摘要
目的 探讨新生儿呼吸窘迫综合征 (NRDS)抗凝和纤溶系统变化及其临床意义。方法 采用ELISA法和免疫浊度法分别测定普通早产儿 2 0例、NRDS患儿 2 7例和健康足月儿 15例血浆蛋白C(PC) ,总蛋白S(TPS)、抗凝血酶Ⅲ (AT Ⅲ )、D 二聚体 (D D)、血管性假性血友病因子 (vWF)水平。结果 NRDS患儿血浆PC、TPS、AT Ⅲ低于普通早产儿和健康足月儿 ,D D、vWF明显高于普通早产儿和健康足月儿 ,普通早产儿PC、TPS低于足月儿 ,AT Ⅲ、D D、vWF则无明显差异。结论 NRDS患儿存在抗凝及纤溶系统的激活及血管内皮细胞损伤 。
Objective To study the changes of anticoagulation and fibrinolysis in neonatal respiratory distress syndrome(NRDS).Methods The levels of plasma protein C(PC),total protein S(TPS),antithrombin Ⅲ(AT-Ⅲ), D-Dimer(D-D) and von Willebrand factor(vWF) were measured with ELSIA assay and immunoturbidimetry in 27 cases NRDS, 20 cases prematures and 15 cases full-term newborns as normal controls.Results The levels of PC, TPS and AT-Ⅲ were lower, but the levels of D-D and vWF were significantly higher than those of prematures and normal controls.The PC,TPS of prematures were lower than normal controls otherwise there is no difference of AT-Ⅲ,D-D,vWF between prematures and normal controls. Conclusions There exists the activation of anticoagulation and fibrinolysis and the injury of vascular endothelium in critical NRDS, and they are early sensitive indexes for the diagnosis of disseminated intravascular coagulation(DIC).
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2004年第4期271-273,共3页
Journal of Applied Clinical Pediatrics
关键词
婴儿
新生
呼吸窘迫综合征
纤维蛋白
纤溶酶原
newborns
neonatal respiratory distress syndrome
blood coagulation
fibrinolysis
