and reduced mortality rate(p<0.05).Conclusion:The prediction model based on machine learning can more accurately assess the prognostic risk of septic children in PICU,showing good clinical application prospects and providing references for individualized treatment and optimal resource allocation.
文摘BACKGROUND Stroke is a leading cause of long-term disability worldwide,and limb motor dysfunction is one of the most common complications affecting the quality of life of patients.AIM To investigate the rehabilitation effects of conventional rehabilitation training combined with electromyographic biofeedback therapy on limb motor dysfunction in stroke survivors.METHODS This observational retrospective cohort study included 60 stroke survivors who underwent post-stroke rehabilitation training in the rehabilitation department of Qilu Hospital of Shandong University(Qingdao)from May 2023 to July 2024.The medical records of the patients were assessed.Eligible patients(N=60)were divided into two groups on the basis of the type of rehabilitation training received:Conventional rehabilitation alone(control group,n=30)and conventional rehabilitation combined with electromyographic biofeedback therapy(biofeedback group,n=30).Upper and lower limb motor function,wrist extension,balance ability,and ankle dorsiflexion range of motion were evaluated before treatment and at 4 weeks and 8 weeks post-treatment by reviewing the patients’electronic medical records.RESULTS At 4 weeks and 8 weeks post-treatment,the biofeedback group showed significantly better Fugl-Meyer assessment scores,Hospital Anxiety and Depression Scale scores,Hamilton Depression Rating Scale scores,Hamilton Anxiety Rating Scale scores,and wrist and ankle active range of motion scores than the control group.CONCLUSION Electromyographic biofeedback therapy combined with conventional rehabilitation can effectively improve upper and lower limb motor function,balance ability,activities of daily living,wrist extension,and ankle dorsiflexion dysfunction in patients post-stroke,with better efficacy than conventional rehabilitation alone.
