摘要
溃疡性结肠炎(ulcerative colitis, UC)是一种病因不明的慢性复发性非特异性炎症性肠病,主要引起结肠黏膜炎症,包括腹泻、便血、腹痛等胃肠道症状。由于通常用皮质类固醇、免疫抑制剂、生物制剂治疗,导致患者的免疫功能受到了一定的抑制作用,进而增加了机会性感染的风险。其中巨细胞病毒(cytomegalovirus, CMV)感染较为常见。因此,CMV感染是UC诱导和维持治疗中的一个棘手问题。故本文就UC合并CMV感染的流行病学、检测手段及治疗策略作一综述。
Ulcerative colitis (UC) is a chronic relapsing nonspecific inflammatory disease of unknown etiology, which mainly causes colonic mucosal inflammation and gastrointestinal symptoms such as diarrhea, blood in the stool, and abdominal pain. Due to the usual treatment with corticosteroids, immuno-suppressants, and biological agents, the patient’s immune function is inhibited to a certain extent, thereby increasing the risk of opportunistic infections. Among them, cytomegalovirus (CMV) infec-tion is more common. Therefore, CMV infection is a thorny problem in the induction and mainte-nance therapy of UC. Therefore, this article reviews the epidemiology, detection methods and treatment strategies of UC complicated with CMV infection.
出处
《临床医学进展》
2022年第8期7627-7633,共7页
Advances in Clinical Medicine
