摘要
目的 研究窒息新生儿抗凝和纤溶系统的变化及其临床意义。方法 采用ELISA法和免疫浊度法测定重度窒息组 2 7例、非重度窒息组 18例和正常对照组 15例足月新生儿的血浆蛋白(PC)、总蛋白S(TPS)、抗凝血酶Ⅲ (AT Ⅲ )、D 二聚体 (D D)、血管性假血友病因子 (vWF)。结果 重度窒息组新生儿血浆PC、TPS、AT Ⅲ低于对照组和轻度窒息组 ,D D、vWF明显高于对照组和轻度窒息组。轻度窒息组和正常对照组各指标均无明显差别。结论 重度窒息新生儿存在抗凝、纤溶系统的激活及血管内皮细胞损伤 。
Objective To study the changes of anticoagulation and fibrinolysis in full-term newborns with asphyxia.Methods The levels of plasma protein C(PC),total protein S(TPS),Antithrombin Ⅲ(AT-Ⅲ),D-Dimer(D-D) and von Willebrand Factor(vWF) were measured with ELSIA assay and immunoturbidimetry in 27 cases full-term newborns,with asphyxia 18 cases non-asphyxia full-term newborns and 15 cases normal full-term newborns as controls.Results The levels of PC,TPS and AT-Ⅲ were lower,but the lev-els of D-D and vWF were significantly higher than those of normal controls,there are no difference between non-asphyxia full-term newborns and normal controls.Conclusion There existed the activation of anticoagulation and fibrinolysis and the injury of vascular endothelium in asphyxia full-term newborns,and they are early and sensitive indexes for the diagnosis of disseminated intravascular coagulation(DIC).
出处
《小儿急救医学》
2004年第3期156-158,共3页
Pediatric Emergency Medicine
